Supplementary Information S1 Prevalence Studies

SUPPLEMENTARY INFORMATIONIn format provided by Wuet al. (doi:10.1038/nrneurol.2017.63)

Supplementary information S1 | Prevalence studies

Prevalence (%) / Cohort (yr.) / n / Overall / 65–69years / 70–74years / 75–79years / 80–84years / 85–89years / 90+years / Ratio (95% CI)
Stockholm study1* / Total / II (1987) / 1739 / 17.5
(16.4, 18.6) / - / - / 5.9
(4.4, 7.5) / 11.2
(9.8, 12.6) / 20.3
(17.3, 23.3) / 36.7
(33.8, 39.6) / (reference)
II (2001) / 1575 / 17.9
(16.8, 19.0) / - / - / 4.6
(3.3, 6.0) / 12.0
(10.6, 13.5) / 19.2
(16.3, 22.1) / 38.6
(35.7, 41.6) / 1.2 (1.0, 1.5)
Men / II (1987) / 549 / 12.8
(11.0, 14.7) / - / - / 5.4
(2.9, 7.9) / 12.6
(9.9, 15.4) / 15.8
(10.2, 21.3) / 23.4
(17.4, 29.5) / (reference)
II (2001) / 422 / 10.8
(9.1, 12.6) / - / - / 6.0
(3.4, 8.7) / 7.7
(5.5, 9.9) / 14.5
(9.2, 19.9) / 25.0
(18.8, 31.2) / 0.9 (0.6, 1.5)
Women / II (1987) / 1748 / 19.2
(17.9, 20.5) / - / - / 6.2
(4.3, 8.2) / 10.5
(8.9, 12.2) / 21.7
(18.2, 25.2) / 39.5
(36.3, 42.7) / (reference)
II (2001) / 1153 / 20.5
(19.1, 21.8) / - / - / 3.9
(2.3, 5.4) / 13.9
(12.0, 15.7) / 20.6
(17.2, 24.0) / 41.5
(38.3, 44.8) / 1.2 (1.0, 1.6)
Nordanstig Study2‡ / Total / I (1995) / 303 / 21.8
(17.3, 26.9) / - / - / 17.7
(10.0, 27.9) / 17.9
(12.1, 25.2) / 32.9
(22.7, 44.4) / (reference)
II (2001) / 384 / 17.4
(13.8, 21.6) / - / - / 12.8
(6.6, 21.7) / 15.2
(10.2, 21.3) / 24.2
(16.8, 32.8) / 0.7 (0.5, 1.0)
Men / I (1995) / 124 / 21.8
(14.9, 30.1) / - / - / 19.4
(8.2, 36.0) / 17.2
(8.9, 28.7) / 37.5
(18.8, 59.4) / (reference)
II (2001) / 158 / 13.3
(8.4, 19.6) / - / - / 6.1
(0.7, 20.2) / 10.7
(5.0, 19.4) / 24.4
(12.4, 40.3) / 0.5 (0.2, 0.9)
Women / I (1995) / 179 / 21.8
(16.0, 28.6) / - / - / 16.3
(6.8, 30.7) / 18.5
(10.8, 28.7) / 30.9
(19.1, 44.8) / (reference)
II (2001) / 226 / 20.4
(15.3, 26.2) / - / - / 17.0
(8.1, 29.8) / 19.1
(11.8, 28.6) / 24.1
(15.1, 35.0) / 0.9 (0.5, 1.4)
Gothenburg study3§ / Total (age 70) / II (1976) / 404 / 2.0
(1.0, 4.0) / - / - / - / - / - / - / (reference)
II (2000) / 499 / 2.4
(1.4, 4.2) / - / - / - / - / - / - / 1.2 (0.5, 3.0)
Men (age 70) / II (1976) / 177 / 1.7
(0.6, 4.9) / - / - / - / - / - / - / (reference)
II (2000) / 229 / 0.9
(0.2, 3.1) / - / - / - / - / - / - / 0.5 (0.1, 3.1)
Women (age 70) / II (1976) / 277 / 2.2
(0.9, 5.0) / - / - / - / - / - / - / (reference)
II (2000) / 270 / 3.7
(2.0, 6.7) / - / - / - / - / - / - / 1.7 (0.6, 5.1)
Total (age 75) / II (1976) / 303 / 5.0
(3.0, 8.0) / - / - / - / - / (reference)
II (2005) / 753 / 6.0
(4.5, 7.9) / - / - / - / - / - / - / 1.2 (0.7, 2.2)
Men (age 75) / II (1976) / 117 / 6.8
(3.5, 12.9) / - / - / - / - / - / - / (reference)
II (2005) / 321 / 6.9
(4.6, 10.2) / - / - / - / - / - / - / 1.0 (0.4, 2.3)
Women (age 75) / II (1976) / 186 / 3.8
(1.8, 7.6) / - / - / - / - / - / - / (reference)
II (2005) / 432 / 5.3
(3.6, 7.9) / - / - / - / - / - / - / 1.4 (0.6, 3.3)
Zaragoza study4|| / Total / II (1988) / 1080 / 5.2
(3.9, 6.6) / 0.7
(0.1, 2.7) / 3.0
(1.4, 5.6) / 4.8
(2.5, 8.1) / 11.5
(6.9, 17.5) / 17.6
(10.8, 26.4) / (reference)
II (1994) / 3715 / 3.9
(3.3, 4.5) / 0.7
(0.3, 1.5) / 2.1
(1.3, 3.4) / 2.2
(1.2, 3.8) / 7.1
(5.0, 9.8) / 16.2
(13.8, 18.7) / 0.8 (0.6, 1.0)
Men / II (1988) / 435 / 5.8
(3.6, 7.9) / 0.9
(0.0, 4.9) / 4.4
(1.6, 9.4) / 7.1
(2.9, 14.0) / 15.5
(7.3, 27.4) / 15.6
(5.3, 32.8) / (reference)
II (1994) / 1516 / 2.3
(1.6, 3.0) / 1.0
(0.3, 2.6) / 1.2
(0.3, 2.9) / 2.0
(0.7, 4.7) / 4.3
(1.9, 8.3) / 10.7
(7.6, 14.4) / 0.4 (0.3, 0.7)
Women / II (1988) / 645 / 4.9
(3.1, 6.6) / 0.6
(0.0, 3.6) / 1.8
(0.4, 5.2) / 3.2
(1.0, 7.3) / 9.1
(4.2, 16.6) / 18.6
(10.3, 29.7) / (reference)
II (1994) / 2199 / 5.0
(4.1, 5.9) / 0.4
(0.1, 1.5) / 2.8
(1.6, 4.7) / 2.4
(1.1, 4.6) / 8.9
(5.9, 12.7) / 19.5
(16.3, 23.0) / 1.0 (0.7, 1.5)
CFAS5|| / Total / II (1991) / 7635 / 8.3
(7.0, 9.6) / 1.9
(0.7, 4.2) / 2.6
(1.1, 4.9) / 6.7
(4.1, 10.6) / 14.1
(10.3, 18.6) / 24.9
(18.7, 31.6) / 36.8
(26.7, 47.8) / (reference)
II (2008) / 7796 / 6.5
(5.9, 7.0) / 1.5
(1.0, 2.1) / 2.7
(2.0, 3.6) / 5.7
(4.6, 6.9) / 10.0
(8.4, 11.8) / 16.1
(13.5, 19.0) / 30.1
(25.0, 35.7) / 0.7 (0.6, 0.9)
Men / II (1991) / 3045 / 7.4
(5.7, 9.1) / 1.7
(0.8, 3.2) / 2.2
(1.2, 4.0) / 5.7
(3.4, 9.2) / 14.6
(8.6, 23.7) / 19.8
(10.3, 34.6) / 68.2
(34.8, 89.6) / (reference)
II (2008) / 3550 / 4.9
(4.2, 5.7) / 1.2
(0.6, 2.3) / 3.0
(2.0, 4.4) / 5.2
(3.8, 7.0) / 10.6
(8.2, 13.7) / 12.8
(9.0, 18.0) / 17.1
(10.6, 26.4) / 0.6 (0.5, 0.8)
Women / II (1991) / 4590 / 9.4
(7.6, 11.2) / 2.0
(1.0, 3.8) / 2.9
(1.7, 5.0) / 7.4
(3.7, 14.6) / 13.9
(9.7, 19.4) / 26.5
(18.1, 37.1) / 32.3
(21.7, 45.0) / (reference)
II (2008) / 4246 / 7.7
(6.8, 8.5) / 1.8
(0.9, 3.6) / 2.5
(1.6, 3.9) / 6.2
(4.5, 8.4) / 9.5
(7.3, 12.3) / 18.1
(14.5, 22.2) / 35.0
(28.4, 42.3) / 0.8 (0.7, 0.9)
Bordeaux farmer study (clinical diagnosis)6¶ / Total / II (1988) / 595 / 5.7
(4.0, 7.9) / 0.7
(0.1, 4.1) / 1.8
(2.2, 6.3) / 4.4
(1.8, 8.9) / 10.4
(5.3, 17.8) / 12.7
(5.6, 23.5) / 26.3
(9.2, 51.2) / (reference)
II (2007) / 906 / 12.0
(9.7, 14.4) / 2.6
(0.9, 6.0) / 4.0
(1.8, 7.4) / 14.4
(10.1, 19.6) / 20.3
(14.7, 27.0) / 20.9
(11.9, 32.6) / 33.3
(11.8, 61.6) / 2.3 (1.5, 3.4)
Men / II (1988) / 252 / 2.8
(1.1, 5.6) / 1.8
(0.1, 9.4) / 2.0
(0.1, 10.5) / 1.4
(0.1, 7.7) / 2.0
(0.1, 10.9) / 9.1
(1.1, 29.2) / 33.3
(0.8, 90.6)
II (2007) / 577 / 11.3
(8.8, 14.1) / 3.1
(0.9, 7.8) / 3.1
(0.8, 7.7) / 16.8
(11.1, 23.9) / 20.3
(13.7, 28.3) / 14.3
(5.4, 28.5) / 16.7
(0.4, 64.1)
Women / II (1988) / 343 / 7.9
(5.3, 11.3) / 0.0 / 1.6
(0.1, 8.7) / 6.7
(2.5, 14.1) / 17.5
(8.8, 29.9) / 14.6
(5.6, 29.2) / 25.0
(7.3, 52.4)
II (2007) / 329 / 11.3
(8.0, 15.2) / 1.6
(0.1, 8.7) / 5.1
(1.7, 11.5) / 10.5
(4.9, 18.9) / 20.4
(10.2, 34.3) / 32.0
(15.0, 53.5) / 44.4
(13.7, 78.8)
Bordeaux farmer study (algorithmic diagnosis)6¶ / Total / II (1988) / 588 / 23.8
(20.4, 27.5) / 3.7
(1.2, 8.4) / 10.7
(5.7, 18.0) / 20.1
(14.2, 27.2) / 41.9
(32.3, 51.8) / 62.3
(49.0, 74.4) / 56.3
(29.9, 80.3) / (reference)
II (2007) / 899 / 14.8
(12.2, 17.4) / 5.4
(2.6, 9.7) / 5.7
(3.1, 9.6) / 14.9
(10.5, 20.1) / 19.4
(13.9, 26.1) / 25.8
(15.8, 38.0) / 60.0
(32.3, 83.7) / 0.6 (0.4, 0.7)
Men / II (1988) / 251 / 18.7
(14.1, 24.1) / 3.5
(0.4, 12.1) / 9.8
(3.3, 21.4) / 12.9
(6.1, 23.0) / 37.5
(24.0, 52.7) / 50.0
(28.2, 71.8) / 66.7
(9.4, 99.2)
II (2007) / 572 / 11.2
(8.4, 14.1) / 4.8
(1.8, 10.2) / 3.1
(0.8, 7.7) / 15.4
(9.9, 22.4) / 19.7
(13.2, 27.7) / 14.6
(5.6, 29.2) / 16.7
(0.4, 64.1)
Women / II (1988) / 337 / 27.6
(22.9, 32.7) / 3.9
(0.8, 10.8) / 11.5
(4.7, 22.2) / 25.8
(17.1, 36.2) / 45.6
(32.4, 59.3) / 69.2
(52.4, 83.0) / 53.9
(25.1, 80.8)
II (2007) / 327 / 16.2
(12.4, 20.7) / 6.6
(1.8, 16.0) / 9.2
(4.3, 16.7) / 14.0
(7.4, 23.1) / 18.8
(9.0, 32.6) / 44.0
(24.4, 65.1) / 88.9
(51.8, 99.7)
Health and Retirement Study7§ / Total / II (2000) / 10546 / 11.8
(10.8, 12.9) / 4.4
(3.5, 5.4) / 6.6
(5.2, 8.1) / 11.1
(9.4, 12.8) / 17.8
(15.5, 20.2) / 28.4
(24.8, 31.9) / 47.0
(42.1, 52.0) / (reference)
II (2012) / 10511 / 9.0
(8.4, 9.7) / 2.6
(1.8, 3.5) / 4.4
(3.4, 5.4) / 7.3
(6.3, 8.2) / 13.9
(12.1, 15.8) / 25.2
(22.1, 28.3) / 37.7
(33.5, 41.9) / 0.8 (0.7, 0.9)
Men / II (2000) / 4482 / 10.4
(9.1, 11.7) / 5.9
(4.5, 7.3) / 6.6
(4.6, 8.7) / 10.7
(8.3, 13.1) / 16.1
(12.3, 19.9) / 26.4
(19.8, 32.9) / 34.2
(25.1, 43.2) / (reference)
II (2012) / 4414 / 7.5
(6.6,8.4) / 2.3
(1.3, 3.3) / 4.5
(2.9, 6.1) / 6.8
(5.6, 8.1) / 14.5
(11.8, 17.2) / 21.0
(16.3, 25.6) / 31.3
(22.0, 40.5) / 0.7 (0.6, 0.8)
Women / II (2000) / 6064 / 12.8
(11.6,13.9) / 3.3
(2.4, 4.1) / 6.6
(5.0, 8.2) / 11.4
(9.2, 13.5) / 18.8
(16.1, 21.6) / 29.3
(25.3, 33.4) / 51.3
(45.7, 56.8) / (reference)
II (2012) / 6097 / 10.2
(9.4,11.0) / 2.9
(1.9, 3.9) / 4.3
(3.0, 5.6) / 7.6
(6.2, 9.0) / 13.6
(10.9, 16.2) / 27.6
(23.8, 31.4) / 40.5
(35.0, 46.0) / 0.8 (0.7, 0.9)
Indianapolis–Ibadan Dementia Project8# / Total / I (1992) / 1500 / 6.8
(5.8, 7.7) / - / 2.5
(1.6, 3.4) / 4.9
(3.5, 6.2) / 9.7
(7.3, 12.1) / 17.5
(12.8, 22.2) / (reference)
II (2001) / 1892 / 7.4
(4.3, 10.6) / - / 1.9
(0.9, 2.9) / 4.7
(2.2, 7.2) / 10.3
(3.6, 16.9) / 23.2
(4.7, 41.6) / 1.1 (0.9, 1.4)
Men / I (1992) / 520 / 5.9
(4.8, 7.0) / - / 2.6
(1.5, 3.7) / 3.8
(2.4, 5.3) / 10.3
(6.7, 13.8) / 13.2
(8.5, 17.9)
II (2001) / 667 / 11.6
(7.0, 16.4) / - / 6.5
(0.2, 12.8) / 8.8
(0.3, 17.4) / 15.8
(4.8, 26.8) / 25.2
(8.7, 41.7) / -
Women / I (1992) / 980 / 7.2
(5.9, 8.4) / - / 2.5
(1.3, 3.6) / 5.4
(3.5, 7.4) / 9.5
(6.3, 12.6) / 19.4
(13.7, 25.2)
II (2001) / 1225 / 5.2
(3.0, 7.5) / - / 2.3
(0.0, 5.1) / 4.5
(0.7, 8.2) / 6.7
(1.6, 11.9) / 13.3
(3.6, 21.0) / -
Hisayama study9|| / Total / I (1985) / 887 / 6.0
(4.4, 7.6) / 1.8
(0.6, 4.2) / 2.6
(0.9, 5.0) / 4.2
(2.3, 8.1) / 15.0
(9.2, 22.9) / 39.9
(25.9, 53.1) / (reference)
II (1992) / 1189 / 4.4
(3.3, 5.6) / 1.3
(0.4, 3.0) / 1.5
(0.6, 3.9) / 5.3
(2.9, 8.9) / 7.9
(5.3, 14.9) / 24.9
(16.7, 33.1) / 0.7 (0.5, 1.0)
III (1998) / 1437 / 5.3
(4.2, 6.4) / 1.0
(0.3, 2.5) / 2.9
(1.5, 5.2) / 5.5
(3.1, 8.8) / 14.4
(9.8, 20.5) / 20.3
(14.2, 26.3) / 0.8 (0.6, 1.1)
IV (2005) / 1566 / 8.3
(7.0, 9.5) / 1.1
(0.3, 2.8) / 3.6
(1.9, 6.0) / 10.5
(7.5, 14.4) / 16.9
(12.5, 22.1) / 41.8
(37.1, 51.2) / 1.3 (1.0, 1.9)
Men / I (1985) / 353 / 5.4
(3.0, 7.8) / 1.7
(0.2, 5.9) / 3.8
(1.1, 9.5) / 1.4
(0.04, 7.7) / 14.6
(6.1, 27.8) / 41.7
(15.2, 72.3) / (reference)
II (1992) / 475 / 3.6
(1.9, 5.3) / 2.1
(0.6, 5.3) / 0.9
(0.2, 5.0) / 5.2
(1.7, 11.6) / 3.9
(0.5, 13.5) / 18.5
(6.3, 38.1) / 0.6 (0.3, 1.3)
III (1998) / 571 / 4.2
(2.6, 5.9) / 1.1
(0.1, 4.1) / 2.2
(0.6, 5.5) / 5.7
(2.1, 12.0) / 13.6
(6.4, 24.3) / 9.8
(2.7, 23.1) / 0.7 (0.4, 1.3)
IV (2005) / 612 / 7.2
(5.3, 9.2) / 1.2
(0.2, 4.5) / 4.1
(1.7, 8.3) / 9.2
(4.3, 14.8) / 15.2
(7.2, 22.4) / 34.5
(22.0, 49.1) / 1.3 (0.7, 2.2)
Women / I (1985) / 534 / 6.6
(4.5, 8.6) / 1.9
(0.4, 5.5) / 1.3
(0.2, 4.7) / 7.0
(3.1, 13.4) / 15.5
(8.0, 26.0) / 38.1
(23.6, 54.4) / (reference)
II (1992) / 714 / 5.3
(3.8, 6.8) / 0.5
(0.1, 2.9) / 2.2
(0.6, 5.5) / 5.4
(2.4, 10.4) / 11.9
(6.5, 19.5) / 31.3
(21.4, 42.6) / 0.7 (0.5, 1.2)
III (1998) / 866 / 6.4
(4.9, 7.9) / 0.9
(0.1, 3.1) / 3.7
(1.6, 7.1) / 5.3
(2.5, 9.8) / 15.1
(9.2, 22.9) / 30.8
(22.9, 39.5) / 0.8 (0.5, 1.3)
IV (2005) / 954 / 9.3
(7.7, 10.9) / 1.0
(0.1, 3.5) / 3.1
(1.3, 6.5) / 11.8
(7.7, 17.1) / 18.7
(13.1, 25.6) / 49.0
(39.1, 55.6) / 1.4 (0.9, 2.1)

*Stockholm study: Overall estimates for the total population were standardised by age and gender and overall estimates for men and women were standardised by age. All estimates were standardised by age withinthe 5-year age group. Ratios were adjusted for age, gender and education. ‡Nordanstig study: All prevalence estimates were unadjusted. Ratios were adjusted for age and gender.§Gothenburg study, Health and Retirement study: All prevalence estimates and ratios were unadjusted.||Zaragoza study, CFAS, Hisayama study: Overall prevalence estimates for the total population were standardised by age and gender and overall estimates for men and women were standardised by age.¶Bordeaux farmer study: Overall estimates for the total population were standardised by age and gender.#Indianapolis-Ibadan Dementia Project: Overall estimates for the total population, men and women were standardised by age.

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