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Appendix e-1. ICD-9 Diagnosis and Procedure Codes Used to Indentify Cohorts
Cohort / Sub-Cohort / ICD-9 Code / CPT Code / Code Description
Autoimmune Conditions
Vasculitis / 446.00 / Polyarteritis nodosa and allied conditions
446.00 / Polyarteritis nodosa
446.10 / Acute febrile mucocutaneous lymph node syndrome (MCLS)
446.20 / Unspecified hypersensitivity angiitis
446.21 / Goodpasture's syndrome
446.29 / Other specified hypersensitivity angiitis
446.30 / Lethal midline granuloma
446.40 / Wegener's granulomatosis
446.50 / Giant cell arteritis
446.60 / Thrombotic microangiopathy
446.70 / Takayasu's disease
273.20 / Other paraproteinemias
Systemic Lupus Erythematosus / 710.00 / Systemic lupus erythematosus
Rheumatoid Arthritis / 714 / Rheumatoid arthritis and other inflammatory polyarthropathies
714 / Rheumatoid arthritis
714.1 / Felty's syndrome
714.2 / Other rheumatoid arthritis with visceral or systemic involvement
714.81 / Rheumatoid lung
Multiple Sclerosis / 340.00 / Multiple sclerosis
Sjogren’s Disease / 710.20 / Sicca syndrome
Non-Hodgkin’s Lymphoma / 200 / Lymphosarcoma and reticulosarcoma and other specified malignant tumors of lymphatic tissue
200 / Reticulosarcoma
200 / Reticulosarcoma, unspecified site, extranodal and solid organ sites
200.01 / Reticulosarcoma of lymph nodes of head, face, and neck
200.02 / Reticulosarcoma of intrathoracic lymph nodes
200.03 / Reticulosarcoma of intra-abdominal lymph nodes
200.04 / Reticulosarcoma of lymph nodes of axilla and upper limb
200.05 / Reticulosarcoma of lymph nodes of inguinal region and lower limb
200.06 / Reticulosarcoma of intrapelvic lymph nodes
200.07 / Reticulosarcoma of spleen
200.08 / Reticulosarcoma of lymph nodes of multiple sites
200.1 / Lymphosarcoma
200.1 / Lymphosarcoma, unspecified site, extranodal and solid organ sites
200.11 / Lymphosarcoma of lymph nodes of head, face, and neck
200.12 / Lymphosarcoma of intrathoracic lymph nodes
200.13 / Lymphosarcoma of intra-abdominal lymph nodes
200.14 / Lymphosarcoma of lymph nodes of axilla and upper limb
200.15 / Lymphosarcoma of lymph nodes of inguinal region and lower limb
200.16 / Lymphosarcoma of intrapelvic lymph nodes
200.17 / Lymphosarcoma of spleen
200.18 / Lymphosarcoma of lymph nodes of multiple sites
200.2 / Burkitt's tumor or lymphoma
200.2 / Burkitt's tumor or lymphoma, unspecified site, extranodal and solid organ sites
200.21 / Burkitt's tumor or lymphoma of lymph nodes of head, face, and neck
200.22 / Burkitt's tumor or lymphoma of intrathoracic lymph nodes
200.23 / Burkitt's tumor or lymphoma of intra-abdominal lymph nodes
200.24 / Burkitt's tumor or lymphoma of lymph nodes of axilla and upper limb
200.25 / Burkitt's tumor or lymphoma of lymph nodes of inguinal region and lower limb
200.26 / Burkitt's tumor or lymphoma of intrapelvic lymph nodes
200.27 / Burkitt's tumor or lymphoma of spleen
200.28 / Burkitt's tumor or lymphoma of lymph nodes of multiple sites
200.3 / Marginal zone lymphoma
200.3 / Marginal zone lymphoma, unspecified site, extranodal and solid organ sites
200.31 / Marginal zone lymphoma, lymph nodes of head, face, and neck
200.32 / Marginal zone lymphoma, intrathoracic lymph nodes
200.33 / Marginal zone lymphoma, intra-abdominal lymph nodes
200.34 / Marginal zone lymphoma, lymph nodes of axilla and upper limb
200.35 / Marginal zone lymphoma, lymph nodes of inguinal region and lower limb
200.36 / Marginal zone lymphoma, intrapelvic lymph nodes
200.37 / Marginal zone lymphoma, spleen
200.38 / Marginal zone lymphoma, lymph nodes of multiple sites
200.4 / Mantle cell lymphoma
200.4 / Mantle cell lymphoma, unspecified site, extranodal and solid organ sites
200.41 / Mantle cell lymphoma, lymph nodes of head, face, and neck
200.42 / Mantle cell lymphoma, intrathoracic lymph nodes
200.43 / Mantle cell lymphoma, intra-abdominal lymph nodes
200.44 / Mantle cell lymphoma, lymph nodes of axilla and upper limb
200.45 / Mantle cell lymphoma, lymph nodes of inguinal region and lower limb
200.46 / Mantle cell lymphoma, intrapelvic lymph nodes
200.47 / Mantle cell lymphoma, spleen
200.48 / Mantle cell lymphoma, lymph nodes of multiple sites
200.5 / Primary central nervous system lymphoma
200.5 / Primary central nervous system lymphoma, unspecified site, extranodal and solid organ sites
200.51 / Primary central nervous system lymphoma, lymph nodes of head, face, and neck
200.52 / Primary central nervous system lymphoma, intrathoracic lymph nodes
200.53 / Primary central nervous system lymphoma, intra-abdominal lymph nodes
200.54 / Primary central nervous system lymphoma, lymph nodes of axilla and upper limb
200.55 / Primary central nervous system lymphoma, lymph nodes of inguinal region and lower limb
200.56 / Primary central nervous system lymphoma, intrapelvic lymph nodes
200.57 / Primary central nervous system lymphoma, spleen
200.58 / Primary central nervous system lymphoma, lymph nodes of multiple sites
200.6 / Anaplastic large cell lymphoma
200.6 / Anaplastic large cell lymphoma, unspecified site, extranodal and solid organ sites
200.61 / Anaplastic large cell lymphoma, lymph nodes of head, face, and neck
200.61 / Anaplastic large cell lymphoma, lymph nodes of head, face, and neck
200.62 / Anaplastic large cell lymphoma, intrathoracic lymph nodes
200.63 / Anaplastic large cell lymphoma, intra-abdominal lymph nodes
200.64 / Anaplastic large cell lymphoma, lymph nodes of axilla and upper limb
200.65 / Anaplastic large cell lymphoma, lymph nodes of inguinal region and lower limb
200.66 / Anaplastic large cell lymphoma, intrapelvic lymph nodes
200.67 / Anaplastic large cell lymphoma, spleen
200.68 / Anaplastic large cell lymphoma, lymph nodes of multiple sites
200.7 / Large cell lymphoma
200.7 / Large cell lymphoma, unspecified site, extranodal and solid organ sites
200.71 / Large cell lymphoma, lymph nodes of head, face, and neck
200.72 / Large cell lymphoma, intrathoracic lymph nodes
200.72 / Large cell lymphoma, intrathoracic lymph nodes
200.73 / Large cell lymphoma, intra-abdominal lymph nodes
200.74 / Large cell lymphoma, lymph nodes of axilla and upper limb
200.75 / Large cell lymphoma, lymph nodes of inguinal region and lower limb
200.76 / Large cell lymphoma, intrapelvic lymph nodes
200.77 / Large cell lymphoma, spleen
200.78 / Large cell lymphoma, lymph nodes of multiple sites
200.8 / Other named variants of lymphosarcoma and reticulosarcoma
200.8 / Other named variants, unspecified site, extranodal and solid organ sites
200.81 / Other named variants of lymphosarcoma and reticulosarcoma of lymph nodes of head, face, and neck
200.82 / Other named variants of lymphosarcoma and reticulosarcoma of intrathoracic lymph nodes
200.83 / Other named variants of lymphosarcoma and reticulosarcoma of intra-abdominal lymph nodes
200.84 / Other named variants of lymphosarcoma and reticulosarcoma of lymph nodes of axilla and upper limb
200.85 / Other named variants of lymphosarcoma and reticulosarcoma of lymph nodes of inguinal region and lower limb
200.86 / Other named variants of lymphosarcoma and reticulosarcoma of intrapelvic lymph nodes
200.87 / Other named variants of lymphosarcoma and reticulosarcoma of spleen
200.88 / Other named variants of lymphosarcoma and reticulosarcoma of lymph nodes of multiple sites
202.xx / Other malignant neoplasms of lymphoid and histiocytic tissue
202.0x / Nodular lymphoma
202.1x / Mycosis fungoides
202.2x / Sezary's disease
202.7x / Peripheral T-cell lymphoma
202.8x / Other malignant lymphomas
Chronic Lymphocytic Leukemia / 204.1x / Chronic lymphoid leukemia
Solid Organ Transplantation
Kidney / 996.81 / Complications of transplanted kidney
55.6x / Other kidney transplantation
50360 / Transplantation of kidney
50365 / Renal allotransplantation, implantation of graft; with recipient nephrectomy
Heart / 996.83 / Complications of transplanted heart
37.5x / Heart transplantation
33945 / Heart transplant, with or without recipient cardiectomy
Lung / 996.84 / Complications of transplanted lung
33.5x / Lung transplant
32851 / Lung transplant, single; without cardiopulmonary bypass
32852 / Lung transplant, single; with cardiopulmonary bypass
32853 / Lung transplant, double (bilateral sequential or en bloc); without cardiopulmonary bypass
32854 / Lung transplant, double (bilateral sequential or en bloc); with cardiopulmonary bypass
Heart-Lung / 33.6 / Combined heart-lung transplantation
33935 / Heart-lung transplant with recipient cardiectomy-pneumonectomy
Liver / 996.82 / Complications of transplanted liver
50.5 / Liver transplant
50.51 / Auxiliary liver transplant
50.59 / Other transplant of liver
47135 / Liver allotransplantation; orthotopic, partial or whole, from cadaver or living donor, any age
47136 / Liver allotransplantation; heterotopic, partial or whole, from cadaver or living donor, any age
Pancreas / 996.86 / Complications of transplanted pancreas
52.8x / Pancreatic transplant, not otherwise specified
48554 / Transplantation of pancreatic allograft
Intestines / 996.87 / Complications of transplanted organ, intestine
Other Organ or Tissue / 996.89 / Complications of other transplanted organ
Bone Marrow Transplantation / 996.85 / Complications of bone marrow transplant
41 / Bone marrow transplant
41 / Bone marrow transplant, not otherwise specified
41.01 / Autologous bone marrow transplant without purging
41.02 / Allogeneic bone marrow transplant with purging
41.03 / Allogeneic bone marrow transplant without purging
41.04 / Autologous hematopoietic stem cell transplant without purging
41.05 / Allogeneic hematopoietic stem cell transplant without purging
41.06 / Cord blood stem cell transplant
41.07 / Autologous hematopoietic stem cell transplant with purging
41.08 / Allogeneic hematopoietic stem cell transplant with purging
41.09 / Autologous bone marrow transplant with purging
38240 / Bone marrow or blood-derived peripheral stem cell transplantation; allogenic
38241 / Bone marrow or blood-derived peripheral stem cell transplantation; autologous
38242 / Bone marrow or blood-derived peripheral stem cell transplantation; allogeneic donor lymphocyte infusions
HIV / 042.x / Human immunodeficiency virus [HIV]
V08 / Asymptomatic human immunodeficiency virus (HIV) infection status
79.53 / Human immunodeficiency virus, type 2 (HIV 2), in conditions classified elsewhere and of unspecified site

Note. ICD-9, International Classification of Diseases, Ninth Revision; CPT, Current Procedural Terminology.

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i3 Drug Safety Confidential 19-Mar-2010