Supplementary Table 1 Patient Characteristics of Study Subjects Included in the Systematic

Supplementary Table 1 Patient characteristics of study subjects included in the systematic meta-analyses

Author / Year / Country / Averageage / Diagnostic criteria / TP / FP / FN / TN / Sens-
itivity / Specif-icity / Pretreatment
PSA (ng/ml)
11C-choline PET/CT
Kitajima et al. / 2014 / America / 65.7 / Histopathologic findings or PSA level / 118 / 3 / 37 / 120 / 76% / 97% / 5.26(0.58-68.3)
Jilg et al. / 2014 / America / 60.6 / Histopathological analysis / 102 / 26 / 9 / 23 / 92% / 47% / 23.3±31.2(2.6-191.3)
Heck et al. / 2014 / Germany / 66.0 / Morphological / 8 / 3 / 6 / 30 / 57% / 90% / 22 (7-29)
Mitchell et al. / 2013 / America / 71.7 / Histopathological analysis / 106 / 11 / 8 / 35 / 93% / 76% / 7.1 (0.0-102.0)
Giovacchiniet al. / 2012 / Switzerlad / 67.0 / Histology / 11 / 1 / 59 / 4 / 90% / 44% / 0.71±0.33(0.23-1.49)
Picchio et al. / 2012 / Italy / 69.0 / PSA level / 24 / 0 / 3 / 51 / 89% / 100% / 21.1
Bergh et al. / 2011 / Germany / 65.9 / Epstein criteria / 363 / 390 / 106 / 317 / 77% / 45% / 10.8 (1.5-70.9)
Budiharto et al. / 2011 / Belgium / 64.6 / Diffusion-weighted imaging / 3 / 1 / 13 / 19 / 19% / 95% / 14.6
Contractor et al. / 2011 / UK / 67.7 / Cross-sectional imaging / 7 / 3 / 2 / 14 / 78% / 82% / 44.25 (8.1-209)
Bertagna et al. / 2011 / Italy / 70.0 / PSA elevation / 6 / 3 / 4 / 32 / 60% / 91% / 5.9
Watanable et al. / 2010 / Japan / 72.2 / Histopathological confirm / 19 / 7 / 7 / 10 / 73% / 59% / 6.7 (2.5-335.3)
Breeuwsma et al. / 2010 / Germany / 71.0 / Histopathological analysis / 57 / 0 / 13 / 10 / 81% / 100% / 23.2 (0.6-54.7)
Fuccio et al. / 2010 / Italy / 70.2 / Imaging data / 19 / 0 / 3 / 3 / 86% / 100% / 11.1 (0.2-37.7)
Giovacchini et al. / 2010 / Italy / 67.0 / Histopathological analysis/ Imaging data/clinical / 145 / 14 / 26 / 173 / 85% / 93% / 3.77
Giovacchini et al. / 2010 / Italy / 68.0 / Histopathological analysis/ Imaging data/clinical / 65 / 10 / 10 / 85 / 87% / 89% / 3.24(0.23-48.6)
Winter et al. / 2010 / Germany / 61.7 / Updated Epstein criteria / 6 / 0 / 0 / 10 / 100% / 100% / 3.04 (0.5-9.55)
Rinnab et al. / 2009 / Germany / 65.0 / Standard uptake value / 29 / 7 / 2 / 3 / 93% / 36% / 25.7 (3.8-176)
Winter et al. / 2009 / Germany / 60.8 / PSA elevation / 9 / 2 / 0 / 12 / 100% / 86% / 3.04 (0.5-9.55)
Li et al. / 2008 / China / 70.6 / Histopathological analysis / 19 / 4 / 2 / 24 / 90% / 86% / 24.5 (1.1-100)
Schiavina et al. / 2008 / Italy / 65.0 / LN metastasis prediction / 9 / 1 / 6 / 41 / 60% / 98% / 16.5 (0.6-70.0)
Giovacchini et al. / 2008 / Italy / 66.0 / Visual assessment / 48 / 27 / 19 / 20 / 72% / 43% / 11.9 (0.2-33)
Reske et al. / 2008 / Germany / 68.0 / Imaging analysis / 23 / 4 / 10 / 12 / 70% / 75% / 2 (0.3-12.1)
Scher et al. / 2007 / Germany / 64.0 / Histopathological examination / 32 / 8 / 5 / 13 / 86% / 62% / 2.4-266
Igerc et al. / 2007 / Austria / 63.5 / Tracer uptake defined as abnormal / 5 / 8 / 0 / 7 / 100% / 47% / 14.06(5.75-
70.8)
Testa et al. / 2007 / Italy / 64.0 / Tholine-plus-creatine to citrate ratios / 53 / 8 / 45 / 50 / 54% / 86% / 13.9 (2.5-70)
Rinnab et al. / 2007 / Germany / 65.9 / PSA levels / 38 / 6 / 2 / 4 / 95% / 40% / 3.62(0.41-13.1)
Scattoni et al. / 2007 / Italy / 65.5 / Morphologic criteria / 19 / 2 / 0 / 4 / 100% / 67% / 4.01 (6.0-18.0)
Reske et al. / 2006 / Germany / 64.0 / Histopathological criteria / 363 / 61 / 86 / 426 / 81% / 87% / 14.4 (2.8-64.3)
Martorana et al. / 2006 / Italy / 64.0 / Radical prostatectomy histopathology / 107 / 15 / 56 / 80 / 66% / 84% / 12 (2.5-70)
Farsad et al. / 2005 / Italy / 64.0 / Step-section histopathologic result / 35 / 3 / 1 / 2 / 97% / 42% / 12.3 (2.0-70)
Kotzerke et al. / 2000 / Germany / 63.0 / Unclear / 1 / 1 / 1 / 9 / 50% / 90% / 23.5 (4.3-76.2)
18F-FCH PET/CT
Poulsen et al. / 2012 / Denmark / 65.5 / Histological result / 30 / 21 / 11 / 148 / 73% / 87% / 20.3 (1-108)
Oprea-Lager et al. / 2012 / Sweden / 63.0 / Histological result / 35 / 1 / 2 / 16 / 95% / 94% / --
Panebiancoet al. / 2012 / Italy / -- / TRUS-biopsy result
/ PSA level / 48 / 2 / 4 / 1 / 92% / 33% / 1.9
Langsteger et al. / 2011 / Austria / 66.0 / European Medicines Agency / 20 / 2 / 2 / 16 / 91% / 89% / --
McCarthy et al. / 2011 / Austria / -- / 150 / 1 / 6 / 26 / 96% / 96% / 1.6-250
Beheshti et al. / 2010 / Austria / 68.0 / FCH-PET and CT / 207 / 3 / 56 / 96 / 79% / 97% / 39.65 (0.1-239)
Beheshti et al. / 2010 / Austria / 63.0 / FCH-PET and CT / 18 / 4 / 22 / 86 / 45% / 96% / 27 (0.25-462)
Poulsen et al. / 2010 / Denmark / 66.2 / Histological result / 3 / 1 / 0 / 21 / 100% / 95% / 20.1 (6-60)
Steuber et al. / 2010 / Germany / 65.0 / Morphologic criteria / 0 / 0 / 31 / 254 / 0% / 100% / 8.1-27
Pelosi et al. / 2008 / Italy / 68.0 / Serum PSA testing / 24 / 1 / 5 / 26 / 83% / 96% / 4.59 (0.1-39)
Pelosi et al. / 2007 / Italy / 67.9 / Unclear / 24 / 1 / 0 / 26 / 100% / 96% / 7.15 ± 9.77
Husarik et al. / 2007 / Switzerland / 63.0 / Histopathological analysis / 1 / 0 / 2 / 22 / 50% / 100% / 11.58 (0.6-162)
Vees et al. / 2007 / Switzerland / 62.0 / Unclear / 3 / 2 / 5 / 1 / 38% / 33% / 0.35(0.11-0.73)
Hacker et al. / 2006 / Austria / 63.9 / McNemar test / 1 / 2 / 9 / 8 / 10% / 80% / 27.1 (9.2-100)
Kwee et al. / 2005 / America / 69.0 / histology / 64 / 17 / 5 / 16 / 93% / 48% / 1.5-222
11C-acetate PET/CT
Haseebuddin et al. / 2013 / America / 61.0 / Histological findings / 17 / 18 / 8 / 64 / 68% / 78% / 11.8(1.4-225.4)
Mena et al. / 2012 / America / 58.0 / Multiparametric MRI and pathology / 47 / 37 / 17 / 66 / 73% / 64% / 7.03 ± 8.88 (1.07-53.5)
Jambor et al. / 2012 / Finland / 65.0 / MRI / 44 / 13 / 6 / 9 / 88% / 41% / --
Jambor et al. / 2010 / Finland / 63.9 / Biopsy findings / 28 / 5 / 7 / 2 / 80% / 29% / 10.1 ± 6.8 (2.9-30.0)
Wachter et al. / 2006 / Austria / 66.0 / Unclear / 12 / 1 / 1 / 3 / 92% / 75% / --
18F-FDG PET/CT
Yang et al. / 2014 / China / 66.3 / PSA levels or metastatic lesions / 13 / 25 / 7 / 55 / 65% / 68% / --
Damle et al. / 2013 / India / 65.0 / McNemar test / 23 / 0 / 9 / 17 / 72% / 100% / --
Hwang et al. / 2012 / Korea / 73.0 / DRE, PSA, biopsy / 20 / 65 / 3 / 32 / 87% / 33.3% / --
Shiiba et al. / 2012 / Japan / 72.4 / Gleason score and histological type / 58 / 18 / 36 / 72 / 62% / 80% / 181.3 ± 433.2
Minamimoto et al. / 2010 / Japan / 68.3 / FDG / 27 / 36 / 25 / 112 / 52% / 76% / --
TRTE
Nygard et al. / 2014 / Norway / 64.2 / D’Amico criteria / 27 / 11 / 37 / 52 / 42% / 83% / 9.2 (2.2-14.4)
Xu et al. / 2014 / China / 68.8 / Repeat biopsy / 35 / 44 / 16 / 100 / 69% / 69% / 4-10
Zhang et al. / 2014 / China / 66.6 / Systematic biopsy / 17 / 4 / 5 / 16 / 78% / 79% / --
Brocket al. / 2013 / Germany / 63.4 / Histopathologic findings / 27 / 8 / 29 / 22 / 49% / 74% / --
Taverna et al. / 2013 / Italy / 64.5 / PSA,DRE, Biopsy sampling / 7 / 25 / 22 / 48 / 24% / 66% / 5.92 (2.5-10)
Rausch et al. / 2012 / Germany / 63.8 / 10-12 core Randomised prostate biopsy / 121 / 36 / 111 / 98 / 52% / 73% / 6.40
Zhang et al. / 2012 / China / 68.6 / Biopsy specimens result / 35 / 6 / 12 / 30 / 75% / 83% / --
Giurgiu et al. / 2011 / Romania / 68.0 / Histopathology findings / 19 / 14 / 9 / 23 / 68% / 62% / --
Kapoor et al. / 2011 / India / 62.1 / 10-core Biopsy / 11 / 5 / 1 / 33 / 92% / 87% / 12.6 (9.8-14.4)
Yan et al. / 2011 / China / 69.6 / Gleason score / 44 / 10 / 4 / 26 / 92% / 72% / --
Aigner et al. / 2010 / America / 57.4 / 10-core Systematic biopsy / 20 / 31 / 3 / 40 / 87% / 56% / --
Romagoli et al. / 2010 / Italy / 66.8 / Biopsy / 18 / 11 / 14 / 65 / 56% / 86% / 14
Tsutsumi et al. / 2010 / Japan / 65.0 / Biopsy / 86 / 29 / 20 / 157 / 81% / 84% / 13.3 (4.1-94)
Ferrari et al. / 2009 / Italy / 61.3 / Biopsy / 20 / 11 / 19 / 34 / 51% / 75% / --
Eggert et al. / 2008 / Germany / -- / PSA levels / 84 / 18 / 105 / 144 / 45% / 89% / --
Kamoi et al. / 2008 / Japan / 68.4 / Biopsy / 27 / 13 / 13 / 54 / 68% / 81% / --
Pallwein et al. / 2008 / Austria / -- / Strain imaging findings / 146 / 91 / 22 / 233 / 87% / 72% / --
Pallwein et al. (1) / 2007 / Austria / 62.3 / Systematic biopsy / 68 / 91 / 13 / 58 / 84% / 49% / ≥ 1.25
Pallwein et al. (2) / 2007 / Austria / 56.0 / Histopathological findings / 28 / 4 / 7 / 81 / 80% / 95% / 4.6 (1.4-16.1)
Sumura et al. / 2007 / Japan / 69.1 / Pathological results / 30 / 13 / 12 / 97 / 71% / 88% / 10.5 (3.7-50.7)
Tsutsumi et al. / 2007 / Japan / 64.0 / Clinicopathological findings / 141 / 71 / 32 / 108 / 82% / 60% / 11 (3.2-32)
Cochlin et al. / 2002 / UK / 64.0 / Grey-scale images and Biopsy / 24 / 9 / 23 / 44 / 51% / 83% / 12 (5-200)
SWE
Correas et al. / 2015 / UK / 65.0 / Transrectal US–guided systematic biopsy results / 124 / 143 / 5 / 808 / 96% / 85% / 7.07 (0.2-60)
Ahmad et al. (1) / 2013 / UK / 69.0 / Histopathology / 30 / 2 / 3 / 15 / 90% / 88% / < 20
Ahmad et al. (2) / 2013 / UK / 69.0 / Histopathology / 31 / 1 / 2 / 16 / 93% / 93% / > 20
Barr et al. / 2012 / America / 64.2 / Biopsy / 25 / 11 / 1 / 281 / 96% / 96% / 5.05