Supplementary Table 1. Median survival age, 15-year survival and standardized mortality rate according to plasma YKL-40 percentile category or smoking status in 7136 participants from the general populations without diagnosis of cancer, ischemic cardiovascular disease or other diseases at the time of blood sampling.
Risk Factor / Median survival age, years(95% confidence interval) / 15-year survival, %
(95% confidence interval) / Standardized mortality rate per 10,000 person-years
(95% confidence interval)
YKL-40 percentile category / All Women Men / All Women Men / All Women Men
0-33% (n=2485) / 84 (84-85) 87 (85-88) 82 (80-83) / 75 (73-76) 77 (74-79) 72 (69-74) / 29 (26-32) 22 (19-26) 39 (33-44)
34-66% (n=2364) / 83 (82-84) 86 (84-87) 79 (77-81) / 73 (70-75) 74 (72-77) 70 (67-73) / 32 (28-35) 24 (20-28) 44 (38-49)
67-90% (n=1642) / 80 (78-82) 84 (82-85) 76 (73-77) / 67 (64-69) 69 (65-72) 65 (61-68) / 43 (38-47) 31 (25-37) 60 (52-69)
91-95% (n=345) / 73 (69-77) 79 (74-81) 68 (62-73) / 61 (56-66) 65 (58-72) 55 (46-63) / 70 (56-83) 50 (37-64) 100 (74-125)
96-100% (n=300) / 72 (67-75) 78 (74-83) 66 (59-70) / 52 (46-58) 59 (50-68) 44 (35-53) / 82 (65-98) 52 (0-∞) 121 (92-151)
Smoking status
Never / 88 (87-90) 88 (87-90) 87 (84-92) / 81 (79-83) 77 (74-79) 89 (86-92) / 18 (15-20) 17 (14-20) 20 (14-25)
Previous / 85 (84-86) 88 (86-89) 81 (80-83) / 70 (67-72) 74 (71-76) 65 (62-68) / 28 (24-32) 20 (14-25) 37 (32-42)
Current / 78 (77-79) 81 (80-82) 74 (73-75) / 66 (64-68) 70 (67-72) 62 (59-64) / 52 (48-56) 39 (35-44) 68 (62-74)
Based on participants from The Copenhagen City Heart Study 1991-1994 examination followed for 16 years. Mortality rate was standardized according to the WHO standard population (Segi: (28).
Supplementary Table 2. Multifatorially* adjusted hazard ratios for early death by plasma YKL-40 percentile category including
adjustment for regression dilution bias
Multifactorially* adjusted hazard ratio by sex and 10-year age-groups percentile of YKL-40 (95% confidence interval)Population / 0-33% / 34-66% / 67-90% / 91-95% / 96-100%
All / 1.0 / 1.1 (1.0-1.3) / 1.4 (1.2-1.6) / 2.0 (1.6-2.4) / 2.2 (1.8-2.7)
Plasma CRP ≤ 1.75 mg/L / 1.0 / 1.0 (0.8-1.2) / 1.4 (1.1-1.7) / 2.1 (1.5-3.1) / 2.7 (1.9-3.9)
Plasma CRP > 1.75 mg/L / 1.0 / 1.2 (1.0-1.4) / 1.3 (1.1-1.6) / 1.8 (1.4-2.3) / 1.9 (1.5-2.5)
Never smokers / 1.0 / 1.0 (0.7-1.3) / 1.6 (1.1-2.2) / 2.8 (1.6-4.8) / 3.0 (1.7-5.6)
Ever smokers / 1.0 / 1.2 (1.0-1.3) / 1.4 (1.2-1.5) / 1.9 (1.5-2.4) / 2.1 (1.7-2.6)
Participants with cancer§ / 1.0 / 1.1 (0.9-1.3) / 1.2 (1.0-1.5) / 1.7 (1.2-2.3) / 2.0 (1.4-2.7)
Participants with ischemic cardiovascular disease§ / 1.0 / 1.2 (1.0-1.4) / 1.3 (1.1-1.6) / 2.1 (1.5-2.9) / 1.8 (1.3-2.5)
Participants with other diseases§# / 1.0 / 1.1 (0.9-1.3) / 1.2 (1.0-1.4) / 1.5 (1.1-2.0) / 1.8 (1.4-2.4)
Numbers of participants vary slightly depending for availability of data. CRP, C-reactive protein. *Hazard ratios were adjusted for gender, age (deciles), and smoking habits (never/previous/current smokers), body mass index, alcohol consumption, plasma cholesterol, systolic blood pressure, physical activity, CRP, and earlier diseases at the time of blood sampling, and corrected for regression dilution bias. §Includes participants with disease prior to and after baseline.
#Diabetes, chronic obstructive pulmonary disease, asthma, rheumatoid arthritis, inflammatory bowel disease, pneumonia, and benign liver disease. Some participants had more than one disease.
Supplementary Table 3. Multifatorially* adjusted hazard ratios for early death by plasma YKL-40 percentile category, disease and timing of blood sampling
Disease
Timing of blood sampling / Participants/Events / 0-33% / 34-66% / 67-90% / 91-95% / 96-100% / P for Trend
Participants with cancer
Diagnosed after blood sampling / 1530/955 / 1.0 / 1.0 (0.9-1.2) / 1.1 (0.9-1.3) / 1.6 (1.2-2.1) / 1.8 (1.4-2.5) / 0.0002
Participants with ischemic cardiovascular disease
Diagnosed after blood sampling / 1441/805 / 1.0 / 1.1 (0.9-1.3) / 1.2 (1.0-1.5) / 1.8 (1.3-2.4) / 1.8 (1.3-2.4) / 0.0003
Participants with other diseases# / 1.0
Diagnosed after blood sampling / 2087/1128 / 1.0 / 1.1 (0.9-1.3) / 1.2 (1.1-1.4) / 1.4 (1.1-1.9) / 1.6 (1.2-2.0) / 0.0004
*Hazard ratios were multifactorially adjusted for gender, age (deciles), and smoking habits (never/previous/current smokers), body mass index, alcohol consumption, plasma cholesterol, systolic blood pressure, physical activity, CRP and other diseases at time of blood sampling.
#Other diseases: Diabetes, chronic obstructive pulmonary disease, asthma, rheumatoid arthritis, inflammatory bowel disease, pneumonia, and benign liver disease. Some participants had more than one disease.