S1. Studies examining body composition and serum changes of lipid metabolism biomarkers in EBC patients receiving adjuvant systemic treatment

Reference / Variables measured / Geographic area / N / Follow-up / Results / Additional findings/comments
Camoriano et al. 1990[1] / Weight / USA / 545 / 6.6 years / Premenopausal pts = +5.9 kg
Postmenopausal pts = +3.6 kg / Weight gain > 5.9 kg associated with 1.5x risk of relapse and 1.6x risk of death
Goodwin et al. 1999 [2] / Weight, BMI, WC, HC,WHR, skinfold thickness / USA / 535 / 12 months / Mean weight gain:
CT group: + 2.5 kg
OT group: + 1.3 kg
Increase in WC and HC without change in WHR / Menopause and CT as independent predictors of weight gain
Kroenke et al. 2005 [3] / BMI / USA / 5204 / 9 years / 1664 pts: + 2.7 kg
746 pts: + 7 kg
1613 pts: no weight variations
1181 pts lost weight. / Weight gain related to higher rates of breast cancer recurrence and mortality
Saquib et al. 2007 [4] / Weight, BMI, / USA / 3088 / 6 years / CT group: OR= 1.65
TAM group: OR = 1.03 / Weight gain independent of types or regimen of CT chosen; gain similar across different treatments; TAM not associated with weight gain
Heideman et al. 2009[5] / Weight / Netherlands / 271 / 3 years / Mean weight gain:
CT group: + 2.2 kg in 1st year / Women receiving combined systemic treatment gained more weight
Trédan et al. 2010 [6] / Weight / France / 272 / 15 months / Mean weight gain:
9th month: + 0.6 kg
15th month: + 1.5 kg / Body weight increase in post-CT period even when given dietary recommendations
Nichols et al. 2009 [7] / Weight, BMI / USA / 3993 / 6.3 years / 1127 pts: + 2.1-6.0 kg
555pts: + 6.1-10 kg
552 pts: > 10 kg
1037 pts: no weight change
722 pts: -2.1 kg. / Each + 5-kg associated with: +12% all-cause mortality, + 13% breast cancer–specific mortality, and + 19% cardiovascular disease mortality
Thivat et al.
2010 [8] / Weight, BMI / France / 111 / 20.4 years / 31% pts had weight variation > 5% / Weight change ( > 5%) associated with an increased risk of both recurrence and death
Gu et al. 2010 [9] / Weight / China / 5014 / 36 months / Mean weight gain:
6th month: + 1.0 kg
18th month: + 2.0 kg
36th month: + 1.0 kg / More weight gain among premenopausal women with advanced disease stage, low BMI at diagnosis, receiving CT or RT during the first 6 months after cancer diagnosis.
Chen et al. 2011 [10] / Weight / China / 4561 / 18 months / Mean weight gain:
18th month: + 1.7 kg
27%: + 2-5 kg
24%: ≥ 5 kg
14%: - 2kg / Greater weight gain
related to younger age, premenopausal status, mixed receptor status, advanced
disease stage, pre-diagnosis weight loss, higher dietary intake, and cigarette smoking
Rodrigues dos Santos et al. 2014 [11] / TC, LDL, TG, BMI / Portugal / 244 / 25 months / LDL-C levels associated with T, Ki67, Stage and Her 2+ status.
LDL-C > 117 mg/dL associated with poorer DFS. / OS no statistically significant association with LDL-C
Vagenas et al. 2015 [12] / Weight / Australia / 287 / 72 months / Median weight gain:
18th month :+ 3.9 kg
(24% of pts)
72th month: + 5.2 kg (39% of pts)
72th month: - 6.4 kg (24% of pts) / Greater weight gain
related to more extensive lymph node removal, RT, and low physical activity levels

Pts= patients; TC=total cholesterol; HDL= high density lipoprotein; LDL= low density lipoprotein; TG=triglycerides; RR= relative risk; WC= waist circumference; HC= hip circumference; WHR= waist-to-hip ratio; HR=hazard risk; TAM=tamoxifen; CT= chemotherapy; RT= radiotherapy

References:

1. Camoriano, J.K., et al., Weight change in women treated with adjuvant therapy or observed following mastectomy for node-positive breast cancer. J Clin Oncol, 1990. 8(8): p. 1327-34.

2. Goodwin, P.J., et al., Adjuvant treatment and onset of menopause predict weight gain after breast cancer diagnosis. J Clin Oncol, 1999. 17(1): p. 120-9.

3. Kroenke, C.H., et al., Weight, weight gain, and survival after breast cancer diagnosis. J Clin Oncol, 2005. 23(7): p. 1370-8.

4. Saquib, N., et al., Weight gain and recovery of pre-cancer weight after breast cancer treatments: evidence from the women's healthy eating and living (WHEL) study. Breast Cancer Res Treat, 2007. 105(2): p. 177-86.

5. Heideman, W.H., et al., The frequency, magnitude and timing of post-diagnosis body weight gain in Dutch breast cancer survivors. Eur J Cancer, 2009. 45(1): p. 119-26.

6. Tredan, O., et al., Body weight change in women receiving adjuvant chemotherapy for breast cancer: a French prospective study. Clin Nutr, 2010. 29(2): p. 187-91.

7. Hazel B. Nichols, A.T.-D., Kathleen M. Egan, et al., Body Mass Index Before and After Breast Cancer Diagnosis: Associations with All-Cause, Breast Cancer, and Cardiovascular Disease Mortality. Cancer Epidemiol Biomarkers Prev, 2009. 18: p. 1403-1409.

8. Thivat, E., et al., Weight change during chemotherapy changes the prognosis in non metastatic breast cancer for the worse. BMC Cancer, 2010. 10: p. 648.

9. Gu, K., et al., Weight change patterns among breast cancer survivors: results from the Shanghai breast cancer survival study. Cancer Causes Control, 2010. 21(4): p. 621-9.

10. Xiaoli Chen, W.L., Kai G, Zhi Chen, Ying Zheng, Wei Zheng, and Xiao Ou Shu, Weight change and its correlates among breast cancer survivors. Nutr Cancer, 2011. 63(4): p. 538–548.

11. Rodrigues Dos Santos, C., et al., Plasma level of LDL-cholesterol at diagnosis is a predictor factor of breast tumor progression. BMC Cancer, 2014. 14: p. 132.

12. Vagenas, D., et al., Weight and weight change following breast cancer: evidence from a prospective, population-based, breast cancer cohort study. BMC Cancer, 2015. 15(1): p. 28.