Supplementary Table 1 Genotype and Allele Frequencies Distribution of H19 Rs2839698 Polymorphism

Supplementary Table 1 Genotype and allele frequencies distribution of H19 rs2839698 polymorphism among CCP-positive RA patients and controls

H19rs2839698 / CCP-positive RA patients (N = 214)
n (%) / Controls (N = 446)
n (%) / Pvalue / OR (95% CI)
Genotype
T/T / 22 (10.3) / 30 (6.7) / 0.60
C/T / 89 (41.6) / 193 (43.3)
C/C / 103 (48.1) / 223 (50.0)
Allele
T / 133 (31.1) / 253 (28.4) / 0.31 / 1.14 (0.89-1.46)
C / 295 (68.9) / 639 (71.6)
Dominant Model
T/T + C/T / 111 (51.9) / 223 (50.0) / 0.72 / 1.07 (0.74-1.54)
C/C / 103 (48.1) / 223 (50.0)
Recessive Model
T/T / 22 (10.3) / 30 (6.7) / 0.31 / 1.39 (0.73-2.64)
C/T + C/C / 192 (89.7) / 416 (93.3)

Regarding genotype comparison and associations under the genetic models (dominant model and recessive model), the P values and corresponding ORs (95 %CIs) were calculated with adjustment for age and sex, and the P values were not corrected for multiple comparison.

Supplementary Table2 Genotype and allele frequencies distribution of H19 rs2839698 polymorphism among CCP-negative RA patients and controls

H19rs2839698 / CCP-negative RA patients (N = 53)
n (%) / Controls (N = 446)
n (%) / Pvalue / OR (95% CI)
Genotype
T/T / 4 (7.5) / 30 (6.7) / 0.71
C/T / 26 (49.1) / 193 (43.3)
C/C / 23 (43.4) / 223 (50.0)
Allele
T / 34 (32.1) / 253 (28.4) / 0.43 / 1.19 (0.77-1.84)
C / 72 (67.9) / 639 (71.6)
Dominant Model
T/T + C/T / 30 (56.6) / 223 (50.0) / 0.41 / 1.29 (0.70-2.36)
C/C / 23 (43.4) / 223 (50.0)
Recessive Model
T/T / 4 (7.5) / 30 (6.7) / 0.73 / 1.22 (0.39-3.83)
C/T + C/C / 49 (92.5) / 416 (93.3)

Supplementary Table 3 Genotype and allele frequencies distribution of H19 rs2839698 polymorphism among RF-positive RA patients and controls

H19rs2839698 / RF-positive RA patients (N = 198)
n (%) / Controls (N = 446)
n (%) / Pvalue / OR (95% CI)
Genotype
T/T / 22 (11.1) / 30 (6.7) / 0.39
C/T / 77 (38.9) / 193 (43.3)
C/C / 99 (50.0) / 223 (50.0)
Allele
T / 121 (30.6) / 253 (28.4) / 0.42 / 1.11 (0.86-1.44)
C / 275 (69.4) / 639 (71.6)
Dominant Model
T/T + C/T / 99 (50.0) / 223 (50.0) / 0.96 / 1.01 (0.70-1.47)
C/C / 99 (50.0) / 223 (50.0)
Recessive Model
T/T / 22 (11.1) / 30 (6.7) / 0.19 / 1.54 (0.81-2.92)
C/T + C/C / 176 (88.9) / 416 (93.3)

Supplementary Table 4 Genotype and allele frequencies distribution of H19 rs2839698 polymorphism among RF-negativeRA patients and controls

H19rs2839698 / RF-negative RA patients (N = 104)
n (%) / Controls (N = 446)
n (%) / Pvalue / OR (95% CI)
Genotype
T/T / 10 (9.6) / 30 (6.7) / 0.49
C/T / 47 (45.2) / 193 (43.3)
C/C / 47 (45.2) / 223 (50.0)
Allele
T / 67 (32.2) / 253 (28.4) / 0.27 / 1.20 (0.87-1.66)
C / 141 (67.8) / 639 (71.6)
Dominant Model
T/T + C/T / 57 (54.8) / 223 (50.0) / 0.48 / 1.18 (0.74-1.89)
C/C / 47 (45.2) / 223 (50.0)
Recessive Model
T/T / 10 (9.6) / 30 (6.7) / 0.26 / 1.61 (0.70-3.67)
C/T + C/C / 94 (90.4) / 416 (93.3)

Supplementary Table5 Genotype and allele frequencies distribution of H19 rs217727 polymorphism among CCP-positive RA patients and controls

H19rs217727 / CCP-positive RA patients (N = 207)
n (%) / Controls (N = 445)
n (%) / Pvalue / OR (95% CI)
Genotype
C/C / 80 (38.6) / 170 (38.2) / 0.50
C/T / 103 (49.8) / 207 (46.5)
T/T / 24 (11.6) / 68 (15.3)
Allele
C / 263 (63.5) / 547 (61.5) / 0.47 / 1.09 (0.86-1.39)
T / 151 (36.5) / 343 (38.5)
Dominant Model
C/C + C/T / 183 (88.4) / 377 (84.7) / 0.24 / 1.39 (0.80-2.40)
T/T / 24 (11.6) / 68 (15.3)
Recessive Model
C/C / 80 (38.6) / 170 (38.2) / 0.73 / 1.07 (0.73-1.57)
C/T + T/T / 127 (61.4) / 275 (61.8)

Supplementary Table6 Genotype and allele frequencies distribution of H19 rs217727 polymorphism among CCP-negative RA patients and controls

H19rs217727 / CCP-negative RA patients (N = 52)
n (%) / Controls (N = 445)
n (%) / Pvalue / OR (95% CI)
Genotype
C/C / 20 (38.5) / 170 (38.2) / 0.93
C/T / 24 (46.2) / 207 (46.5)
T/T / 8 (15.4) / 68 (15.3)
Allele
C / 64 (61.5) / 547 (61.5) / 0.99 / 1.00 (0.66-1.52)
T / 40 (38.5) / 343 (38.5)
Dominant Model
C/C + C/T / 44 (84.6) / 377 (84.7) / 0.81 / 0.90 (0.39-2.10)
T/T / 8 (15.4) / 68 (15.3)
Recessive Model
C/C / 20 (38.5) / 170 (38.2) / 0.83 / 1.07 (0.57-2.00)
C/T + T/T / 32 (61.5) / 275 (61.8)

Supplementary Table 7 Genotype and allele frequencies distribution of H19 rs217727 polymorphism among RF-positive RA patients and controls

H19rs217727 / RF-positive RA patients (N = 192)
n (%) / Controls (N = 445)
n (%) / Pvalue / OR (95% CI)
Genotype
C/C / 74 (38.5) / 170 (38.2) / 0.71
C/T / 93 (48.4) / 207 (46.5)
T/T / 25 (13.0) / 68 (15.3)
Allele
C / 241 (62.8) / 547 (61.5) / 0.66 / 1.06 (0.83-1.35)
T / 143 (37.2) / 343 (38.5)
Dominant Model
C/C + C/T / 167 (87.0) / 377 (84.7) / 0.41 / 1.26 (0.73-2.17)
T/T / 25 (13.0) / 68 (15.3)
Recessive Model
C/C / 74 (38.5) / 170 (38.2) / 0.75 / 1.07 (0.72-1.58)
C/T + T/T / 118 (61.5) / 275 (61.8)

Supplementary Table 8 Genotype and allele frequencies distribution of H19 rs217727 polymorphism among RF-negative RA patients and controls

H19rs217727 / RF-negative RA patients (N = 102)
n (%) / Controls (N = 445)
n (%) / Pvalue / OR (95% CI)
Genotype
C/C / 44 (43.1) / 170 (38.2) / 0.44
C/T / 43 (42.2) / 207 (46.5)
T/T / 15 (14.7) / 68 (15.3)
Allele
C / 131 (64.2) / 547 (61.5) / 0.47 / 1.13 (0.82-1.54)
T / 73 (35.8) / 343 (38.5)
Dominant Model
C/C + C/T / 87 (85.3) / 377 (84.7) / 0.77 / 0.90 (0.47-1.75)
T/T / 15 (14.7) / 68 (15.3)
Recessive Model
C/C / 44 (43.1) / 170 (38.2) / 0.28 / 1.30 (0.81-2.09)
C/T + T/T / 58 (56.9) / 275 (61.8)

Supplementary Table 9 Genotype and allele frequencies distribution of HOTAIR rs12826786 polymorphism among CCP-positive RA patients and controls

HOTAIR rs12826786 / CCP-positive RA patients (N = 214)
n (%) / Controls (N = 446)
n (%) / Pvalue / OR (95% CI)
Genotype
T/T / 12 (5.6) / 18 (4.0) / 0.32
C/T / 70 (32.7) / 130 (29.1)
C/C / 132 (61.7) / 298 (66.8)
Allele
T / 94 (22.0) / 166 (18.6) / 0.15 / 1.23 (0.93-1.64)
C / 334 (78.0) / 726 (81.4)
Dominant Model
T/T + C/T / 82 (38.3) / 148 (33.2) / 0.13 / 1.34 (0.92-1.97)
C/C / 132 (61.7) / 298 (66.8)
Recessive Model
T/T / 12 (5.6) / 18 (4.0) / 0.61 / 1.26 (0.53-2.99)
C/T + C/C / 202 (94.4) / 428 (96.0)

Supplementary Table 10 Genotype and allele frequencies distribution of HOTAIR rs12826786 polymorphism among CCP-negative RA patients and controls

HOTAIR rs12826786 / CCP-negative RA patients (N = 53)
n (%) / Controls (N = 446)
n (%) / Pvalue / OR (95% CI)
Genotype
T/T / 0 (0) / 18 (4.0) / 0.98
C/T / 15 (28.3) / 130 (29.1)
C/C / 38 (71.7) / 298 (66.8)
Allele
T / 15 (14.2) / 166 (18.6) / 0.26 / 0.72 (0.41-1.28)
C / 91 (85.8) / 726 (81.4)
Dominant Model
T/T + C/T / 15 (28.3) / 148 (33.2) / 0.56 / 0.82 (0.42-1.60)
C/C / 38 (71.7) / 298 (66.8)
Recessive Model
T/T / 0 (0) / 18 (4.0) / - / -
C/T + C/C / 53 (100.0) / 428 (96.0)

Supplementary Table 11 Genotype and allele frequencies distribution of HOTAIR rs12826786 polymorphism amongRF-positive RA patients and controls

HOTAIR rs12826786 / RF-positive RA patients (N = 198)
n (%) / Controls (N = 446)
n (%) / Pvalue / OR (95% CI)
Genotype
T/T / 10 (5.1) / 18 (4.0) / 0.24
C/T / 68 (34.3) / 130 (29.1)
C/C / 120 (60.6) / 298 (66.8)
Allele
T / 88 (22.2) / 166 (18.6) / 0.13 / 1.25 (0.93-1.67)
C / 308 (77.8) / 726 (81.4)
Dominant Model
T/T + C/T / 78 (39.4) / 148 (33.2) / 0.09 / 1.40 (0.95-2.06)
C/C / 120 (60.6) / 298 (66.8)
Recessive Model
T/T / 10 (5.1) / 18 (4.0) / 0.53 / 1.33 (0.54-3.28)
C/T + C/C / 188 (94.9) / 428 (96.0)

Supplementary Table 12 Genotype and allele frequencies distribution of HOTAIR rs12826786 polymorphism among RF-negative RA patients and controls

HOTAIR rs12826786 / RF-negative RA patients (N = 104)
n (%) / Controls (N = 446)
n (%) / Pvalue / OR (95% CI)
Genotype
T/T / 4 (3.8) / 18 (4.0) / 0.90
C/T / 29 (27.9) / 130 (29.1)
C/C / 71 (68.3) / 298 (66.8)
Allele
T / 37 (17.8) / 166 (18.6) / 0.78 / 0.95 (0.64-1.40)
C / 171 (82.8) / 726 (81.4)
Dominant Model
T/T + C/T / 33 (31.7) / 148 (33.2) / 0.91 / 0.97 (0.59-1.61)
C/C / 71 (68.3) / 298 (66.8)
Recessive Model
T/T / 4 (3.8) / 18 (4.0) / 0.65 / 0.74 (0.20-2.78)
C/T + C/C / 100 (96.2) / 428 (96.0)