Supplemental Table 1. NHL subtype definitions

ICD-O-3 topography and morphology codes
B-cell lymphoma subtype
Burkitt lymphoma/leukemia / 9687, 9826
Chronic lymphocytic lymphoma/small
lymphocytic lymphoma / 9670, 9823
Diffuse large B-cell lymphoma / 9678-9680, 9684, 9688, 9735, 9737
Follicular lymphoma / 9690, 9691, 9695, 9698, 9597
LPL/WM / 9671, 9761
Mantle cell / 9673
Marginal zone / 9689, 9699, 9760, 9764, 9699, 9715
T-cell lymphoma subtype
Peripheral T-cell lymphoma / 9702, 9705, 9708, 9709, 9717, 9724, 9726
ALCL / 9714
Primary cutaneous ALCL / 9718
Mycosis fungoides/Sezary's syndrome / 9700, 9701
Hepatosplenic T-cell lymphoma / 9716
NK/T cell lymphoma / 9719
All T-cell lymphoma combined / 9702-9718
Precursor B- or T-cell lymphoblastic leukemia/lymphoma (ALL) / 9727-9729, 9835-9837, 9811, 9812, 9815
NHL, other / 9762, 9827, 9831-9834, 9940, 9948
NHL, not otherwise specified / 9590-9595, 9675, 9820, 9970, 9596
All non-Hodgkin lymphoma / 9590-9595, 9670, 9671, 9673, 9675, 9678-9680, 9684, 9687, 9689, 9690, 9691, 9695, 9698, 9699, 9700, 9701, 9702, 9705, 9708, 9709, 9714, 9715, 9716, 9717, 9718, 9719, 9727-9729, 9760, 9761, 9762, 9764, 9820, 9823, 9826, 9827, 9831-9837, 9940, 9948, 9970, 9596, 9597, 9688, 9724, 9726, 9735, 9737, 9811, 9812, 9815
CNS Lymphoma / Any of the ICD-O-3 codes listed above (e.g. any NHL that has a topography code for CNS (C70.0-C72.9))

Abbreviations: LPL/WM (lymphoplasmacytic lymphoma/Waldenström macroglobulinemia, ALCL (anaplastic large cell lymphoma),

NK (natural killer), ALL (acute lymphoblastic leukemia/lymphoma), NHL (non-Hodgkin lymphoma)

Supplemental Table 2. Risk of NHL subtypes by calendar year among people registered with HIV infection or AIDS in the U.S.

NHL Subtypes / 1996-2002 / 2003-2010
Cases / SIR / 95% CI / Cases / SIR / 95% CI / Pdifferenceb
AIDS-defining
DLBCL / 799 / 23.2 / 21.6-24.8 / 605 / 13.4 / 12.3-14.5 / <0.0001
Burkitt / 101 / 31.9 / 26.0-38.8 / 161 / 34.9 / 29.7-40.7 / 0.25
Central Nervous
System / 296 / 56.4 / 50.1-63.2 / 168 / 37.5 / 32.0-43.6 / 0.04
NHL-NOS / 611 / 25.0 / 23.1-27.1 / 273 / 13.6 / 12.0-15.3 / <0.0001
Non-AIDS-defining
Follicular / 23 / 1.9 / 1.2-2.8 / 21 / 1.0 / 0.6-1.5 / 0.11
CLL/SLL / 18 / 1.3 / 0.8-2.1 / 12 / 0.5 / 0.3-0.9 / 0.01
Marginal Zone / 12 / 2.8 / 1.5-5.0 / 19 / 2.2 / 1.3-3.4 / 0.99
Mantle Cell / 4 / 2.0 / 0.6-5.2 / 2 / 0.5 / 0.1-1.9 / 0.20
LPL/WM / 7 / 4.6 / 1.8-9.4 / 7 / 3.0 / 1.2-6.1 / 0.92
ALCL / 51 / 20.2 / 15.0-26.5 / 17 / 7.5 / 4.4-12.0 / 0.001
Primary Cutaneous
ALCL / 2 / 9.0 / 1.1-32.5 / 1 / 1.8 / 0.1-10.1 / 0.19
Peripheral T-cell / 15 / 4.1 / 2.3-6.7 / 24 / 3.3 / 2.1-5.0 / 0.65
MF/SS / 3 / 1.3 / 0.3-3.7 / 2 / 0.5 / 0.1-1.8 / 0.41
Natural Killer/T-cell / 2 / 5.2 / 0.6-18.7 / 2 / 3.1 / 0.4-11.2 / 0.66
ALLc / 14 / 2.9 / 1.6-4.9 / 13 / 2.0 / 1.0-3.3 / 0.21
Other Specified / 3 / 1.1 / 0.2-3.2 / 4 / 1.1 / 0.3-2.8 / 0.97
Overall NHLd / 1665 / 14.9 / 14.2-15.6 / 1163 / 7.5 / 7.1-7.9 / <0.0001

IR, incidence rate; SIR, standardized incidence ratio; 95% CI, 95% confidence interval; DLBCL, diffuse large B-cell lymphoma; NHL, non-Hodgkin lymphoma; NOS, not otherwise specified; CLL/SLL, chronic lymphocytic leukemia/small lymphocytic lymphoma; LPL/WM, lymphoplasmacytic lymphoma/Waldenström macroglobulinemia; ALCL, anaplastic large cell lymphoma; MF/SS, mycosis fungoides/Sézary syndrome; ALL, acute lymphoblastic leukemia/lymphoma

a Cases per 100,000 person-years

b Test for difference in SIRs by calendar period, using Poisson regression models with sex and age

c Includes all precursor lymphoid neoplasms

d The number of overall NHL cases is the sum of the subtypes listed excluding central nervous system lymphomas, which are included in the appropriate histologic subtype categories

Note: 1996-2002 = 652912 person-years; 2003-2010 = 806904 person-years

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