Supplementary Fig. 1Excellent outcome according to quartiles for leukocyte counts, LMR, NLR, and NMR on Day 1.There were no differences of outcomes according to quartiles for leukocyte counts and NMR on day 1. More excellent outcomes were showed in higher quartile for LMR (p=0.029) and in lower quartile for NLR (p0.011) on day 1.

Supplementary Table 1 The neutrophils, lymphocytes, monocyte counts and their respective ratios on day 1 and 7

Excellent outcome
Present (n=51) / Absent (n=51) / p
Day 1
Neutrophil / 5.49 ± 2.57 / 6.00 ± 3.00 / 0.567
Lymphocyte / 2.18 ± 1.08 / 1.91 ± 0.89 / 0.140
Monocyte / 0.59 ± 0.21 / 0.53 ± 0.20 / 0.656
NLR / 3.40 ± 3.510 / 3.86 ± 2.73 / 0.207
NMR / 14.46 ± 28.41 / 12.54 ± 7.29 / 0.224
LMR / 4.58 ± 3.18 / 3.91 ± 1.86 / 0.243
Day 7
Neutrophil / 5.71 ± 7.66 / 5.82 ± 2.31 / 0.007
Lymphocyte / 1.99 ± 0.61 / 1.74 ± 0.49 / 0.030
Monocyte / 0.59 ± 0.24 / 0.73 ± 0.32 / 0.007
NLR / 3.00 ± 2.788 / 3.667 ± 1.93 / < 0.001
NMR / 9.82 ± 10.17 / 8.80 ± 4.48 / 0.536
LMR / 3.89 ± 1.83 / 2.72 ± 1.32 / < 0.001

NLR, neutrophil-to-monocyte ratio; NMR, neutrophil-to-monocyte ratio; LMR, lymphocyte-to-monocyte ratio.

Values are mean ± standard deviation.

Supplementary Table 2 Simple logistic regression analyses of the variables associated with the excellent outcome

Excellent outcome
Independent variable / OR (95% CI) / P value
Age / - / -
Sex (female) / - / -
Initial NIHSS score / 0.87 (0.82-0.93) / <0.001
DWI-ASPECTS / 1.42 (1.17-1.71) / <0.001
Pneumonia / 0.469 (0.111-1.987) / 0.304
UTI / 0.466 (0.130-2.545) / 0.466
Pneumonia or UTI / 0.309 (0.09-1.05) / 0.059
Days above 37.5℃ / 0.747 (0.557-1.002) / 0.052
Day 1
Neutrophil / 0.94 (0.81-1.1) / 0.717
Lymphocyte / 1.34 (0.87-2.04) / 0.178
Monocyte / 1.52 (0.23-10.31) / 0.666
NLR / 0.95 (0.84-1.08) / 0.457
NMR / 1.01 (0.98-1.03) / 0.648
LMR / 1.12 (0.94-1.34) / 0.213
Day 7
Neutrophil / 1.00 (0.93-1.07) / 0.922
Lymphocyte / 2.41 (1.10-5.28) / 0.028
Monocyte / 0.15 (0.03-0.69) / 0.015
NLR / 0.88 (0.74-1.06) / 0.175
NMR / 1.02 (0.96-1.08) / 0.527
LMR / 1.64 (1.22-2.20) / 0.001

IQR,interquartile range; NIHSS, National Institutes of Health Stroke Scale; DWI, diffusion-weighted imaging; ASPECT, Alberta Stroke Program Early CT Score; UTI,urinary tract infection;NLR, neutrophil-to-monocyte ratio; NMR, neutrophil-to-monocyte ratio; LMR, lymphocyte-to-monocyte ratio.