Supplementary Table 1. Predictive values of lymphocyte phenotyping in autoimmune diseases.

Study / Predictive factor / Cut-off / Sensitivity / Specificity / PPV / NPV
Fedele 2014 [16] / IgD+CD27- naïve B cells / 60% / 75.0% / 53.0% / NA / NA
Ponchel 2014 [21] / CD4+CD45RBhighCD45RA+CD62L+ naïve T cells / 68% / 79.0% / 62.0% / 66.0% / 76.0%
Kuuliala 2015 [73] / pSTAT3 in CD4+ and CD8+ T cells / NA / NA / NA / NA / NA
Citro 2015 [78] / Apoptotic-epitope specific CD8+ T cells / NA / NA / NA / NA / NA
Daien 2014 [22] / CD27+ memory B cells / 26% / 92.0% / 71.0% / 85.0% / 83.0%
Chen 2011 [24] / Th17 cells / ≥ 40pg/mL / 66.7% / 83.3% / NA / NA
Daien 2015 [28] / CD3-CD56+ NK cells / NA / NA / NA / NA / NA
Kikuchi 2015 [79] / No association / No association
Scarsi 2010 [33] / No association / No association
Scarsi 2011 [34] / CD4+CD28– T cells / < 28 cells/μL / 60.0% / 77.3% / NA / NA
Gazeau 2016 [35] / B cells / ≥ 265cells/mm3 / 57.1% / 100.0% / 100.0% / 57.1%
Roll 2008 [36] / CD27+ B cells / no association
Möller 2009 [37] / IgD+CD27- naive B cells / NA / NA / NA / NA / NA
Vital 2010 [38] / CD19+/-CD27++CD38++ pre-plasmablasts cells / NA / NA / NA / NA / NA
Brezinschek 2012 [39] / CD19+IgD-CD27++(+/-CD38hi) plasmablasts / NA / NA / NA / NA / NA
Sellam 2011 [40] / Naïve B cells and CD27+ memory B cells / NA / NA / NA / NA / NA
Stradner 2016 [42] / Total lymphocytes (Ly) and plasmablasts / Ly 2910/μL + plasmablasts >2.85% / 93.3% / 44.8% / NA / NA
Adlowitz 2015 [80] / No association / No association
Lacki 1997 [49] / No association / No association
Jónsdóttir 2008 [56] / CD19+lymphocytes / NA / NA / NA / NA / NA
Lindholm 2008 [55] / CD19+ B cells / NA / NA / NA / NA / NA
Furie 2008 [57] / CD20+ / 5% / NA / NA / NA / NA
Stohl 2012 [58] / No association / No association
Delli 2016 [65] / B cells / NA / NA / NA / NA / NA
Cornec 2016 [64] / CD20+ B cells / NA / NA / NA / NA / NA
Cornec 2016 [63] / Focus score / NA / NA / NA / NA / NA
Seror 2015 [69] / NK cells / NA / NA / NA / NA / NA

NA: not available; NPV: negative predictive value; PPV: positive predictive value.