Supplementary Material (ESI) for CrystEngComm

This journal is © The Royal Society of Chemistry 2001

Table 2 Survey of published crystal structure prediction studies

Molecule

/

Name

/

No. of known polymorphs

/

Space group

/

Z’ (Z)

/

Program

/

Year

/

Reference

/

Comment

/

Aspirin

/

1

/

P21/c

/

1 (4)

/

PROMET

Polymorph Predictor /

1995

1999 /

1

2 / G
L
/

Paracetamol

/

3

/

I: P21/c

II: Pbca
III: not determined /

1 (4)

1 (8) / Polymorph Predictor MOLPAK/DMAREL /

1998

2001 /

3

4 / G(I), L(II)
G(I), L(II)
/

Allopurinol

/

1

/

P21/c

/

1 (4)

/

MOLPAK/DMAREL

/

1997

/

5

/

G

/

Estrone

/

3

/

P21

P212121
P212121 /

2 (4)

1 (4)
1 (4) /

Polymorph Predictor

/

1996

/

6

/ G, L, r(P212121)
/

Progesterone

/

2

/

P212121

P212121 /

1 (4)

1 (4) /

Polymorph Predictor

/

1999

/

7

/

G( r

L( r
/

Prednisolone tert-butylacetate

/

2

/ P212121
+ not determined / 1 (4) / Polymorph Predictor / 1998 / 3 / L, r, p
/

Primidone

/

2

/

A: P21/c

B: Pbca /

1 (4)

1 (8) /

Polymorph Predictor

/

1999

/ 7 / L(A), r, p
L(B), r
/

Pigment red

/

1

/

P

/

0.5 (1)

/

Polymorph Predictor

/

1993

/

8

/

L, p

/

Quinacridone

/

3

/

not determined)

(not determined)

P21/c

/

0.5 (2)

/

Polymorph Predictor

/

1996

/

6

/ G(p
L(p, a
/

Indigo

/

2

/

A: P21/c

B: P21/c /

0.5 (2)

0.5 (2) /

MOLPAK/DMAREL

/

1998

/

9

/

G(A)

L(B)

/ Yellow pigment '0137' / 1 / Pna21 / 1 (4) / CRYSCA / 1995 / 10 / G, a
/

Pigment yellow 74

/

1

/

P

/

1 (2)

/

CRYSCA

/

1999

/

11

/

G, r

/

Formic acid

/

1

/ Pna21 (chain) / 1 (4) /

CRYSTALG

MOLPAK/DMAREL

/

2000

2000

/

12

13

/

X

L

/

Tetrolic acid

/

2

/

P (dimer)

 P21(chain)

/

1 (2)

1 (2) /

PROMET

MOLPAK/DMAREL /

1997

2000 /

14

13 /

L(), r

L()
/

Acetic acid

/

2

/

I: Pna21 (chain)

II: P21/c (dimer, high pressure) /

1 (4)

/

Polymorph Predictor

Polymorph Predictor
+ UPACK (systematic) /

1998

1998 /

15

16 / L(I,II), p
L(I,II)
/

Benzoic acid

/

1

/ P21/c (dimer) / 1 (4) /

MOLPAK/DMAREL

/

2000

/

13

/

G

/

Terephthalic acid

/

2

/

P

P /

0.5 (1)

0.5 (1) /

Polymorph Predictor

/

1996

/

6

/

L (refine to either), X, p

/

Bromoacetic acid

/

2

/

I: P21/c (dimer)

II: Pccn (dimer) /

1 (4)

1 (4) /

Polymorph Predictor

/

1998

/

15

/ X(I)
/

Chloroacetic acid

/

2

/

P21/c (tetramer)

P21/c (dimer) /

2 (8)

1 (4) /

Polymorph Predictor

/

1998

/

15

/ L()
/

Fluoroacetic acid

/

1

/

P21/c (dimer)

/

1 (4)

/

Polymorph Predictor

/

1998

/

15

/

L

/

Maleic anhydride

/

1

/

P212121

/

1 (4)

/

CRYSTALG

/

2000

/ 12 / G
/

Succinic anhydride

/

1

/

P212121

/

1 (4)

/

CRYSTALG

/

2000

/ 12 / G
/

Trimellitic anhydride

/

1

/

P212121

/

1 (4)

/

Polymorph Predictor

/

1998

/

17

/ L, p
/

Benzene

/

5

/

I: Pbca

III: P21/c

(high pressure)

II: not determined
IV: not determined /

0.5 (4)

0.5 (2) /

PMC

MPA
MDCP
CRYSTALG
ICE9
MPA
Polymorph Predictor
UPACK (systematic)
CRYSTALG / 1984
–1989
1994–1995
1995
1995
1996
1996
1996
1996
1998
1998 /

18–22

23,24
25

26

27

28

29

6
30
31 / G(I), L(III), L(II), a
Low pressure: G(I), L(III)
P < 1.4 GPa: G(I)
P > 1.4 GPa: G(III)
G(I), L(III)
G(I), L(III)
L(I)
M(I), M(III)
G(II), a
(0.5 GPa < P < 1.0 GPa) (special investigation for form II)
G(I), L(III)

G(I), L(III), II: a, p

G(I), L(III)
/

4,5,6,7-Tetrahydro-2,8-di-isopropylidene-4,7-methano-2H-indene

/

1

/

P

/

1 (2)

/

PROMET

/

1991

/

32

/

L, r

/

9,10-Di-isopropylidene-tricyclo[4.3.0.12,5]deca-3,7-diene

/

1

/

P212121

/

1 (4)

/

PROMET

/

1991

/

32

/

G

/

1,4,7,10-Tetramethyl-dibenzo[a,e]cyclo-octene

/

1

/

P

/

1 (2)

/

PROMET

/

1991

/

32

/

G

/

1-Methyl-4-hexylbenzene

/

1

/

P

/

1 (2)

/

PROMET

/

1991

/

32

/

L, r

/

cis,cis-Dodecahydrotriptycene

/

1

/

P

/

1 (2)

/

PROMET

/

1991

/

32

/

L, r

/

1,3,5-Trineopentylbenzene

/

1

/

P

/

1 (2)

/

PROMET

/

1991

/

32

/

X, r

/

9-tert-Butyl-9-(9-fluorenyl)fluorene

/

1

/

P

/

1 (2)

/

PROMET

/

1991

/

32

/

X, r

/

[2.0.0](1,3)-Benzeno(1,8)-naphthaleno(1,3)-benzenophane

/

1

/

P

/

1 (2)

/

PROMET

/

1991

/

32

/

X, r

/

2,2-Dimethyl-3-(2-naphthyl)butane

/

1

/

P21

/

1 (2)

/

PROMET

/

1991

/

32

/

X, r

/

1-tert-Butyl-4-n-butylbenzene

/

1

/

Pc

/

1 (2)

/

PROMET

/

1991

/

32

/

L, r

/

9-(2-Methyl-1-naphthyl)-fluorene

/

1

/

P21/n

/

1 (4)

/

PROMET

/

1991

/

32

/

L, r

/

Dicyclohepta[de,ij]naphthalene

/

1

/

P21/c

/

1 (4)

/

PROMET

/

1991

/

32

/

G

/

3,4:5,6-Dibenzophenanthrene

/

2

/

P21/c

C2/c /

1 (4)

1.5 (12) /

PROMET

/

1991

/

32

/

X(P21/c), r

/

Bi(anthracene-9,10-dimethylene)

/

1

/

P21/c

/

0.5 (2)

/

PROMET

/

1991

/

32

/

L, r

/

9c-Methyl-9cH-cyclopenta[jk]fluorene

/

1

/

P212121

/

1 (4)

/

PROMET

/

1991

/

32

/

X, r

/

1,2-Diphenylbenzene

/

1

/

P212121

/

1 (4)

/

PROMET

/

1991

/

32

/

L, r

/

1,2-Diphenylcyclopentene

/

1

/

P21

/

1 (2)

/

PROMET

/

1991

/

32

/

X

/

3,11-Dimethylene-3a,4,6,7,10,10b-hexahydro-4,10a:7,10-dimethano-3H-cyclohept[e]indene (prediction prior to synthesis)

/

0

/

Unknown

/

Unknown

/

PROMET

/

1991

/

32

/

a

/

Ethene

/

1

/

P21/n

/

0.5 (2)

/

Polymorph Predictor

/

1992

/

33

/

M

/

Hexamethylbenzene

/

1

/

P

/

0.5 (1)

/

Polymorph Predictor

CRYSCA /

1992

1994 /

33

34 /

M

G, r
/

Bicyclohexylidene

/

1

/

P

/

0.5 (1)

/

ICE9

/

1996

/

27

/

G

/

Pentacene

/

1

/

P

/

1 (2)

/

ICE9

/

1996

/

27

/

X

/

Dibenz[a,h]anthracene

/

2

/

A: P21

B: Pcab /

1 (2)

0.5 (4) /

ICE9

/

1996

/

27

/

L(A)

L(B)

/

Trindan

/

1

/

P21/c

/

1 (4)

/

ICE9

/

1996

/

27

/

L

/

Pyrene

/

1

/

P21/a

/

1 (4)

/

ICE9

/

1996

/

27

/

L

/

Durene

/

1

/

P21/a

/

0.5 (2)

/

ICE9

/

1996

/

27

/

L

/

Naphthalene

/

1

/

P21/a

/

0.5 (2)

/

ICE9

/

1996

/

27

/

L

/

Anthracene

/

1

/

P21/a

/

0.5 (2)

/

ICE9

/

1996

/

27

/

L

/

Tetracene

/

1

/

P

/

1 (2)

/

ICE9

/

1996

/

27

/

X

/

Phenanthrene

/

2

/

P21

P21/c /

1 (2)

1 (4) /

ICE9

/

1996

/

27

/

L(P21)

/

Triphenylene

/

1

/

P212121

/

1 (4)

/

ICE9

/

1996

/

27

/

L

/

Perylene

/

2

/

P21/a

P21/c (not fully determined)

/

1 (4)

0.5 (2) /

ICE9

/

1996

/

27

/

L(

/

n-Hexane

/

1

/

P

/

0.5 (1)

/

ICE9

Mpg

/

1996

1999 /

27

35 /

G

M
/

n-Octane

/

1

/

P

/

0.5 (1)

/

ICE9

Mpg

/

1996

1999 /

27

35 /

L

M
/

n-Pentane

/

1

/

Pbcn

/

0.5 (4)

/

Mpg

/

1999

/

35

/

M

/

Adamantane

/

1

/ /

0.25 (2)

/

Mpg

/

1999

/

35

/

M

/

Iceane

/

1

/

P63/m

/

1/6 (2)

/

Mpg

/

1999

/

35

/

M

/

Pentaspiro[2.0.0.2.0.2.0.0.2.0]tridecane

/

1

/

Pbcn

/

0.5 (2)

/

Mpg

/

1999

/

35

/

M

/

4,5-Dimethyl-9,10-dihydrophenanthrene

/

1

/

P

/

1 (2)

/

Mpg

/

1999

/

36

/

G

/

sym-Hexahydropyrene

/

1

/

P21/c

/

0.5 (2)

/

Mpg

/

1999

/

36

/

G

/

1,2-Dihydrocyclo-butabenzene

/

1

/

P

/

1 (2)

/

Mpg

/

1999

/

36

/

G

/

Methanol

/

3

/

P212121

 disordered
 not determined /

1 (4)

/

Polymorph Predictor + ab initio-derived ff

/

1999

/

37

/

G(

/

Ethanol

/

2

/

Pc

P21/c (high pressure)

/

2 (4)

1 (4) /

Polymorph Predictor

+ ab initio-derived ff

UPACK (random) /

1999

2000 /

37

38 /

L(both)

L(both)
/

Galactitol

/

1

/

P21/c

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

L, r

/

D-glycero-L-galacto-Heptitol

/

1

/

P21

/

1 (2)

/

UPACK (systematic)

/

1999

/

39

/

G, r

/

D-Altritol

/

1

/

P21

/

1 (2)

/

UPACK (systematic)

/

1999

/

39

/

L, r

/

D-glycero-L-gulo-Heptitol

/

1

/

P21212

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G, r

/

meso-glycero-allo-Heptitol

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

L, r

/

muco-Inositol

1,2,4,5,6-cyclohexane-hexol /

1

/

P21/c

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G, r

/

Ribitol

/

1

/

P21/c

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G, r

/

meso-D-glycero-L-ido-Heptitol

/

1

/

P

/

1 (2)

/

UPACK (systematic)

/

1999

/

39

/

L, r

/

meso-D-glycero-L-altro-Heptitol

/

1

/

Pbca

/

1 (8)

/

UPACK (systematic)

/

1999

/

39

/

X, r

/

DL-glycero-DL-galacto-Heptitol

/

1

/

Cc

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G, r

/

D-Iditol

/

1

/

P21

/

1 (2)

/

UPACK (systematic)

/

1999

/

39

/

G, r

/

D-Glucitol

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G, r

/

D-Mannitol

/

2

/

: P212121

: P212121 /

1 (4)

1 (4) /

UPACK (systematic)

/

1999

/

39

/

G(r

L(), r

/

Allitol

/

1

/

P21/c

/

0.5 (2)

/

UPACK (systematic)

/

1999

/

39

/

G, r

/

DL-Arabinitol

/

1

/

Pna21

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G, r

/

DL-Mannitol

/

1

/

Pna21

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G, r

/

epi-Inositol

/

1

/

P21/c

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G, r

/

D-glycero-L-allo-Heptitol

/

1

/

P21212

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G, r

/

L-chiro-Inositol

/

1

/

P21

/

1 (2)

/

UPACK (systematic)

/

1999

/

39

/

L, r

/

DL-Iditol

/

1

/

P21/c

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

X, r

/

D-glycero-D-manno-Heptitol

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G, r

/

Xylitol

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G, r

/

neo-Inositol

/

1

/

P

/

0.5 (1)

/

UPACK (systematic)

/

1999

/

39

/

G, r

/

Glycol

/

1

/

P212121

/

1 (4)

/

UPACK (systematic) + ab initio-derived ff

+ extended ab initio ff and lattice vibrations /

2000

2001 /

40

41,42 /

L

G(free energy)
/

Glycerol

/

1

/

P212121

/

1 (4)

/

UPACK (systematic) + ab initio-derived ff

+ extended ab initio ff and lattice vibrations /

2000

2001 /

40

41,42 /

G

L(2nd free energy)
/

-D-Galactose

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

UPACK (systematic) /

1995

1999 /

43

39

/

G, r

L
/

-D-Glucose

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

UPACK (systematic) /

1995

1999 /

43

39

/

L, r

L
/

-D-Talose

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

UPACK (systematic) /

1995

1999

/

43

39

/

G, r

L
/

-D-Allose

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

UPACK (systematic) /

1995

1999 /

43

39

/

L, r

L
/

-D-Galactose

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

UPACK (systematic) /

1995

1999 /

43

39

/

L, r

L
/

-D-Glucose

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

UPACK (systematic) /

1995

1999 /

43

39

/

L, r

L
/

Methyl -D-altropyranoside

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

L

/

Methyl -D-glucopyranoside

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

L

/

Methyl -D-mannopyranoside

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G

/

Methyl -D-galactopyranoside

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G

/

-L-Arabinose

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

L

/

-D-manno-2-Heptulose

/

1

/

P21

/

1 (2)

/

UPACK (systematic)

/

1999

/

39

/

L

/

-L-Fucose

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G

/

Methyl 7-deoxy-L-glycero--D-galacto-heptopyranoside

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

L

/

-Glucoheptose

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G

/

2-Deoxy--D-arabino-hexapyranose

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

L

/

3-O-Methyl--D-glucopyranose

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G

/

1-Deoxy-1-methyl--D-glucopyranose

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

L

/

1,5-Anhydro-D-glucitol

/

1

/

P21

/

1 (2)

/

UPACK (systematic)

/

1999

/

39

/

L

/

2-Desoxy--D-lyxohexose

/

1

/

P21

/

1 (2)

/

UPACK (systematic)

/

1999

/

39

/

L

/

-D-Fructopyranose

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G

/

-L-Lyxopyranose

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

L

/

Methyl -L-arabinoside

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

L

/

Methyl -L-arabinopyranoside

/

1

/

P21

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

L

/

Methyl -D-arabinopyranoside

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G

/

Methyl -D-ribopyranoside

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

L

/

Methyl -D-lyxopyranoside

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

L

/

Methyl 6-deoxy--D-idopyranoside

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

G

/

Methyl -xyloside

/

1

/

P21

/

1 (2)

/

UPACK (systematic)

/

1999

/

39

/

L

/

-L-Xylopyranose

/

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

L

/

Methyl -L-fucopyranoside

/

1

/

P21

/

1 (2)

/

UPACK (systematic)

/

1999

/

39

/

L

/

Methyl -L-rhamnopyranoside

(Methyl 6-deoxy--L-mannopyranoside) /

1

/

P212121

/

1 (4)

/

UPACK (systematic)

/

1999

/

39

/

X

/

-D-Mannose

/

1

/

P212121

/

2 (8)

/

UPACK (random)

/

2000

/

38

/

X

/

Azobis(isobutyronitrile)

/

1

/

P

/

0.5 (1)

/

Polymorph Predictor

/

1992

/

44

/

G, r

/

4,8-Dimethoxy-3,7-diazatricyclo[4.2.2.22,5]-dodeca-3,7,9,11-tetraene

/

1

/

P

/

0.5 (1)

/

Polymorph Predictor

/

1992

/

44

/

G, r

/

cyclo-L-Alanyl-L-alanyl

/

1

/

P1

/

1 (1)

/

Polymorph Predictor

Polymorph Predictor /

1992

1993 /

44

45

/ L, r
L
/ cyclo-Bis(dehydroalanyl)-3,6-dimethylenepiperazine-2,5-dione /

1

/

P21

/

1 (2)

/

Polymorph Predictor

/

1992–

1993

/

44–46

/

L

/

Isoiridomyrmecin

/

1

/

P21

/

0.5 (1)

/

Polymorph Predictor

Polymorph Predictor
Perlstein / 1992

1992

1999

/ 44

46

47 / X

G, r

G, r

/

2,4,6-Trinitro-N-methyl-diphenylamine

/

1

/

P21/c

/

1 (4)

/

MOLPAK/WMIN

/

1993

/

48

/

G

/

Methyl-D-glucopyranoside tetranitrate

/

1

/

P212121

/

1 (4)

/

MOLPAK/WMIN

/

1993

/

48

/

G

/

cis-1,3,5,7-Tetranitro-1,3,5,7-tetraazadecalin

/

1

/

P21

/

1 (2)

/

MOLPAK/WMIN

/

1993

/

48

/

G

/

2,3-Dimethyl-2,3-dinitrobutane

/

1

/

P

/

1 (2)

/

MOLPAK/WMIN

/

1993

/

48

/

L

/

1,4-Dinitrocyclo-octatetraene

/

1

/

Pna21

/

1 (4)

/

MOLPAK/WMIN

/

1993

/

48

/

M

/

2-Nitro-6,7,8,9-tetrahydronaphtho[2,1-b]furan

/

1

/

P

/

1 (2)

/

MOLPAK/WMIN

/

1993

/

48

/

M

/

2-Methoxy-N-(4-nitrobenzylidene)-5-pyridylamine

/

2

/

P21/c

P21 /

1 (4)

1 (2) /

MOLPAK/WMIN

/

1993

/

48

/

M(P21)

/

1,5-Dinitro-3,7-methylene-1,3,5,7-tetraazocane

/

1

/

P21/c

/

1 (4)

/

MOLPAK/WMIN

/

1993

/

48

/

M

/

1,8-Dinitronaphthalene

/

2

/

P212121

Form II: I2/a /

1 (4)

1 (8) /

MOLPAK/WMIN

/

1993

/ 48 / L(P212121)
/

1,1,5,5-Tetranitro[4]peristylane

/

1

/ P21 /

1 (2)

/

MOLPAK/WMIN

/

1994

/

49

/

G, p

/

Pyrimidine

/

1

/

Pna21

/

1 (4)

/

MDCP

CRYSTALG /

1995

2000 /

25

12 /

X

X
/

Imidazole

/

1

/

P21/c

/

1(4)

/

CRYSTALG

/

2000

/

12

/

G

/

m-Nitroaniline

/

1

/

Pbc21

/

1 (4)

/

MPA

/

1995

/

50

/

G

/

1,2-Dimethoxyethane

/

1

/

C2/c

/

0.5 (4)

/

MDCP

/

1995

/

51

/ G(C2/c)
/

4-Amidinoindanone guanylhydrazone

/

2

/

A: P21/c

B: P /

1 (4)

1 (2) /

Polymorph Predictor

/

1996

/

52

/

L(A)

G(B), r, p
/

7-Dimethylaminocyclopenta[c]coumarin

/

2

/

Pbca

Pna21 /

1 (8)

1 (4) /

PROMET

/

1996

/

53

/

G(Pbca)

L(Pna21)
/

Urea

/

1

/

P21m

/

0.25 (2)

/

Polymorph Predictor

MPA

Mpg /

1996

1996

1999 /

6

28

35 /

G

M

G
/

Formamide

/

1

/

P21/n

/

1 (4)

/

CRYSTALG

/

2000

/

12

/

G

/

Alloxan

/

1

/

P41212

/

0.5 (4)

/

MOLPAK/DMAREL

/

1997

/

54

/

G

/

2-Pyridone

/

1

/

P212121

/

1 (4)

/

PROMET

MOLPAK/WMIN /

1997

/

55

+ discussion /

G

L

/

6-Azauracil

/

1

/

P212121

/

1 (4)

/

MOLPAK/DMAREL

/

1997

/ 5 /

L(~G)

/

5-Azauracil

/

1

/

Pbca

/

1 (8)

/

MOLPAK/DMAREL

/

1999

/

56

/

G, a

/

Uracil

/

1

/

P21/a

/

1 (4)

/

MOLPAK/DMAREL

/

1997

/

5

/

G

/

2-Amino-5-nitropyrimidine

/

3

/

I: P21/c

II: P21/n
III: Pccn /

1 (4)

1 (4)
1 (4) /

MOLPAK/DMAREL

/

1998

/

57

/ G(I and II), X
X(III)
/

3,6-Bis(diazo)cyclo-hexanetetraone

/

1

/

P21/c

/

0.5 (2)

/

Mpg

/

1999

/

35

/

M

/

3’, 5’-Di-O-acetyl-(2’S)-deoxy-2’-fluoro-2’-((4-methoxyphenyl)sulfinyl))uridine

/

1

/

P1

/

1 (1)

/

Perlstein

/

1999

/

47

/

G, r

/

(–)-1-(4-dimethylaminophenyl)-2-(2-hydroxypropylamino)cyclobutene-3,4-dione

/

1

/

P1

/

1 (1)

/

Perlstein

/

1999

/

47

/

G, r

/ Tetrahydrofuran / 1 / C2/c / 0.5 (4) / CRYSCA / 1994 / 34 / G, r
/

1,4-Dioxane

/

2

/

I: P21/c

II: P21/c /

0.5 (2)

0.5 (2) /

UPACK (systematic)

+ ab initio-derived ff

/

1999

/

37

/

G(I)

L(II)

/ 4,4,5,5-Tetramethyl-4,5-dihydro-1H-imidazol-1-oxyl 3-oxide [2-hydronitronylnitroxide radical (HNN)] /

2

/

: P21/c

: P21/c /

1 (4)

4 (16) /

PROMET

/

1999

/ 58 / G(p
/

3,6-(Cyclotetramethylene)-2,5-diketopiperazine

/

1

/

P

/

0.5 (1)

/

Chin

/

1999

/

59

/

G, p

/

3,6-(Tetramethyl)-2,5-diketopiperazine

/

1

/

P

/

0.5 (1)

/

Chin

/

1999

/

59

/

G, p

/

3,6-(4,4-Dimethylcyclohexane)-2,5-diketopiperazine

/

1

/

P

/

0.5 (1)

/

Chin

/

1999

/

59

/

G, p

/

1,2-Dichlorobenzene

/

1

/ P21/n /

1 (4)

/

PROMET

/

2001

/

60

/

X, a

/

1,3-Dichlorobenzene

/

1

/

P21/c

/

2 (8)

/

PROMET

/

2001

/

60

/

X, a

/

1,4-Dichlorobenzene

/

3

/

P21/a

P
: P21/c /

0.5 (2)

0.5 (1)
0.5 (2) /

PROMET

/

2001

/

60

/

X(

L(

L

/ Hexasilylbenzene / 1 / P / 0.5 (1) / CRYSCA / 1994 / 34 / G, r

CO2

/

Carbon dioxide

/

2

/

Pa3

Cmca (high pressure) /

1 (4)

1 (4) / MDCP / 1995 / 61 / G(Pa3)
G(Cmca) (at high pressure)

Cl2

/

Chlorine

/

1

/

Cmca

/

MPA

/

1997

/

62

/

L

S6

/

Hexasulfur

/

1

/

R

/

1/6 (1)

/

CRYSTALG

/

1998

/

31

/

L

C60
+ predictions for (C60)2 / C60 fullerene / Complex with disorder / Pa3-P/H / PMC / 1999 / 63 / G(P/H)
/ Pentamethylferrocene,
Cp*FeCp / 1 / P / 1 (2) / CRYSCA / 1994 / 11,34,64 / G, a
/ Decamethylruthenocene,
(Cp*)2Ru
/ 1 / P21/m / 0.5 (2) / CRYSCA / 1994 / 34,64 / G, r
/ Bis(mesitylene)niobium / 1 / P / 1 (2) / CRYSCA / 1994 / 34,64 / G, r
/ (µ-4:3-1,4-Dimethyl-2,3-dimethylenecyclopentenyl)bis(µ-hydrido)bis(5-tetramethylcyclopentadienyl)dititanium / 1 / Pnma / 0.5 (4) / CRYSCA / 1994 / 34,64 / G, r
/ (5-Pentamethylcyclopentadienyl)(4-trimethylenemethane)rhodium,
Cp*Rh(TMM) / 1 / P21/c / 1 (4) / CRYSCA / 1994 / 34,64 / G, r
/ (4-Trimethylenemethane)tricarbonylruthenium,
(TMM)Ru(CO)3 / 1 / P / 1 (2) / CRYSCA / 1994 / 34,64 / G
/ (4-Cyclobutadiene)tricarbonyliron,
(C4H4)Fe(CO)3 / 1 / Pnma / 0.5 (4) / CRYSCA / 1994 / 34,64 / G
Cr(CO)6 / Chromium hexacarbonyl / 1 / Pnma / 0.5 (4) / CRYSCA / 1994 / 34 / G
Ni(CO)4 / Nickel tetracarbonyl / 1 / Pa / 1/3 (8) / CRYSCA / 1994 / 34,64 / G
/

2,4-Di-O-methyl--D-galactopyranose monohydrate

/

1

/

P212121

/

1 (4)

/

UPACK (random)

/

2000

/

38

/

L

/

Methyl 7-deoxy-D-glycero--D-galacto-heptopyranoside monohydrate

/

1

/

C2

/

1 (4)

/

UPACK (random)

/

2000

/

38

/

L

/

Methyl α-D-galactopyranoside monohydrate

/

1

/

P212121

/

1 (4)

/

UPACK (random)

/

2000

/

38

/

L

/

α-L-Rhamnose monohydrate

/

1

/

P21

/

1 (2)

/

UPACK (random)

/

2000

/

38

/

L

/

(+) -Ononitol monohydrate

/

1

/

P1

/

1 (1)

/

UPACK (random)

/

2000

/

38

/

L

/

α-D-Glucose monohydrate

/

1

/

P21

/

1 (2)

/

UPACK (random)

/

2000

/

38

/

L

/

D-manno-3-Heptulose monohydrate

/

1

/

P212121

/

1 (4)

/

UPACK (random)

/

2000

/

38

/

L

/

meso-D-glycero-L-altro-Heptitol monohydrate

/

1

/

C2/c

/

1 (8)

/

UPACK (random)

/

2000

/

38

/

X

/

myo-Inositol dihydrate

/

1

/

P21/a

/

1 (4)

/

UPACK (random)

/

2000

/

38

/

X

The molecular crystals are sorted into groups (alcohols, carboxylic acids, drugs, hydrocarbons, molecular magnets, pigments, polyalcohols, pyranoses, other and hydrates). Closely related molecules within each group are together, but otherwise the molecules in each group are listed by publication year of first study. The programs are as defined in Table 1, though some significant variants are distinguished. The comments include the following points:

GThe experimental structure has been found as the global minimum in the search.

LThe experimental structure has been found in the search among the low energy minima, but not as the global minimum.

MThe experimental structure has been found in the search, but no further information has been provided about the structures and relative

energies of other low energy minima.

XThe experimental structure has not been found in the search.

aThe prediction has been made in advance of an experimental investigation. In some cases, the prediction was then used to solve the crystal structures which were previously (and are listed as) undetermined.

rThe search has just been restricted to the experimental space group.

pPowder diffraction data has been used in the study.

References to survey

1A. Gavezzotti and G. Filipinni, J. Am. Chem. Soc., 1995, 117, 12299.

2R. S. Payne, R. C. Rowe, R. J. Roberts, M. H. Charlton and R. Docherty, J. Comput. Chem., 1999, 20, 262.

3P. Verwer and F.J.J. Leusen, in Reviews in Computational Chemistry, ed. K. B. Lipkowitz and D. B. Boyd, John Wiley and Sons, Inc., New York, 1998, p. 327.

4T. Beyer, G. M. Day and S. L. Price, J. Am. Chem. Soc., 2001, 123, 5086.

5S. L. Price and K. S. Wibley, J. Phys. Chem. A, 1997, 101, 2198.

6F. J. J. Leusen, J. Cryst. Growth, 1996, 166, 900.

7R. S. Payne, R. J. Roberts, R. C. Rowe and R. Docherty, Int. J. Pharm., 1999, 177, 231.

8H. R. Karfunkel, B. Rohde, F. J. J. Leusen, R. J. Gdanitz and G. Rihs, J. Comput. Chem., 1993, 14, 1125.

9S. L. Price and T. Beyer, Trans. ACA, 1998, 33, 23.

10M. U. Schmidt and U. Englert, European Crystallographic Meeting 16, Lund, Sweden, 1995.

11M. U. Schmidt, in Crystal Engineering: From Molecules to Crystals to Materials, ed. D. Braga, F. Grepioni and A. G. Orpen, Kluwer, Dordrecht, 1999, pp. 331–348.

12J. Pillardy, R. J. Wawak, Y. A. Arnautova, C. Czaplewski and H. A. Scheraga, J. Am. Chem. Soc., 2000, 122, 907.

13T. Beyer and S. L. Price, J. Phys. Chem. B, 2000, 104, 2647.

14A. Gavezzotti, G. Filippini, J. Kroon, B. P. van Eijck and P. Klewinghaus, Chem. Eur. J., 1997, 3, 893.

15R. S. Payne, R. J. Roberts, R. C. Rowe and R. Docherty, J. Comput. Chem., 1998, 19, 1.

16W. T. M. Mooij, B. P. van Eijck, S. L. Price, P. Verwer and J. Kroon, J. Comput. Chem., 1998, 19, 459 .

17J. A. Kaduk, J. T. Golab and F. J. J. Leusen, Cryst. Eng., 1998, 1, 277.

18A. V. Dzyabchenko, J. Struct. Chem., 1984, 25, 416.

19A. V. Dzyabchenko, J. Struct. Chem., 1984, 25, 559.

20A. V. Dzyabchenko and M. V. Bazilevskii, J. Struct. Chem., 1985, 26, 553.

21A. V. Dzyabchenko, J. Struct. Chem., 1987, 28, 862.

22A. V. Dzyabchenko, Sov. Phys. Crystallogr., 1989, 34, 131.

23T. Shoda, K. Yamahara, K. Okazaki and D. E. Williams, J. Mol. Struct. (THEOCHEM), 1994, 119, 321.

24T. Shoda, K. Yamahara, K. Okazaki and D. E. Williams, J. Mol. Struct. (THEOCHEM), 1995, 333, 267.

25N. Tajima, T. Tanaka, T. Arikawa, T. Sakurai, S. Teramae and T. Hirano, Bull. Chem. Soc. Jpn., 1995, 68, 519.

26K. D. Gibson and H. A. Scheraga, J. Phys. Chem., 1995, 99, 3765.

27A. M. Chaka, R. Zaniewski, W. Youngs, C. Tessier and G. Klopman, Acta Crystallogr., Sect. B, 1996, 52, 165.

28D. E. Williams, Acta Crystallogr., Sect. A, 1996, 52, 326.

29M. M. Thiéry and C. Rérat, J. Chem. Phys., 1996, 104, 9079.

30B. P. van Eijck, A. L. Spek, W. T. M. Mooij and J. Kroon, Acta Crystallogr., Sect. B, 1998, 54, 291.

31R. J. Wawak, J. Pillardy, A. Liwo, K. D. Gibson and H. A. Scheraga, J. Phys. Chem. A, 1998, 102, 2904.

32A. Gavezzotti, J. Am. Chem. Soc., 1991, 113, 4622.

33R. J. Gdanitz, Chem. Phys. Lett., 1992, 190, 391.

34M. U. Schmidt, Kristallberechnungen Metallorganischer Molekülverbindungen, Verlag Shaker, Technische Universität Aachen, Aachen, Germany, 1995.

35D. Gao and D. E. Williams, Acta Crystallogr., Sect. A, 1999, 55, 621.

36D. E. Williams, in Crystal Engineering: From Molecules to Crystals to Materials, ed. D. Braga, F. Grepioni and A. G. Orpen, Kluwer, Dordrecht, 1999, pp. 295–310.

37W. T. M. Mooij, B. P. van Eijck and J. Kroon, J. Phys. Chem. A, 1999, 103, 9883.

38B. P. van Eijck and J. Kroon, Acta Crystallogr., Sect. B, 2000, 56, 535.

39B. P. van Eijck and J. Kroon, J. Comput. Chem., 1999, 20, 799.

40W. T. M. Mooij, B. P. van Eijck and J. Kroon, J. Am. Chem. Soc., 2000, 122, 3500.

41B. P. van Eijck, W. T. M. Mooij and J. Kroon, J. Comput. Chem., 2001, 22, 805.

42B. P. van Eijck, J. Comput. Chem., 2001, 22, 816.

43B. P. van Eijck, W. T. Mooij and J. Kroon, Acta Crystallogr., Sect. B, 1995, 51, 99.

44H. R. Karfunkel and R. J. Gdanitz, J. Comput. Chem., 1992, 13, 1171.

45H. R. Karfunkel, F. J. J. Leusen and R. J. Gdanitz, J. Comput.-Aided Mater. Des., 1993, 1, 177.

46H. R. Karfunkel and F. J. J. Leusen, speedup, 1992, 6, 43.

47J. Perlstein, in Crystal Engineering: From Molecules to Crystals to Materials, ed. D. Braga, F. Grepioni and A. G. Orpen, Kluwer, Dordrecht, 1999, pp. 23–42.

48J. R. Holden, Z. Du and H. L. Ammon, J. Comput. Chem., 1993, 14, 422.

49H. L. Ammon, Z. Du, J. R. Holden and L. A. Paquette, Acta Crystallogr., Sect. B, 1994, 50, 216.

50T. Shoda and D. E. Williams, J. Mol. Struct. (THEOCHEM), 1995, 357, 1.

51T. Arikawa, N. Tajima, S. Tsuzuki, K. Tanabe and T. Hirano, J. Mol. Struct. (THEOCHEM), 1995, 339, 115.

52H. R. Karfunkel, Z. J. Wu, A. Burkhard, G. Rihs, D. Sinnreich, H. M. Bürger and J. Stanek, Acta Crystallogr., Sect. B, 1996, 52, 555.

53A. Gavezzotti, Acta Crystallogr., Sect. B, 1996, 52, 201.

54D. S. Coombes, G. K. Nagi and S. L. Price, Chem. Phys. Lett., 1997, 265, 532.

55A. Gavezzotti, Faraday Discuss., 1997, 106, 63.

56B. P. Potter, R. A. Palmer, R. Withnall, B. Z. Chowdhry and S. L. Price, J. Mol. Struct., 1999, 485–486, 349.

57C. B Aakeröy, M Nieuwenhuyzen and S. L. Price, J. Am. Chem. Soc., 1998, 120, 8986.

58G. Filippini, A. Gavezzotti and J. J. Novoa, Acta Crystallogr., Sect. B, 1999, 55, 543.

59D. N. Chin, T. R. Palmore and G. M. Whitesides, J. Am. Chem. Soc., 1999, 121, 2115.

60R. Boese, M.T. Kirchener, J.D. Dunitz, G. Filippini and A. Gavezzotti, Helv. Chim. Acta, 2001, 84, 1561.

61T. Hirano, S. Tsuzuki, K. Tanabe and N. Tajima, Chem. Lett., 1995, 1073.

62D. E. Williams and D. Gao, Inorg. Chem., 1997, 36, 782.

63A. V. Dzyabchenko, V. Agafonov and V. A. Davydov, J. Phys. Chem. A, 1999, 103, 2812.

64M. U. Schmidt and U. Englert, J. Chem. Soc., Dalton Trans., 1996, 2077.