Subacute Exposure to N-Ethyl Perfluorooctanesulfonamidoethanol Results in the Formation

Subacute Exposure to N-Ethyl Perfluorooctanesulfonamidoethanol Results in the Formation of Perfluorooctanesulfonate and Alters Superoxide Dismutase Levels in Female Rats

SUPPORTING MATERIAL

Wei Xie1, Qian Wu2, Izabela Kania-Korwel1, Job C. Tharappel3, Sanjay Telu1, Mitchell C. Coleman4, Howard P. Glauert3,5, Kurunthachalam Kannan2, S. V. Santhana Mariappan6, Douglas R. Spitz4, Jamie Weydert7, Hans-Joachim Lehmler1*

1Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, Iowa City, IA 52242, USA; 2Wadsworth Center, New York State Department of Health and Department of Environmental Health Sciences, State University of New York, Empire State Plaza, Albany, NY 12201-0509, USA; 3Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40506, USA; 4Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA; 5Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40506, USA; 6Department of Chemistry, College of Liberal Arts and Sciences, The University of Iowa, Iowa City, IA 52242, USA; 7Department of Pathology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.

*Corresponding author:

Hans-Joachim Lehmler,

100 Oakdale Campus, #221 IREH, Iowa City, IA

Phone: +1-319-335-4211

Fax: +1-319-335-4290

Table of Content

Fig. S1: Representative CPMG spectral sections of serum from a ciprofibrate-treated rat (rat #90).

Fig. S2: Representative ZGPR spectral sections of serum from a ciprofibrate-treated rat (rat #90).

Fig. S3: Representative 2DHOMOJ spectral cross-sections of serum from a ciprofibrate-treated rat (rat #90). J-correlation peaks in the aromatic chemical shift region are very weak and not shown.

Fig. S4: Plot of the loadings of Principal Component 1 versus spectral region.

Fig. S1: Representative CPMG spectral sections of serum from a ciprofibrate-treated rat (rat #90).

Fig. S2: Representative ZGPR spectral sections of serum from a ciprofibrate-treated rat (rat #90).

Fig. S3: Representative 2DHOMOJ spectral cross-sections of serum from a ciprofibrate-treated rat (rat #90). J-correlation peaks in the aromatic chemical shift region are very weak and not shown.

Fig. S4: Plot of the loadings of Principal Component 1 versus spectral region.