Supplementary Table 1. Conservancy of E2 protein epitopes with HCV 3a and HCV 1a sequences from various countries

Peptide / 3a genotype / Minimum Identity / 1a genotype / Minimum Identity
India / Japan / United Kingdom / United States / Pakistan / United States / United Kingdom / France / Japan
YGVGSGVVGWAV / YGVGSGMVGWAL / YGVGSGMVGWAL / YGVGSGMVGWAL / YGVGSGMVGWAL / 83.33% / YGVGSSVVSWAI / YGVGSSIVSWAI / YGVGSSIVSWAI / YGVGSSIVSWAI / YGVGSSIVSWAI / 66.67%
FNQGWGPLTDGN / FKQGWGPLTDAN / FKQGWGPLTDAN / FRQGWGSLTDAN / FKQGWGPLTDAN / 75.00% / FDQGWGPISYTN / FDQGWGPISYAN / FDQGWGPITHAN / FAQGWGPISHVN / FDQGWGPIRHAN / 58.33%
DIYGGNGRRGND / NIYGGEKRETNR / NIYGGGGNPQNE / NIYGGEGSHKDG / NIYGGGGNPHNE / 41.67% / CVIGGVGNNTLH / CVIGGAGNNTLH / CVIGGVGNNTLH / GGVGNNTLRCPT / Absent / 0.00%
TTDAKGVPTYNW / TTDAKGAPTYNW / TTDAKGVPTYTW / TTDAEGTPTYDW / TTDAKGVPTYTW / 75.00% / TTDRAGVPTYNW / TTDKAGAPTYNW / TTDVLGVPTYTW / TTDKLGAPTYNW / TTNRLGVPTYSW / 66.67%
QLINTNGSWHIN / QLVNTNGSWHIN / QLVNTNGSWHIN / QLVNTNGSWHIN / QLVNTNGSWHIN / 91.67% / QLINTNGSWHIN / QLINTNGSWHIN / QLINTNGSWHIN / QLINTNGSWHIN / QLINTNGSWHIN / 100.00%
EDRDRSEQHPLL / EDRDRSEQSPLL / EDRDRSEQHPLL / EDRDRSEQHPLL / EDRDRSEQHPLL / 91.67% / DDRDRSELSPLL / DDRDRSELSPLL / DDRDRSELSPLL / DDRDRSELSPLL / DDRDRSELSPLL / 75.00%
GAGPWLTPRCMV / GAGPWITPRCMV / GAGPWLTPRCMV / GAGPWLTPRRLI / GAGPWLTPRCMV / 75.00% / GSGPWITPRCLV / GSGPWITPRCLV / GSGPWITPRCLV / GSGPWITPRCLV / GSGPWITPRCLV / 75.00%
PVYCFTPSPVVV / PVYCFTPSPVVV / PVYCFTPSPVVV / PVYCFTPSPVVV / PVYCFTPSPVVV / 100.00% / PVYCFTPSPVVV / PVYCFTPSPVVV / PVYCFTPSPVVV / PVYCFTPSPVVV / PVYCFTPSPVVV / 100.00%
YRYRFNSTGCPS / YYHKFNSTGCPH / YYHKFNSTGCPE / YYHKFNSTGCPQ / YYHKFNSTGCPQ / 66.67% / YYHKFNSSGCPE / YHHRFNSSGCPE / YYHKFNSSGCPE / YYNKFNSSGCPE / YYHKFNSSGCPE / 58.33%
ALNCNDSINTGF / ALNCNDSINTGF / ALNCNESINTGF / ALNCNESINTGF / ALNCDDSINTGF / 91.67% / ALNCNGSLDAGW / ALNCNASLDTGW / ALNCNASLDTGW / ALNCNASLETGW / ALNCNASLDTGW / 58.33%
SGPSDDKPYCWH / TGPSDERPYCWH / TGPSDDRPYCWH / TGSSDDKPYCWH / TGPSDDKPYCWH / 75.00% / GSGPEHRPYCWH / GSGPEHRPYCWH / GSGPEHRPYCWH / GSGPEQRPYCWH / GSGPEHRPYCWH / 41.67%
SFTPMPALSTGL / SFTPMPALSTGL / SFTPMPALSTGL / SFTPMPALSTGL / SFTPMPALSTGL / 100.00% / SFTTLPALTTGL / SFTTLPALTTGL / SFTTLPALTTGL / SFTTLPALTTGL / SFTTLPALTTGL / 75.00%
YPYRLWHYPCTV / YPYRLWHYPCTV / YPYRLWHYPCTV / YPYRLWHYPCTV / YPYRLWHYPCTV / 100.00% / YPYRLWHYPCTI / YAYRLWHYPCTV / YPYRLWHYPCTV / YPYRLWHYPCTV / YPYRLWHYPCTV / 91.67%
AACNWTRGERCD / AACNWTRGERCD / AACNWTRGERCD / AACNWTRGERCN / AACNWTRGERCD / 91.67% / AACNWTRGERCD / VACNWTRGERCD / AACNWTRGERCD / AACNWTRGERCD / VACNWTRGERCD / 91.67%
FFNQGWGPL / YFKQGWGPL / SFKQGWGPL / YFRQGWGSL / FFKQGWGPL / 66.67% / DFDQGWGPI / DFDQGWGPI / DFDQGWGPI / YFAQGWGPI / DFDQGWGPI / 66.67%
TPSPVVVGT / TPSPVVVGT / TPSPVVVGT / TPSPVVVGT / TPSPVVVGT / 100.00% / TPSPVVVGT / TPSPVVVGT / TPSPVVVGT / TPSPVVVGT / TPSPVVVGT / 100.00%
FNSTGCPSM / FNSTGCPHR / FNSTGCPER / FNSTGCPQR / FNSTGCPQR / 77.78% / FNSSGCPER / FNSSGCPER / FNSSGCPER / FNSSGCPER / FNSSGCPER / 66.67%
INTNGSWHI / VNTNGSWHI / VNTNGSWHI / VNTNGSWHI / VNTNGSWHI / 88.89% / INTNGSWHI / INTNGSWHI / INTNGSWHI / INTNGSWHI / INTNGSWHI / 100.00%
VYCFTPSPV / VYCFTPSPV / VYCFTPSPV / VYCFTPSPV / VYCFTPSPV / 100.00% / VYCFTPSPV / VYCFTPSPV / VYCFTPSPV / VYCFTPSPV / VYCFTPSPV / 100.00%
VVVGTTDAK / VVVGTTDAK / VVVGTTDAK / VVVGTTDAE / VVVGTTDAK / 88.89% / VVVGTTDRA / VVVGTTDKA / VVVGTTDVL / VVVGTTDKL / VVVGTTNRL / 66.67%
YRFNSTGCP / HKFNSTGCP / HKFNSTGCP / HKFNSTGCP / HKFNSTGCP / 77.78% / HKFNSSGCP / HRFNSSGCP / HKFNSSGCP / NKFNSSGCP / HKFNSSGCP / 66.67%
WHYAPRSCS / WHYPPRPCG / WHYAPRPCT / WHYAPRPCD / WHYAPRRCG / 66.67% / WHYPPKPCG / WHYPPKPCG / WHYPPKPCG / WHYAPRPCG / WHYPPKPCG / 55.56%
WTRGERCDI / WTRGERCDI / WTRGERCDV / WTRGERCNI / WTRGERCDI / 88.89% / WTRGERCDL / WTRGERCDL / WTRGERCDL / WTRGERCDL / WTRGERCDL / 88.89%
FIAGLIYRY / FIAGLFYYH / FIAGLIYYH / FIAGLFYYH / FIAGLFYYH / 66.67% / WIVGLFYYH / WIAGLFYHH / WVAGLFYYH / WIAGLFYYN / WVAGLFYYH / 44.44%
FTPSPVVVG / FTPSPVVVG / FTPSPVVVG / FTPSPVVVG / FTPSPVVVG / 100.00% / FTPSPVVVG / FTPSPVVVG / FTPSPVVVG / FTPSPVVVG / FTPSPVVVG / 100.00%
WHYPCTVNF / WHYPCTVNY / WHYPCTVNF / WHYPCTVNF / WHYPCTVNF / 88.89% / WHYPCTINY / WHYPCTVNY / WHYPCTVNY / WHYPCTVNY / WHYPCTVNY / 77.78%
YRYRFNSTG / YYHKFNSTG / YYHKFNSTG / YYHKFNSTG / YYHKFNSTG / 66.67% / YYHKFNSSG / YHHRFNSSG / YYHKFNSSG / YYNKFNSSG / YYHKFNSSG / 55.56%
FTLFKVRMF / YTLFKVRMF / FTSFKVRMF / FTLFKVRMF / FTLFKMRTF / 77.78% / YTLFKVRMY / YTLFKVRMY / YTLFKVRMY / YTLFKIRMY / YTLFKVRMY / 66.67%
VGGFEHRLS / VGGLEHRFD / VGGFEHRFD / VGGFEHRFN / VGGFEHRFT / 66.67% / VGGVEHRLE / VGGVEHRLE / VGGVEHRLE / VGGVEHRLQ / VGGVEHRLE / 77.78%
YCFTPSPVV / YCFTPSPVV / YCFTPSPVV / YCFTPSPVV / YCFTPSPVV / 100.00% / YCFTPSPVV / YCFTPSPVV / YCFTPSPVV / YCFTPSPVV / YCFTPSPVV / 100.00%
YPCTVNFTL / YPCTVNYTL / YPCTVNFTS / YPCTVNFTL / YPCTVNFTL / 88.89% / YPCTINYTL / YPCTVNYTL / YPCTVNYTL / YPCTVNYTL / YPCTVNYTL / 77.78%
FEHRLSAAC / LEHRFDAAC / FEHRFDAAC / FEHRFNAAC / FEHRFTAAC / 66.67% / VEHRLEAAC / VEHRLEVAC / VEHRLEAAC / VEHRLQAAC / VEHRLEVAC / 66.67%
IEDRDRSEQ / IEDRDRSEQ / VEDRDRSEQ / IEDRDRSEQ / IEDRDRSEQ / 88.89% / LDDRDRSEL / LDDRDRSEL / LDDRDRSEL / LDDRDRSEL / LDDRDRSEL / 66.67%
YCWHYAPRS / YCWHYPPRP / YCWHYAPRP / YCWHYAPRP / YCWHYAPRR / 77.78% / YCWHYPPKP / YCWHYPPKP / YCWHYPPKP / YCWHYAPRP / YCWHYPPKP / 66.67%
YGGNGRRGN / YGGEKRETN / YGGGGNPQN / YGGEGSHKD / YGGGGNPHN / 44.44% / IGGVGNNTL / IGGAGNNTL / IGGVGNNTL / VGNNTLRCP / Absent / 0.00%
FRKHPEATY / FRKHPGATY / FRKHPEATY / FRKHPEATC / FRKHPEATY / 88.89% / FRKHPEATY / FRKHPEATY / FRKHPEATY / FRKHPEATY / FRKHPEATY / 100.00%
YRLWHYPCT / YRLWHYPCT / YRLWHYPCT / YRLWHYPCT / YRLWHYPCT / 100.00% / YRLWHYPCT / YRLWHYPCT / YRLWHYPCT / YRLWHYPCT / YRLWHYPCT / 100.00%
VNFTLFKVR / VNYTLFKVR / VNFTSFKVR / VNFTLFKVR / VNFTLFKMR / 88.89% / INYTLFKVR / VNYTLFKVR / VNYTLFKVR / VNYTLFKIR / VNYTLFKVR / 77.78%
IYRYRFNST / FYYHKFNST / IYYHKFNST / FYYHKFNST / FYYHKFNST / 55.56% / FYYHKFNSS / FYHHRFNSS / FYYHKFNSS / FYYNKFNSS / FYYHKFNSS / 44.44%
IAGLIYRYR / IAGLFYYHK / IAGLIYYHK / IAGLFYYHK / IAGLFYYHK / 55.56% / IAGLFYYHK / IAGLFYHHR / VAGLFYYHK / IAGLFYYNK / VAGLFYYHK / 44.44%

Note: The amino acid residues which vary in other countries are shown in bold face while matching residues are shown in regular face. Minimum identity is identity percentage of least identical peptide sequence among various countries.