Table 5. Comparison of age-related motor function declines in humans and mouse model.
Percentage Decline from Young (%)Source / Measures / Age (yrs)
50-59 / 60-69 / 70-79 / 80-89
Locomotion / Sex
Ble 2005 / 4 m walk / M / 0 / 2 / 5 / 33
Bohannon 1997a / 7 m walk / M / 0 / 2 / 5
Lord et al. 1996 / 7.2 m walk / F / 7 / 18 / 22 / 30
Oberg 1993 / 5.5 m walk / M / +1 (gain) / +4 (gain) / 4
Bohannon 2011 / Meta-analysis / M / +5 (gain) / 1 / 7 / 29
Vereeck 2008 / Timed Up & Go / M/F / 11 / 27 / 52 / 77
Average / 2 / 8 / 14 / 42
Present Study / Locomotion score / M / 8 / 31
Strength / Sex
Burke et al. 1953 / Handgrip / M / 17 / 19 / 41
Mathiowetz etal. 1985 / Handgrip / M / 11 / 25 / 38
Kallman et al. 1990 / Handgrip / M / 9 / 16 / 29
Hunter et al. 2000 / Handgrip / F / 16 / 22 / 35 / 38
Werle et al. 2009 / Handgrip / M / 2 / 15 / 27 / 50
Vandervoort et al. 1986 / Plantar flexors / M / 21 / 29 / 45
Vandervoort et al. 1986 / Plantar flexors / F / 20 / 22 / 55
Bemben et al. 1991 / Plantar flexors / M / 18 / 37
Hunter et al. 2000 / Plantar flexors / F / 16 / 28 / 37 / 55
Bohannon et al. 1997b / Knee extensors / M / 19 / 34 / 36
Bohannon et al. 1997b / Knee extensors / F / 30 / 42 / 56
Hunter et al. 2000 / Knee extensors / F / 31 / 41 / 50 / 56
Average / M/F / 19 / 26 / 40 / 50
Present Study / Strength score / M / 26 / 49
Balance and Coordination / Sex
Gill 2001 / One leg stance time / M/F / 50 / 77
Vereeck 2008 / Foam stand / M/F / 0 / 0 / 13 / 34
Tandem Romberg / M/F / 4 / 6 / 40 / 56
1 leg stand eyes open / M/F / 1 / 0 / 8 / 29
1 leg stand eyes close / M/F / 21 / 28 / 68 / 82
Tandem gait / M/F / 0 / 0 / 14 / 30
Dynamic gait / M/F / 0 / 0 / 3 / 8
Tang & Woollacott 1998 / Sharpened Romberg / M/F / 45
1 leg stand eyes open / M/F / 49
Average / 11 / 6 / 34 / 45
Present Study / Coordination score / M / 35 / 39
Endurance and Cardiorespiratory Fitness / Train
Pimentel et al. 2003 / 10km run time / ET / 21 / 47
Leyk et al. 2007 / Marathon run time / ET / 19 / 26 / 48
Leyk et al. 2007 / Half-marathon time / ET / 11 / 25 / 48
Average / 17 / 26 / 48
Present Study / Endurance score / Sed / 10 / 21
Present Study / Endurance run distance / Sed / 19 / 30
Percent declines from young humans (20-29 years) were estimated from representative studies within each subdomain. In the present study, the percent declines from young mice (3 month) for each subdomain are presented for 20-month and 26-month old mice between age categories at percentages mean human lifespan.
References for Supplemental Table 5
Bemben MG, Massey BH, Bemben DA, Misner JE, Boileau RA (1991) Isometric muscle force production as a function of age in healthy 20- to 74-yr-old men. Med Sci Sports Exerc 23: 1302-1310.
Ble A, Volpato S, Zuliani G, Guralnik JM, Bandinelli S, Lauretani F, Batali B, Maraldi C, Fellin R, Ferrucci L (2005) Executive function correlates with walking speed in older persons: the InCHIANTI study. J Am Geriatr Soc 53(3): 410-415.
Bohannon RW (1997a) Comfortable and maximum walking speed of adults aged 20 to 79 years: reference values and determinants. Age Ageing 26: 15-19.
Bohannon RW (1997b) Reference values for the extremity muscle strength obtained by hand-held dynamometry from adults aged 20-79 years. Arch Phys Med Rehab 78: 26-32.
Bohannon RW, Andrews AW (2011). Normal walking speed: a descriptive meta-analysis. Physiotherapy 97: 182-189.
Burke WE, Tuttle WW, Thompson CW, Janney CD, Weber RJ (1953) The relation of grip strength and grip-strength endurance to age. J Appl Physiol 5: 628-630.
Gill J, Allum JHJ, Carpenter MG, Held-Ziolkowska M, Adkin AL, Honegger F, Pierchala K (2001) Trunk sway measures of postural stability during clinical balance tests: effects of age. J Gerontol A Biol Sci Med Sci 56(7): M438-M447.
Hunter SK, Thompson MW, Adams RD (2000) Relationships among age-associated strength changes and physical activity level, limb dominance, and muscle group in women. J Gerontol A Biol Sci Med Sci 55(6): B264-73.
Kallman DA, Plato CC, Tobin JD (1990) The role of muscle loss in the age-related decline of grip strength: cross-sectional and longitudinal perspectives. J Gerontol A Biol Sci Med Sci 45: M82-M88.
Leyk D, Erley O, Ridder D, Leurs M, Rüther T, Wunderlich M, Sievert A, Baum K, Essfeld D (2007) Age-related changes in marathon and half-marathon performances. Int J Sports Med 28(6): 513-517.
Lord SR, Lloyd DG, Li SK (1996) Sensori-motor function, gait patterns and falls in community-dwelling women. Age Ageing 25(4): 292-9.
Mathiowetz V, Kashman N, Volland G, Weber K, Dowe M, Rogers S (1985) Grip and pinch strength: normative data for adults. Arch Phys Med Rehab 66: 69-74.
Öberg T, Karsznia A, Öberg K (1993) Basic gait parameters: reference data for normal subjects, 10 to 79 years of age. J Rehabil Res Dev 30: 210-223.
Pimentel AE, Gentile CL, Tanaka H, Seals DR, Gates PE (2003) Greater rate of decline in maximal aerobic capacity with age in endurance-trained than in sedentary men. J Appl Physiol 94: 2406-2413.
Tang PF, Woollacott MH (1998) Inefficient postural responses to unexpected slips during walking in older adults. J Gerontol A Biol Sci Med Sci 53A(6): M471-M480.
Vandervoort AA, McComas AJ (1986) Contractile changes in opposing muscles of the human ankle joint with aging. J Appl Physiol 61: 361-367.
Vereeck L, Wuyts F, Truijen S, Van de Heyning P (2008) Clinical assessment of balance: normative data, and gender and age effects. Int J Audiol 47: 67-75.
Werle S, Golhahn J, Drerup S, Simmen BR, Sprott H, Herren DB (2009) Age- and gender-specific normative data of grip and pinch strength in a healthy adult swiss population. J Hand Surg Eur Vol 34E: 76-84.
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