Supplemental Table S4: Functional Analysis of the Differentially Expressed Genes Identified

Supplemental Table S4: Functional analysis of the differentially expressed genes identified in WTIPIR vs. Nox2-/-IPIR comparison

Relevant Functions / P Value / No of Molecules
Endocrine System Disorders / 3.4E-13-6.58E-03 / RGS1,SPP1,C3,LGALS3,LCN2,AQP1,SERPINA3,CDS1,DUSP1,TIMP1,IL1B,CTNNB1,C2
Metabolic Disease / 3.4E-13-1.2E-03 / RGS1,SPP1,C3,LGALS3,LCN2,AQP1,SERPINA3,CDS1,CCL2,DUSP1,TIMP1,IL1B,NPPA,C2
Cellular Movement / 2.21E-12-6.58E-03 / RGS1,LGALS3,MMP3,PTN,CCL24,SERPINA3,CCL2,DKK3,TIMP1,CFB,CCL8,CTNNB1,KLF2,SPP1,C3,FCGR2A,CD69,LCN2,ALOX5AP,SELPLG,TIMP4,SCGB1A1,CD40,DUSP1,CORO1A,C4A,CCL21,IL1B,RAMP3,NPPA,SFRP1,C2
Hematological System Development and Function / 2.21E-12-6.58E-03 / RGS1,LGALS3,MMP3,CCL24,C1QA,SERPINA3,LGALS4,C1QC,LYZ,HBB (includes EG:3043),CCL2,DKK3,TIMP1,CFB,CCL8,CTNNB1,KLF2,SIGLEC1,C3,SPP1,FCGR2A,CD69,HBA1,LCN2,ALOX5AP,VSIG4,SPON2,SELPLG,SCGB1A1,CD40,DUSP1,CD72,CORO1A,C4A,CCL21,IL1B,NPPA,C2,CLEC10A
Immune Cell Trafficking / 2.21E-12-6.56E-03 / RGS1,LGALS3,MMP3,CCL24,LGALS4,SERPINA3,C1QA,LYZ,CCL2,TIMP1,CFB,CCL8,KLF2,SPP1,C3,FCGR2A,CD69,LCN2,ALOX5AP,SPON2,SELPLG,SCGB1A1,CD40,DUSP1,CORO1A,CCL21,C4A,IL1B,NPPA,C2
Inflammatory Response / 6.89E-12-6.56E-03 / RGS1,LGALS3,MMP3,CCL24,LGALS4,SERPINA3,C1QA,C1QB,LYZ,CCL2,TIMP1,HLA-B,CFB,CCL8,AIF1,KLF2,C3,SPP1,FCGR2A,CD69,LCN2,ALOX5AP,CAPG,IFI27L2,SPON2,SELPLG,SCGB1A1,CD40,DUSP1,CORO1A,CCL21,C4A,IL1B,NPPA,CLEC10A,C2
Connective Tissue Disorders / 2.09E-09-6.58E-03 / ATP8A1 (includes EG:10396),MMP3,CCL24,C1QA,SERPINA3,SH3GL2,IDE,LYZ,CCL2,TIMP1,HLA-B,CFB,CCL8,AIF1,CTNNB1,ACTA1,KCNV2,C3,SPP1,FCGR2A,CD69,VSIG4,ALOX5AP,TIMP4,CD68,CD40,DUSP1,CD72,C4A,CCL21,IL1B,C2
Inflammatory Disease / 2.09E-09-6.58E-03 / LGALS3,ATP8A1 (includes EG:10396),MMP3,CA4,CCL24,LGALS4,SERPINA3,C1QA,LYZ,IDE,SH3GL2,CCL2,DKK3,TIMP1,STX8,HLA-B,CFB,CCL8,AIF1,CTNNB1,ACTA1,KCNV2,C3,SPP1,FCGR2A,CD69,AQP1,VSIG4,ALOX5AP,SCGB1A1,TIMP4,CD68,CD40,DUSP1,CD72,BIK,C4A,CCL21,ANO4,IL1B,C2
Skeletal and Muscular Disorders / 2.09E-09-6.58E-03 / ATP8A1 (includes EG:10396),MMP3,CA4,CCL24,C1QA,SERPINA3,SH3GL2,IDE,LYZ,MDH1,TUBB2B,CDS1,CCL2,DKK3,TIMP1,CFB,HLA-B,MYL4,CCL8,AIF1,PRG4 (includes EG:10216),CTNNB1,ACTA1,KCNV2,SPP1,C3,DBP,FCGR2A,CD69,LCN2,AQP1,ALOX5AP,VSIG4,MYH7,TIMP4,TACC2,CD40,CD68,SLC17A7,TRIM63,DUSP1,CD72,C4A,CCL21,IL1B,RAMP3,NPPA,C2
Antigen Presentation / 6.43E-09-6.56E-03 / RGS1,SPP1,C3,LGALS3,MMP3,FCGR2A,CD69,LCN2,CCL24,C1QA,SPON2,SELPLG,CD40,CCL2,TIMP1,CORO1A,C4A,CFB,CCL21,IL1B,CCL8,C2,CLEC10A
Humoral Immune Response / 6.43E-09-4.85E-03 / RGS1,SIGLEC1,C3,SPP1,FCGR2A,CD69,C1QA,SELPLG,CD40,CD72,C4A,CCL21,CFB,IL1B,CTNNB1,C2
Renal and Urological Disease / 7.78E-09-5.47E-03 / SPP1,LGALS3,C3,FCGR2A,CA4,LCN2,HBA1,AQP1,C1QA,SERPINA3,UBD,CCL2,DUSP1,DKK3,TIMP1,CFB,C4A,IL1B,SFRP1,NPPA,CTNNB1,C2
Cell-To-Cell Signaling and Interaction / 4.44E-08-6.58E-03 / RGS1,LGALS3,PTN,CCL24,C1QA,LGALS4,LYZ,GPNMB,CCL2,TIMP1,DKK3,CCL8,CTNNB1,KLF2,C3,SPP1,FCGR2A,CD69,LCN2,CAPG,SELPLG,SPON2,SCGB1A1,CD40,CD68,DUSP1,CD72,CORO1A,CCL21,C4A,IL1B,NPPA,CLEC10A
Tissue Development / 4.44E-08-6.58E-03 / RGS1,LGALS3,MMP3,PTN,CCL24,LGALS4,C1QA,GPNMB,CCL2,DKK3,TIMP1,CTNNB1,KLF2,SPP1,C3,FCGR2A,LCN2,SELPLG,SPON2,CD40,DUSP1,CD72,CORO1A,CCL21,C4A,IL1B,SFRP1,NPPA
Tissue Morphology / 1.04E-07-6.13E-03 / LGALS3,MMP3,PTN,CCL24,C1QA,PCOLCE,HBB (includes EG:3043),CCL2,TIMP1,DKK3,MYL4,CTNNB1,KLF2,ACTA1,SIGLEC1,C3,SPP1,FCGR2A,CD69,AQP1,VSIG4,MYH7,SELPLG,GAMT,CD40,TRIM63,CD72,CCL21,BIK,C4A,IL1B
Organismal Injury and Abnormalities / 4.38E-07-4.26E-03 / C3,SPP1,LGALS3,FCGR2A,CCL24,C1QA,MYH7,HBB (includes EG:3043),CCL2,TIMP1,DUSP1,HLA-B,C4A,CFB,IL1B,CCL8,CTNNB1,C2
Cell-mediated Immune Response / 5.81E-07-6.58E-03 / SPP1,LGALS3,C3,FCGR2A,CD69,CCL24,LGALS4,SELPLG,CD40,CCL2,CORO1A,CCL21,IL1B,CCL8,NPPA,CTNNB1,KLF2,CLEC10A
Cell Morphology / 5.95E-07-6.58E-03 / RAB4A,SPP1,LGALS3,FCGR2A,LCN2,CCL24,CAPG,SERPINA3,HBB (includes EG:3043),CCL2,CD40,TACC2,DKK3,CORO1A,CCL21,IL1B,CCL8,NPPA,SFRP1,AIF1,CTNNB1,KLF2,NRN1
Cellular Development / 5.95E-07-6.58E-03 / RAB4A,LGALS3,MMP3,PTN,CCL24,C1QC,LGALS4,SERPINA3,HBB (includes EG:3043),CCL2,TIMP1,CCL8,AIF1,PRG4 (includes EG:10216),CTNNB1,KLF2,C3,SPP1,FCGR2A,CD69,LCN2,HBA1,CAPG,HSPA2,CD40,DUSP1,CD72,CORO1A,CCL21,IL1B,SFRP1,NPPA,CLEC10A
Cell Death / 6.2E-07-6.41E-03 / LGALS3,MMP3,PTN,SERPINA3,C1QA,LGALS4,SH3GL2,LYZ,MDH1,ACIN1,CCL2,TIMP1,DKK3,HLA-B,AIF1,CTNNB1,KLF2,SPP1,C3,FCGR2A,CD69,HBA1,LCN2,HSPA2,UBD,TIMP4,CD68,CD40,DUSP1,BIK,IL1B,NPPA,SFRP1,CLEC10A
Cardiovascular System Development and Function / 1.01E-06-6.58E-03 / C3,LGALS3,SPP1,MMP3,PTN,HBA1,CCL24,C1QA,MYL7,SELPLG,CCL2,CD40,TRIM63,ABRA,TIMP1,DUSP1,C4A,IL1B,NPPA,CTNNB1,KLF2
Immunological Disease / 1.02E-06-6.58E-03 / ATP8A1 (includes EG:10396),MMP3,CCL24,SERPINA3,C1QA,LYZ,IDE,SH3GL2,CCL2,TIMP1,HLA-B,CFB,CCL8,AIF1,CFP,ACTA1,SIGLEC1,KCNV2,C3,SPP1,FCGR2A,CD69,HBA1,VSIG4,TACC2,CD40,CD68,DUSP1,CCL21,C4A,ANO4,IL1B,C2
Cardiovascular Disease / 1.1E-06-6.58E-03 / RGS1,ATP8A1 (includes EG:10396),RAB4A,MMP3,CA4,C1QA,SH3GL2,CDS1,CCL2,TIMP1,CFB,STX8,CTNNB1,KLF2,ACTA1,ANO10,KCNV2,SPP1,C3,LCN2,HBA1,ALOX5AP,MYH7,FCN2,TACC2,CD40,CD68,DUSP1,TRIM63,ANO4,IL1B,NPPA,C2
Hematological Disease / 1.1E-06-2.38E-03 / HBB (includes EG:3043),C3,FCGR2A,LCN2,CFB,IL1B,C1QA,CTNNB1,KLF2,C2
Hypersensitivity Response / 1.52E-06-3.86E-03 / SCGB1A1,LGALS3,C3,CCL2,FCGR2A,C4A,CCL21,IL1B,CCL24,CCL8,SELPLG
Lymphoid Tissue Structure and Development / 2.95E-06-5.11E-03 / LGALS3,SPP1,C3,MMP3,FCGR2A,CCL24,C1QA,SELPLG,CCL2,CD40,CORO1A,CCL21,IL1B,CCL8
Cellular Growth and Proliferation / 5.46E-06-6.58E-03 / LGALS3,MMP3,PTN,FOLR2,CCL24,LGALS4,GPNMB,ACIN1,CCL2,DKK3,TIMP1,CFB,AIF1,PRG4 (includes EG:10216),CTNNB1,NRN1,KLF2,SIGLEC1,C3,SPP1,LCN2,VSIG4,TIMP4,SCGB1A1,CD40,TACC2,DUSP1,CD72,CORO1A,CCL21,IL1B,SFRP1,NPPA,CLEC10A
Skeletal and Muscular System Development and Function / 9.5E-06-6.58E-03 / SPP1,C3,PTN,C1QA,MYH7,PCOLCE,CD40,CCL2,GAMT,DUSP1,TIMP1,TRIM63,C4A,IL1B,MYL4,RAMP3,AIF1,CTNNB1,KLF2,ACTA1
Lipid Metabolism / 1.83E-05-6.58E-03 / SCGB1A1,HBB (includes EG:3043),C3,CCL2,CD40,FCGR2A,CCL21,ALOX5AP,IL1B,IDE,NPPA
Molecular Transport / 1.83E-05-6.58E-03 / RGS1,LGALS3,SPP1,C3,FCGR2A,HBA1,ALOX5AP,CCL24,LYZ,CCL2,CD40,CD72,BIK,C4A,CCL21,IL1B,CCL8,NPPA,KLF2
Small Molecule Biochemistry / 1.83E-05-6.58E-03 / C3,SPP1,FCGR2A,ALOX5AP,IDE,SCGB1A1,HBB (includes EG:3043),CD40,CCL2,BIK,CCL21,IL1B,NPPA
Cancer / 1.96E-05-6.58E-03 / RGS1,LGALS3,MMP3,PTN,CCL24,SERPINA3,LGALS4,LYZ,MDH1,PCOLCE,HBB (includes EG:3043),CCL2,TIMP1,HLA-B,CFB,CTNNB1,NRN1,SIGLEC1,SPP1,C3,FCGR2A,CD69,LCN2,HBA1,AQP1,CAPG,IFI27L2,SPON2,SCGB1A1,TIMP4,CD68,TACC2,CD40,DUSP1,SULT1A1,CCL21,C4A,IL1B,SFRP1,CLEC10A
Cell Signaling / 2.85E-05-3.79E-03 / RGS1,LGALS3,SPP1,C3,FCGR2A,PTN,HBA1,CCL24,LYZ,CCL2,CD40,DUSP1,CD72,BIK,C4A,CCL21,IL1B,CCL8,NPPA,KLF2
Vitamin and Mineral Metabolism / 2.85E-05-3.79E-03 / RGS1,LGALS3,SPP1,C3,FCGR2A,HBA1,CCL24,LYZ,CCL2,CD40,CD72,BIK,C4A,CCL21,IL1B,CCL8,NPPA,KLF2
Cellular Function and Maintenance / 3.15E-05-6.58E-03 / SPP1,LGALS3,C3,FCGR2A,CAPG,C1QA,LGALS4,HSPA2,SELPLG,CD40,CORO1A,CCL21,IL1B,NPPA,CTNNB1,KLF2,CLEC10A
Reproductive System Disease / 3.21E-05-5.91E-03 / SIGLEC1,RGS1,C3,SPP1,MMP3,CD69,LCN2,HBA1,SPON2,TIMP4,HBB (includes EG:3043),CD68,CCL2,TIMP1,DUSP1,CFB,SFRP1,CTNNB1,CLEC10A
Hepatic System Disease / 4.29E-05-3.19E-03 / C3,LGALS3,SPP1,TIMP1,CTNNB1
Free Radical Scavenging / 6.24E-05-6.24E-05 / CCL2,FCGR2A,IL1B,NPPA
Drug Metabolism / 1.18E-04-6.58E-03 / HBB (includes EG:3043),CD40,FCGR2A,IL1B,NPPA
Cellular Assembly and Organization / 1.46E-04-6.58E-03 / C3,FCGR2A,SERPINA3,IDE,SH3GL2,CORO1A,CCL21,IL1B,SFRP1,NPPA,CTNNB1,KLF2,ACTA1
Neurological Disease / 1.76E-04-6.58E-03 / SIGLEC1,C3,SPP1,SERPINA3,C1QA,IDE,CD40,CCL2,DUSP1,TIMP1,C4A,HLA-B,CCL21,IL1B
Ophthalmic Disease / 1.76E-04-5.71E-03 / C3,TIMP1,CA4,CFB,IL1B,LYZ,C2,GPNMB
Renal and Urological System Development and Function / 1.79E-04-6.58E-03 / SCGB1A1,DUSP1,LCN2,CCL21,IL1B
Connective Tissue Development and Function / 1.9E-04-5.47E-03 / SPP1,C3,LGALS3,MMP3,PTN,PCOLCE,CCL2,TIMP1,IL1B,NPPA,SFRP1,PRG4 (includes EG:10216),CTNNB1
Infectious Disease / 2.07E-04-4.32E-03 / C3,LAPTM5,SPP1,FCGR2A,CD69,CA4,LCN2,ALOX5AP,C1QA,LYZ,SELPLG,UBD,CD40,CCL2,SRPK3,TIMP1,DUSP1,OTUD1,IL1B,CCL8,NPPA,PRG4 (includes EG:10216),KLF2,C2
Nervous System Development and Function / 2.1E-04-6.58E-03 / C3,SPP1,CD40,DBP,SLC17A7,CCL21,IL1B,NPPA,PER2
Organismal Survival / 2.16E-04-4.23E-03 / C3,CA4,AQP1,MYH7,LYZ,IDE,MYL7,UBD,HBB (includes EG:3043),CCL2,CD40,SLC17A7,DUSP1,CCL21,CFB,C4A,IL1B,KLF2
Embryonic Development / 2.75E-04-6.58E-03 / SCGB1A1,C3,SPP1,TIMP1,IL1B,SFRP1,CTNNB1
Reproductive System Development and Function / 2.75E-04-6.58E-03 / SCGB1A1,LGALS3,C3,SPP1,TIMP1,IL1B,CTNNB1,HSPA2
Hematopoiesis / 2.77E-04-6.58E-03 / SPP1,LGALS3,C3,FCGR2A,CD69,LCN2,HBA1,CCL24,C1QC,LGALS4,HBB (includes EG:3043),CD40,IL1B,NPPA,CTNNB1,KLF2,CLEC10A
Respiratory Disease / 2.92E-04-4.1E-03 / SPP1,C3,LGALS3,CA4,LCN2,CCL24,LYZ,SCGB1A1,HBB (includes EG:3043),CCL2,CD68,TIMP1,CFB,CCL21,IL1B,C2
Post-Translational Modification / 3.95E-04-3.95E-04 / SPP1,CD40,FCGR2A,DUSP1,CD72,PTN,IL1B
Hepatic System Development and Function / 4.05E-04-5.47E-03 / LGALS3,C3,SPP1,TIMP1,PTN,IL1B,CTNNB1
Organismal Development / 4.25E-04-6.58E-03 / C3, LGALS3, CD40, MMP3, CCL2, TIMP1, IL1B, AQP1, CCL24, CTNNB1, KLF2, MYL7
Auditory Disease / 5.07E-04-4.26E-03 / MMP3,CCL21,KLF2
Carbohydrate Metabolism / 8.82E-04-6.58E-03 / CD40,FCGR2A,CCL21,IL1B
Gastrointestinal Disease / 8.82E-04-6.58E-03 / SIGLEC1,SPP1,LGALS3,MMP3,LCN2,SERPINA3,LGALS4,CAPG,LYZ,PCOLCE,SPON2,CCL2,TIMP1,CFB,IL1B,SFRP1,CTNNB1,NRN1,C2
Genetic Disorder / 9.32E-04-6.58E-03 / SIGLEC1,C3,SPP1,MMP3,CA4,LCN2,CCL24,TIMP4,SCGB1A1,CD68,CCL2,DUSP1,TIMP1,CFB,SFRP1,PRG4 (includes EG:10216),CTNNB1,C2,ACTA1
Developmental Disorder / 1.01E-03-6.58E-03 / LGALS3,RAB4A,MMP3,TIMP1,DUSP1,TRIM63,IL1B,NPPA,CTNNB1
Infection Mechanism / 1.1E-03-1.17E-03 / C3,CD40,IL1B,C1QA,LYZ
DNA Replication, Recombination, and Repair / 1.11E-03-1.11E-03 / LGALS3, SPP1, CD40, DUSP1, PTN, IL1B, NPPA, CTNNB1, KLF2
Protein Synthesis / 1.43E-03-2.64E-03 / SPP1,HBB (includes EG:3043),FCGR2A,HBA1,IL1B,IDE,CTNNB1
Dermatological Diseases and Conditions / 1.5E-03-3.7E-03 / RGS1,MMP3,FCGR2A,ALOX5AP,CCL24,UBD,DUSP1,CD72,C4A,CFB,HLA-B,IL1B,CTNNB1
Gene Expression / 1.5E-03-6.58E-03 / CD40,IL1B,SFRP1,CTNNB1
Endocrine System Development and Function / 1.87E-03-3.19E-03 / IL1B,NPPA
Cell Cycle / 2.27E-03-6.58E-03 / LGALS3,SPP1,C3,CD40,DUSP1,IL1B,LGALS4,AIF1,NPPA,CTNNB1
Cellular Compromise / 2.27E-03-3.19E-03 / SPP1,C3,IL1B
Behavior / 2.71E-03-2.71E-03 / DBP,PER2
Digestive System Development and Function / 2.71E-03-2.71E-03 / C3,AQP1
Antimicrobial Response / 3.17E-03-3.17E-03 / CD40,LCN2,CCL8,IFI27L2
Organ Development / 4.58E-03-6.58E-03 / TRIM63,ABRA,TIMP1,IL1B
Respiratory System Development and Function / 6.58E-03-6.58E-03 / NPPA