Spring 2017 Advanced Virology Topics & Papers
Topic: Innate immunity to viral infection
Instructors – Carolina Lopez, Susan Weiss, Holly Ramage & Paul Bates (course director)
Jan 23 Organizational Meeting
Jan 30 Is BST2 new PRR? Paul presenter: Mary
1) Innate sensing of HIV-1 assembly by Tetherin induces NFκB-dependent proinflammatory responses
Galão RP, Le Tortorec A, Pickering S, Kueck T, Neil SJ. Cell Host Microbe. 2012 Nov 15;12(5):633-44.
2) The sensing of Ebola virus expression and the induction of NF-κβ by BST2 are independent of virion-entrapment. (under review).
Feb 6 RNase L Susan presenter: Devin
1) Small self-RNA generated by RNase L amplifies antiviral innate immunity.
Malathi K, Dong B, Gale M Jr, Silverman RH. Nature. 2007 Aug 16;448(7155):816-9.
2) Viral phosphodiesterases that antagonize double-stranded RNA signaling to RNase L by degrading 2-5A.
Silverman RH, Weiss SR. J Interferon Cytokine Res. 2014 Jun;34(6):455-63. Review
Feb 13 RLR sensing and regulation Carolina presenter: Louis
1) Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates. Nature.2014 Goubau D et al.
2) Post-translational Control of Intracellular PathogenSensingPathways. Trends Immunol.2017 Chiang C,Gack MU. (Review)
Feb 20 Type I/III IFNs Carolina presenter: Courtney
1) A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection.Proc Natl AcadSci U S A.2017. Saxena Ket al.
2) Guarding the frontiers: the biology of type III interferons.Wack A et al. Nat Immunol. 2015. (Review).
Feb 27 IFN evasion Carolina presenter: Shannon
1)A viral RNA structural element alters host recognition of nonself RNA.Science.2014 Hyde JLet. Al.
2)Viral evasion of DNA-stimulated innate immune responsesCellular & Molecular Immunology(2017)Maria HChristensenet al
March 6 Trim 5a - a structure-based PRR Paul presenter: Louis
1) Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5a. Jonathan M Wagner, Marcin D Roganowicz, KatarzynaSkorupka, Steven L Alam, Devin Christensen, Ginna Doss, Yueping Wan, Gabriel A Frank, Barbie K Ganser-Pornillos, Wesley I Sundquist, Owen Pornillos.
2) Closing the net on retroviruses. Luban J. Elife. 2016 Jul 7;5. pii: e18243. doi: 10.7554/eLife.18243 (Review)
March 13 RNase L Susan presenter: Mary
1) Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology. Zhao L, Jha BK, Wu A, Elliott R, Ziebuhr J, Gorbalenya AE, Silverman RH, Weiss SR. Cell Host Microbe. 2012 Jun 14;11(6):607-16.
2) Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation.
Thornbrough JM, Jha BK, Yount B, Goldstein SA, Li Y, Elliott R, Sims AC, Baric RS, Silverman RH, Weiss SR.
MBio. 2016 Mar 29;7(2):e00258. doi: 10.1128/mBio.00258-16.
March 20 IFITMs – What, where & how?? Paul presenter: Shannon
1)The Antiviral Effector IFITM3 Disrupts Intracellular Cholesterol Homeostasis to Block Viral Entry. SamadAmini-Bavil-Olyaee, Youn Jung Choi, Jun Han Lee, Mude Shi, I-Chueh Huang, Michael Farzan, and Jae U. Jung. Cell Host & Microbe 13, 452–464, April 17, 2013.
2)
March 27 ADAR Susan presenter: Courtney
1) Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development. Pestal K, Funk CC, Snyder JM, Price ND, Treuting PM, Stetson DB. Immunity. 2015 Nov 17;43(5):933-44. doi: 10.1016/j.immuni.2015.11.001.
April 3 TBD Holly presenter: Devin