Robert G. Sitrin, M.D.
Updated May 11, 2012
Robert Gary Sitrin, M.D.
Professor of Internal Medicine
University of Michigan Health Systems
3920L Taubman Center
Ann Arbor, MI 48109-5360
(734) 763-9077
Education and Training
9/65-6/69 Detroit Country Day School
9/69-5/73 University of Michigan, Ann Arbor, Michigan, B.S. Zoology, (High Honors and Distinction)
8/73-5/77 University of Michigan Medical School, Ann Arbor, Michigan, M.D., (Cum Laude)
6/77-6/78 Internship In Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan
7/78-6/80 Residency in Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan
7/80-6/83 Fellowship, Cardiovascular Research Institute University of California, San Francisco, San Francisco, California
Certification and Licensure
Board Certification: Internal Medicine, 1980
Pulmonary Medicine, 1982
Medical Licensure: California, 1980 - 1984
Michigan, 1983 - Present
Academic, Administrative, and Clinical Appointments
7/82-6/83 Attending Physician, Respiratory Care Division, VA Medical Center, San Francisco, California
7/83-8/85 Instructor of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan
9/85-8/91 Assistant Professor of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan
9/91-8/97 Associate Professor of Internal Medicine (With Tenure), University of Michigan Medical School, Ann Arbor, Michigan
9/97-present Professor of Internal Medicine (With Tenure), University of Michigan Medical School, Ann Arbor, Michigan
Research Interests
1. Home-based monitoring and sleep-disordered breathing in neuromuscular respiratory failure.
2. Leukocyte activation, adhesion, and movement, with emphasis on the function of lipid raft microdomains in regulation of neutrophil activation signaling.
3. Roles of coagulation and fibrinolytic factors in the pathogenesis of inflammatory lung injury.
Grants
a) Present and Active
Dept. of Defense Spinal Cord Injury Research Program, Congressionally Directed Medical Research Programs. “Home-Based Diagnosis and Management of Sleep-Related Breathing Disorders in Spinal Cord Injury”. Total Direct Costs $813,000. 10/01/11-9/30/15.
b) Summary of Major Previous Grants
NIH. "Alveolar Macrophages, Coagulation and Fibrinolysis", 7/1/84-6/30/89 ($72,000 Annual Direct Costs; $360,000 Total Direct Costs).
American Lung Association (R.G. Sitrin, Principal Investigator, 20% Effort), "Fibrin Deposition In Acute Lung Injury: The Role of Pulmonary Macrophages", 7/1/84-6/30/86 ($17,500 Annual Direct Costs; $35,000 Total Direct Costs).
Rackham Faculty Grant (R.G. Sitrin, Principal Investigator, 20% Effort), "The Role of Alveolar Macrophages In Pulmonary Fibrin Deposition and Clearance", 4/1/84-3/31/85 ($10,000 Total Direct Costs).
NIH/NHLBI Grant 2-RO1-Hl39672 (R.G. Sitrin, Principal Investigator, 35% Effort), "Plasminogen Activator In Inflammatory Lung Diseases", 4/1/88-3/31/95 ($91,011 Annual Direct Costs; $637,077 Total Direct Costs).
NIH/NHLBI 1 P50-Hl46487 (R.G. Sitrin, Co-Principal Investigator, 20% Effort), "Lung Alveolar Epithelial Cells and Fibrinolysis" (Richard H. Simon, Co-Principal Investigator, Project 3) Specialized Center of Research In Occupational and Immunologic Lung Diseases (Galen B. Toews, Program Director), 12/1/91-11/30/96 ($147,548 Annual Direct Costs Project 3; $693,996 Total Direct Costs Project 3; $5,827,001 Total Direct Costs SCOR Program)
NIH/NHLBI 1 RO1-Hl53283 (R.G. Sitrin, Principal Investigator, 35% Effort), "The Urokinase-Cd87 System In Macrophage Activation", 7/1/95-5/31/01 ($179,696 Annual Direct Costs; $831,973 Total Direct Costs).
NIH/NHLBI 1 P50-Hl56402 (R.G. Sitrin, Co-Investigator, 5% Effort) "Gene Transfer of Fibrinolytic Agents In Lung Fibrosis" (Richard H. Simon, Principal Investigator, Project 4), Specialized Center of Research In Pathobiology of Fibrotic Lung Disease (Galen B. Toews, Program Director), 12/1/96-11/30/01 ($158,417 Annual Direct Costs Proj. 4; $858,044 Total Direct Costs Project 4; $6,295,188 Total Direct Costs SCOR Program).
NIH/NHLBI HL66108-01 (R.G. Sitrin, Co-Investigator, 5% Effort) "A New Paradigm for Fibrosis: Monocyte Activation of TGF" (Clay Marsh, Ohio State University, Principal Investigator), 12/27/2000 - 11/30/2004 ($800,000 Total Direct Costs).
NIH/NHLBI 2RO1-Hl53283 (R.G. Sitrin, Principal Investigator, 35% Effort), "The Urokinase-CD87 System in Macrophage Activation", 04/01/01-03/31/05 (Total direct costs $718,784).
NIH/NHLBI "Lipid Raft Microdomains in Neutrophil Function" RO1 (R.G. Sitrin, Principal Investigator, 35% Effort), Total direct costs: $1,250,000 (1/1/06-3/31/11).
Honors and Awards
1972 Phi Beta Kappa
1977 Alpha Omega Alpha
1982 Finalist, Cecile Lehman Meyer Research Forum, American College of Chest
Physicians
2005 Special Recognition Award, Department of Internal Medicine, University of
Michigan Health System. For Contributions to the Medical Student Teaching Program
Memberships in Professional Societies
1980- American Thoracic Society
1989 Abstract Reviewer, American Thoracic Society
1989 Chair, Symposium On "Receptor Biology and the Immune Response", American Thoracic Society Meeting
1989 Chair, Symposium On "Mechanisms of Pulmonary Fibrosis", American Thoracic Society Meeting
1993 Co-Chair, Symposium On "Resolution and Repair of Inflammatory Lung Injury", American Thoracic Society Meeting
1984-96 American Federation for Clinical Research
1984- Michigan Thoracic Society
1980- American College of Chest Physicians (Fellow, 1984)
1989- Central Society for Clinical Research
1993- Clerkship Directors in Internal Medicine
1996- American Society of Clinical Investigation
1996- American Federation for Medical Research
1997- American Physiological Society
1999- American Association for the Advancement of Science
Editorial Positions, Boards, and Peer-Review Service
1996-1999 American Journal of Physiology: Lung Cellular & Molecular Physiology
Peer-review service
Journal of Clinical Investigation
American Review of Respiratory Disease
American Journal of Respiratory Cell and Molecular Biology
The Journal of Biological Chemistry
The Journal of Immunology
Journal of Laboratory and Clinical Medicine
Journal of Leukocyte Biology
The New England Journal of Medicine
The American Journal of Physiology
Chest
Lung
American Journal of Respiratory and Critical Care Medicine
Blood
Brit. J. Cancer
Study Sections
1988 Ad Hoc Reviewer, American Heart Association Research Award
1989 Ad Hoc Reviewer, VA Merit Review Board
1992 Ad Hoc Reviewer, Cystic Fibrosis Association of Canada
1997 Ad Hoc Reviewer, VA Merit Review Board (2)
1997 Ad Hoc Reviewer, Biomedical Research Council, University of Michigan
1998 Ad Hoc Reviewer, Biomedical Research Council, University of Michigan
2002 Ad Hoc Member, Lung Biology and Pathology Study Section, National Heart, Lung and Blood Institute, National Institutes of Health
2006 Ad Hoc Member, Lung Cellular, Molecular, and Immunobiology
Study Section, National Institutes of Health
2009 Ad Hoc Reviewer, Challenge grants, Member, Lung Cellular, Molecular, and Immunobiology Study Section, National Institutes of Health
Teaching
National
Symposium on Intra-Alveolar Coagulation and Fibrinolysis In Acute Lung Injury, American Thoracic Society Meeting, 1990.
Symposium on Resolution and Repair of Inflammatory Lung Injury, American Thoracic Society Meeting, 1993.
Symposium on Pathways of Fibrin Turnover and Acute Lung Injury, American Thoracic Society Meeting, 1999.
National Institutes of Health Symposium on Fibrin Biology in Lung Development, Injury, and Cancer, 1999.
Symposium on Pathways of Proteases and their Inhibitors in the Injured Lung, American Thoracic Society Meeting, 2002.
Symposium on Neutrophil Activation and Migration in Infectious and Inflammatory Lung Injury, American Thoracic Society Meeting, 2008.
University of Michigan
Supervision and teaching of postdoctoral fellows in research methods, preparation of research grants, presentations, and manuscripts: Jeffrey Hasday, 1984-1986; Margaret R. Gyetko, 1986-1988, Thomas J. Gross, 1988-91
Mentor, senior resident research projects: M Michaelson, M.D. "Tetracycline Pleurodesis", 1984. S. Krafcik, M.D. "Wegener's Granulomatosis In The Elderly" 1992. S. Cookinham, M.D. “Selective Localization of Pro-Inflammatory Signaling Pathways in the Lipid Raft Microdomains of Human Neutrophil Plasma Membranes”.
Supervision and teaching of postdoctoral fellows in pulmonary function testing interpretation, 4 weeks/year, 1983-present
Supervision and teaching of postdoctoral fellows in bronchoscopy procedures, approximately 15 days/year, 1983-present
Advances In Internal Medicine Pulmonary Course Coordinator, 1984
Attending physician in Internal Medicine (Critical Care Medicine Unit), approximately 1 month/year, University of Michigan Medical Center, 1983-2011
Attending physician in Pulmonary, approximately 1-2 months/year, University of Michigan Medical Center, 1983-2011
Preceptor, Introduction to Physical Diagnosis (M1's), 1983-Present
Lecturer, "Introduction To Pulmonary Disease", Dental School Graduate Students, University of Michigan, 1983, 1984
Lecturer, Pathology Research Conference, "Macrophage Mediated Coagulation and Fibrinolysis", 1984
Lecturer, Advances In Internal Medicine Course, "Chronic Management of COPD", 1985
Lecturer, Allergy Research Conference, "Mononuclear Phagocytes and Fibrin Turnover", 1986
Lecturer, Advances In Internal Medicine Course, "Hypersensitivity Pneumonitis", 1989
Lecturer, Pulmonary Medicine Conference, "The Paralyzed Chest Wall", September 1983
Lecturer, Pulmonary Medicine Conference, "Pulmonary Manifestation of Aids", 1983
Lecturer, Internal Medicine Noon Conference, "Allergic Alveolitis", 1984
Lecturer, Pulmonary Medicine Conference, "Selected Aspects of Pneumococcal Disease", July 17, 1984
Lecturer, Internal Medicine Grand Rounds, "Coagulation Abnormalities In Lung Injury", September 1984
Lecturer, Pulmonary Medicine Conference, "Chronic Management of COPD", 1985
Lecturer, Pulmonary Medicine Conference, "Host Defenses In the Lung", July 23, 1985
Lecturer, Pulmonary Medicine Conference, "The Paralyzed Thorax - Physiology and Management", January 7, 1986
Lecturer, Pulmonary Medicine Conference, "Eosinophilic Pneumonias", April 1, 1986
Lecturer, Pulmonary Medicine Conference, "Hypersensitivity Pneumonitis", August 19, 1986
Lecturer, Ann Arbor Veterans Administration Medical Center Grand Rounds, "Oxygen Therapy", 1987
Lecturer, Pulmonary Medicine Conference, "Pulmonary Host Defenses", January 6, 1987
Lecturer, Internal Medicine Grand Rounds, "Immunotherapy of Bacterial Pneumonias", March 1987
Lecturer, Pulmonary Medicine Conference, "Physiology and Management of The Paralyzed Thorax, August 4, 1987
Lecturer, Pulmonary Research Conference, "Macrophage Activation", September 3, 1987
Lecturer, Pulmonary Medicine Conference, "Pulmonary Grand Rounds", January 15, 1988
Lecturer, Pulmonary Medicine Conference, "Coagulation and Lung Injury", August 9, 1988
Lecturer, Pulmonary Research Conference, "Macrophage Activation", August 18, 1988
Lecturer, Pulmonary Medicine Conference, "Hypersensitivity Pneumonitis", February 28, 1989
Lecturer, Pulmonary Medicine Conference, "Macrophage Activation", July 6, 1989
Lecturer, Pulmonary Research Conference, "Regulation of Macrophage Proteolytic Activity", October 20, 1989
Lecturer, Pulmonary Clinical Conference, "Pulmonary Management of Neuromuscular Diseases", March 30, 1990
Lecturer, Internal Medicine Noon Conference, "Pulmonary Management of Neuromuscular Diseases", August 6, 1990
Lecturer, Pulmonary Clinical Conference, "Complications of Chronic Steroid Therapy", Sept. 18, 1990
Lecturer, Pulmonary Research Conference, "Writing Skills For The Medical Literature", Mar 1, 1991
Lecturer, Internal Medicine House officer Basic Science Seminar, "Fibrinolysis In Inflammatory Lung Disease", Mar 15, 1991
Lecturer, ICS 600, "Occupational and Inhalational Lung Diseases", 1984-1993
Lecturer, Pulmonary Clinical Conference, "High Resolution CT In Lymphangitic Cancer, July 16,1991
Lecturer, Pulmonary Clinical Conference, "Fatal Asthma", Aug. 15, 1991
Lecturer, Pulmonary Research Conference, "Plasminogen Activator Receptors", Sept. 13, 1991
Lecturer In Internal Medicine, Approximately 4 Lectures Per Year, 1985-Present
Tutor for third year student on internal medicine with academic difficulties, Sept. 1991.
Lecturer, Pulmonary Clinical Conference, "TAO Therapy In Asthma", Jan. 28, 1992
Lecturer, Ics 600, "Pulmonary Case Discussions", 1992,1993
Lecturer, Pulmonary Clinical Conference, "Complications of Corticosteroid Therapy", July 14, 1992
Lecturer, Pulmonary Research Conference, "Proteases and The Immune Response", Oct. 2, 1992
Lecturer, "Law, Medicine, and Bioethics", University of Michigan Law School, Feb. 17, 1993
Lecturer, Pulmonary Clinical Conference, "Pulmonary Management of Neuromuscular Diseases", March 18, 1993
Lecturer, Internal Medicine Noon Conference, "Fatal Asthma", Apr. 22, 1993
Lecturer, "Advances In Internal Medicine" Course "Fatal Asthma: How To Avoid It", Apr. 27, 1993
Lecturer, "Law, Medicine, and Bioethics", University of Michigan Law School, Nov. 9, 1993
Case Management Conference for Internal Medicine Subinterns, 2/16/94; 7/13/94; 11/30/94; 7/19/95
Lecturer, Pulmonary Research Conference, "The Urokinase-CD87 System and Leukocyte Activation", November 11, 1994
M2 Respiratory Sequence Small Group Session Leader, November 11, 1994
Pulmonary Fellow's Critical Care Conference "Case Presentations", 1/24/95
Lecturer, Pulmonary Research Conference, "The Urokinase-CD87 System In Leukocyte Activation Signaling", April 19, 1996.
Lecturer, Pulmonary Clinical Conference, "Pulmonary/Critical Care Aspects of Spinal Cord Injury", June 6, 1996.
Lecturer, Pulmonary Clinical Conference, "The Fatal Asthma attack", August 29, 1996.
M2 Respiratory Sequence Small Group Session Leader, November 15, 1996
Lecturer, "Law, Medicine, and Bioethics", University of Michigan Law School, Mar 25, 1997
Lecturer, Pulmonary Clinical Conference, "The Manufacturer’s Guide to Complications of Corticosteroid Therapy", September 18, 1997.
Lecturer, Pulmonary Research Conference, "Hemostatic/Fibrinolytic Pathways in Macrophage Activation", December 12, 1997.
Pulmonary Fellow’s Journal Club, February 11, 1998
Physical Diagnosis Lab, February 17, 1998
Lecturer, Pulmonary Clinical Conference, "Pulmonary/Critical Care Management in Spinal Cord Injury", September 10, 1998.
Internal Medicine Chief's Rounds, 4/19/95; 6/5/95; 2/22/96; 3/18/96
Internal Medicine Morning Report, 12/15/94; 1/20/95; 1/27/95; 4/19/95; 6/5/95; 9/28/95; 12/13/95; 2/22/96; 3/18/96; 4/3/96; 4/24/96; 2/28/97; 5/9/97; 9/5/97, 10/31/97, 12/4/97, 4/7/98, 8/6/98, 3/25/99, 6/8/99, 7/29/99, 9/29/2009, 12/11/2009
Physical Diagnosis Lab, January 19, 1999
Pulmonary Fellow’s Seminar “Writing for the Scientific Literature”, January 27, 1999
Lecturer, Pulmonary Research Conference, "CD87 in Leukocyte Activation Signaling", March 26, 1999
Lecturer, Pharmacology Seminar “The coagulation and fibrinolytic systems in leukocyte activation signaling”, May 5, 1999
Pulmonary Fellow’s Journal Club, May 26, 1999
Physical Diagnosis Lab, January 18, 2000
Lecturer, Pulmonary Research Conference, "Urokinase Receptors and Leukocyte Activation Signaling", January 21, 2000
Pulmonary Fellow’s Journal Club, March 1, 2000
Physical Diagnosis Lab, October 10, 2000
Lecturer, Internal Medicine Research Conference, "Urokinase Receptors (CD87) in Leukocyte Activation Signaling", October 11, 2000.
Lecturer, Pulmonary Clinical Conference, "Pulmonary/Critical Care Management in Spinal Cord Injury", November 30, 2000.
Pulmonary Fellow’s Journal Club, January 10, 2001
Pulmonary Fellow’s Seminar “Writing for the Scientific Literature”, February 28, 2001
Pulmonary Fellow’s Journal Club, April 11, 2001
Physical Diagnosis Lab, October 9, 2001
Lecturer, Pulmonary Clinical Conference, "Complications of Corticosteroid Therapy", November 8, 2001
Pulmonary Fellow’s Journal Club, March 19, 2002
Lecturer, Pulmonary Research Conference, "Update on Urokinase Receptors and Leukocyte Activation Signaling", April 26, 2002
Physical Diagnosis Lab, October 8, 2002
Pulmonary Fellow’s Seminar “Writing for the Scientific Literature”, December 10, 2002
Lecturer, Pulmonary Clinical Conference, "Pulmonary Aspiration Syndromes", December 12, 2002
Pulmonary Fellow’s Journal Club, April 29, 2003
Pulmonary Fellow’s Journal Club, July 15, 2003
Pulmonary Fellow’s Journal Club, December 16, 2003
Lecturer, Pulmonary Clinical Conference, "Diagnosis and Management of Malignant Pleural Effusions", December 18, 2003
Physical Diagnosis Lab, February 3, 2004
Lecturer, Internal Medicine Research Conference, "Lipid Raft Microdomains in Neutrophil Function", April 22, 2004.
Pulmonary Fellow’s Journal Club, August 17, 2004.
Pulmonary Fellow’s Seminar “Writing for the Scientific Literature”, August 24, 2004.
Lecturer, Pulmonary Clinical Conference, "Spinal Cord Injury for the Pulmonary/Critical Care Specialist", December 16, 2004.
Pulmonary Fellow’s Journal Club, February 8, 2005.
Pulmonary Fellow’s Seminar “Writing Skills Seminar”, September 13, 2005.
M2 Respiratory Sequence Small Group Session, September 16, 2005.
M1 Pulmonary Physical Diagnosis Lab, November 29, 2005
Pulmonary Fellow’s Journal Club, February 28, 2006.
Lecturer, Pulmonary Clinical Conference, "Diagnosis and Management of Malignant Pleural Effusions", February 28, 2006.
Lecturer, Pulmonary Clinical Conference, "Spinal Cord Injury for the Pulmonary/Critical Care Specialist", July 18, 2006.
Lecturer, Internal Medicine Conference, “Pulmonary and Critical Care Issues with Spinal Cord Injuries”, August 31, 2006.
Lecturer, Pulmonary Research Conference, "Lipid Raft Microdomains and Neutrophil Function", February 8, 2007.
Lecturer, Pulmonary Clinical Conference, "Neuromuscular Respiratory Failure", January 29, 2008.
Pulmonary Fellow’s Seminar “Writing for the Scientific Literature”, November 17, 2008.
Lecturer, Pulmonary Clinical Conference, "Pulmonary Function Testing", March 31, 2009.
Pulmonary Fellow’s Seminar “Proteases”, November 10, 2009.