Rajiv Gandhi University of Health Scicences

RAJIV GANDHIUNIVERSITY OF HEALTH SCICENCES,

BANGALORE, KARNATAKA

SYNOPSIS BY

DR.KISHORKUMAR.A.RAJAPUROHIT

FOR THE DEGREE OF AYURVEDA VACHASPATHI

M.D AYURVEDA IN ROGA NIDANA

2012

TITLE OF THE TOPIC

“A STUDY ON AETIOPATHOGENESIS OF APATHYA NIMITTAJA MADHUMEHA W.S.R TO NIDDM TYPE2 AND ITS SAMPRAPTI VIGHATANA BY NISHATRIPHALADI YOGA”

NAME OF THE INSTITUTE

GOVERNMENT AYURVEDIC MEDICAL COLLEGE

DHANWANTARI ROAD

BANGALORE-09

KARNATAKA

RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES

BANGALORE KARNATAKA

PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION

FROM,

DR.KISHORKUMAR.A.RAJAPUROHIT

First M.D(AYU) Department of Roga Nidana.

Government Ayurvedic Medical College

Bangalore-560009

TO,

THE REGISTRAR,

Rajiv Gandhi University of Health Sciences,

Bangalore-41.

THROUGH,

THE PRINCIPAL AND HOD OF P.G STUDIES IN ROGA NIDANA,

Government Ayurvedic Medical College,

Bangalore – 09

Respected sir,

Subject – Topic for Dissertation-Submission of completedproforma.

I request you to kindly register the under mentioned subject against my name as the topic for dissertation in partial fulfillment of M.D(Ayurveda) in Roga nidana underRajiv Gandhi University of Health Sciences Bangalore.

TITLE OF THE DISSERTATION

“A STUDY ON AETIOPATHOGENESIS OF APATHYA NIMITTAJA MADHUMEHA W.S.R TO NIDDM TYPE2 AND ITS SAMPRAPTI VIGHATANA BY NISHATRIPHALADI YOGA”

I am here with enclosing completed proforma for registration of the subject for dissertation.

Thanking you

Place:Bangalore yours faithfully

Date :

(Dr.Kishorkumar.A.Rajapurohit)

6. BRIEF RESUME OF INTENDED WORK:

NEED FOR THE STUDY :

Madhumeha is a disease of antiquity. The reference pertaining to Madhumeha are available in some of the most ancient texts including Charaka samhita. Hippocrates has also made specific reference to Diabetes.

The incidence of Diabetes has shown an alarming increase around the world. The developing countries following in thefoot steps of developed countries in life style have also started recording an increased incidence of Madhumeha.

Diabetes mellitus which was once known as Richman’s disease has now become Common man’s disease. As per WHO, 150 million peopleare reported to be suffering from Diabetes. The incidence of Diabetes mellitus in India is rising very fast almost three times to that of what is recorded in world1.

A series of epidemiological studies carried out by Diabetes mellitus Research Centre in Chennai has stated that, the prevalence of Diabetes mellitus had steadily increased among urban Indian adults from 5.2% in 1984 to 13.9% in 2000. It is estimated that there are about 33 million adults suffering with Diabetes mellitus in India. This number is expected to increase to 57.2 million by the year 20251.

The management of DM still remains unsatisfactory in spite of many advanced medicines and pathological investigations. Almost all treatment aspects focus towards increased blood sugar and use of oral or parental hypoglycemic drugs. Drug intolerance, hypersensitivity, resistance to insulin, the danger of acute and chronic complications, the fear of hypoglycemic series make it all to search out safe, effective, long lasting treatment. Such treatments which breaks the pathological process of DM & prevent its complications are available in Ayurveda.

An effort is made here in to understand the Samprapti of Madhumeha in a better manner and also to understand the process of Samprapti vighatana by Nisha Triphaladi Yoga.

6.2 REVIEW OF LITERATURE:

The knowledge of nidana is essential to know the nature of disease, its sadhyasadhyata & chikitsa.

1. In charaka samhitha disease Madhumeha described in nidana sthana 4th chapter& in chikitsashana 6th chapter. 2

1. In Sushruta samhitha disease has been described in nidana sthana 6th chapter in Chikitsa sthana 11th chapter and 13th chapter.3

1. In Astanga hridya disease has been described in nidana sthana 10th chapter & in chikitsa sthana 12th chapter.4

1. In madhava nidana the description of disease in 33rd chapter.5

1. In Yoga ratnakara Madhumeha mentioned in 34th chapter.6

PREVIOUS DISSERTATION WORK DONE: 7

1. 2000. Hombal Shashidhar T- The effect of bhumyamalakadi churna in madhumeha (w s r to its hypoglycemic effect) page no-195 SL NO-3
2. 2004. Ahuja Harish . A clinical study on the efficacy of virechana & medohara rasayana in managemeny of madhumeha w s r to Diabetes mellitus – L 2921. Vikruti vignana page no-44 SL NO-975
3. 2005. Tikoo Ajay- A clinical study on role of virechana karma in management of madhumeha w s r to Diabetes melliteus- P K page no-45 SL NO-1000

6.3 OBJECTIVE OF THE STUDY :

1)The present study is intended to understand the aetiopathogenesis of Madhumeha w.s.r. to Non Insulin Dependent Diabetes Mellitus Type 2.

2)The study is aimed to understand the process of samprapti vighatana of Madhumeha through the use of Nisha triphaladi yoga.

7.METHODOLOGY:

7.1 SOURCE OF DATA:

For the present study patients will be randomly selected from the OPD and IPD of Shri Jayachamarajendra institute of Indian Medicine Hospital(Teaching Hospital of G.A.M.C) Bangalore.

7.2 COMPOSTION OF TRIAL DRUG:

NISHA TRIPHALADI YOGA:6

INGREDIENTS:

Preparation of Medicine:

All the ingredients are collected after proper identification. The useful parts and the ratio of the individual ingredients are as per classical reference. Preparation will be undertaken with good manufacturing practice.

7.3METHODS OF COLLECTION OF DATA :

Both male and female patients for the age groupof 40 to 60 years attending the OPD and IPD of Shri Jayachamarajendra Institute of Indian Medicine Hospital ( Teaching hospital of G.A.M.C,) Bangalore.

7.3a STUDY DESIGN

1. Patients fulfilling the inclusion criteria selected for the study will be divided into 2 groups. Group A and Group B with 20 patients in each group
2. Patients in group A will be administered Nisha triphaladi yoga Hima 1 pala in a day and also be kept on appropriate Pathya Ahara and Vihara.
3. Patients in Group B kept as Control Group only on Pathya Ahara and Vihara.
4. The Findings are statistically analyzed by using Chisquared Test.

7.3b SAMPLE SIZE

A Minimum of 40 patients. 20 patients in each group selected for the present study.

7.3c Inclusion Criteria

Patients satisfying following criteria are selected for the study.

1)Patients having classical features of madhumeha like

Prabhuta mutrata

Avila mutrata

Pipasa adhikya

Karapada daha and suptata

2)Patients are between age group of 40-60yrs irrespective of sex ,religion & occupation etc selected for study.

3)FBS ranging- 126-200 mg/dl

PPBS ranging–180-250mg/dl

7.3dExclusion Criteria

1. Patients with other systemic disorders like Cardiac illness, Bronchial Asthma, HTN, Endocrine disorders and Pregnancy.
2. Age group less than 40yrs & more than 60 years.
3. Patients havingSahaja prameha.
4. Patients with complications of NIDDM Type 2

7.3e Diagnostic criteria

Patients are diagnosed clinically on the basis of signssymptoms and also through laboratory investigations as mentioned under inclusion criteria.

7.3 f Posology

NISHATRIPHALADI YOGA HIMA – 1 pala

7.3gDuration of the Study - 48 Days

7.3hFollow up – 15 Days

7.3iAssessment Criteria

The Assessment will be made on the basis of the following subjective and objective parameters.Conclusion will be drawn on the basis Chi-squared Test &Students t test.

7.3j Subjective Parameters –

1) Prabhuta mutrata

2)Avila mutrata

3)Pipasa adhikya

4) Karapada daha and suptata

7.3kObjective Parameters–8

1)FBS

2)PPBS

3)Corresponding Urine sugar

7.3lLaboratory Investigations9

1)FBS

2)PPBS

3) Corresponding Urine sugar

7.4Does this study require any investigation/ intervention to be conducted on patients or other human or animals?. If so please describe briefly.

YES the study will be a clinical study

7.5 Whether the Ethical clearance has been obtained from the institution?.

YES

8BIBILIOGRAPHY:

1. Agnivesha. Charakasamhita, revised by chraka and Drdhabla with the Ayuveda Dipika commentary of Chakrapanidatta and edited by Vaidya Yadavaji Trikamji Acharya. Reprint 2009. Pub: Chaukambha Surabharati Prakashan; Varanasi; Chikitsa sthana ch:6, Sl:14 Page No.446.

1. Sushruta. Sushruta Samitha with the Nibanda Sanngraha commentary of Sri Dalhana Achary and the Naychandrika Panjika of Sri Gayadas Achary on Nidana Stana, Edited By Vaidya Jadavji Trikamji Achary, and rest by Narayan Ram Acharya. Pub: Chaukambha Surabharati Prakashan;Varanasi;printed in 2008. Nidana sthanam 6th shloka 6; Page No 290. Chikitsa SthanamChapter 11, Shloka 3, Page No 451.

1. Vagbhata. Astanga Hrdaya with Saravangasundara of Arunadatta and Ayuveda Rasayana of Hemadri, Annotated by Dr.Anna Moreshwara Kunte. and Krishna Ramchandra Shastri Navre. edited by Pt.Hari SadhasivaShastri Paradakara, Reprint-2007, Pub: Chaukambha Surabharati Prakashan;Varanasi; Nidana Sthana Chapter 10, shloka 07, Page 502.

1. Madhava Nidanam (Uttarardham), Madhava. madhukosh vyakha samanvitam tatha cha Vimala-Madhudhara hindi vyakha, vyakhyakara Dr. Brahmanamd Tripathi, Pub: Chaukambha Surabharati Prakashan;Varanasi; printed 2009. Chapter 33, shloka 6. Page no 9

1. Yoga Ratnakara with ‘Vaidyaprabha’ Hindi teeka edited by Dr. Indradev Tripathi and Dr. Daya Shankar Tripathi. Printed by Chaukambha Krishnadas Academy, Varanasi. Printed in 2007. Pp 525 & 531

1. Vaidhya Bagheal, MS Research in Ayurvada.2nd edtion, Jamnagar; mridu ayuvedic Publication and Sales; 2005. PP 381.

1. Harsh Mohan. Text book of Pathology. Edition 6th , published by Jaypee brothers medical publishers(p) limited. Printed 2010. Pp 828.

1. Robbins Basic Pathology. Edition- 8th, published by Elsevier, a division of Reed Elsevier India Private Limited, Logix Park, First Floor, A-4&A-5. Sector 16, Noida, UP. Reprinted 2009. Pp 775