Animal Administration Standard Operating Procedure (SOP) for Agents With The GHS Signal word

Danger

Chemical Name

GHS Classification: Signal Word: DANGER

Pictograms:

Additional Classifications:

Purpose:According to the Safety Data Sheet (SDS) special precautions must be taken when working with the chemical described below. The following information includes animal administration, chemical characteristics, followed by recommendations for handling prior to administration,and any paperwork needed in order to use the chemical in the laboratory. This Standard Operating Procedure will be followed along with the requirements of the Chemical Hygiene Plan.

Brief description of agent use:

Section 1:Brief Safety Overview

●The Principal Investigator is responsible for training employees using the material on site. The training should include a discussion of the known and potential hazards; an explanation of the relevant policies, techniques and procedures including the proper use of personal protective equipment, emergency/spill procedures and containment equipment (engineering controls).

●Limit access to authorized users.

●Minimize the possibility of inadvertent ingestion, inhalation and direct skin or eye contact with the substance.

●Chemical has been entered in the Chemical Inventory (EHS Assistant)

●Require annual training.

  • Records of usage will be recorded for all DEA controlled substances. Non-controlled substances do not require specific records to be kept of their usage.
  • Controlled substances require special precautions for use and disposal outlined in The Ohio State University Individual Investigator Use of Controlled Substances in Research. Review the controlled substances policy if in use in your laboratory.

Section 2:Animal Administration

  • Route of Administration (Injection*, inhalant, topical, or oral):

* For injections: Syringes will be used to measure and dispense injectables. Re-capping is typically not performed and syringes will be disposed into an appropriate sharps container after one use. If re-capping is necessary, a one-handed re-capping process should be used. For additional information on the handling of syringes please contact your EHS representative.

  • Agent Administration Location (Injection site, area agent applied to, etc):
  • Dosagegiven to animals:
  • Laboratory location where agent is being administered to animals:

Section 3: Research Laboratory Procedures

  • Handling: Brief description of handling procedures prior to animal administration (mixing procedures*/ dilutions*/vehicles etc):

* If agents have been mixed or diluted the agents must clearly labeled with the correct chemical name and date of preparation.

  • Storage:When not in use, agents will be stored in room ROOM #, BUILDING at the appropriate temperature, either -80˚C, -20˚C, 4˚C or room temperature. Agents should be checked to verify that the agent is not past the expiration date. Controlled substances will be secured in an appropriate lock box

Location – Engineering controls

Ventilation (example: Fume Hood, Canopy Hoods, etc):

Designated area (specify):

Bio-Safety Cabinet

PPE required:

Skin/Body Protection (example: Lab Coat)

Eye protection

Face shield

Respirator (example: N95):

Hand protection (example: Nitrile gloves):

  • Cleanup/Decontamination procedures for work area after use:
  • Disposal Procedures

Section 4:Occupational Exposures

  • Routes of Exposure

Skin -

Inhalation -

Ingestion-

Injection-

  • Toxicological Effects

Acute Effects/ Precautionary Safety Measures:

Chronic Effects/ Precautionary Safety Measures:

  • Occupation Exposure Response and First Aid Measures

Skin -

Eyes -

Inhalation -

Ingestion -

  • Emergency Procedure for Chemical Spills and Accidental Releases

This Standard Operating Procedure must be placed in the Chemical Hygiene Plan and the SDS must be accessible. Also, all laboratory personnel must be familiar with safe handling practices (i.e., training with documentation of training) when working with these chemicals. This must be incorporated into the comprehensive chemical hygiene plan of the laboratory. If you have any questions regarding a comprehensive mandatory laboratory chemical hygiene plan please contact your Representative at Environmental Health and Safety (292-1284).For any other questions or concerns, please contact:

PI contact information

Name:

Primary Contact Number:

Emergency Contact Number:

P.I. Signature ______

Created: January 2014Revised: xxxx Page 1