Ramon Bataller Alberola
Curriculum Vitae, 2/23/2016
1
CURRICULUM VITAE
RAMON BATALLER ALBEROLA, MD, PhD
Associate Professor
University of North Carolina at Chapel Hill
Home:
113 Cheswick Court
Carrboro, NC 27510
Phone: 919-428-0631
Work:
7340-A Medical Biomolecular Research Building
Division of Hepatology and Gastroenterology
Departments of Medicine and Nutrition
University of North Carolina at Chapel Hill
Chapel Hill, NC 27599-7461
Phone: 919-966-4812
Fax: 919-962-2943
Email:
Education
1/1995 – 7/2000Research Fellow, Liver Unit, Hospital Clínic (PhD degree),
Barcelona, Spain
1/1991 – 12/1994Resident and Board Certification, Gastroenterology, Hospital Clínic, Barcelona, Spain
10/1984 –7/1990School of Medicine, University of Valencia (MD degree),
Valencia, Spain
9/1980 – 6/1984High School: Colegio Maristas, Valencia, Spain
Professional Experience
11/2011 – PresentAssociate Professor, Departments of Medicine and
Nutrition, University of North Carolina at Chapel Hill
2013 – 2015Staff Researcher, Institut d’Investigacions Biomediques
August Pi i Sunyer (IDIBAPS), Barcelona, Spain
7/2003 – 10/2011Staff member and Senior specialist, Liver Unit,
Hospital Clínic, Barcelona, Spain
8/2000 – 6/2003Postdoctoral Fellow, University of North Carolina at Chapel
Hill
2/1997 – 4/1997Visiting Fellow, Free University of Brussels, Brussels,
Belgium
9/1995 – 12/1995Visiting Fellow, Università degli Studi di Firenze, Florence,
Italy
1/1995 – 12/1998Faculty Member, Emergency Room, Hospital Clínic,
Barcelona, Spain
1/1991 – 12/1994Resident, Hospital Clinic, Barcelona, Spain
1/1987 – 7/1990 Intern, Department of Internal Medicine, Hospital Clínic,
Valencia, Spain
Honors and Awards
2015Honorary Member of the Faculty of Medicine, University of Antiquia, Colombia
2011Best poster presentation, 46th Annual Meeting of theEuropean
Association for the Study of the Liver, Berlin
2010Research Recognition Award from the Institut d’Investigacions
Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona
2010Premi Excel.lencia Professional, Col.legi de Metges de Barcelona, Barcelona, Spain
2003Postdoctoral Research Fellowship Award from the American Liver
Foundation. “Investigation of the cellular and molecular mechanisms of hepatitis C virus-induced liver fibrosis,” Chapel Hill, NC
2000 – 2002Post-doctoral fellowship from the Spanish Association for the Study of the Liver
2000Extraordinary Award for the Doctoral thesis, University of
Barcelona, Spain
1999Best poster presentation, 34th Annual Meeting of the European
Association for the Study of the Liver, Napoli
1999Best communication on portal hypertension, 34th Annual Meeting
of theEuropean Association for the Study of the Liver, Napoli
1997Best communication on portal hypertension, 32nd Annual Meeting
of theEuropean Association for the Study of the Liver, London
1996 – 1999Predoctoral fellowship, Consell Interdepartamental de Recerca i
Tecnologia de la Generalitat de Catalunya (CIRIT), Barcelona
1994Emili Letang Award (top senior resident fellowship), Hospital Clínic,
Barcelona, Spain
1994Post-residency fellowship, Hospital Clínic, Barcelona, Spain
1989Young Researcher Award from the Consejo Superior de
Investigaciones Científicas, Madrid, Spain
Memberships & Scientific Associations
2016 – presentMember of the Latinonoamerican Association for the Study of the Liver (ALEH)
2015 – presentHonorary Professor, University of Antioquia, Colombia
2014 – presentAssociate Member, UNC Lineberger Comprehensive Cancer
2013 – presentMember of the American Association for the Study of the Liver (AASLD)
2013 – presentMember of the Research Society of Alcoholism (RSA)
2013 – presentMember of the International Society in Biomedical Research in Alcoholism (ISBRA)
2009 – presentMember of the European Association for the Study of the Liver (EASL)
Scientific Journals
2014 – presentCo-editor, Journal of Hepatology
2012 – presentEditorial Board Member, Nature Reviews in Gastroenterology and
Hepatology
2009 – presentEditorial Board Member, Gastroenterology Research and Practice
2006 – presentEditorial Board Member, World Journal of Gastroenterology
2008 – 2011Associate Editor, Gut
2007 – 2010Editorial Board, Gastroenterology
Other Professional Activities
2013-presentOverall Principal investigator fro the NIAAA-funded InTeam consortium
2012Co-organizer and chair, Post-graduate Course on “Alcoholic Liver
Disease”, EASL International Liver Congress, Barcelona, Spain
2012Developer, EASL smartphone application, iLiver. Presentation
during the EASL International Liver Congress, Barcelona, Spain
2010Co-organizer and chair, EASL Monotematic Conference on
“Alcoholic Liver Disease”, Athens, Greece
2006 – 2011Member of the Tissue Committee, Hospital Clinic, Barcelona
2010 - presentConsultant activities, Ferrer, Gilead, NovImmune, Sandhill, Vital Therapeutics, Oncozyme and Sanofi.
2004 – 2007Coordinator of the Transplant Waiting List, Hospital Clinic,
Barcelona, Spain
Publications
Original Articles
1.Affo S, Rodrigo D, Blaya D, Ibanez-Morales O, Cool MD, Millan C, Altamirano JT, Arroyo V, Caballeria J, Bataller R, Gines P, Sancho-Bru P. Chemokine Receptor Ccr6 deficiency alters hepatic inflammatory cell recruitment and promotes liver inflammation and fibrosis. PlosOne 2015 21;10(12):e0145147.
2.Hmoud BS, PatelK, BatallerR, SingalAK. Corticosteroids and occurrence of and mortality from infections in severe alcoholic hepatitis: A meta-analysis of randomized trials. Liv Inter 2015 (in press).
3.Dubuquoy L, Louvet A, Lassailly G, Truant S, Boleslawski E, Artru F, Maggiotto F, Gantier E, Buob D, Leteurtre E, Cannesson A, Dharancy S, Moreno C, Pruvot FR, Bataller R, Mathurin P. Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis. Gut 2015;64:1949-60.
4.Morales-Ibanez O, Affò S, Rodrigo-Torres D, Blaya D, Millán C, Coll M, Perea L, Odena G, Knorpp T, Templin MF, Moreno M, Altamirano J, Miquel R, Arroyo V, Ginès P, Caballería J, Sancho-Bru P, Bataller R. Kinase analysis in alcoholic hepatitis identifies p90RSK as a potential mediator of liver fibrogenesis. Gut 2015;64:1949-60.
5.Xu MJ, Cai Y, Wang H, Altamirano J, Chang B, Bertola A, Odena G, Lu J, Tanaka N, Matsusue K, Matsubara T, Mukhopadhyay P, Kimura S,Pacher P, Gonzalez FJ, Bataller R, Gao B. Fat-specific protein 27/CIDEC promotes alcoholic steatohepatitis in mouse and humans. Gastroenterology 2015;149:1030-41.
6.Michelena J, Altamirano J, Abraldes JG, Affò S, Morales-Ibanez O, Sancho-Bru P, DominguezM, García-Pagán JC, Fernández J, Arroyo V, Gines P, Louvet A, Mathurin P, Mehal WZ, Caballería J, Bataller R. Systemic inflammatory response and serum lipopolysaccharide levels predict multiorgan failure and death in alcoholic hepatitis. Hepatology 2015;62:762-72.
7.Pauta M, Ribera J, Melgar-Lesmes P, Casals G, Rodriguez-Vita J,Reichenbach V, Fernandez-Varo G, Morales-Romero B, Bataller R, Michelena J, Altamirano J, Jiménez W, Morales-Ruiz M. Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition.Liv Inter 2015;35:1383-92.
8.Peixoto E, Atorrasagasti C, Aquino JB, Militello R, Bayo J, Fiore E, Piccioni F, Salvatierra E, Alaniz L, García MG, Bataller R, Corrales F, Gidekel M, Podhajcer O, Colombo MI, Mazzolini G. SPARC (secreted protein acidic and rich in cysteine) knockdown protects mice from acute liver injury by reducing vascular endothelial cell damage. Gene Ther 2015;22:9-19.
9.Rodrigo-Torres D, Affò S, Coll M, Morales-Ibanez O, Millán C, Blaya D, Alvarez-Guaita A, Rentero C, Lozano JJ, Maestro MA, Solar M, Arroyo V, Caballería J, van Grunsven LA, Enrich C, Ginès P,Bataller R, Sancho-Bru P. The biliary epithelium gives rise to liver progenitor cells. Hepatology2014;60:1367-77.
10.Affò S, Morales-Ibanez O, Rodrigo-Torres D, Altamirano J, Blaya D, Dapito DH, Millán C, Coll M, Caviglia JM, Arroyo V, Caballería J, Schwabe RF, Ginès P, Bataller R, Sancho-Bru P.CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis. Gut 2014;63:1782-92.
11.Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens SM Jr, You M. Deletion of SIRT1 from hepatocytes in mice disrupts Lipin-1 signaling and aggravates alcoholic fatty liver. Gastroenterology 2014;146:801-11.
12.Altamirano J, Miquel R, Katoonizadeh A, Abraldes JG, Duarte-Rojo A, Louvet A, Agustin S, Mookerjee RP, Michelena J, Smyrk TC, Buob M, Leteurtre E, Rincon D, Ruiz P, García-Pagán JC, Guerrero-Marquez G, Jones PD, Barritt IV AS, Arroyo V, Bruguera M, Bañares R, Ginès P, Caballería J, Roskams T, Nevens F, Jalan R, Mathurin P, Shah VH, Bataller R. A histologic scoring system for prognosis of patients with alcoholic hepatitis. Gastroenterology 2014;146:1231-9.
13.Orman ES, Hayashi PH, Bataller R, Barritt AS. Paracentesis is associated with reduced mortality in patients hospitalized with cirrhosis and ascites. Clin Gastroenterol Hepatol 2014;12:496-503.
14.López-Vicario C, González-Périz A, Rius B, Morán-Salvador E, García-Alonso V, Lozano JJ, Bataller R, Cofán M, Kang JX, Arroyo V, Clària J, Titos E. Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis. Gut 2014;63:344-55.
15.Morales-Ibañez O, Domínguez M, Ki SH, Marcos M, Chaves JF, Nguyen-Khac E, Houchi H, Affò S, Sancho-Bru P, Altamirano J, Michelena J, García-Pagán JC, Abraldes JG, Arroyo V, Caballería J, Laso FJ, Gao B, Bataller R. Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis. Hepatology 2013;58:1742-56.
16.Atorrasagasti C, Peixoto E, Aquino JB, Kippes N, Malvicini M, Alaniz L, Garcia M, Piccioni F, Fiore EJ, Bayo J, Bataller R, Guruceaga E, Corrales F, Podhajcer O, Mazzolini G. Lack of the matricellular protein SPARC (Secreted Protein, Acidic and Rich in Cysteine) attenuates liver fibrogenesis in mice. PLoS One 2013;8:e54962.
17.De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Millán C, Brenner DA, Vivarelli M, Mocchegiani F, Marzioni M, Benedetti A, Svegliati-Baroni G. Semaphorin 7A contributes to TGF-β-mediated liver fibrogenesis. Am J Pathol 2013;183:820-30.
18.Fernandez A, Matias N, Fucho R, Ribas V, Von Montfort C, Nuño N, Baulies A, Martinez L, Tarrats N, Mari M, Colell A, Morales A, Dubuquoy L, Mathurin P, Bataller R, Caballeria J, Elena M, Balsinde J, Kaplowitz N, Garcia-Ruiz C, Fernandez-Checa JC. ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading. J Hepatol 2013;59:805-13.
19.Affò S, Dominguez M, Lozano JJ, Sancho-Bru P, Rodrigo-Torres D, Morales-Ibañez O, Moreno M, Millán C, Loaeza-del-Castillo A, Altamirano J, García-Pagán JC, Arroyo V, Ginès P, Caballeria J, Bataller R. Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targetsin alcoholic hepatitis. Gut 2013;62:452-60.
20.Uehara T, Ainslie GR, Kutanzi K, Pogribny IP, Muskhelishvili L, Izawa T, Yamate J, Kosyk O, Shymonyak S, Bradford BU, Boorman GA, Bataller R, Rusyn I. Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis. Toxicol Sci 2013;132:53-63.
21.García-Ayllón MS, Millán C, Serra-Basante C, Bataller R, Sáez-Valero J. Readthrough acetylcholinesterase is increased in human liver cirrhosis. PLoS One 2012;7(9):e44598.
22.Dapito DH, Mencin A, Gwak GY, Pradere JP, Jang MK, Mederacke I, Caviglia JM, Khiabanian H, Adeyemi A, Bataller R, Lefkowitch JH, Bower M, Friedman R, Sartor RB, Rabadan R, Schwabe RF. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 2012;21:504-16.
23.Altamirano J, Bataller R, Cárdenas A, Michelena J, Freixa N, Monrás M, Ríos J, Liccioni A, Caballería J, Gual A, Lligoña A. Predictive factors of abstinence in patients undergoing liver transplantation for alcoholic liver disease. Ann Hepatol 2012;11:213-21.
24.Sancho-Bru P, Altamirano J, Rodrigo-Torres D, Coll M, Millán C, José Lozano J, Miquel R, Arroyo V, Caballería J, Ginès P, Bataller R. Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis. Hepatology 2012;55:1931-41.
25.Liu J, Zhou L, Xiong K, Godlewski G, Mukhopadhyay B, Tam J, Yin S, Gao P, Shan X, Pickel J, Bataller R, O'Hare J, Scherer T, Buettner C, Kunos G. Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice. Gastroenterology 2012;142:1218-28.
26.Steenkiste CV, Ribera J, Geerts A, Pauta M, Tugues S, Casteleyn C, Libbrecht L, Olievier K, Schroyen B, Reynaert H, van Grunsven LA, Blomme B, Coulon S, Heindryckx F, De Vos M, Stassen JM, Vinckier S, Altamirano J, Bataller R, Carmeliet P, Van Vlierberghe H, Colle I, Morales-Ruiz M. Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice. Hepatology 2011;53:1629-40.
27.Altamirano J, Higuera-de laTijera F, Duarte-Rojo A, Martínez-Vázquez MA, Abraldes JG, Herrera-Jimenez LE, Michelena J, Zapata L, Perez-Hernández J, Torre A, Gonzáles-González JA, Dominguez M, Arroyo V, Ginès P, Caballería J, Bataller R. The amount of alcohol consumption negatively impacts short-term mortality in Mexican patients with alcoholic hepatitis. Am J Gastroenterol 2011;106:1472-80.
28.Melgar-Lesmes P, Pauta M, Reichenbach V, Casals G, Ros J, Bataller R, Morales-Ruiz M, Jiménez W. Hypoxia and proinflammatory factors upregulate apelin receptor expression in human stellate cells and hepatocytes. Gut 2011;60:1404-11.
29.Altamirano J, Fagundes C, Dominguez M, García E, Michelena J, Cárdenas A, Guevara M, Pereira G, Torres-Vigil K, Arroyo V, Caballería J, Ginès P, Bataller R. Acute kidney injury is an early predictor of mortality for patients with alcoholic hepatitis. Clin Gastroenterol Hepatol 2012;10:65-71.
30.Melgar-Lesmes P, Casals G, Pauta M, Ros J, Reichenbach V, Bataller R, Morales-Ruiz M, Jimenez W. Apelin mediates the induction of profibrogenic genes in human hepatic stellate cells. Endocrinology 2010;151:5306-14.
31.Ki SH, Park O, Zheng M, Kolls J, Morales-Ibañez O, Bataller R, Gao B. Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic plus binge ethanol feeding: Role of STAT3. Hepatology 2010;52:1291-300.
32.Moles A, Tarrats N, Morales A, Domínguez M, Bataller R, Caballería J, García-Ruiz C, Fernández-Checa JC, Marí M. Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis. Am J Pathol 2010;177:1214-24.
33.Albillos A, Nieto M, Ubeda M, Muñoz L, Fraile B, Reyes E, Lledó L, Blanco I, Pastor O, Salas C, Lario M, Monserrat J, Bataller R, Álvarez-Mon M. The biological response modifier AM3 attenuates the inflammatory cell response and hepatic fibrosis in rats with biliary cirrhosis. Gut 2010;59:943-52.
34.Azzalini L, Ferrer E, Ramalho LN, Moreno M, Domínguez M, Colmenero J, Peinado VI, Barberà JA, Arroyo V, Ginès P, Caballería J, Bataller R. Cigarette smoking exacerbates non-alcoholic fatty liver disease in obese rats. Hepatology 2010;51:1567-76.
35.Moreno M, Chaves JF, Sancho-Bru P, Ramalho F, Ramalho LN, Mansego ML, Ivorra C, Dominguez M, Conde L, Millán C, Marí M, Colmenero J, Lozano JJ, Jares P, Vidal J, Forns X, Arroyo V, Caballería J, Ginès P, Bataller R. Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans. Hepatology 2010;51:974-85.
36.Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V, Brenner DA, Ginès G, Bataller R. Hepatocarcinoma cells stimulate growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. Liver International 2010;30:31-41.
37.Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K, Brenner DA, Ginès P, Bataller R. Reduction of advanced liver fibrosis by targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Hepatology 2010;51:942-52.
38.Kluwe J, Pradere JP, Gwak GY, Mencin A, De Minicis S, Osterreicher CH, Colmenero J, Bataller R, Schwabe RF. Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition. Gastroenterology 2010;138:347-59.
39.Colmenero J, Bataller R, Sancho-Bru P, Dominguez M, Moreno M, Forns X, Bruguera M, Arroyo V, Brenner DA, Ginès P. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol 2009; 297:G726-34.
40.Oakley F, Teoh V, Ching-A-Sue G, Bataller R, Colmenero J, Jonsson JR, Eliopoulos AG, Watson MR, Manas D, Mann DA. Angiotensin II activates IkappaB kinase phosphorylation of RelA at Ser536 to promote myofibroblast survival and liver fibrosis. Gastroenterology 2009;136:2334-44.
41.Domínguez M, Miquel R, Colmenero J, Moreno M, García-Pagán JC, Bosch J, Arroyo V, Ginès P, Caballeria J, Bataller R. Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis. Gastroenterology 2009;136:1639-50.
42.Ferré N, Martínez-Clemente M, López-Parra M, González-Périz A, Horrillo R, Planagumà A, Camps J, Joven J, Tres A, Guardiola F, Bataller R, Arroyo V, Clària J. Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols. Am J Physiol Gastrointest Liver Physiol 2009;296:G553-62.
43.Moreno M, Ramalho LN, Sancho-Bru P, Ruiz-Ortega M, Ramalho F, Abraldes JG, Colmenero J, Dominguez M, Egido J, Arroyo V, Ginès P, Bataller R. Atorvastatin attenuates angiotensin II-induced inflammatory and pro-fibrogenic actions in the liver. Am J Physiol 2009;296:G147-56.
44.Domínguez M, Rincón D, González-Abraldes J, Miquel R, Colmenero J, Bellot P, García-Pagán JC, Fernández-Caspistrán R, Moreno M, Bañares R, Arroyo V, Caballería J, Ginès P, Bataller R. A new scoring system for prognostic stratification of patients with alcoholic hepatitis. Am J Gastroenterol 2008;103:2747-56.
45.Botella-Lopez A, de Madaria E, Jover R, Bataller R, Sancho-Bru P, Candela A, Compañ A, Pérez-Mateo M, Martinez S, Sáez-Valero J. Reelin is overexpressed in the liver and plasma of bile duct ligated rats and its levels and glycosylation are altered in plasma of humans with cirrhosis. Int J Biochem Cell Biol 2008;40:766-75.
46.Rodríguez-Vilarrupla A, Graupera M, Matei V, Bataller R, Abraldes JG, Bosch J, García-Pagán JC. Large-conductance calcium-activated potassium channels modulate vascular tone in experimental cirrhosis. Liver Int 2008;28:566-73.
47.Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ármalo LN, Colmenero J, Marí M, Joan Clària J, Jiménez J, Arroyo V, Brenner DA, Ginès P. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Gastroenterology 2007;133:2019-28.
48.Cisneros L, Londoño MC, Blasco C, Bataller R, Miquel R, Bruguera M, Ginès P, Rimola A. Hepatic stellate cell activation in liver transplant patients with hepatitis C recurrence and in non-transplanted patients with chronic hepatitis C. Liver Transpl 2007;13:1017-27.
49.Fatjó F, Sancho-Bru P, Fernández-Solà J, Sacanella E, Estruch R, Bataller R, Nicolás JM. Up-regulation of myocardial L-Type Ca(2+) channel in chronic alcoholic subjects without cardiomyopathy. Alcohol Clin Exp Res 2007;31:1099-105.
50.Colmenero J, Bataller R, Sancho-Bru P, Bellot P, Miquel R, Moreno M, Bosch J, Arroyo V, Caballería J, Ginès P. Hepatic expression of candidate genes in patients with alcoholic hepatitis: correlation with disease severity. Gastroenterology 2007;132:687-97.
51.Bertolani C, Sancho-Bru P, Failli P, Bataller R, Aleffi S, DeFranco R, Mazzinghi B, Romagnani P, Milani S, Ginès P, Colmenero J, Parola M, Gelmini S, Tarquini R, Laffi G, Pinzani M, Marra F. Resistin as an intrahepatic cytokine: overexpression during chronic injury and induction of pro-inflammatory actions in hepatic stellate cells. Am J Pathol 2006;169:2042-53.
52.Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V, Brenner DA, Ginès P. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells.Am J Physiol Gastrointest Liver Physiol 2006;291:G877-84.
53.Yang L, Magness ST, Bataller R, Rippe RA, Brenner DA. NF-kB activation in Kupffer cells after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol 2005;289:G530-8.
54.Sancho-Bru P, Bataller R, Gasull X, Ginès P, Colmenero J, Khurdayan V, Gual A, Nicolás JM, Arroyo V, Rodés V. Genomic and functional characterization of stellate cells isolated from human cirrhotic livers. J Hepatol 2005;43:272-82.
55.Yang L,Bataller R, Dulyx J, Coffman TM, Rippe RA, Ginès P, Brenner DA. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Hepatol 2005;43:317-23.
56.Bataller R, Gabele E, Parsons CJ, Morris T, Yang L, Schoonhoven R, Brenner DA, Rippe RA. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct ligated rats. Hepatology 2005;41:1046-55.
57.Gabele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW, Rippe RA. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. J Biol Chem 2005;280:13374-82.
58.Magness ST, Bataller R, Yang L, Brenner DA. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology 2004;40:1151-59.
59.Bataller R, Paik YH, Lindquist JN, Lemasters JJ, Brenner DA. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology 2004;126:529-40.
60.Stefanovic B, Stefanovic L, Schnabl B, Bataller R, Brenner DA. TRAM2 protein interacts with endoplasmic reticulum Ca++ pump SERCA 2b and is necessary for collagen type I synthesis. Mol Cell Biol 2004;24:1758-68.
61.Schwabe RF, Bataller R, Brenner DA. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Am J Physiol 2003;285:G949-58.
62.Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ, Brenner DA. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest 2003;112:1383-94.
63.Bataller R, Gabele E, Ling Y, Schoonhoven R, Brenner DA, Rippe RA. Prolonged infusion of angiotensin II into normal rats induces hepatic stellate cells activation and proinflammatory events in the liver. Am J Physiol 2003;285:G642-51.
64.De las Heras D, Fernandez J, Ginès P, Cárdenas A, Ortega R, Navasa M, Barbera JA, Calahorra B, Guevara M, Bataller R, Jimenez W, Arroyo V, Rodés J. Increased carbon monoxide production in patients with cirrhosis with and without spontaneous bacterial peritonitis. Hepatology 2003;38:452-9.
65.Vinas O, Bataller R, Sancho-Bru P, Ginès P, Berenguer C, Enrich C, Nicolás JM, Ercilla G, Gallart T, Vives J, Arroyo V, Rodés J. Human hepatic stellate cells show features of antigen-presenting cells and stimulate lymphocyte proliferation. Hepatology 2003;38:919-29.
66.Bataller R, Ginès P, Sancho-Bru P, Lora JM, Al-Garawi A, Solé M, Nicolás JM, Jiménez JM, Weich N, Gutierrez-Ramos JC, Arroyo V, Rodés J. Activated human hepatic stellate cells express the components of the renin-angiotensin system and synthesize angiotensin II. Gastroenterology 2003;125:117-25.
67.Paik YH, Schwabe R, Bataller R, Russo MP, Jobin C, Brenner DA. Toll-like receptor 4 mediates inflammatory effects by bacterial lipopolysaccharide in activated human hepatic stellate cells. Hepatology 2003;37:1043-55.
68.Ortega R, Ginès P, Uriz J, Cárdenas A, Calahorra B, De Las Heras D, Guevara M, Bataller R, Jiménez W, Arroyo V, Rodés J. Terlipressin therapy with and without albumin for patients with hepatorenal syndrome: Results of a prospective, nonrandomized study. Hepatology 2002;36:941-8.
69.Uriz J, Ginès P, Ortega R, Jimenez W, Cárdenas A, Calahorra B, Sort P, Fernandez J, Bataller R, Arroyo V, Rivera F, Rodés J. Increased plasma levels of neuropeptide Y in hepatorenal syndrome. J Hepatol 2002;36:349-55.
70.Gasull X, Bataller R, Ginès P, Sancho-Bru P, Nicolás JM, Görbig MN, Ferrer E, Badía E, Gual A, Arroyo V, Rodés J. Human myofibroblastic hepatic stellate cells express Ca2+-activated K+ channels that modulate the effects of endothelin-1 and nitric oxide. J Hepatol 2001;35:739-48.
71.Bataller R, Gasull X, Ginès P, Hellemans K, Görbig MN, Nicolás JM, Sancho-Bru P, De las Heras D, Gual A, Geerts A, Arroyo V, Rodés J. In vitro and in vivo activation of rat hepatic stellate cells results in de novo expression of L-type voltage-operated calcium channels. Hepatology 2001;33:956-62.
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