Research Field Highlight
Yabin Guo(郭雅彬)
Research field highlight
Next-generation sequencing, Bioinformatics/programming, Cancer biology, Cell signaling.
Education
Ph.D., 08/2000-07/2005 Institute of Basic Medical Sciences, Peking Union Medical College & Chinese Academy of Medical Sciences
Beijing, 100005, China
Major: Biochemistry and Molecular Biology
Bachelor of Engineering, 09/1992-06/1996
School of Biopharmaceutics
China Pharmaceutical University
Nanjing, 210009, China
Major: Biopharmaceutics
Research Experiences
09/2011-
Identification of cancer-related genes using high-throughput transposon mutagenesis and studies on mechanisms of new identified oncogenes.
Supervisor: Kathryn O’Donnell, Ph. D.
Department of Molecular Biology, UT Southwestern Medical Center.
08/2006-08/2011
High throughput study on transposon/retrotransposon integration.
Supervisor: Henry L. Levin, Ph. D.
Section on Eukaryotic Transposable Elements, Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health
09/2000-10/2005
Research on the tumoricidal activity and mechanism of a novel anti-human DR5 (TRAIL receptor 2) monoclonal antibody
Advisor: Prof. Yanxin Liuand Prof. Dexian Zheng.
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, PUMC & CAMS
Award
NIH Intramural AIDS Research Fellowship (IARF), 2009
Publications
1.Guo Y, Updegraff BL, Park S, Durakoglugil D, Cruz VH, Maddux S, Hwang TH, O'Donnell KA. Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis.Cancer Res. 2016;76(4):773-86.
3. Guo Y, Singh P, Levin HL. Along terminal repeat retrotransposon of Schizosaccharomyces japonicas integrates upstream of RNA pol III transcribed genes. Mobile DNA 2015; 6(1):19
5. Chatterjee AG, Esnault C, Guo Y, Hung S, McQueen PG, Levin HL.Serial number tagging reveals a prominent sequence preference of retrotransposon integration.Nucleic Acids Research. 2014 Sep 1;42(13):8449-60.
6. Guo Y, Park JM, Cui B, Humes E, Gangadharan S, Hung S, FitzGerald PC, Hoe KL, Grewal SI, Craig NL, Levin HL.Integration profiling of gene function with dense maps of transposon integration.Genetics. 2013 Oct;195(2):599-609.
7. Rhind N, Chen Z, Yassour M, Thompson DA, Haas BJ, Habib N, Wapinski I, Roy S, Lin MF, Heiman DI, Young SK, Furuya K, Guo Y,et al, Nusbaum C.Comparative functional genomics of the fission yeasts.Science 2011 May:20;332(6032):930-6.
8. Guo Y, Levin HL.High-throughput sequencing of retrotransposon integration provides a saturated profile of target activity in Schizosaccharomyces pombe.Genome Research. 2010 Feb;20(2):239-48. Epub 2009 Dec 29.
9. Chen F, Guo YB, Liu SL, Zheng DX, Liu YX. Construction and expression of anti-tumor necrosis factor related apoptosis-inducing ligand receptor death receptor 5 chimeric antibody in eukaryotic cells. Zhongguo Yi Xue Ke Xue Yuan Xue Bao2008 Dec;30(6):690-5.
10. Shi J, Liu Y, Zheng Y, Guo Y, Zhang J, Cheung PT, Xu R and Zheng D.Therapeutic expression of an anti-death receptor 5 single-chain fixed-variable region prevents tumor growth in mice.Cancer Research. 2006 Dec 15; 66(24): 11946-53.
11. Guo Y, Chen C, Zheng Y, Zhang J, Tao X, Liu S, Zheng D and Liu Y.A novel anti-human DR5 monoclonal antibody with tumoricidal activity induces caspase-dependent and caspase-independent cell death.J. Biol. Chem. 2005 Dec 23;280(51):41940-52. Epub 2005 Oct 18.
Patent
Yanxin Liu, Yabin Guo and Dexian Zheng. MONOCLONAL ANTIBODY (AD5-10) AGAINST TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND RECEPTOR DR5, THE PRODUCING METHOD AND USES THEREOF. European Patent Application EP1790663.
Invited Lectures
1. Ultra high-throughput sequencing of transposon integration provides a genome-wide profile of essential sequences in Schizosaccharomyces pombe. MidAtlantic Transposon Meeting 2010, Baltimore, MD.
2. Ultra high throughput sequencing reveals LTR-retrotransposon integration favors stress activated promoters in schizosaccharomyces pombe. Cold Spring Harbor Laboratory Meeting on Retroviruses2009, Cold Spring Harbor, NY.
3. DR5 mediated caspase-independent cell death in Jurkat T cells. 3nd Congress of the Federation of Immunology Societies of Asia-Oceania, 2005, Hangzhou, China.
Poster Presentations at Conferences (selected)
1. Guo Y, Updegraff BL, Park S, Durakoglugil D, Burton V, Maddux S, Hwang TH, O’Donnell KA.Identification of novel genes and pathways that drive B-cell malignancies using the Sleeping Beauty transposon system. Keystone Symposium on Molecular and cellular Biology, Mobile Genetic Elements and Genome Evolution 2014, Santa Fe, NM.
2.Guo Y, Maddux S, O’Donnell KA. An ex vivo Sleeping Beauty mutagenesis screen to identify genes that drive lymphomagenesis. Innovations in Cancer Prevention and Research Conference 2012,Austin, TX.
3.GuoY, Grewal SI, Levin HL. The significance of duplicate reads in high throughput sequencing of integration sites. Cold Spring Harbor Laboratory Meeting on Retroviruses 2010.Cold Spring Harbor, NY.
4. Guo Y, Levin HL. A saturated map of transposon targets reveals stress activated promoters are favored positions for integration of Tf1 in Schizosaccharomyces pombe. 2nd ASM Conference on Mobile DNA, 2010, Montreal, Canada.
5. Guo Y, Tao X, Liu Y, Zheng D. A study on the interaction of TRAIL (Apo2L) and DR5. 10th SCBA International Symposium, 2004, Beijing, China.