Protein Data Dichotomized at Best Cut-Point

Supplemental Table 5.MultivariateCox-regression analysis for the protein and clinical data of the training cohort.

Histology / Parameter / HR / p-value / 95% CI
All NSCLC
Adenocarcinoma
Squamous cell carcinoma
All NSCLC
Adenocarcinoma
Squamous cell carcinoma
All NSCLC
Adenocarcinoma
Squamous cell carcinoma
All NSCLC
Adenocarcinoma
Squamous cell carcinoma
All NSCLC
Adenocarcinoma
Squamous cell carcinoma / MKI67
Age
Stage
PS
MKI67
Age
Stage
PS
MKI67
Age
Stage
PS
TTF1
Age
Stage
PS
TTF1
Age
Stage
PS
TTF1
Age
Stage
PS
EZH2
Age
Stage
PS
EZH2
Age
Stage
PS
EZH2
Age
Stage
PS
CADM1
Age
Stage
PS
CADM1
Age
Stage
PS
CADM1
Age
Stage
PS
SLC2A1
Age
Stage
PS
SLC2A1
Age
Stage
PS
SLC2A1
Age
Stage
PS / 1.251
1.512
1.859
1.582
2.081
1.711
2.112
1435
1.822
1.520
1.814
1.737
0.783
1.521
1.956
1539
0.580
1.608
2.168
1.543
0.757
1.596
1.775
1.635
1.229
1.531
1.879
1.556
1.660
1.682
1.842
1.438
Inf
1.614
1.852
1.661
0.690
1.548
1.848
1.559
0.574
1.589
1.984
1.473
0
1.594
1.725
1.744
1.383
1.564
1.951
1.516
1.889
1.931
2.091
1.355
1.712
1.527
1.930
1.598 / 0.174
0.009
0.001
0.002
0.005
0.013
0.001
0.083
0.555
0.112
0.021
0.036
0.105
0.008
0.001
0.005
0.010
0.028
0.001
0.040
0.541
0.081
0.027
0.074
0.201
0.007
0.001
0.004
0.019
0.015
0.005
0.082
0.997
0.073
0.018
0.055
0.015
0.006
0.001
0.003
0.008
0.033
0.001
0.064
0.996
0.075
0.034
0.034
0.063
0.005
0.001
0.006
0.003
0.003
0.001
0.145
0.124
0.110
0.013
0.082 / (0.906-1.729)
(1.108-2.063)
(1.364-2.534)
(1.175-2.129)
(1.254-3.454)
(1.120-2.615)
(1.384-3.224)
(0.954-2.160)
(0.249-13.329)
(0.906-2.550)
(1.094-3.007)
(1.037-2.909)
(0.583-1.052)
(1.114-2.077)
(1.442-2.653)
(1.143-2.074)
(0.385-0.876)
(1.051-2.458)
(1.419-3.311)
(1.020-2.335)
(0.310-1.849)
(0.945-2.698)
(1.068-2.949)
(0.953-2.806)
(0.896-1.686)
(1.123-2.089)
(1.382-2.557)
(1.156-2.094)
(1.085-2.538)
(1.106-2.560)
(1.202-2.824)
(0.955-2.165)
(0 - Inf)
(0.957-2.723)
(1.111-3.088)
(0.989-2.790)
(0.513-0.930)
(1.133-2.115)
(1.358-2.513)
(1.158-2.098)
(0.382-0.863)
(1.038-2.432)
(1.300-3.027)
(0.978-2.217)
(0 - Inf)
(0.953-2.664)
(1.042-2.855)
(1.042-2.917)
(0.983-1.946)
(1.145-2.137)
(1.439-2.644)
(1.124-2.044)
(1.238-2.883)
(1.248-2.990)
(1.375-3.180)
(0.901-2.038)
(0.862-3.397)
(0.909-2.564)
(1.148-3.245)
(0.942-2.711)

HR: Hazard Ratio. CI: Confidence Interval. NSCLC: non-small cell lung cancer. PS: performance status

Protein data dichotomized at best cut-point

Age at diagnosis: ≤70 years vs. >70 years; Stage: IA + IB vs. II–IV; Performance status according to WHO: 0 vs. 1–4