Supplemental Data

Table e-1 Univariable analysis of predictors of early recurrent ICH in patients with cerebral amyloid angiopathy

Variable / HR / 95% CI / p Value
Demographic variables
Age, years / 1.01 / 0.96-1.06 / 0.648
Sex, female / 0.86 / 0.36-2.04 / 0.735
Hypertension / 0.57 / 0.24-1.34 / 0.194
Diabetes mellitus / 0.04 / 0.00-13.29 / 0.279
Warfarin use / 0.64 / 0.15-2.76 / 0.548
Aspirin use / 0.55 / 0.21-1.40 / 0.209
Statin use / 0.74 / 0.29-1.92 / 0.540
Previous symptomatic ICH / 4.01 / 1.35-11.91 / 0.013
APOE e2 (≥ 1 copy) / 1.17 / 0.33-4.09 / 0.812
APOE e4 (≥ 1 copy) / 0.69 / 0.24-2.00 / 0.499
MRI
Fazekas scale
Grade 0-1 (reference)
Grade2-3 / 1.17 / 0.39-3.48 / 0.776
cSS present / 3.66 / 1.52-8.84 / 0.004
No cSS (reference)
Focal, ≤ 3sulci / 2.73 / 0.78-9.57 / 0.118
Disseminated, >3 sulci / 4.61 / 1.64-12.96 / 0.004
Acute cSAH present / 3.48 / 1.28-9.51 / 0.015
Number of CMBs
0 (reference)
1 / 1.69 / 0.51-5.63 / 0.389
2-4 / 2.39 / 0.83-6.88 / 0.107
≥5 / 1.12 / 0.30-4.21 / 0.869
CT
Index ICH volume,ml / 1.01 / 0.99-1.04 / 0.192
CT-WMH present (posterior) / 2.03 / 0.85-4.81 / 0.110
Acute cSAH present / 4.39 / 1.48-13.05 / 0.008

Abbreviations: CI = confidence interval; CMBs = cerebral microbleeds; cSAH = convexity subarachnoid hemorrhage; cSS = cortical superficial siderosis; CT= computed tomography scan; CT-WMH = CT-defined white matter hypodensity; HR = hazard ratio; ICH = intracerebral hemorrhage; MRI = magnetic resonance imaging. Hazard ratio point estimates were obtained via Cox regression.

Table e-2 Baseline characteristics of patients with probable or definite CAA and possible CAA.

All CAA / Possible CAA / Probable or definite CAA
Number of patients / 292 / 116 / 176
Demographic variables
Age, years / 76.44±8.83 / 75.16±10.11 / 77.29±7.79
Sex, female / 153 (52.4) / 58 (50.0) / 95 (54.0)
Hypertensiona / 193 (66.3) / 79 (68.1) / 114 (65.1)
Systolic blood pressureb / 134 (127.0,143.0) / 134.2 (127.8,142.8) / 134 (126.6,143.1)
Diastolic blood pressureb / 76 (71.0,81.3) / 76 (71.5, 81.0) / 76.0 (71.0,80.0)
Diabetes mellitusa / 38 (13.1) / 21 (18.1) / 17 (9.7)
Warfarin usea / 41 (14.1) / 16 (13.8) / 25 (14.3)
Aspirin usec / 123 (42.4) / 51 (44.3) / 72 (41.1)
Statin used / 99 (34.4) / 43 (37.7) / 56 (32.2)
Previous symptomatic ICHa / 17 (5.8) / 0 (0) / 17 (9.7)
APOE e2 (≥ 1 copy)e / 28 (17.7) / 11 (18.6) / 17 (17.2)
APOE e4 (≥ 1 copy)e / 61 (38.6) / 26 (44.1) / 35 (35.4)
MRI
Fazekas scale / 2 (2,3) / 2 (1,2) / 2 (2,3)
cSS present / 49 (16.8) / 5 (4.3) / 44 (25.0)
Focal, ≤ 3sulci / 23 (7.9) / 1 (0.9) / 22 (12.5)
Disseminated, >3 sulci / 26 (8.9) / 4 (3.4) / 22 (12.5)
Acute cSAH present / 27 (9.2) / 7 (6.0) / 20 (11.4)
Number of CMBs
0 / 147 (50.3) / 107 (92.2) / 40 (22.7)
1 / 42 (14.4) / 9 (7.8) / 33 (18.8)
2-4 / 50 (17.1) / 0 (0) / 50 (28.4)
≥5 / 53 (18.2) / 0 (0) / 53 (30.1)
Index event to MRI time, days / 2 (1,4) / 2 (1,4) / 2 (1,4)
CT
Index ICH volume,mlf / 19 (9.1,35.5) / 20.5 (10.4,38.0) / 18.3 (8.0,33.8)
CT-WMH present (posterior) / 115 (39.4) / 27 (23.2) / 88 (50.0)
Acute cSAH present / 18 (6.2) / 5 (4.3) / 13 (7.4)
Index event to CT time, days / 1 (0,1) / 1 (0,1) / 1 (0,2)

Values are displayed as mean ± standard deviation, median (25th, 75th quartile), or n (%).

Abbreviations: CAA = cerebral amyloid angiopathy; CMBs = cerebral microbleeds; cSAH = convexity subarachnoid hemorrhage; cSS = cortical superficial siderosis; CT= computed tomography scan; CT-WMH = CT-defined white matter hypodensity; ICH = intracerebral hemorrhage; MRI = magnetic resonance imaging.

a 1 patient with missing data, b 19 patients with missing data,c 2 patients with missing data, d 4 patients with missing data, e 158 patients consented for APOE genotype testing, f 5 patients with missing data.

*consisted of 237 patients without recurrent ICH and 34 patients with late recurrent ICH.

Figure e-1 Frequency distribution of recurrent lobar intracerebral hemorrhage in cerebral amyloid angiopathy patients.

Bar chart represents frequency distribution of recurrent lobar intracerebral hemorrhage (ICH) in cerebral amyloid angiopathy patients (n=55). Recurrent lobar ICH commonly occurred before 6 months after index lobar ICH, causing a skewed distribution of recurrence pattern.