Supplemental Figure 1 s1

Supplemental Figure 1:

A.

SE7VKGGADMKRVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGY
SE63...... Q......
SE5...... Q......
C98-370...... Q......
MW2...... Q......
SE50...... Q......
N315...... Q......
J28...... Q......
SE7RQITQLIQQGQCDILCCYRLNRLHRNLKNALKLIKLCQTYHVHILSAHDGYFDMDQAFDR
SE63...... V......
SE5...... V......
C98-370...... V......
MW2...... V......
SE50..M...... R.....V......
N315..M...... V......
J28..M...... V......
SE7LKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYHNGTFIINQNESPTV
SE63......
SE5......
C98-370......
MW2......
SE50...... D......
N315F...... A...S......
J28F...... A...S......
SE7KAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPS
SE63......
SE5......
C98-370......
MW2......
SE50......
N315......
J28......
SE7IVSTSIYEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPK
SE63......
SE5......
C98-370......
MW2......
SE50...... S......
N315...... S....S...I...S...... T...... V......
J28...... S....S...I...S...... T...... V......
SE7NMNASRFVCDFKGINAQTLEDKVLEVCRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTL
SE63......
SE5......
C98-370......
MW2......
SE50...... G...... I.
N315...... K...... G......
J28...... K...... G......
SE7TQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQNIIQKRFTLNILYP
SE63......
SE5......
C98-370......
MW2..K...... NT...... M...
SE50...... T......
N315...... TV......
J28...... TV......
SE7YIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
SE63......
SE5......
C98-370......
MW2..DE.L...S.T.M...... T.....
SE50...... A......
N315......
J28......

B.

MW2MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMN
N315......
SE5......
SE7...... C......
SE63......
J52...... E......
C98-370......
SE50...... D......
MW2RPELQRILKDAKDGYIDCVMVYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTS
N315...... E......
SE5...... M.....E.N......
SE7...... M.....E.N......
SE63...... M.....E.N...... L......
J52...... M.....E.N......
C98-370...... M.....E.N......
SE50...... M.....E.N....TI......
MW2SGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGNLPLGYDKIPNSKHELMINQH
N315......
SE5...... D......
SE7...... D......
SE63...... D.....D......
J52...... D......
C98-370...... D......
SE50...... D......
MW2EANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
N315......
SE5...... C......
SE7...... C......
SE63...... C......
J52...... C......
C98-370...... C......
SE50......
MW2YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGII
N315......
SE5......
SE7......
SE63......
J52......
C98-370......
SE50...... E......
MW2HCPQCGAPMAASNTTNTLKDGTKKRIRYYSCSNFRNKGSKVCSANSVRANVIEDYVMKQI
N315...... D......
SE5...... D......
SE7...... D......
SE63...... D......
J52...... D......
C98-370...... D......
SE50...... D......
MW2LEIVKSDKIIERVVARVNQENQVDCASLHHDIAYKQQQYDEVQIKLNNLIKTIEDNPDLT
N315...... V.Q...TH...... G.A......
SE5...... V.Q...TH...... G.A...... I......
SE7...... V.Q...TH...... G.A...... I......
SE63...... V.Q...TH...... G.A...... I......
J52...... V.Q...TH...... A.G.A...... I......
C98-370...... V.Q...TH...... G.A...... I......
SE50...... V.Q...... K..G.A...... T......
MW2SVIRPSIQKYEKQLNDITYQINQLKNQQNEDKTLFDAKEISKLLQHIFHDIKHIEKSRLK
N315...... N...... P......
SE5...... N......
SE7...... N......
SE63...... N......
J52...... N......
C98-370...... N......
SE50...... N...... S.....Q...... Q....M......
MW2ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYL
N315......
SE5.S...... E......
SE7......
SE63......
J52......
C98-370......
SE50...... N.R......
MW2TI
N315..
SE5..
SE7..
SE63..
J52..
C98-370..
SE50..

Supplemental Figure 1: Amino Acid Sequence Alignments for CcrA and CcrB. A. CcrA amino acid alignment. Eight of the eleven CcrA sequences are shown. CcrA from stains C99-529, J35, and J52 are identical to that of C98-370 (shown). B. CcrB amino acid alignment. Eight of the eleven CcrB sequences are shown. CcrB from strain N315 (shown) and J28 have the identical CcrB sequence, and the sequences of C98-370 (shown), C99-529, and J35 are also identical.