Supplementary Material s131

Supplementary material

Figure legend

Figure S1. Resting-state functional connectivity within group and between maps of subregions in right hemisphere. First column shows the subregions defined in inferior parietal lobule. The second and third columns shows the within group statistical maps of HCs and patients with Alzheimer’s disease, respectively, with statistical threshold set at P < 0.05, corrected. Hot and cold color represent for positive and negative functional connections, respectively. Last column shows the between-group statistical maps, with statistical threshold set at P < 0.05, corrected. Hot and cold color represent for increased and decreased functional connectivities in Alzheimer’s disease group comparing to healthy control group respectively. ROIs, regions of interest; NC, normal control; AD, Alzheimer’s disease.

Table S1 Regions showing differences of IPL sub-regional (ROI 1-4) connectivity between the AD patients and HCs after GM correction

ROIs / Brain regions / BA / Cluster
Voxels / MNI coordinates, mm / Maximum Z
x / y / z
PF.R (1’) / L. Cerebellum / NA / 49 / -30 / -48 / -54 / -3.94
R. IPL / 40 / 64 / 42 / -54 / 54 / -3.68
L. MFG / 46 / 49 / -36 / 33 / 15 / -3.62
PFcm.R (2’) / R. PCu / 7 / 88 / 6 / -54 / 60 / -3.42
R. Putamen / NA / 60 / 15 / 9 / -3 / 3.42
PFop.R (3’) / L. IPL / 40 / 69 / -54 / -30 / 51 / -4.35
L. MTG / 37 / 52 / -48 / -69 / 3 / -3.63
L/R. SMA / 6 / 67 / -9 / 0 / 72 / -3.28
PFt.R (4’) / R. PrCG / 6/4 / 98 / -57 / -3 / 9 / -3.70
R. SMA / 6 / 105 / 6 / 3 / 60 / -3.57

Between groups differences were determined by two-sample t tests (P< 0.05, corrected). ROIs, regions of interest; BA, Brodmann’s area; MNI, Montreal Neurological Institute; x, y, z, coordinates of primary peak locations in the MNI space; Z, statistical value of peak voxel showing differences between two groups. NA, not applicable; L, left; R, right; IPL, Inferior Parietal Lobule; MFG, Middle Frontal Gyrus; PCu, Precuneus; MTG, Middle Temporal Gyrus; SMA, Supplementary Motor Area; PrCG, Precentral Gyrus.

Table S2 Regions showing differences of IPL sub-regional (ROI 5) connectivity between the AD patients and HCs after GM correction

ROI / Brain regions / BA / Cluster
Voxels / MNI coordinates, mm / Maximum Z
x / y / z
PFm.R (5’) / L. SPG / 7 / 112 / -30 / -72 / 27 / -4.00
L. ITG / 37 / 91 / -48 / -60 / 3 / -3.94
R. PreCG / 6 / 265 / 36 / 0 / 54 / -3.67
L. SFG / 8 / 63 / -24 / 36 / 42 / -3.18
R. MFG / 47 / 158 / 45 / 33 / 27 / -3.17
R. SPG / 7 / 104 / 39 / -42 / 45 / -3.03
L/R. PCC / 31 / 183 / 6 / -42 / 42 / 3.67
L. ANG / 39 / 177 / -51 / -54 / 33 / 3.28

Between groups differences were determined by two-sample t tests (P< 0.05, corrected). ROI, region of interest; BA, Brodmann’s area; MNI, Montreal Neurological Institute; x, y, z, coordinates of primary peak locations in the MNI space; Z, statistical value of peak voxel showing differences between two groups. NA, not applicable; L, left; R, right; SPG, Superior Parietal Gyrus; ITG, Inferior Temporal Gyrus; PreCG, Precentral Gyrus; SFG, Superior Frontal Gyrus; MFG, Middle Frontal Gyrus; PCC, Posterior Cingulate Cortex; ANG, Angular Gyrus.

Table S3 Regions showing differences of IPL sub-regional (ROI 6-7) connectivity between the AD patients and HCs after GM correction

ROIs / Brain regions / BA / Cluster
Voxels / MNI coordinates, mm / Maximum Z
x / y / z
PGa.R (6’) / L. IFG / 47 / 49 / -48 / 27 / -3 / -3.84
R. MFG / 10 / 46 / 30 / 57 / -6 / -3.18
R/L. PCu/PCC / 31/7 / 587 / 3 / -42 / 36 / 4.76
L. ANG/IPL / 39 / 341 / -45 / -69 / 39 / 4.58
R. THA / NA / 57 / 12 / -27 / 9 / 4.56
R. Cerebellum / NA / 84 / 54 / -57 / -33 / 4.15
PGp.R (7’) / L/R. SFG / 10 / 141 / -3 / 63 / 18 / -3.64
R. MFG / 11 / 52 / 6 / 45 / -12 / -3.36
L/R. PCC / 23/31 / 196 / 0 / -24 / 30 / 4.35
L. IPL/ANG / 40/39 / 324 / -57 / -42 / 48 / 4.08
R. IPL / 40 / 63 / 48 / -54 / 45 / 3.27

Between groups differences were determined by two-sample ttests (P< 0.05, corrected). ROIs, regions of interest;BA, Brodmann’s area; MNI, Montreal Neurological Institute; x, y, z, coordinates of primary peak locations in the MNI space; Z, statistical value of peak voxel showing differences between two groups. NA, not applicable; L, left; R, right; IFG, Inferior Frontal Gyrus; MFG, Middle Frontal Gyrus; PCu, Precuneus; PCC, Posterior Cingulate Cortex; ANG, Angular Gyrus; THA, Thalamus; SFG, Superior Frontal Gyrus; IPL, Inferior Parietal Lobule.