Selected Mircury LNA Microrna Array Papers
Selected miRCURY LNA™microRNA Array papers
The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1.
Wang et al. The Journal of Neuroscience, January 30, 2008, 28(5):1213-1223
Wang et al., used the miRCURY LNA™ Array to demonstrate that miRs contribute to the development of the neurodegenerative disease, Alzheimer’s Disease. The data was confirmed by in situ hybridization and northern blot analysis using LNA™ Detection probes.
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MicroRNAs: Novel Regulators Involved in the Pathogenesis of Psoriasis?
Sonkoly E. et al., PLoS ONE. 2007, v.2:e610
Sonkoly et al. used the miRCURY LNA™ Arrays to demonstrate that psoriasis is characterized by a specific miRNA expression profile that differs from that of healthy skin or another chronic inflammatory disease, atopic eczema. These data were confirmed by real-time PCR.
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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Valadi H. et al., Nat. Cell Biol. 2007 v.9 (6):654-659
Valadi et al. used the miRCURY LNA™ Array to identify the miRNA in exosomes. The results showed that exosomes carry approximately 121 miRNAs and some miRNA were found to be expressed to a greater extent in the exosomes compared to their donor cells.
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MicroRNA expression dynamics during murine and human erythroid differentiation.
Zhan M. et al., Exp. Hematol. 2007, v.35 (7):1015-25.
Zhan et al., used the miRCURY LNA™ Arrays to showe that miR-451 is most significantly upregulated during erythroid maturation. The paper also shows excellent correlation between miRCURY LNA™ Array results and qPCR results. Furthermore, functional studies using miR-451 LNA Knockdown oligonucleotides, confirmed that this miR is associated with erythroid maturation.
More papers are listed on the next pages
Publications based on results generated with miRCURY LNA™ Arrays
Altered miRNA Repertoire in the Simplified Chordate, Oikopleura dioica
Fu X. et al., Mol. Biol. Evol., Jun 2008; 25: 1067 - 1080.
Programmed Cell Death 4 (PDCD4) Is an Important Functional Target of the MicroRNA miR-21 in Breast Cancer Cells
Frankel et al. J. Biol. Chem., Jan 2008; 283: 1026 - 1033.
A GATA-1-regulated microRNA locus essential for erythropoiesis.
Dore et al., PNAS, Mar 2008; 105: 3333 - 3338.
microRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis.
Wong & Tellam, J. Biol. Chem., Feb 2008; 10.1074/jbc.M709614200
The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1.
Wang et al. The Journal of Neuroscience, January 30, 2008, 28(5):1213-1223;
MicroRNA expression in the adult mouse central nervous system.
Bak et al., RNA. 2008 Mar;14(3):432-44. PMID: 18230762
MicroRNA Expression Profiling in Human Ovarian Cancer: miR-214 Induces Cell Survival and Cisplatin Resistance by Targeting PTEN.
Yang et al., Cancer Res., Jan 2008; 68: 425 - 433.
MicroRNA expression profiling in classic Hodgkin lymphoma.
Navarro et al., Blood, Mar 2008; 111: 2825 - 2832.
miChip: an array-based method for microRNA expression profiling using locked nucleic acid capture probes.
Castoldi et al., Nature Protocols 2008, 3(2): 321-9. PMID: 18274534
miChip: a microarray platform for expression profiling of microRNAs based on locked nucleic acid (LNA) oligonucleotide capture probes.
Castoldi et al., Methods. 2007 Oct;43(2):146-52. PMID: 17889802
Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer.
Sempere et al.,Cancer Res. 2007 Dec 15;67(24):11612-20. PMID: 18089790
Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells.
Venturini L. et al., Blood 2007, v.109 (10):4399-405
Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells.
Suarez Y., et al., Circ Res. 2007, v.100 (8):1164-73
Isolation of Microarray-Grade Total RNA, MicroRNA, and DNA from a Single PAXgene Blood RNA Tube.
Kruhøffer M., et al., J. Mol. Diag. 2007, v.9 (4)
microRNAs in Adult Rodent Liver Are Refractory to Dioxin Treatment
Moffat I. Et al. Toxicol. Sci. 2007, v. 99(2), p. 470-488
Systematic analysis of microRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples
Xi Y., et al. RNA, 2007, v.13(10), p. 1668 - 1674
MicroRNA gene expression in the mouse inner ear
Weston et al., Brain Res., 2006, 1111:95-104. PMID: 16904081
A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA).
Castoldi M et al., RNA 2006, v.12 (5):913-20
Mouse microRNA profiles determined with a new and sensitive cloning method
Takada S., et al. NAR, 2006, v.34 (17): e115
Publications based on results generated by Exiqon’s miRNA Profiling Services using miRCURY LNA™ Arrays
Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa. Loscher et al., Genome Biol. 2007 Nov 22;8(11):R248 PMID: 18034880
miRNA Profiling of Naїve, Effector and Memory CD8 T Cells
Wu H. et al., PLoS ONE. 2007, v.2(10):e1020
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Valadi H. et al., Nat. Cell Biol. 2007 v.9 (6):654-659
MicroRNA expression dynamics during murine and human erythroid differentiation.
Zhan M. et al., Exp. Hematol. 2007, v.35 (7):1015-25.
Global microRNA profiles in cervical squamous cell carcinoma depend on Drosha expression levels.
Muralidhar B. el al., J. Pathol. 2007, v.212 (4):368-377
MicroRNAs: Novel Regulators Involved in the Pathogenesis of Psoriasis?
Sonkoly E. et al., PLoS ONE. 2007, v.2:e610
Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis.
Kuehbacher A. et al., Circ. Res. 2007, v.101 (1):59-68
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June 2008