NES/ASAP Pharmacy Vocational Training Scheme

Specialist module

Infection and Antimicrobial Stewardship

Stage 3

Resources 11th May 2014 v1.8


Please note that, with the exception of text books, the majority of resources within these lists will be available free of charge. Those which require either free registration or require a fee to be paid are annotated accordingly.

It is assumed that all participants will have registered with The Knowledge Network (TKN) and will have an Athens Password. Some of the URL links for such resources will link you direct to the article once you have entered your Athens password - if this fails, you should be able to access the article yourself via TKN.

Articles from the Journal of Antimicrobial Chemotherapy are available on the BSAC website or via TKN

There are a few resources listed which are on the YouTube platform and may not be accessible from NHS premises. These may require to be viewed from home or on a personal electronic device.

For webinars and videos the approximate running time is given in brackets after the name of the presentation

We would welcome your feedback - please contact NES Pharmacy if you have any comments about these resources or if you have trouble accessing any of the key resources.

Contents / Page number
Bibliography
Suggested texts - to be used for background knowledge as available locally for appropriate elements / 5
Element 1 Introduction to Antimicrobial Stewardship Core resources / 7
Element 2 Essential microbiology, resistance and basic immune function / 11
Element 3 Antimicrobial agents by therapeutic class / 15
Element 4 Healthcare Acquired Infection (HAI) / 17
Element 5 Sepsis Diagnosis and Management / 21
Element 6 Acute respiratory tract infection incorporating pneumonia and COPD / 23
Element 7 - Urinary tract infection (UTI) / 26
Element 8 Skin and soft tissue infection (SSTI) / 29
Element 9 Surgical infection & prophylaxis / 33
Element 10 Pharmacokinetics (PK) pharmacodynamics (PD) and therapeutic drug monitoring (TDM) / 35
Element 11 Data analysis and presentation Incorporating interpretation of audit data / 39
Element 12 Meningitis and CNS Infection / 41
Element 13 Endocarditis and Cardiovascular Infection / 44
Element 14 Bone & Joint Infections / 46
Element 15 Gastrointestinal (GI) infections / 48
Element 16 - Antibiotics used in pregnancy, neonates and paediatrics / 51
Element 17 Sexually transmitted infection (STI), human immunodeficiency virus (HIV) & other blood borne virus (BBV) / 56
Element 18 Tropical infectious diseases / 62
Element 19 Chronic respiratory tract infections - tuberculosis (TB), cystic fibrosis (CF) and non-CF bronchiectasis / 65
Element 20 Fungal infections / 68
Element 21 Outpatient parenteral antimicrobial therapy (OPAT) / 70

Bibliography

Suggested texts - to be used for background knowledge as available locally for appropriate elements /
Resource ID / Name of resource / Resource owner / Presenter
/Author / URL link direct to resource / Date Resource Accessed/ Comments /
210 / Antimicrobial Chemotherapy 6th Ed 2012 if available / Oxford University Press / Finch RG
219 / Sanford Guide 2013 if available / Antimicrobial Therapy Inc / Gilbert et al (Eds) / http://www.sanfordguide.com/
296 / Manual of Clinical microbiology 9th Ed 2007 (on TKN) / ASM press / Murray PR et al / https://www.123library.org/bookdetails/?id=2814
299 / Reese & Betts' practical approach to infectious diseases 5th Ed 2003 (on TKN) / Lippincott Williams and Wilkins / Betts RF et al / http://www.knowledge.scot.nhs.uk/home/library/books/books-results.aspx?q=ctitle:(string(%22reese%22%2c+mode%3d%22and%22)+and+string(%22betts%22%2c+mode%3d%22and%22))&pm=fql&title=reese+and+betts&srt=rptitle100sub50bod20
329 / Kucers' The Use of Antibiotics 6th Ed if available / ASM Press & Hodder Arnold / Grayson ML
330 / Principles and Practice of Infectious Diseases 7th Ed if available / Elsevier Churchill Livingstone / Mandell GL et al
292 / Notes on medical Microbiology 4th Ed 2002 if available / Churchill Livingstone / Timbury MC et al
293 / Clinical bacteriology 2003 if available / Manson Publishing / Struthers JK et al
384 / Infection and Immunity 3rd Ed 2008 or 4th Ed 2013 if available / Oxford University Press / Playfair J Bancroft G
385 / Basic & Clinical Immunology if available / Churchill Livingstone / Peakman M Vergani D
374 / British National Formulary (BNF) / BMJ/RPS / http://www.medicinescomplete.com/about/index.htm
375 / British National Formulary for Children (BNF-C) / BMJ/RPS / http://www.medicinescomplete.com/about/index.htm
442 / Stockley's Drug Interactions (Via TKN) / Medicines Complete / http://www.medicinescomplete.com/mc/stockley/current/
301 / ABC of Sepsis 2010 if available - comes highly recommended / BMJ Books Wiley Blackwell / Daniels R
378 / Infectious Diseases of the Fetus and Newborn (7th Edition) if available / Elsevier / Remington J et al / http://www.amazon.co.uk/dp/1416064001/ref=rdr_ext_tmb
479 / Medications and Mothers' Milk 2012 if available / Hale Publishing / Hale T
440 / Neonatal Formulary (6th ED) with updates 2011 if available / Wiley / Hey E (Editor) / http://www.neonatalformulary.com/default.asp
376 / Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk 9th ed (via TKN) / Lippincott Williams & Wilkins / Briggs G / http://www.knowledge.scot.nhs.uk
302 / ABC of HIV and AIDS 6th Ed 2012 if available (comes highly recommended but would need to be purchased) / BMJ Books Wiley Blackwell / Alder MW
346 / Oxford Handbook of Tropical Medicine 2005 (New edition published in 2014) if available / Oxford Press / Eddleston M et al / http://www.talcuk.org/books/oxford-handbook-of-tropical-medicine-3rd-edition.htm
430 / Manson's Tropical Diseases 23rd Ed 2013 if available / Elsevier / Farrar J et al (Ed)
429 / Hunter's Tropical Medicine and Emerging Infectious Disease: Expert Consult -2013 Online and Print, 9e if available / Elsevier / Magill AJ et al (ED)
501 / Oxford Textbook of Medicine 2003 (via TKN) / Oxford University Press / Warrell D Ed / http://www.knowledge.scot.nhs.uk/
513 / Applied Pharmacokinetics & Pharmacodynamics: Principles of Therapeutic Drug Monitoring 2006 / Lippincott Williams & Wilkins / Burton ME et al (Editors)


Resources for Element 1 Introduction to Antimicrobial Stewardship

CORE RESOURCES

Element 1 - INTRODUCTION TO ANTIMICROBIAL STEWARDSHIP - CORE RESOURCES /
Resource ID / Name of resource / Resource owner / Presenter
/Author / URL link direct to resource / Date Resource Accessed/ Comments /
SAPG & SCOTTISH GOVERNMENT REFERENCES
Scottish Antimicrobial Prescribers Group (SAPG) website / Scottish Medicines Consortium / SAPG / http://www.scottishmedicines.org.uk/SAPG/Scottish_Antimicrobial_Prescribing_Group__SAPG_
8 / Training on Use of Antimicrobials in Clinical Practice (SAPG) (60 mins)
(Additional CPD section not compulsory) / NES / HIS/SAPG / http://www.nes.scot.nhs.uk/education-and-training/by-theme-initiative/healthcare-associated-infections/training-resources/antimicrobials-in-clinical-practice.aspx
107 / Good Practice Recommendations for Antimicrobial Use in Frail Elderly Patients in NHS Scotland / SAPG / SAPG / http://www.scottishmedicines.org.uk/files/sapg/SAPG_Recommendations_for_antibiotic_use_in_frail_elderly_-_February_2013.pdf
121 / SAPG Good Practice Recommendations for Hospital Antimicrobial Stewardship in NHS Scotland / SAPG / SAPG / http://www.scottishmedicines.org.uk/files/sapg/Good_practice_recommendations_for_hospital_antimicrobial_stewardship_2012.pdf
138 / Scot MARAP 2008 (Due for update in 2013/14) / Scottish Government / http://www.scotland.gov.uk/Publications/2008/03/12153030/0
LOCAL HEALTH BOARD REFERENCES
Local health board website or intranet
OTHER ANTIMICROBIAL STEWARDSHIP REFERENCES
140 / Guidelines for Developing an Institutional Program to Enhance Antimicrobial Stewardship / Clinical Infectious Diseases 2007; 44:159–77 / Dellit TH et al / http://www.idsociety.org/Antimicrobial_Agents/#Antimicrobial Stewardship
390 / Antimicrobial Stewardship Start Smart then Focus / Department of Health / https://www.gov.uk/government/publications/antimicrobial-stewardship-start-smart-then-focus
SCOTTISH PATIENT SAFETY PROGRAMME REFERENCES
489 / Scottish Patient Safety Programme Website / SPSP / Health Improvement Scotland / http://www.scottishpatientsafetyprogramme.scot.nhs.uk/programme

SUPPLEMENTARY RESOURCES

Element 1 INTRODUCTION TO ANTIMICROBIAL STEWARDSHIP - SUPPLEMENTARY RESOURCES /
Resource ID / Name of resource / Resource owner / Presenter
/Author / URL link direct to resource / Date Resource Accessed/ Comments /
SAPG & SCOTTISH GOVERNMENT REFERENCES
118 / SAPG Good Practice Guidance on Ratification of Antimicrobial Policies / SAPG / SAPG / http://www.scottishmedicines.org.uk/files/GOOD_PRACTICE_GUIDANCE_ON_RATIFICATION_OF_ANTIMICROBIAL_POLICIES.pdf
114 / Recommendations for Good Antimicrobial Practice in Acute Hospitals 2005 / Scottish Government / http://www.scotland.gov.uk/Resource/Doc/69582/0017099.pdf
110 / (SAPG): development and impact of the Scottish National Antimicrobial Stewardship Programme (via TKN) / Int J Antimicrob Agents 2011; 38(1): 16-26 / Nathwani D et al / http://www.sciencedirect.com/science/article/pii/S0924857911001026
113 / Antimicrobial stewardship in Scotland: impact of a national programme / Antimicrob Res Inf Cont 2012, 1:7 / Nathwani D et al / http://www.aricjournal.com/content/1/1/7
OTHER ANTIMICROBIAL STEWARDSHIP REFERENCES
19 / Antimicrobials & Infection Management (10 hours to complete full module - can dip in for specific subjects) / NES / NI Centre for Pharmacy Learning & Development / http://www.nes.scot.nhs.uk/education-and-training/by-discipline/pharmacy/about-nes-pharmacy/educational-resources/resources-by-topic/infectious-diseases/antibiotics/antimicrobials-and-infection-management.aspx
109 / From intermittent antibiotic point prevalence surveys to quality improvement: experience in Scottish hospitals / Antimicrob Res Inf Cont 2013;2:3 / Malcolm W et al / http://www.aricjournal.com/content/2/1/3
117 / Antimicrobial Stewardship in Australian Hospitals / ACSQH / Duguid M Cruikshank M / http://www.safetyandquality.gov.au/publications/antimicrobial-stewardship/
230 / Annual Report of the Chief Medical Officer 2011: Volume Two
This publication provides a comprehensive overview of the threat of antimicrobial resistance and infectious diseases. / Department of Health / Davies S / https://www.gov.uk/government/publications/chief-medical-officer-annual-report-volume-2
231 / The missing care bundle: antibiotic prescribing in hospitals (via TKN or Athens login) / Int J Ant Agents 2007; 30:25-29 / Cooke FJ et al / http://www.ijaaonline.com/article/S0924-8579(07)00146-X/abstract
187 / Interventions to improve antibiotic prescribing practices for hospital inpatients (via TKN or Athens login) / CDSR 2013, Issue 4. Art. No.: CD003543. / Davey P et al / http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003543.pub3/abstract
305 / Effectiveness of the interventions in antimicrobial stewardship: What works? Updated Cochrane systematic review and systematic review methodology (via TKN) (60 mins) / ASAP Shared Space / Davey P / http://www.elib.scot.nhs.uk/SharedSpace/pharmacy/Uploads/2013/Jun/20130614155109_Cochrane%20Webinar%20PDavey.pdf
306 / Understanding the Determinants of Antimicrobial Prescribing Within Hospitals: The Role of “Prescribing Etiquette” / Clin Infect Dis. (2013) 57 (2): 188-196 / Charani E et al / http://cid.oxfordjournals.org/content/57/2/188.long

Resources for Element 2 Essential microbiology, resistance and basic immune function

CORE RESOURCES

Element 2 - ESSENTIAL PHARMACEUTICAL MICROBIOLOGY, BACTERIAL RESISTANCE & BASIC IMMUNE FUNCTION - CORE RESOURCES /
Resource ID / Name of resource / Resource owner / Presenter
/Author / URL link direct to resource / Date Resource Accessed/ Comments /
MICROBIOLOGY & LAB REFERENCES
1 / Bugs and Drugs Part 1 (30 mins) / NES / Kieran Hand / http://www.nes.scot.nhs.uk/education-and-training/by-discipline/pharmacy/about-nes-pharmacy/educational-resources/webinars-and-virtual-patient-scenarios/webcasts/bugs-and-drugs-part-1.aspx
15 / Basic Microbiology (2 hours) / NES / NES/LearnPro / http://www.nes.scot.nhs.uk/education-and-training/by-theme-initiative/healthcare-associated-infections/online-short-courses/basic-microbiology.aspx
337 / A Microbiologists View of Bugs & Drugs for ASAP (50 mins) / NES / Alistair Leonard / http://www.nes.scot.nhs.uk/education-and-training/by-discipline/pharmacy/about-nes-pharmacy/educational-resources/resources-by-topic/infectious-diseases/antibiotics/a-microbiologists-view-of-bugs-and-drugs-for-asap.aspx
436 / An insight into the National Reference Laboratory (47 mins) / NES / John Coia / http://www.nes.scot.nhs.uk/education-and-training/by-discipline/pharmacy/about-nes-pharmacy/educational-resources/resources-by-topic/infectious-diseases/antibiotics/an-insight-into-the-national-reference-laboratories-for-asap.aspx
BACTERIAL RESISTANCE REFERENCES
12 / Bacterial Resistance (2 hours) / NES / NES/LearnPro / http://www.nes.scot.nhs.uk/education-and-training/by-theme-initiative/healthcare-associated-infections/online-short-courses/bacterial-resistance.aspx
13 / Multi-resistant Gram Negative Bacilli (MRGNB) (15 mins) / NES / NES/LearnPro / http://www.nes.scot.nhs.uk/education-and-training/by-theme-initiative/healthcare-associated-infections/online-short-courses/multi-resistant-gram-negative-bacilli-(mrgnb).aspx
138 / Scot MARAP 2008 due for update in 2013/14 / Scottish Government / http://www.scotland.gov.uk/Publications/2008/03/12153030/0
BASIC IMMUNE FUNCTION REFERENCES
386 / Clinical Guidelines for Immunoglobulin Use 2nd Ed update March 2012 / Department of Health / http://www.nsd.scot.nhs.uk/Documents/clinimmumoMarch12.pdf
101 / Your Immune System 101: Introduction to Clinical Immunology (YouTube - skip adverts) (90 mins) / UCSF / Dr Katherine Gundling / http://www.youtube.com/watch?v=_oI0jVN4TTI&feature=player_detailpage
102 / Basic Immunology - Nuts and Bolts of the Immune System (YouTube - skip adverts) (90 mins) / UCSF / Dr Anthony De Franco / http://www.youtube.com/watch?feature=player_detailpage&v=mFNxXfwlP3A

SUPPLEMENTARY RESOURCES

Element 2 - ESSENTIAL PHARMACEUTICAL MICROBIOLOGY, BACTERIAL RESISTANCE & BASIC IMMUNE FUNCTION - SUPPLEMENTARY RESOURCES /
Resource ID / Name of resource / Resource owner / Presenter
/Author / URL link direct to resource / Date Resource Accessed/ Comments /
MICROBIOLOGY & LAB REFERENCES
466 / BSAC Methods for Antimicrobial Susceptibility Testing Version 12 May 2013 / BSAC / BSAC / http://bsacstage.pharma-mix.com////wp-content/uploads/2012/02/Version-12-Apr-2013_final.pdf
207 / Guidelines on the laboratory diagnosis and susceptibility testing of MRSA / J Antimicrob Chemother 2005; 56: 1000 - 1018 / Brown DFJ et al / http://jac.oxfordjournals.org/content/56/6/1000.full.pdf
221 / Guidance on the diagnosis and management of PVL-associated Staphylococcus aureas infection 2008 / HPA/DoH / HPA/DoH / http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1218699411960
52 / BSAC antimicrobial susceptibility testing – from Stokes to European harmonization to world? (20 mins) / BSAC / Dr Derek Brown / http://bsac.org.uk/events/past-events-2011/spring-meeting-agm-2011/spring-meeting-2011/
BACTERIAL RESISTANCE REFERENCES
276 / Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe (TKN or Athens login) / Eur Clin Microbiol Infect 2012;18: 413–431 / Canton R et al / http://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2012.03821.x/abstract
278 / Has the era of untreatable infections arrived? / J Antimicrob Chemother 2009;64 Suppl1:i29-i36 / Livermore DM / http://jac.oxfordjournals.org/content/64/suppl_1/i29.full.pdf+html
7 / Patterns of Antimicrobial Use and Resistance in Scotland(MSc) (56 mins) / NES / William Malcolm / http://www.video3uk.com/login.aspx
20 / Avoiding Antibiotic Resistance: the role of the pharmacy team (NB quite old resource, may soon be replaced) (6 hours to complete whole module - can dip in for specific subjects) / NES / NES Portal / http://www.nes.scot.nhs.uk/education-and-training/by-discipline/pharmacy/about-nes-pharmacy/educational-resources/resources-by-topic/infectious-diseases/antibiotics/avoiding-antibiotic-resistancethe-role-of-the-pharmacy-team.aspx
44 / What is happening now? Epidemiology of resistance (20 mins) / BSAC / Prof Neil Woodford / http://bsac.org.uk/events/past-events-2013/bsac-spring-meeting-2013/bsac-spring-meeting-agm-2013-videos/
45 / Carbapenemases in Practice (29 mins) / BSAC / Dr Andrew Dodgson / http://bsac.org.uk/events/past-events-2013/bsac-spring-meeting-2013/bsac-spring-meeting-agm-2013-videos/
46 / Neisseria gonorrhea – the first untreatable infection (20 mins) / BSAC / Prof Catherine Ison / http://bsac.org.uk/events/past-events-2013/bsac-spring-meeting-2013/bsac-spring-meeting-agm-2013-videos/
48 / VRE – one difficult Gram positive after another. Treatment options for severe infections (26 mins) / BSAC / Dr Nick Brown / http://bsac.org.uk/events/past-events-2013/bsac-spring-meeting-2013/bsac-spring-meeting-agm-2013-videos/
49 / Optimisation of combination therapy for treatment of Pseudomonas aeruginosa (10 mins) / BSAC / Dr Alexander Cochrane / http://bsac.org.uk/events/past-events-2013/bsac-spring-meeting-2013/bsac-spring-meeting-agm-2013-videos/
51 / New Uses for Old Agents (25 mins) / BSAC / Dr Kieran Hand / http://bsac.org.uk/events/past-events-2013/bsac-spring-meeting-2013/bsac-spring-meeting-agm-2013-videos/
60 / Antibiotic cycling - a worthwhile weapon against gram negative resistance? (30 mins) / BSAC / Bob Masterton / http://www.online-web-presentations.com/BSAC_2010/
111 / Overview of strategies for overcoming the challenge of antimicrobial resistance / Expert Rev. Clin. Pharmacol. 3(5), 667–686 (2010) / Davey P et al / http://www.scottishmedicines.org.uk/files/sapg/Davey_2010.pdf
209 / Effective antibacterials: at what cost? The economics of antibacterial resistance and its control / J. Antimicrob. Chemother.2012; 66: 1948-1953 / WhiteAR / http://jac.oxfordjournals.org/content/66/9/1948.full.pdf
212 / Risks of extended-spectrum beta-lactamases (via TKN/Athens login) / DTB 2008;46:21-24 / http://dtb.bmj.com/content/46/3/21.full
222 / The evolving threat of antimicrobial resistance / WHO / http://whqlibdoc.who.int/publications/2012/9789241503181_eng.pdf
223 / The Future of antibiotics resistance / n engl j med 368;4 nejm.org january 24, 2013 / Spellberg B et al / http://www.nejm.org/doi/pdf/10.1056/NEJMp1215093
271 / Antibiotic Prescribing - Reduce and Resist (via TKN) / ASAP Shared Space / Philip C / http://www.elib.scot.nhs.uk/SharedSpace/pharmacy/Uploads/2010/Sep/20100922142033_quiz%20section%20Reduce%20and%20resist%20section%202010.pdf
275 / Susceptibility of Klebsiella pneumoniae Isolates from Intra-Abdominal Infections and Molecular Characterization of Ertapenem-Resistant Isolates / Antimicrob Agents Chemother. 2011 55(8): 3917–3921 / Hawser SP et al / http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147618/
BASIC IMMUNE FUNCTION REFERENCES
379 / Immunisation against infectious disease: the Green Book / Department of Health / https://www.gov.uk/government/organisations/public-health-england/series/immunisation-against-infectious-disease-the-green-book
384 / Infection and Immunity 3rd Ed 2008 or 4th Ed 2013 if available / Oxford University Press / Playfair J Bancroft G
385 / Basic & Clinical Immunology if available / Churchill Livingstone / Peakman M Vergani D


Resources for Element 3 Antimicrobial agents by therapeutic class