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Supplement to manuscript “Real-world cost-effectiveness of cetuximab in locally advanced squamous cell carcinoma of the head and neck”: unit costs and outcomes study cost results

Main unit costs for the outcomes study (Euro 2011)*
Resource use item / Unit costs
Anaesthesia for CT / € 57
Bone densitometry scan / € 145
Bonescintigraphy / € 189
Bronchoscopy / € 497
Cetuximab i.v. 100 mg (20 ml) / €209
Chemotherapy palliative / € 2,163
Colonoscopy / € 429
Consultation by telephone / € 13
CT airways, abdomen / € 218
CT brain/skull, face, spine, arm / € 197
CT guided biopsy / € 183
CT mastoid/petrosum / € 239
CT thorax / € 253
Dual-energy X-ray absorptiometry / € 107
Electromyography / € 68
Evaluateelectrocardiogram / € 19
Evaluation of swallowing / € 54
Gastric or duodenal feeding tube / € 134
Gastroscopy/duodenoscopy / € 384
Gastrostomy / € 411
Hyperbaric oxygen / € 175
Intensive care day / € 2,107
Laboratory tests (per day) / € 37
Laryngoscopy / € 147
Larynxextirpation / € 4,983
Lobectomy / € 5,957
MRI brain, cervicalspine, lumbosacralspine, skull / € 253
Nasopharyngoscopy / € 97
Oesophagoscopy / € 166
Oesophagus swallowing X-ray / € 141
Oncology day-care treatment, university hospital / € 225
Oncology inpatient hospital day, university hospital / € 666
Oncology outpatient visit, university hospital / € 127
Palliative radiotherapy / € 1,828
Pathology / € 56
Percutaneous endoscopic gastrostomy / € 474
PET scan (partial) / € 1,025
PET scan (total body) / € 1,455
Radical neck dissection / € 1,897
Radiotherapy / € 8,840
Regionalneck dissection, one side / € 845
Scintigraphy for inflammation / € 703
Teeth extraction / € 330
Thoracotomy / € 4,853
Thoraxdrain / € 2,756
Tracheotomy / € 770
Ultrasound face and/or sinuses, thyroid gland and/or neck, arms or legs, heart and/or thorax, abdomen / € 78
Ultrasound guided biopsy or X-ray guided biopsy / € 104
Ultrasoundskull ororbitae / € 72
X-ray guidance during surgery / € 134
X-ray skull, face, teeth, jaw, thoracal spine, knee, leg, wrist/hand/fingers, ankle/foot / € 48
X-ray stomach and duodenum / € 148
X-ray thorax, larynx and trachea, abdomen, lumbar spine, cervical spine, shoulder, pelvis, X-ray guidance / € 51
*Obtainedfrom Dutch tariff lists ( Z-index ( andmicrocosting studies (Tan SS, Van Gils CW, Franken MG, Hakkaart-van Roijen L, Uyl-de Groot CA. The unit costs of inpatient hospital days, outpatient visits, and daycare treatments in the fields of oncology and hematology. Value Health 2010 Sep-Oct;13(6):712-719, Tan SS, Hakkaart-van Roijen L, Al MJ, Bouwmans CA, Hoogendoorn ME, Spronk PE, et al. A microcosting study of intensive care unit stay in the Netherlands. J Intensive Care Med 2008 Jul-Aug;23(4):250-257, Hakkaart-van Roijen L, Tan SS, Bouwmans CAM. Handleiding voor kostenonderzoek. 2010. Available at: (accessed Jan 2014)). Applied 2010 inflation rate: 1.3 (CBS Statline).
Outcomes study total mean costs per patient (Euro 2011)
RT + C
N = 31 / RT alone
N = 31 / Total
N = 61 / Total
N = 23
Treatment costs / Follow-up costs / Post-progression costs
Inpatient hospital days / 5,518 / 3,049 / 3,797 / 13,282
Intensive care unit days / 68 / 0 / 1,105 / 367
Day-care treatments / 1,074 / 15 / 40 / 0
Outpatient visits / 1,609 / 621 / 2,090 / 1,123
Consultations by telephone / 2 / 2 / 9 / 10
Treatment (cetuximab and/or RT) / 15,430 / 8,840 / 0 / 0
Laboratory / 337 / 76 / 221 / 477
Radiology and nuclear medicine / 200 / 146 / 598 / 906
Pathology / 2 / 7 / 44 / 56
Other procedures, tests and treatments (incl. surgery) / 475 / 107 / 609 / 2,024
Total costs per patient
Mean / 24,714 / 12,862 / 8,514 / 18,244
SD / 9,695 / 11,713 / 16,001 / 30,475
Meanduration (months) / 2.5 / 2.3 / 14.3 / 6.8
Meancosts per month / 9,886 / 5,592 / 597 / 2,703