Supplementary Table 1. Details of LactucaIndica samples collected.The date and the location of Sample collection and the amount of lactucin measured by HPLC were included. Different accession codes were given when samples have morphological differences although they were collected at same location.Location number 51 – 53 were provided by National Agrobiodiversity Center.

Location No. / Accession code / collection date / Address / Lactucin amount
(ug/g dry weight) / longitude / latitude
1 / SLI1501-2 / 5.23.2015 / 317-4, Maesan-ri, Sinpyeong-myeon, Dangjin-si, Chungcheongnam-do / 9.78 / 126°48'46.19'' / 36°55'45.52''
SLI1501-4 / 47.65
2 / SLI1502-3 / 5.23.2015 / 31-7, Yugu-ri, Yugu-eup, Gongju-si, Chungcheongnam-do / 32.48 / 126°58'52.82'' / 36°33'36.21''
SLI1502-5 / 28.83
3 / SLI1503-8 / 5.23.2015 / 339-5, Hagam-ri, Jeongsan-myeon, Cheongyang-gun, Chungcheongnam-do / 16.46 / 126°56'15.19'' / 36°23'14.26''
4 / SLI1504-9 / 5.23.2015 / San1-65, Maryang-ri, Seo-myeon, Seocheon-gun, Chungcheongnam-do / 16.34 / 126°30'00.99'' / 36°08'44.89''
5 / SLI1505-5 / 5.23.2015 / 1030, Pyeonggyo-ri, Baeksan-myeon, Buan-gun, Jeollabuk-do / 19.40 / 126°46'45.77'' / 35°42'31.77''
6 / SLI1506-4 / 5.23.2015 / San108, Baeksong-ri, Sillim-myeon, Gochang-gun, Jeollabuk-do / 9.89 / 126°40'30.23'' / 35°28'13.56''
SLI1506-9 / 9.76
7 / SLI1507-4 / 5.23.2015 / 346-1, Jinyang-ri, Hampyeong-eup, Hampyeong-gun, Jeollanam-do / 44.98 / 126°29'40.66'' / 35°05'22.27''
8 / SLI1508-2 / 5.23.2015 / 897, Dongho-ri, Samho-eup, Yeongam-gun, Jeollanam-do / 31.66 / 126°30'40.95'' / 34°45'04.78''
9 / SLI1509-9 / 5.24.2015 / 1850-4, Dunjeon-ri, Gunnae-myeon, Jindo-gun, Jeollanam-do / 72.36 / 126°17'35.24'' / 34°31'33.58''
10 / SLI1510-2 / 5.24.2015 / 661-9, Childong-ri, Beolgyo-eup, Boseong-gun, Jeollanam-do / 30.39 / 127°18'22.62'' / 34°50'18.33''
11 / SLI1511-3 / 5.24.2015 / San4-1, Doi-dong, Gwangyang-si, Jeollanam-do / 39.40 / 127°41'09.26'' / 34°56'09.04''
12 / SLI1512-3 / 5.24.2015 / 1191-1, Sindo-ri, Yongbang-myeon, Gurye-gun, Jeollanam-do / 25.66 / 127°25'27.51'' / 35°15'39.04''
13 / SLI1513-4 / 5.24.2015 / 243-3, Sikjeong-dong, Namwon-si, Jeollabuk-do / 16.15 / 127°25'13.81'' / 35°26'21.19''
14 / SLI1514-6 / 5.24.2015 / 702, Osan-ri, Osu-myeon, Imsil-gun, Jeollabuk-do / 34.50 / 127°18'43.52'' / 35°33'33.00''
15 / SLI1515-3 / 5.24.2015 / 419-4, Oegung-ri, Seongsu-myeon, Jinan-gun, Jeollabuk-do / 98.69 / 127°19'36.99'' / 35°42'45.66''
16 / SLI1516-4 / 5.24.2015 / 554-1, Buksu-ri, Baebang-eup, Asan-si, Chungcheongnam-do / 29.39 / 127°04'16.67'' / 36°46'41.33''
17 / SLI1517-3 / 5.29.2015 / 276, Gyereuk-ri, Miyang-myeon, Anseong-si, Gyeonggi-do / 33.77 / 127°15'13.5'' / 36°58'43.89''
18 / SLI1518-8 / 5.29.2015 / 974, Jeungcheon-ri, Jeungpyeong-eup, Jeungpyeong-gun, Chungcheongbuk-do / 31.01 / 127°35'58.21'' / 36°46'31.04''
19 / SLI1519-4 / 5.29.2015 / 223, Hangnim-ri, Boeun-eup, Boeun-gun, Chungcheongbuk-do / 31.95 / 127°43'41.56'' / 36°31'26.59''
SLI1519-10 / 34.57
20 / SLI1520-9 / 5.29.2015 / 450-1, Mijeon-ri, Yongsan-myeon, Yeongdong-gun, Chungcheongbuk-do / 91.06 / 127°49'21.72'' / 36°17'25.56''
21 / SLI1521-5 / 5.29.2015 / 1384-1, Malheul-ri, Mari-myeon, Geochang-gun, Gyeongsangnam-do / 23.87 / 127°50'01.19'' / 35°40'44.71''
22 / SLI1522-3 / 5.29.2015 / San7-12, Teuk-ri, Geumseo-myeon, Sancheong-gun, Gyeongsangnam-do / 4.77 / 127°52'24.53'' / 35°25'52.26''
23 / SLI1523-4 / 5.29.2015 / 357-1, Massang-ri, Daeui-myeon, Uiryeong-gun, Gyeongsangnam-do / 8.99 / 128°06'23.09'' / 35°22'11.31''
24 / SLI1524-6 / 5.29.2015 / 93, Daebyeok-ri, Changseon-myeon, Namhae-gun, Gyeongsangnam-do / 15.37 / 128°01'05.92'' / 34°53'52.03''
25 / SLI1525-2 / 5.3.2015 / Dupo-ri, Samsan-myeon, Goseong-gun, Gyeongsangnam-do / 32.28 / 128°17'06.45'' / 34°55'55.43''
26 / SLI1526-1 / 5.3.2015 / 713, Namgi-ri, Sanoe-myeon, Miryang-si, Gyeongsangnam-do / 27.71 / 128°46'40.14'' / 35°30'39.21''
27 / SLI1527-5 / 5.3.2015 / 1233-1, Gunggeunjeong-ri, Ulju-gun, Ulsan / 53.45 / 129°03'47.58'' / 35°36'58.40''
28 / SLI1528-2 / 5.3.2015 / San467-3, Sannae-myeon, Gyeongju-si, Gyeongsangbuk-do / 1.94 / 129°03'32.48'' / 35°42'11.47''
SLI1528-3 / 26.38
SLI1528-7 / 13.33
29 / SLI1529-1 / 5.3.2015 / 614, Bonchondong, Yeongcheon-si, Gyeongsangbuk-do / 22.36 / 128°57'19.65'' / 35°55'35.90''
30 / SLI1530-3 / 5.3.2015 / 391, Yugok-dong, Mungyeong-si, Gyeongsangbuk-do / 36.10 / 128°09'11.24'' / 36°37'07.30''
31 / SLI1531-8 / 5.3.2015 / 287-4, Haguam-ri, Jungangtap-myeon, Chungju-si, Chungcheongbuk-do / 3.91 / 127°50'23.11'' / 37°01'17.95''
32 / SLI1532-6 / 6.5.2015 / 150, Misa-ri, Seorak-myeon, Gapyeong-gun, Gyeonggi-do / 21.11 / 127°32'45.65'' / 37°42'04.07''
33 / SLI1533-9 / 6.5.2015 / 1010-1, Gunja-ri, Dongsan-myeon, Chuncheon-si, Gangwon-do / 11.21 / 127°43'41.50'' / 37°45'02.54''
34 / SLI1534-6 / 6.5.2015 / San75-1, Haoan-ri, Hongcheon-eup, Hongcheon-gun, Gangwon-do / 5.05 / 127°50'53.92'' / 37°39'59.07''
35 / SLI1535-5 / 6.5.2015 / San96-2, Jogok-ri, Hoengseong-eup, Hoengseong-gun, Gangwon-do / 13.71 / 128°00'43.01'' / 37°29'13.80''
36 / SLI1536-7 / 6.5.2015 / 663-4, Jangpyeong-ri, Yongpyeong-myeon, Pyeongchang-gun, Gangwon-do / 14.39 / 128°24'42.60'' / 37°35'10.21''
37 / SLI1537-2 / 6.5.2015 / 299-3, Obong-ri, Seongsan-myeon, Gangneung-si, Gangwon-do / 11.37 / 128°49'20.38'' / 37°42'28.31''
38 / SLI1538-10 / 6.5.2015 / 39-7, Gwangdong-ri, Hajang-myeon, Samcheok-si, Gangwon-do / 5.53 / 128°57'02.74'' / 37°20'35.44''
39 / SLI1539-1 / 6.5.2015 / 287-5, Sangsami-dong, Taebaek-si, Gangwon-do / 16.37 / 128°59'20.74'' / 37°16'57.54''
40 / SLI1540-1 / 6.5.2015 / San67-9, Tanggok-ri, Gagok-myeon, Samcheok-si, Gangwon-do / 8.35 / 129°14'18.31'' / 37°09'14.97''
SLI1540-7 / 9.71
41 / SLI1541-3 / 6.5.2015 / 5-4, Deoksin-ri, Wonnam-myeon, Uljin-gun, Gyeongsangbuk-do / 20.12 / 129°24'57.44'' / 36°53'03.22''
42 / SLI1542-3 / 6.6.2015 / 61-2, Samsa-ri, Ganggu-myeon, Yeongdeok-gun, Gyeongsangbuk-do / 26.50 / 129°22'46.09'' / 36°20'58.22''
43 / SLI1543-10 / 6.6.2015 / San28, Goejeong-ri, Jinbo-myeon, Cheongsong-gun, Gyeongsangbuk-do / 17.28 / 129°09'03.16'' / 36°29'32.90''
44 / SLI1544-7 / 6.6.2015 / 223, Sechon-ri, Danchon-myeon, Uiseong-gun, Gyeongsangbuk-do / 16.02 / 128°40'50.34'' / 36°26'23.95''
45 / SLI1545-6 / 6.6.2015 / 574-9, Maekok-ri, Pungsan-eup, Andong-si, Gyeongsangbuk-do / 7.18 / 128°33'34.34'' / 36°35'05.57''
46 / SLI1546-6 / 6.6.2015 / 441-11, Daechon-ri, Bonghyeon-myeon, Yeongju-si, Gyeongsangbuk-do / 9.00 / 128°31'38.93'' / 36°51'00.39''
47 / SLI1547-6 / 6.6.2015 / 408, Wollim-ri, Geumseong-myeon, Jecheon-si, Chungcheongbuk-do / 48.46 / 128°10'44.13'' / 37°04'23.56''
48 / SLI1548-5 / 6.6.2015 / San78-1, Godam-dong, Icheon-si, Gyeonggi-do / 21.42 / 127°27'58.99'' / 37°14'33.84''
49 / SLI1551-8 / 6.13.2015 / 292, Jeon-gok-ri, Jeongok-eup, Yeoncheon-gun, Gyeonggi-do / 2.69 / 127°03'58.79'' / 38°01'21.41''
50 / SLI1552-9 / 6.13.2015 / 673-14, Oji-ri, Dongsong-eup, Cheorwon-gun, Gangwon-do / 2.40 / 127°13'49.41'' / 38°11'16.74''
SLI1552-10 / 3.77
Institute
51 / IT240838 / Sangju-si, Gyeongsangbuk-do / 67.65 / National Agrobiodiversity Center
52 / K249284 / Jeongnam-myeon, Hwaseong, Gyeonggi-do / 40.58 / National Agrobiodiversity Center
53 / K040623 / Heungjeong-ri, Bongpyeong-myeon, Pyeongchang-gun, Gangwon-do / 48.96 / National Agrobiodiversity Center