Principle of Immunobiology (4Credits) & Discussion(2 Credits)
Course Director：Dr. Bing Su
Monday，Wednesday:10:00-11:40, Location: Room 602, Zhiyuan College
Tuesday: 14:00-15:40 (Discussion), Location: Room 602, Zhiyuan College
Textbook: ImmunoBiology,by Kenneth Murphy (Janeway’s ImmunoBiology), Garland Science; 8th Edition (July 25, 2011)
This course is a half-year course which introduces the basic principles of modern immunobiology. It will focus on the generation, development and regulation of the immune system and its function in human epidemics, immunological diseases, inflammation and tumor. The aim of this course is not only to elucidate these key principles of immunology, but also to discuss its history of discovery and some major experimental techniques. The course will also introduce the close relationship of immunology to the other sub disciplines of life science and research methods. This course is not only suitable for the students who majors in life science or medical science, but is also good for the students who major in biomedical engineering who want to pick up some basic knowledge in immunology.
Exams: There're two exams for this course. Each one will count for 50% of the final score.
Instructors
Bing Su (苏冰),, , Ph.D.Professor, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Immunology
Xiaojing Ma (马小京),, Ph.D.Professor,Shanghai Jiaotong University School of Life Science and Biotechnology
Huji Xu (徐沪济), , M.D. & Ph.D., Department of Rheumatology, The Second Military Medical University Associated Changzheng Hospital
Anlong Xu (徐安龙), , Ph.D., Beijing University of Chinese Medicine
Biao Zheng (郑彪), , Ph.D. Professor, East China Normal University
Guanjie Chen (陈广洁),, Ph.D.Professor, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Immunology
Chen Dong (董晨), , Ph.D. Professor, Tsinghua University School of Medicine;
Lei Shen（沈蕾）,
Overseas Guest Lecturers
Yuan Zhuang (庄原),, Ph.D. Professor, Duke University Medical Center
Yang Liu (刘阳), , Ph.D. Center for Cancer and Immunology Research, Children's National MedicalCenter
Pan Zheng (郑盼), , M.D. & Ph.D. Center for Cancer and Immunology Research, Children's National MedicalCenter
Yang Xu (徐洋), , Ph.D. Professor, Division of biological sciences, Section of Molecular Biology, UC San Diego
Yinon Ben-Neriah, , M.D. & Ph.D., Lautenberg Center for Immunology, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
Xiaoxia Li (李晓霞),, Ph.D., Department of Immunology, Cleveland Clinic
Liang Zhou (周亮), , Ph.D., Associate Professor of Pathology and Microbiology-Immunology, Northwestern University
FlorentGinhoux, , Ph.D., SingaporeImmunologyNetwork
Laurent Rénia, , Ph.D., Singapore Immunology Network
Principle of Immunobiology (4Credits) & Discussion(2 Credits)
Course Director：Dr. Bing Su
Monday，Wednesday:10:00-11:40, Location: Room 602, Zhiyuan College
Tuesday: 14:00-15:40 (Discussion), Location: Room 602, Zhiyuan College
Course Introduction
Sept.14 (1)Course Introduction and Requirements (Bing Su)
Sept.15 Discussion (Bing Su)
Sept.16(2)Introduction to the Immune System (Bing Su) (Chapter 1)
Innate Immune Recognition and Inflammation
Sept.21(3)Innate Immune Recognitionby PRRs:TLR(Yinon Ben-Neriah)(Chapter 2)
Sept.22 Discussion (Yinon Ben-Neriah)
Sept.23 (4)Inflammation, infection and acute phase responses(Yinon Ben-Neriah)(Chapter 2)
Development of Lymphocytes
Sept.25(5)Immunoglobulin:GeneStructureofBCRandRearrangement
(YuanZhuang)(Chapter4)18：00-19：40
Sept.28(6)V(D)JRecombinationandEarlyStageBCellDevelopment
(YuanZhuang)(Chapter4,8)
Sept.28Discussion(YuanZhuang)18：00-19：40
Sept.29(7)ThymusandTCellDevelopment(YuanZhuang)(Chapter8)14：00-15：40
Sept.29Discussion(YuanZhuang) 16：00-17：40
Sept.30(8)TLymphocyteMaturationandMigrationintheLymphoidOrgans
(YuanZhuang)(Chapter8)
(National Day Holiday Oct.1-Oct.7)
Adaptive Immune Receptor and Antigen Recognition
Oct.12 (9)Molecular Structure, Classification and Function of Ig, T Cell Receptor and
Antigen Recognition(Bing Su)(Chapter 3,4)
Oct.12(10)BCR and TCR Signal Transduction (Bing Su)(Chapter 6,7) 18:00-19:40
Oct.13Discussion (Bing Su)
Oct.19(11)FlowTechnologyI(ShenLei)18:00-19:40
Oct.21(12)Flow Technology II (Shen Lei)
Generation and Regulation of Adaptive Immunity
Oct.26(13)T cell Activation and Differentiation (Chen Dong)(Chapter 9)18：00-19：40
Oct.27Discussion(Chen Dong)
Oct.28(14)Effector T cells, Transcriptional factors, Cytokines andSignalingPathways
(Chen Dong)(Chapter 9)
Oct. 29 (15)Immunological Function of monocyte, macropahge and DC
(FlorentGinhoux) (Chapter 3)18：00-19：40
Nov.2 Discussion (FlorentGinhoux)
Nov. 2Mid Exam 18:00-20:00 下院102
MHC and Antigen Presentation
Nov.9 MHC Gene and Structure (Pan Zheng)(Chapter 5)
Nov.10 MHC I Molecule and MHC II Molecule Antigen Presentation (Pan Zheng) (Chapter 5) 正课
Nov.11APC and T Cell Interaction (Pan Zheng)
Nov.11 (18)Ig Class Switch, Somatic Hypermutation and Affinity Maturation, memory B cell
(Yang Xu)(Chapter 10,11) 18：00-19：40
Nov. 16 Discussion (Yang Liu, CTLA-4 in immune regulation, papers 1 and 2)讨论课
Nov.17 Discussion (Yang Liu, cell death and immune activation, papers 3 and 4)
Nov.18 Immunodeficiency (student presentation, Pan Zheng and Yang Liu) (Chapter 12, 15)
The Immune System in Health and Disease
Nov.18(21)Tumor Immunology (Xiaoxia Li)(Chapter 13)18：00-19：40
Nov.19Discussion(Xiaoxia Li)18：00-19：40
Nov.23 (22)Mucosal Immunology and Microbiota (Liang Zhou) (Chapter 12)
Nov.24Discussion (Liang Zhou)
Nov.26(23)B Cell Mediated Immune Response and Germinal Center Response
(Biao Zheng)(Chapter 10) 18:00-19:40
Innate and Adaptive Immunity and Immune Memory
Nov.30 (24)The induction of adaptive Immunity by Innate Immune Response
(Xiaojing Ma) (Chapter 8)
Dec.1Discussion (Xiaojing Ma)
Dec.2(25)Immune Memory (Xiaojing Ma) (Chapter 8)
Dec.7 (26)Vaccine (Laurent Rénia) (Chapter 16)
Dec.8 Discussion (Laurent Rénia)
Dec.9 (27)Tropical diseases (Laurent Rénia)
The Immune System in Health and Disease
Dec.16(28)Skin Immunity (Florent Ginhoux)
Dec.16Discussion (Florent Ginhoux) 12:00-13:40
Dec.17(29)Immune Response to Infection (virus, fungi, bacteria) (Florent Ginhoux) (Chapter 11) 12:00-13:40
Dec.21(30, 31)Immune Evolution(Xu Anlong) (Chapter 16) 8:00-9:40, 10:00-11:40
Dec.22 Discussion(Xu Anlong)
Dec.23Open
Dec.28(32)Autoimmune Diseases (SLE、RA、Diabetes etc.) (Xu Huji) (Chapter 13)
Dec.29Discussion (Xu Huji)
Dec.30 (33)Transplant Immunology (Guangjie Chen)(Chapter 13)
Jan.4 Final exam