Supplemental Table S1: Odds ratios and 95% confidence intervals for genetic variants in SLC23A1 and SLC23A2 and gastric cancer by anatomic location (non-cardia, cardia) and histologic subtype (intestinal, diffuse), EPIC-Eurogast study

Gene, SNP / Controls / Non-cardia cases / Cardia cases / Intestinal cases / Diffuse cases
MAF / MAF / OR (95%CI) / MAF / OR (95%CI) / MAF / OR (95%CI) / MAF / OR (95%CI)
SLC23A1
rs6596471
AG+GG vs AA / 0.721 / 0.717 / 0.93 (0.66- 1.29) / 0.743 / 0.93 (0.62- 1.41) / 0.734 / 0.93 (0.63- 1.35) / 0.728 / 0.86 (0.58- 1.26)
rs6596473
CG+CC vs GG / 0.670 / 0.686 / 0.92 (0.66- 1.29) / 0.727 / 0.86 (0.56- 1.31) / 0.693 / 1.05 (0.71- 1.55) / 0.713 / 0.73 (0.49- 1.06)
rs11950646
AG+GG vs AA / 0.656 / 0.666 / 0.99 (0.71- 1.39) / 0.715 / 0.86 (0.57- 1.30) / 0.680 / 1.05 (0.72- 1.55) / 0.702 / 0.70 (0.47- 1.03)
rs33972313
GA+AA vs GG / 0.973 / 0.970 / 1.35 (0.67- 2.73) / 0.981 / 0.54 (0.19- 1.56) / 0.980 / 0.80 (0.31- 2.08) / 0.988 / 0.47 (0.14- 1.56)
SLC23A2
rs6052937
CA+AA vs CC / 0.852 / 0.834 / 1.11 (0.78- 1.60) / 0.858 / 1.04 (0.65- 1.66) / 0.837 / 1.06 (0.70- 1.60) / 0.844 / 1.16 (0.77- 1.77)
rs3787456
GA+AA vs GG / 0.975 / 0.978 / 0.97 (0.44- 2.13) / 0.949 / 2.05 (0.99- 4.24) / 0.968 / 1.15 (0.50- 2.61) / 0.977 / 0.95 (0.39- 2.30)
rs6116569
CT+TT vs CC / 0.555 / 0.511 / 1.63 (1.11- 2.39) / 0.561 / 1.01 (0.65- 1.57) / 0.508 / 1.50 (0.97- 2.32) / 0.566 / 1.20 (0.79- 1.83)
rs17339746
CG+GG vs CC / 0.893 / 0.903 / 0.98 (0.65- 1.50) / 0.901 / 0.72 (0.42- 1.24) / 0.888 / 1.02 (0.63- 1.62) / 0.917 / 0.79 (0.47- 1.33)
rs6052961
CT+TT vs CC / 0.622 / 0.657 / 0.77 (0.55- 1.07) / 0.664 / 0.81 (0.53- 1.23) / 0.687 / 0.71 (0.49- 1.04) / 0.617 / 0.93 (0.63- 1.38)
rs17339942
CT+TT vs CC / 0.931 / 0.922 / 1.29 (0.81- 2.05) / 0.951 / 0.76 (0.38- 1.52) / 0.931 / 1.12 (0.64- 1.95) / 0.933 / 0.96 (0.54- 1.69)
rs1776963
CT+TT vs CC / 0.820 / 0.809 / 1.13 (0.80- 1.60) / 0.816 / 1.23 (0.79- 1.90) / 0.821 / 1.04 (0.69- 1.56) / 0.795 / 1.18 (0.79- 1.76)
rs1715380
GC+CC vs GG / 0.784 / 0.760 / 1.23 (0.88- 1.72) / 0.813 / 0.87 (0.58- 1.36) / 0.794 / 0.98 (0.66- 1.45) / 0.773 / 0.98 (0.66- 1.45)
rs6133175
AG+GG vs AA / 0.657 / 0.649 / 0.94 (0.67- 1.30) / 0.617 / 1.21 (0.79- 1.84) / 0.619 / 1.06 (0.72- 1.55) / 0.672 / 0.89 (0.61- 1.30)
rs3914810
CT+TT vs CC / 0.616 / 0.617 / 0.79 (0.55- 1.13) / 0.561 / 1.03 (0.64- 1.65) / 0.569 / 1.12 (0.73- 1.72) / 0.606 / 0.89 (0.59- 1.33)
rs6139587
AT+TT vs AA / 0.563 / 0.589 / 0.96 (0.67- 1.37) / 0.519 / 1.03 (0.65- 1.64) / 0.593 / 0.74 (0.50- 1.10) / 0.551 / 1.07 (0.71- 1.63)
rs6053005
CT+TT vs CC / 0.561 / 0.555 / 0.81 (0.57- 1.15) / 0.561 / 0.97 (0.62- 1.53) / 0.512 / 1.05 (0.69- 1.59) / 0.559 / 0.83 (0.55- 1.25)
rs2326576
TC+CC vs TT / 0.564 / 0.541 / 1.06 (0.75- 1.51) / 0.533 / 1.16 (0.74- 1.84) / 0.524 / 1.17 (0.77- 1.78) / 0.551 / 1.27 (0.83- 1.94)
rs6053034
GT+TT vs GG / 0.833 / 0.820 / 1.13 (0.80- 1.62) / 0.841 / 1.22 (0.78- 1.92) / 0.802 / 1.34 (0.90- 2.00) / 0.820 / 1.24 (0.83- 1.85)
rs8126456
CT+TT vs CC / 0.956 / 0.950 / 1.22 (0.70- 2.13) / 0.967 / 0.95 (0.42- 2.14) / 0.940 / 1.58 (0.87- 2.85) / 0.957 / 0.99 (0.50- 1.95)
rs1279685
GA+AA vs GG / 0.760 / 0.743 / 1.26 (0.90- 1.76) / 0.724 / 1.40 (0.93- 2.11) / 0.714 / 1.48 (1.01- 2.15) / 0.777 / 0.98 (0.66- 1.45)

Odds ratios (OR) and 95% confidence intervals (CIs) adjusted for age at recruitment (5-year categories), sex, country, smoking status, baseline H pylori infection status, and season of blood draw. All controls (n=1284) served as the comparison group for ORs based on anatomic location (n=181 non-cardia, n=107 cardia) and histologic subtype (n=126 intestinal, n=128 diffuse).

SNP, single nucleotide polymorphism; MAF, minor allele frequency.