Supplementary Table 1 Genotypes and Estimated Allele Prevalence of Apolipoprotein E (APOE)

Supplementary Table 1 Genotypes and estimated allele prevalence of apolipoprotein E (APOE) polymorphism in subjects with no cognitive impairment (NoCI) according to different age groups.

50 ≤ Age ≤ 65 / 65 < Age ≤ 80 / Age > 80 / Group 1 vs. Group 2 / Group 1 vs. Group 3
(Group 1) / (Group 2) / (Group 3) / p / OR / (95% CI) / p / OR / (95% CI)
e2/e2 / 1 / (0.64%) / 1 / (0.37%) / - / - / 0.999 / 0.561 / (0.015 – 20.763) / 0.498 / - / -
e2/e3 / 14 / (8.97%) / 32 / (11.76%) / 17 / (12.06) / 0.510 / 1.283 / (0.627 – 2.657) / 0.703 / 1.192 / (0.526 – 2.710)
e2/e4 / 3 / (1.92%) / - / - / 3 / (2.13%) / 0.048 / - / - / 0.999 / 0.981 / (0.154 – 6.253)
e3/e3 / 105 / (67.31%) / 187 / (68.75%) / 107 / (75.89%) / Reference / Reference
e3/e4 / 33 / (21.15%) / 51 / (18.75%) / 13 / (9.22%) / 0.608 / 0.868 / (0.512 – 1.474) / 0.009 / 0.387 / (0.181 – 0.813)
e4/e4 / - / - / 1 / (0.37%) / 1 / (0.71%) / 0.999 / - / - / 0.999 / - / -
HWE / p = 0.479 / p = 0.184 / p = 0.428
e2 / 19 / (0.061) / 34 / (0.063) / 20 / (0.071) / 0.999 / 1.006 / (0.453 – 1.875) / 0.868 / 1.109 / (0.552 – 2.230)
e3 / 257 / (0.824) / 457 / (0.840) / 244 / (0.865) / Reference / Reference
e4 / 36 / (0.115) / 53 / (0.097) / 18 / (0.064) / 0.416 / 0.828 / (0.516 – 1.331) / 0.032 / 0.527 / (0.279 – 0.987)

Group2 vs. Group 3

Genotypes: p = 0.999 (e2/e2), p = 0.873; OR = 1.077, 95% CI 0.548 - 2.133 (e2/e3), p = 0.050 (e2/e4), p = 0.013; OR = 2.245, 95% CI 1.122 - 4.560 (e3/e4), and p = 0.999; OR = 0.572, 95% CI 0.015 - 21.155 (e4/e4).

Alleles: p = 0.768; OR = 0.908, 95% CI 0.494 - 1.676 (e2), p = 0.116; OR = 1.572, 95% CI 0.874 - 2.853 (e4).