Scottish Government Health Directorates

ETM 6 June 2014

ETMRC (2014) 2nd Meeting

Scottish Government Health Directorates

Chief Scientist Office

Experimental and Translational Medicine Research Committee

Minute of the meeting of the ETMRC on 6 June 2014 held in Conference Rooms A&B, St Andrew’s House, Edinburgh, at 9:30 am.

Present: / Scottish Government:
Professor Eleanor Davies
Dr Fiona Denison
Professor Ruth Jarrett
Professor Alistair Leanord
Dr Andrew McIntosh
Professor Keith Muir / Dr Alan McNair
Ms Diane Brockie
Mr Michael McLeod
Dr Russell Petty
Professor Philip Rowe
Professor Donald Salter
Ms Barbara Lamb (Lay Member)
Ms Joanna McGregor (Lay Member)

1. Apologies for absence and intimations

Professor Siddarthan Chandran, Dr Elaina Collie-Duguid, Dr Faisel Khan

Professor Sarah Howie, Professor Alasdair MacLullich Dr Calum Sutherland

and Dr Simon Powis sent their apologies.

2. Approval of minutes of ETMRC meeting held on 27 December 2013

The minutes of the meeting were approved.

3. Matters arising from the ETMRC meeting held on 6 June 2014 - full details of the 7 successful applications from the meeting are attached at Annex A.

4. Final Reports

4.1 Dr Philip Leonard Riches, University of Edinburgh (ETM/46)

Do neutralising antibodies to osteoprotegerin explain the association between cardiovascular disease and osteoporosis.

Speakers – Sutherland / MacLullich / Denison

The Committee graded the as report as Satisfactory

4.2 Professor Helen Colhoun, University of Dundee (ETM/47)

Scottish diabetes research network type1 diabetes bioresource.

Speakers – Davies / McIntosh / Chandran

The Committee graded the as report as Good

4.3 Dr A.J.E Green (ETM/58)

Development and evaluation of a disease-specific diagnostic test for Creutzfeldt-Jakob disease based on the detection of PrP in the cerebrospinal fluid using real-time QuIC analysis.

Speakers – Collie-Duguid / Khan / Petty

The Committee graded the as report as Good

4.4 Professor Rob Mairs, University of Glasgow (ETM/60)

Evaluation of melanin-targeted radiotherapy in combination with cytotoxic drugs and the role of bystander effects in the treatment of melanoma.

Speakers –Petty / Howie / Salter

The Committee graded the as report as Good

4.5 Professor Adriano Rossi, University of Edinburgh (ETM/86)

Augmenting human eosinophil apoptosis; the role of cyclin-dependent kinase inhibitors

Speakers – Collie-Duguid / Leanord / Davies

CSO is working with the PI to resolve the issues if possible

4.6 Professor G. Graham (ETM/115)

Assessing the value and function of D6 as a novel marker of inflammatory diseases.

Speakers – Collie-Duguid / MacLullich / Sutherland

CSO is working with the PI to resolve the issues if possible

4.7 Professor David Newby, University of Edinburgh(ETM/160)

Novel imaging approaches to identify unstable coronary plaques.

Speakers – Khan / Muir / Rowe

The Committee graded the as report as Excellent

5. Applications

5.1 Professor Allan D. Struthers, Professor Rory McCrimmon, Professor Chim Lang, Dr Eleanor Dow. University of Dundee / NHS Tayside (ETM/352)

Moving towards a new personalised medicine approach to primary prevention in diabetes: The first steps.

Speakers – Muir / Chandran / McIntosh

The committee recommended funding for this project

5.2 Dr Monika Harvey, Professor Keith Muir, Dr Marie-Helene Grosbras, Professor Matthew Walters. NHS Greater Glasgow & Clyde (ETM/353)

Non-invasive brain stimulation in stroke patients.

Speakers – Rowe / McIntosh / MacLullich

The committee recommended funding for this project

5.3 Professor Helen Galley, Professor Nigel Webster, Professor John Norrie, Dr Lorna Aucott, Dr Damon Lowes. University of Aberdeen / NHS Grampian (ETM/358)

A pilot study of oral melatonin in patients with sepsis

Speakers – Leanord / Howie / Khan

The committee recommended funding for this project

5.4 Professor Kamil R. Kranc, Patrick J. Pollard. University of Edinburgh (ETM/362)

Targeting metabolism to eradicate human leukaemic stem cells.

Speakers – Petty / Howie / Salter

The committee did not recommend funding for this project

5.5 Dr Malcolm John Watson, Dr Alex McConnachie, Dr Alison Wood. NHS Greater Glasgow and Clyde (ETM/364)

A project to determine the dose of levobupivacaine required to provide greater than 12 hours of pain relief for patients with a fractured hip.

Speakers – MacLullich / Denison / Salter

The committee did not recommend funding for this project

5.6 Jennifer Robson, David Newby, Marc Dweck, Edwin van Beek, Graeme Weir, Alex Vesey. University of Edinburgh / NHS Lothian (ETM/365)

18F-sodium fluoride imaging of abdominal aortic aneurysms.

Speakers – Muir / MacLullich / Leanord

The committee recommended funding for this project

5.7 Nicholas Reid Leslie, Rafael Pulido. Heriot Watt University (ETM/371)

Optimising PTEN-long for use as a biologic cancer therapy.

Speakers – Howie / Davies / Khan

The committee did not recommend funding for this project

5.8 Dr Christina Halsey, Professor Eyal Gottlieb, Dr Pawel Herzyk. University of Glasgow (ETM/374)

Identifying novel targets for eradication of acute lymphoblastic leukaemia in the central nervous system.

Speakers – Chandran / Petty / Denison

The committee recommended funding for this project

5.9 Professor Anita J Simmers, Professor Dennis Levi, Ms Heather Murray, Dr Richard Harrad. Glasgow Caledonian University (ETM/375)

Perceptual learning in enhanced amblyopia treatment (PLEAT): an exploratory randomised control trial in the treatment of amblyopia.

Speakers – Denison / McIntosh / Rowe

The committee recommended funding for this project

5.10 Professor Mihalis Panagiotidis, Dr. George Goussetis, Professor Marc Philip Yves Desmulliez, Dr Ewan R S Brown. Heriot-Watt University (ETM/377)

Turn the heat on malignant melanoma: novel insights of microwave-induced hyperthermia in promoting therapeutic effectiveness

Speakers - Leanord / Chandran / Khan

The committee did not recommend funding for this project

5.11 Dr Stelios Psycharakis, Dr Simon Coleman, Ms Linda Linton, Dr Konstantinos Kaliarntas. Edinburgh Napier University (ETM/378)

The WATER project: Which AquaTic ExeRcises work best? Identifying muscle recruitment for aquatic exercises used in interventions for core strengthening and rehabilitation from musculoskeletal disorders.

Speakers – Rowe / Salter / Howie

The committee recommended funding for this project

6. Any other business

7. Date of next meeting

Thursday 4 December 2014, conference rooms A&B, St. Andrew’s House, Edinburgh, 9:30 am.

Annex A

Matters arising from the minutes of the ETMRC meeting held on 6 June 2014

3.1 Dr Monika Harvey, Professor Keith Muir, Dr Marie-Helene Grosbras, Professor Matthew Walters. NHS Greater Glasgow & Clyde (ETM/353)

Non-invasive brain stimulation in stroke patients.