Supplementary table 1. Primer sequences of selected genes used in quantitative RT-PCR analysis

Genes / Primer sequence / Fragment size (bp) / Annealing temperatures (0C)
26S / FP 5’-CACAATGATAGGAAGAGCCGAC-3’
RP 5’-CAAGGGAACGGGCTTGGCAGAATC-3’ / 500 / 58
HK / FP 5’-ATGCTCCTTACCTACGTTCA-3’
RP 5’-TCCTAACTGAACCCTCAAGA-3’ / 108 / 52
PK / FP 5’-AGCTTGTGGCTAAGTACAGG-3’
RP 5’-TCCCCTGAATATGAGACTGT-3’ / 128 / 53
ICDH / FP 5’-TCGACATGATAACGTGGATA-3’
RP 5’-TGTTATGACCTTGAGGCTCT-3’ / 112 / 52
MDH / FP 5’-CTGATTCTCAAGGAATTTGC-3’
RP 5’-TACCTGCACTTTCAACCTCT-3’ / 114 / 51
G-6-PDH / FP 5’-GAAACCTGAGCATATTCGAG -3’
RP 5’-GTTGTCTGGAACTGTTGGAT -3’ / 124 / 52
DAHPS / FP 5’-ACACCATTAAAGCTCCTTGT -3’
RP 5’-TAACAGTCTGAGATCCACCA -3’ / 171 / 59
PAL / FP 5’- GCAAGATAGATACGCTCTAA-3’
RP 5’- GTTCCTTGAGACGTCAAT-3’ / 136 / 49
DXPS / FP 5’-ACATTTAAGTTCAAGTCTGGGAGTG-3’
RP 5’-ATGTGCACTCTCTTCTCTTTTAGGA-3’ / 110 / 56
ISPD / FP 5’-GAGAAAAGTGTATCTGTGCTTCTTAG-3’
RP 5’-AATAACCTGCGGTGTATGCATTTCC-3’ / 150 / 56
HMGR / FP 5’-CGTTCATCTACCTTCTAGGGTTCTT-3’
RP 5’-GACATAACAACTTCTTCATCGTCCT-3’ / 100 / 60
PMK / FP 5’-TGGATGTTGTCGCATCAGCACCTGG-3’
RP 5’-GTAATAGGCAGTCCACTCGCTTCAA-3’ / 100 / 58
GS / FP 5’-TGGGTAGATTAGAAGCCAGA -3’
RP 5’-CTGGTGATTTCTACCAGCTC -3’ / 139 / 52
G-10-H / FP 5’-TATCGAGCTTTTCAGTGGAT -3’
RP 5’-GATGTGAGTCCTGTCGATTT -3’ / 136 / 52

Supplementary table 2. Variation observed based upon squared cosine values for genes and their PC’s

Gene / F1 / F2 / F3 / F4
PAL / Obs1 / 0.340 / 0.241 / 0.287 / 0.132
DAHPS / Obs2 / 0.927 / 0.055 / 0.003 / 0.015
DXPS / Obs3 / 0.857 / 0.065 / 0.077 / 0.001
ISPD / Obs4 / 0.057 / 0.926 / 0.017 / 0.000
G-6-PDH / Obs5 / 0.875 / 0.050 / 0.074 / 0.000
G-10-H / Obs6 / 0.899 / 0.004 / 0.041 / 0.056
GS / Obs7 / 0.652 / 0.237 / 0.030 / 0.081
HK / Obs8 / 0.957 / 0.002 / 0.023 / 0.018
PK / Obs9 / 0.783 / 0.059 / 0.000 / 0.157
HMGR / Obs10 / 0.868 / 0.023 / 0.104 / 0.005
PMK / Obs11 / 0.774 / 0.023 / 0.198 / 0.005
ICDH / Obs12 / 0.563 / 0.108 / 0.310 / 0.019
MDH / Obs13 / 0.955 / 0.042 / 0.002 / 0.002

Supplementary table 3. Abbreviations in Figure 1.

Abbreviations / Name / Abbreviations / Name
G-6-P / Glucose-6-phosphate / PGmu / Phosphoglycerate mutase
F-6-P / Fructose-6-phosphate / PK / Pyruvate kinase
F-1,6-BP / Fructose-1,6-bisphosphate / ICDH / Isocitrate dehydrogenase
DHAP / Dihydroxyacetonephosphate / MDH / Malate dehydrogenase
G-3-P / Glyceraldehyde-3-phosphate / AKG DH complex / Α- keto glutarate dehydrogenase complex
1,3-BPG / 1,3-bisphosphoglycerate / G6PDH / Glucose-6-phosphate dehydrogenase
3-PG / 3-phosphoglycerate / 6PGDH / 6-Phosphogluconate dehydrogenase
2-PG / 2-phosphoglycerate / Ru-5-PI / Ribulose-5-phosphate isomerase
PEP / Phosphoenolpyruvate / Ru-5-PE / Ribulose-5-phosphate 3-epimerase
6-PGL / 6-phosphogluconolactone / TK / Transketolase
Ru-5-P / Ribulose-5-phosphate / DAHPS / 3-Deoxy-D-arabinoheptulosonate 7-phosphate synthase
Ri-5-P / Ribose-5-phosphate / DHQS / Dehydroquinate synthase
X-5-P / Xylulose-5-phosphate / DHQD / Dehydroquinate dehydratase
S-7-P / Sedoheptulose-7-phosphate / SD / Shikimate dehydrogenase
E-4-P / Erythrose-4-phosphate / SK / Shikimate kinase
DOXP / 1-deoxy-D-xylulose-5-phosphate / EPSPS / 5-enolpyruvylshikimate-3-phosphate synthase
MEP / 2-C-methyl-D-erythritol / CS / Chorismate synthase
CDP-ME / 4-(CDP)-2-methyl-D-erythritol / CM / Chorismate mutase
CDP-ME 2-P / 4-(CDP)-2-methyl-D-erythritol 2-phosphate / PPA-AT / Prephenate aminotransferase
CME-PP / 2-C-methyl-D-erythritol 2,4-cyclopyrophosphate / ADT / Arogenate dehydratase
HMBPP / 1-hydroxy-2-methyl 2-(E)-butenyl-4-pyrophosphate / PAL / Phenylalanine ammonia lyase
IPP / Isopentenyl pyrophosphate / DXPS / 1-deoxy-D-xylulose-5-phosphate synthase
DMAPP / Dimethylallyl pyrophosphate / DXPR / 1-deoxy-D-xylulose-5-phosphate reductoisomerase
DAHP / 3-Deoxy-D-arabinoheptulosonate 7-phosphate / ISPD / 4-diphosphocytidyl-2C-methyl-D-erythritol synthase
DHQ / 3-dehydroquinate / ISPE / 4-diphosphocytidyl-2C-methyl-D-erythritol kinase
DHS / 3-dehydroshikimate
EPSP / 5-enolpyruvylshikimate-3-phosphate / MECPS / 2-C-methyl-D-erythritol 2,4-cyclopyrophosphate synthase
Phe / Phenylalanine / HDS / 1-hydroxy-2-methyl 2-(E)-butenyl-4-pyrophosphate synthase
HMG CoA / 3-hydroxy-3-methylglutaryl coenzyme A / ISPH / 1-hydroxy-2-methyl 2-(E)-butenyl-4-pyrophosphate reductase
GPP / Geranyl pyrophosphate / IPPI / Isopentenyl pyrophosphate delta-isomerase
8-epideoxy LA / 8-epideoxy loganic acid / AACT / Acetoacetyl-CoA thiolase
MA / Mussaenosidic acid / HMGS / Hydroxymethylglutaryl-CoA synthase
Deoxy GPA / Deoxy geniposidic acid / HMGR / Hydroxymethylglutaryl-CoA reductase
GPA / Geniposidic acid / MVK / Mevalonate kinase
HK / Hexokinase / PMK / Phosphomevalonate kinase
PGI / Phosphoglucose isomerise / PMD / Diphosphomevalonate decarboxylase
PFK / Phosphofructokinase / GPPS / Geranyl pyrophosphate synthase
TPI / Triosephosphate isomerase / GS / Geraniol synthase
GAPDH / Glyceraldehyde-3-phosphate dehydrogenase / G-10-H / Geraniol-10-hydroxylase
PGK / Phosphoglycerate kinase / TCA / Tricarboxylic acid