Article title: Anthropometric characteristics and risk of lymphoid and myeloid Leukemia in theEuropean Prospective Investigation into Cancer and Nutrition (EPIC)
Journal name:Cancer Causes and Control
Author names:Fatemeh Saberi Hosnijeh1,2, Isabelle Romieu3, Valentina Gallo4, Elio Riboli4, Anne Tjønneland5, Jytte Halkjær5, Guy Fagherazzi6,7, Françoise Clavel-Chapelon6,7, Laure Dossus6,7, Annie Lukanova8, Rudolf Kaaks8, Antonia Trichopoulou9,10, Pagona Lagiou9,11, Michael Katsoulis10, Salvatore Panico12, Giovanna Tagliabue13, Catalina Bonet14, Miren Dorronsoro15, José María Huerta16,17, Eva Ardanaz17,18, Maria-José Sánchez 17,19, Dorthe Johansen20, Signe Borgquist21, Petra Peeters22, H. Bas Bueno-de-Mesquita23,24, Martine M Ros23,25, Ruth C. Travis26, Timothy J. Key26, Paolo Vineis4*, Roel Vermeulen1,22*
Affiliation:1 Institute for Risk Assessment Sciences (IRAS), Division Environmental Epidemiology, Utrecht University, Netherlands; 2 Zanjan University of medical science, Zanjan, Iran; 3 International Agency for Research on Cancer (IARC-WHO), Lyon, France; 4Division of Epidemiology, Public Health and Primary Care, Faculty of Medicine,Imperial College, London, UK; 5Danish Cancer Society Research Center, Copenhagen,Denmark; 6Inserm, U1018, Gustave Roussy Institute, F-94805, Villejuif, France; 7Paris South University, UMRS 1018, F-94805, Villejuif, France; 8Division of Cancer Epidemiology German Cancer Research Centre Heidelberg, Germany; 9 WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece; 101 Hellenic Health Foundation, Athens, Greece; 11 Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece; 12 Department of Clinical and Experimental Medicine Federico II University, Naples, Italy; 13 Environmental Epidemiology and Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; 14Unit of Nutrition, Environment and Cancer,Catalan Institute of Oncology (ICO),Barcelona, Spain; 15 Public health Division of Gipuzkoa, Basque Regional Health Department and Biodonostia/Ciberesp,Spain; 16 Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain; 17 CIBER Epidemiología y Salud Pública (CIBERESP), Spain;18 Navarre Public Health Institute,Pamplona,Spain; 19 AndalusianSchoolof Public Health, Granada (Spain); 20Department of Surgery, Malmö University Hospital, Lund University, Malmö, Sweden; 21Clinical Sciences, Department of Oncology, Lund University, Sweden;22 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands; 23National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; 24 Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands; 25 Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands ;26 Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
* Co-last authors
E-mail address of the corresponding author:
Roel Vermeulen
Institute for Risk Assessment Sciences
Division Environmental Epidemiology
Jenalaan 18D, PO Box 80178
3508 TD, Utrecht, The Netherlands
Tel: +31 30 253 9448
Fax: +31 30 253 9499
E-mail:
Online Resource 5. Sex-specific RR and 95% CI for leukemia risk in relation to anthropometric characteristics excluding cases with less than 2 years follow-up
Multivariate modelAll leukemia / Myeloid leukemia / Lymphoid leukemia
Female / n / RR (95% CI) / n / RR (95% CI) / n / RR (95% CI)
Body mass index
<22.48
22.48-24.96
24.97-28.23
≥28.24
P-trend / 35
72
85
66 / Ref.
1.72 (1.15-2.59)
1.89 (1.27-2.81)
1.49 (0.98-2.28)
0.11 / 17
25
42
34 / Ref.
1.26 (0.68-2.34)
1.99 (1.13-3.53)
1.69 (0.93-3.09)
0.04 / 14
43
36
31 / Ref.
1.54 (1.39-4.66)
1.98 (1.06-3.70)
1.75 (0.92-3.35)
0.39
Height
<157
157.0-161.3
161.4-166.0
≥166.1
P-trend / 64
52
72
70 / Ref.
0.80 (0.55-1.16)
1.06 (0.73-1.51)
1.20 (0.81-1.75)
0.17 / 31
22
36
29 / Ref.
0.69 (0.39-1.21)
1.08 (0.64-1.81)
1.04 (0.59-1.84)
0.52 / 24
29
34
37 / Ref.
1.14 (0.65-1.99)
1.23 (0.70-2.16)
1.52 (0.85-2.71)
0.13
Weight
<58.7
58.7-65.2
65.3-73.9
≥74
P-trend / 49
54
74
81 / Ref.
0.94 (0.64-1.39)
1.18 (0.81-1.72)
1.26 (0.87-1.84)
0.11 / 21
24
32
41 / Ref.
1.03 (0.57-1.86)
1.30 (0.73-2.29)
1.67 (0.96-2.91)
0.05 / 19
27
41
37 / Ref.
1.15 (0.64-2.08)
1.57 (0.89-2.74)
1.36 (0.76-2.42)
0.22
Hip circumference
<96
96-100.9
101-106.9
≥107
P-trend / 46
65
62
73 / Ref.
1.38 (0.94-2.02)
1.28 (0.87-1.90)
1.42 (0.97-2.09)
0.13 / 26
24
27
37 / Ref.
0.96 (0.55-1.69)
1.09 (0.63-1.90)
1.44 (0.85-2.43)
0.14 / 15
35
33
33 / Ref.
2.18 (1.18-4.02)
1.97 (1.06-3.67)
1.87 (0.99-3.51)
0.14
Waist circumference
<73.1
73.1-79.9
80.0-88
≥88.1
P-trend / 51
55
69
71 / Ref.
1.09 (0.74-1.59)
1.15 (0.79-1.66)
1.24 (0.85-1.81)
0.26 / 21
26
25
42 / Ref.
1.33 (0.75-2.38)
1.13 (0.63-2.05)
2.12 (1.22-3.69)
0.01 / 24
26
38
28 / Ref.
1.04 (0.60-1.82)
1.25 (0.74-2.11)
0.96 (0.54-1.70)
0.95
WHR
<0.76
0.76-0.79
0.80-0.84
≥0.85
P-trend / 58
64
63
61 / Ref.
1.06 (0.74-1.52)
0.91 (0.64-1.31)
0.98 (0.67-1.42)
0.71 / 19
30
33
32 / Ref.
1.53 (0.86-2.72)
1.52 (0.86-2.70)
1.76 (0.98-3.16)
0.08 / 33
31
26
26 / Ref.
0.90 (0.55-1.47
0.65 (0.39-1.10)
0.70 (0.41-1.20)
0.10
Male
Body mass index
<24.22
24.22-26.30
26.31-29.72
≥29.73
P-trend / 71
86
82
74 / Ref.
1.12 (0.82-1.54)
1.06 (0.77-1.46)
0.98 (0.70-1.37)
0.82 / 26
35
31
28 / Ref.
1.27 (0.76-2.11)
1.13 (0.67-1.91)
1.07 (0.62-1.86)
0.95 / 39
48
44
38 / Ref.
1.13 (0.74-1.73)
1.03 (0.66-1.59)
0.90 (0.57-1.42)
0.55
Height
<169.7
169.7-174.9
175-179.9
≥180
P-trend / 70
90
72
83 / Ref.
1.29 (0.93-1.78)
1.10 (0.77-1.55)
1.36 (0.96-1.93)
0.19 / 32
29
22
38 / Ref.
0.94 (0.56-1.59)
0.78 (0.44-1.38)
1.47 (0.87-2.50)
0.20 / 34
48
45
43 / Ref.
1.36 (0.86-2.15)
1.34 (0.84-2.16)
1.36 (0.83-2.23)
0.29
Weight
<73.1
73.1-80.0
80.1-88.0
≥88.1
P-trend / 76
69
79
89 / Ref.
0.86 (0.62-1.20)
0.97 (0.70-1.35)
1.11 (0.79-1.56)
0.39 / 25
31
30
34 / Ref.
1.26 (0.74-2.17)
1.23 (0.71-2.16)
1.42 (0.80-2.53)
0.27 / 44
34
44
47 / Ref.
0.69 (0.44-1.10)
0.86 (0.56-1.34)
0.92 (0.59-1.45)
0.99
Hip circumference
<97.0
97.0-100.9
101.0-105.0
≥105.1-180
P-trend / 65
73
75
76 / Ref.
1.10 (0.79-1.55)
1.07 (0.76-1.51)
1.24 (0.88-1.76)
0.30 / 24
27
30
30 / Ref.
1.12 (0.64-1.94)
1.15 (0.66-2.00)
1.29 (0.73-2.29)
0.39 / 36
41
40
38 / Ref.
1.11 (0.71-1.75)
1.02 (0.64-1.63)
1.12 (0.69-1.81)
0.77
Waist circumference
<88.5
88.5-94.9
95-101.9
≥102
P-trend / 54
73
79
83 / Ref.
1.21 (0.85-1.73)
1.22 (0.86-1.74)
1.28 (0.90-1.83)
0.21 / 20
29
30
32 / Ref.
1.34 (0.76-2.38)
1.31 (0.74-2.34)
1.42 (0.80-2.55)
0.29 / 30
41
41
43 / Ref.
1.20 (0.75-1.93)
1.10 (0.68-1.78)
1.14 (0.70-1.84)
0.74
WHR
<0.91
0.91-0.94
0.95-0.98
≥0.99
P-trend / 54
80
80
75 / Ref.
1.36 (0.96-1.92)
1.34 (0.94-1.90)
1.31 (0.92-1.87)
0.20 / 21
33
25
32 / Ref.
1.50 (0.86-2.60)
1.16 (0.64-2.08)
1.62 (0.92-2.85)
0.21 / 28
41
49
37 / Ref.
1.31 (0.81-2.13)
1.51 (0.94-2.41)
1.16 (0.70-1.91)
0.52
AML / CML / CLL
Female
Body mass index
<22.48
22.48-24.96
24.97-28.23
≥28.24
P-trend / 9
14
26
14 / Ref.
1.27 (0.55-2.94)
2.14 (0.99-4.61)
1.19 (0.50-2.82)
0.44 / 5
4
9
10 / Ref.
0.73 (0.19-2.72)
1.57 (0.51-4.78)
1.75 (0.56-5.43)
0.17 / 12
34
31
27 / Ref.
2.32 (1.20-4.49)
1.96 (1.00-3.85)
1.76 (0.88-3.53)
0.33
Height
<157
157.0-161.3
161.4-166.0
≥166.1
P-trend / 17
11
20
15 / Ref.
0.66 (0.31-1.44)
1.21 (0.60-2.42)
1.16 (0.53-2.51)
0.41 / 8
5
8
7 / Ref.
0.64 (0.20-2.02)
0.98 (0.34-2.88)
0.99 (0.31-3.19)
0.84 / 22
22
30
30 / Ref.
0.92 (0.50-1.69)
1.14 (0.63-2.06)
1.27 (0.68-2.35)
0.30
Weight
<58.7
58.7-65.2
65.3-73.9
≥74
P-trend / 13
12
18
20 / Ref.
0.80 (0.36-1.77)
1.11 (0.53-2.33)
1.24 (0.59-2.60)
0.38 / 5
6
8
9 / Ref.
1.08 (0.32-3.59)
1.37 (0.43-4.35)
1.55 (0.49-4.90)
0.39 / 18
23
30
33 / Ref.
1.03 (0.55-1.92)
1.19 (0.65-2.18)
1.26 (0.69-2.30)
0.38
Hip circumference
<96
96-100.9
101-106.9
≥107
P-trend / 17
14
13
18 / Ref.
0.84 (0.41-1.72)
0.78 (0.37-1.63)
1.03 (0.51-2.07)
0.97 / 6
3
9
7 / Ref.
0.53 (0.13-2.14)
1.52 (0.52-4.47)
1.05 (0.33-3.38)
0.57 / 13
29
26
31 / Ref.
2.01 (1.04-3.90)
1.72 (0.87-3.38)
1.94 (0.99-3.79)
0.12
Waist circumference
<73.1
73.1-79.9
80.0-88
≥88.1
P-trend / 11
14
15
22 / Ref.
1.33 (0.60-2.95)
1.25 (0.57-2.77)
2.05 (0.95-4.38)
0.08 / 6
8
3
8 / Ref.
1.39 (0.48-4.06)
0.43 (0.11-1.79)
1.13 (0.35-3.62)
0.77 / 21
20
33
25 / Ref.
0.89 (0.48-1.65)
1.20 (0.68-2.09)
0.93 (0.51-1.72)
0.92
WHR
<0.76
0.76-0.79
0.80-0.84
≥0.85
P-trend / 7
18
20
17 / Ref.
2.45 (1.02-5.55)
2.45 (1.03-5.15)
2.46 (1.00-6.06)
0.08 / 8
6
6
5 / Ref.
0.68 (0.23-1.97)
0.57 (0.19-1.69)
0.53 (0.16-1.74)
0.26 / 28
25
24
22 / Ref.
0.86 (0.50-1.48)
0.71 (0.41-1.23)
0.68 (0.38-1.22)
0.15
Male
Body mass index
<24.22
24.22-26.30
26.31-29.72
≥29.73
P-trend / 14
16
22
13 / Ref.
1.03 (0.50-2.11)
1.37 (0.69-2.70)
0.82 (0.38-1.80)
0.87 / 5
9
1
7 / Ref.
1.67 (0.56-5.00)
0.20 (0.19-1.63)
1.40 (0.41-4.60)
0.86 / 36
47
35
36 / Ref.
1.20 (0.77-1.85)
0.88 (0.55-1.40)
0.92 (0.57-1.48)
0.44
Height
<169.7
169.7-174.9
175-179.9
≥180
P-trend / 14
15
13
23 / Ref.
1.16 (0.54-2.45)
1.11 (0.50-2.49)
2.21 (1.05-4.69)
0.04 / 10
3
3
7 / Ref.
0.37 (0.10-1.36)
0.45 (0.12-1.73)
1.32 (0.44-3.94)
0.77 / 32
43
41
39 / Ref.
1.29 (0.80-2.06)
1.28 (0.79-2.10)
1.31 (0.79-2.18)
0.35
Weight
<73.1
73.1-80.0
80.1-88.0
≥88.1
P-trend / 12
17
19
17 / Ref.
1.24 (0.58-2.64)
1.29 (0.60-2.76)
1.09 (0.48-2.46)
0.88 / 8
3
3
8 / Ref.
0.48 (0.12-1.84)
0.51 (0.13-2.08)
1.49 (0.46-4.83)
0.54 / 41
32
39
42 / Ref.
0.70 (0.44-1.12)
0.82 (0.52-1.30)
0.86 (0.55-1.42)
0.81
Hip circumference
<97.0
97.0-100.9
101.0-105.0
≥105.1-180
P-trend / 12
13
16
18 / Ref.
0.95 (0.43-2.10)
0.98 (0.45-2.13)
1.15 (0.52-2.54)
0.69 / 7
4
5
5 / Ref.
0.60 (0.17-2.07)
0.71 (0.21-2.36)
0.78 (0.22-2.76)
0.74 / 33
38
35
34 / Ref.
1.12 (0.70-1.80)
0.97 (0.60-1.59)
1.08 (0.65-1.80)
0.92
Waist circumference
<88.5
88.5-94.9
95-101.9
≥102
P-trend / 10
13
17
19 / Ref.
1.06 (0.46-2.44)
1.23 (0.56-2.73)
1.32 (0.60-2.93)
0.43 / 5
5
6
5 / Ref.
0.97 (0.28-3.39)
1.18 (0.35-3.98)
1.03 (0.28-3.80)
0.88 / 27
38
35
40 / Ref.
1.21 (0.74-1.99)
1.02 (0.61-1.70)
1.15 (0.69-1.90)
0.81
WHR
<0.91
0.91-0.94
0.95-0.98
≥0.99
P-trend / 10
19
11
19 / Ref.
1.69 (0.78-3.64)
0.99 (0.42-2.35)
1.85 (0.85-4.03)
0.29 / 3
4
9
5 / Ref.
1.37 (0.30-6.14)
3.22 (0.86-12.08)
2.07 (0.48-8.92)
0.16 / 25
39
41
35 / Ref.
1.36 (0.82-2.25)
1.37 (0.83-2.26)
1.18 (0.70-1.99)
0.62
RR: relative risks; CI: confidence intervals; AML: acute myeloid leukemia; CML: chronic myeloid leukemia; CLL: chronic lymphoid leukemia; Multivariate models adjusted for recruitment age and study country; Multivariate models for height were further adjusted for BMI ; Multivariate models for weight, waist circumference, hip circumference and waist to hip ratio (WHR) were further adjusted for height; Tests of linear trend across categories were conducted by fitting a model treating the quartile categories as a single ordinal variable.