Supplementary material 2. Baseline and 1-year anthropometric and metabolic values (means) by treatment group

Table S2a.Baseline and 1-year anthropometric and metabolic values (means) by treatment group (ITT)

Quetiapine / Ziprasidone / Aripiprazole
Mean (SD) / Mean (SD) / Mean (SD)
Baseline / 1 year / Baseline / 1 year / Baseline / 1 year
WEIGHT
Weight (kg) / 67.4 (11.3) / 73.9 (14.4) / 67.5 (15.1) / 73.3 (17.3) / 64.4 (13.8) / 72.3 (14.5)
BMI (kg/m2) / 23.6 (3.3) / 26.0 (4.1) / 23.8 (3.9) / 25.9 (4.3) / 22.4 (3.5) / 25.5 (3.9)
GLUCOSE PARAMETERS
Glucose (mg/dl) / 86.0 (7.9) / 86.7 (7.3) / 87.9 (10.4) / 88.1 (11.3) / 86.6 (15.0) / 89.6 (10.5)
Insulin total (μU/ml) / 8.4 (4.2) / 9.8 (5.4) / 9.8 (6.1) / 10.2 (8.3) / 8.8 (4.8) / 10.8 (5.8)
HOMA index / 1.8 (0-9) / 2.2 (1.3) / 2.2 (1.4) / 2.3 (2.0) / 2.0 (1.2) / 2.4 (1.4)
Triglyceride/HDL index / 1.8 (1.0) / 2.4 (1.5) / 1.6 (1.0) / 1.8 (1.1) / 1.6 (1.2) / 2.0 (1.3)
LIPID PARAMETERS
Cholesterol (mg/dl) / 175.8 (34.2) / 195.4 (43.8) / 181.8 (35.1) / 188.7 (37.9) / 169.1 (37.0) / 189.2 (43.3)
LDL cholesterol (mg/dl) / 107.0 (28.0) / 122.5 (40.8) / 115.4 (29.8) / 122.4 (29.2) / 99.2 (28.3) / 115.5 (38.1)
HDL cholesterol (mg/dl) / 52.4 (12.4) / 50.7 (13.2) / 50.8 (12.4) / 54.5 (12.9) / 55.4 (17.6) / 55.2 (16.6)
Triglycerides (mg/dl) / 84.3 (36.3) / 109.0 (53.6) / 76.7 (32.1) / 91.0 (45.6) / 79.5 (39.0) / 99.65 (53.8)

Table S2b.Baseline and 1-year anthropometric and metabolic values (means) by treatment group (per protocol)

Quetiapine
(N= 8) / Ziprasidone
(N=20) / Aripiprazole
(N=37)
Mean (SD) / Mean (SD) / Mean (SD)
Baseline / 1 year / Baseline / 1 year / Baseline / 1 year
WEIGHT
Weight (kg) / 71.8 (10.7) / 76.8 (13.2) / 66.9 (13.3) / 67.8 (11.9) / 65.8 (14.0) / 75.0 (14.9)
BMI (kg/m2) / 25.4 (4.0) / 27.1 (4.4) / 24.8 (4.2) / 25.2 (3.9) / 22.7 (3.5) / 25.9 (3.9)
GLUCOSE PARAMETERS
Glucose (mg/dl) / 86.2 (6.1) / 87.1 (9.2) / 90.9 (8.5) / 88.2 (9.7) / 85.8 (15.9) / 88.7 (10.8)
Insulin total (μU/ml) / 8.6 (4.8) / 12.5 (7.0) / 9.2 (6.8) / 7.4 (3.9) / 8.5 (4.5) / 10.7 (5.1)
HOMA index / 1.8 (1.0) / 2.9 (1.8) / 2.1 (1.4) / 1.6 (0.9) / 1.9 (1.1) / 2.4 (1.3)
Triglyceride/HDL index / 1.7 (0.6) / 4.2 (1.8) / 1.9 (1.3) / 1.7 (1.1) / 1.6 (1.2) / 2.0 (1.4)
LIPID PARAMETERS
Cholesterol (mg/dl) / 190.6 (40.7) / 202.4 (33.3) / 187.2 (37.9) / 181.8 (41.8) / 164.9 (34.6) / 181.8 (41.8)
LDL cholesterol (mg/dl) / 126.7 (35.3) / 122.5 (33.1) / 122.9 (33.8) / 115.6 (25.6) / 99.7 (27.8) / 111.0 (35.4)
HDL cholesterol (mg/dl) / 51.7 (5.7) / 44.9 (11.7) / 47.5 (11.5) / 54.6 (11.3) / 53.6 (18.4) / 54.0 (16.3)
Triglycerides (mg/dl) / 88.1(30.6) / 175.4 (53.1) / 84.5 (39.1) / 87.4 (41.4) / 75.1 (34.3) / 95.3 (57.3)