c0 [µg/l] / cmax [µg/l] / tmax [h] / AUC(0-12h) [µg/l*h] / half-life [h] / c0 [mg/l] / cmax [mg/l] / tmax [h] / AUC(0-12h) [mg/l*h] / half-life [h]
d +5 / d +21 / d +5 / d +21 / d +5 / d +21 / d +5 / d +21 / d +5 / d +21 / d +5 / d +21 / d +5 / d +21 / d +5 / d +21 / d +5 / d +21 / d +5 / d +21
I / 25.3 / 11.4 / 41.6 / 20.8 / 1.0 / 2.0 / 375.6 / 178.1 / 12.9 / 16.1 / 1.3 / 0.3 / 17.4 / 5.1 / 0.5 / 1.0 / 38.3 / 7.9 / 3.0 / 5.1
II / 13.4 / 19.1 / 24.8 / 36.5 / 4.0 / 6.0 / 213.9 / 324.7 / 8.8 / # / 0.6 / 0.2 / 5.8 / 10.4 / 3.0 / 1.0 / 36.3 / 25.7 / 3.8 / 3.5
III / 37.3 / 43.2 / 65.2 / 80.7 / 2.0 / 2.0 / 589.3 / 592.8 / 14.6 / 12.6 / 0.3 / 0.3 / 21.2 / 12.2 / 1.5 / 1.5 / 31.7 / 23.8 / 1.8 / 4.4
IV / 23.0 / 26.2 / 43.4 / 58.0 / 1.5 / 1.5 / 330.8 / 432.1 / 21.5 / 7.6 / 0.3 / 0.3 / 25.2 / 25.2 / 1.0 / 1.0 / 24.2 / 29.6 / 3.0 / 8.9
V* / 17.3 / 17.7 / 75.3 / 33.5 / 6.0 / 4.0 / 571.6 / 286.7 / # / 7.6 / 1.3 / 0.4 / 9.8 / 15.6 / 1.0 / 1.0 / 32.2 / 34.7 / # / 3.4
VI / 14.4 / 23.7 / 26.4 / 48.1 / 1.5 / 6.0 / 225.1 / 421.4 / 14.9 / # / 0.3 / 0.5 / 9.2 / 5.8 / 2.0 / 3.0 / 40.5 / 30.8 / 6.7 / 3.0
VII / 10.5 / 15.9 / 23.5 / 30.6 / 4.0 / 1.5 / 192.5 / 232.4 / 8.1 / 14.2 / 0.2 / 0.1 / 2.4 / 5.2 / 2.0 / 1.5 / 10.7 / 14.1 / 9.2 / 2.7
VIII† / 19.3 / – / 43.2 / – / 0.5 / – / 290.0 / – / 33.17 / – / 1.2 / – / 4.8 / – / 0.5 / – / 22.5 / – / # / –
Median / 18.3 / 19.1 / 42.4 / 36.5 / 1.8 / 2.0 / 310.4 / 324.7 / 14.6 / 12.6 / 0.5 / 0.3 / 9.5 / 10.4 / 1.3 / 1.0 / 32.0 / 25.7 / 3.4 / 3.5
S.2: Pharmacokinetic Data after HSCT on day+5 und+21
Blood samples were collected on day +5 and +21 before and 0.5, 1, 1.5, 2, 3, 4, 6 and12 h after morning drug adjustment. Data of all recipients are shown additional the median of by diversify day +5 and +21. RAD001: everolimus; MPA: mycophenolic acid; c0: trough level; cmax: maximal concentration; tmax: time to reach maximal concentration; AUC(0-12h): area under the curve over 12 h after drug administration; *) Dose adjustment after pharmacokinetic on d +5 to 1.0mg RAD001 morning dose,1.5mg RAD001 evening dose; #) half-life could not be calculated by a missing decrease of blood levels during the twelve hours of collecting time; †) Dog died at day +19 after HSCT