Curriculum vitae
Date Prepared: / July 30, 2012Name: / Olga Theresa (Hardy) Gupta, M.D.
Office Address: / 5323 Harry Hines Blvd., Dallas, TX 75390-9063
Work Phone: / 214-648-3501
Work E-Mail: /
Work Fax: / 214-648-9772
Place of Birth: / Silver Spring, MD
Education
Year / Degree(Honors) / Field of Study
(Thesis advisor for PhDs) / Institution
1992-1996 / B.S. (cum laude) / Biomedical Engineering / Duke University, Durham, NC
1996-2000 / M.D. / University of California, San Francisco, CA
2008-2010 / M.S. / Clinical Investigation (Michael Czech, PhD) / University of Massachusetts Medical School, Worcester, MA
Postdoctoral Training[Include residency/fellowship]
Year(s) / Titles / Specialty/Discipline(Lab PI for postdoc research) / Institution
2000-2003 / Resident / Pediatrics / Duke University, Durham, NC
2003-2006 / Fellow / Pediatric Endocrinology ( Klaus Kaestner, PhD) / The Children’s Hospital of Philadelphia, Philadelphia, PA
Current Licensure and Certification
LicensurePhysician, Texas and Massachusetts
Board and Other Certification Pediatrics 2003; Pediatric Endocrinology, 2008
Honors and Awards
Year / Name of Honor/Award / Awarding Organization2001 / Primary Care Certificate of Excellence / Duke Children’s
2003 / Billie Wright Adams, M.D. Scholar, Pediatrics Section / National Medical Association
2005-2006 / Research Fellowship Grant / Lawson Wilkins Pediatric Endocrine Society
2005 / First Place Poster / National Cooperative Growth Study, Genentech
2006 / Outstanding Patient-Oriented Research Poster / Institute for Diabetes, Obesity and Metabolism Spring Symposium and Kroc Lecture
2009 / Best paper published in 2008 in the section “Novel Insights from Clinical Practice” / Hormone Research
2010 / Poster Award / Translational Medicine and Science Retreat
2011 / Poster Award / Translational Medicine and Science Retreat
2012 / Dedman Family Scholar in Clinical Care / University of Texas Southwestern
Faculty Academic Appointments
Year(s) / Academic Title / Department / Academic Institution2006-2007 / Instructor / Pediatrics / University of Pennsylvania School of Medicine, Philadelphia, PA
2007-2012 / Assistant Professor / Pediatrics / University of Massachusetts Medical School, Worcester, MA
2012-present / Assistant Professor / Pediatrics / University of Texas Southwestern Medical Center, Dallas, TX
Appointments at Hospitals/Affiliated Institutions
PastYear(s) / Position Title / Department/Division / Institution
Current
Year(s) / Position Title / Department/Division / Institution
Other Professional Positions[Industry, foundation, private practice]
Year(s) / Position Title / Institution2006-2007 / Medical Director / ADA Donovan McNabb Diabetes Camp, Green Lane, PA
2007-2012 / Medical Director / Barton Diabetes Camp, Oxford, MA
Major Administrative/Leadership Positions[Do not include Professional Society positions]
Year(s) / Position Title / InstitutionCommittee Service (Member, unless noted otherwise) [Do not include Professional Society positions]
Year(s) / Name of Committee / Institution/OrganizationUTSW
2009-2010 / Faculty Forward, a task force designed to improve faculty satisfaction and retention / University of Massachusetts Medical School,Worcester, MA
Hospital
State/Regional
2009-2012 / Medical Advisory Committee / Clara Barton and Joslin Diabetes Camps
National/International
Professional Societies[List all society committees, leadership, and course leadership roles here]
Dates / Society Name, member2000-2003 / American Academy of Pediatrics
2003-2006 / American Association of Clinical Endocrinologists
2003-present / The Endocrine Society
2003-present / American Diabetes Association
2003-present / Pediatric Endocrinology Society
Committees
Fellowships
Grant Review Activities
Year(s) / Name of Review Committee / OrganizationEditorial Activities
Year(s) / Journal NameEditor/Associate Editor
Editorial Board
Ad Hoc Reviewer
Grant Support
Present / Grantor:National Institutes of HealthTitle of Project:Pet ownership and diabetes management: Evaluation of the impact of responsible pet ownership on glycemic control in youth with type 1 diabetes mellitus
Role (Principal Investigator, Co-Investigator):Co-Investigator
Annual amount and date (direct costs only):
Total amount of award (if multi-year) and dates (direct costs only):1/15/2012-12/31/2013 $100,000 direct
Past / Grantor:Center for Clinical and Translational Science, University of Massachusetts Medical School
Title of Project:Capacity Building at GoKids Boston, An Intercampus Initiative:
Evaluation of the effects of a multicomponent wellness intervention designed for inner-city high school students on metabolic parameters
Role (Principal Investigator, Co-Investigator):Co-Investigator
Annual amount and date (direct costs only):
Total amount of award (if multi-year) and dates (direct costs only): $150,000 10/01/09-9/30/2011
Past / Grantor:Center for Clinical and Translational Science, University of Massachusetts Medical School
Title of Project:Adipose tissue inflammation and insulin resistance: Evaluation of genetic and histologic traits that correlate with insulin resistance in morbid obesity in adults undergoing gastric bypass surgery
Role (Principal Investigator, Co-Investigator):Co-Investigator
Annual amount and date (direct costs only):
Total amount of award (if multi-year) and dates (direct costs only):07/01/07-03/15/12
$125,000 direct
Past / Grantor:Diabetes and Endocrinology Research Center, University of Massachusetts Medical School
Title of Project:Innate immunity and metabolism:Evaluation of the role of inflammation in the metabolic sequelae associated with childhood obesity
Role (Principal Investigator, Co-Investigator):Principal Investigator
Annual amount and date (direct costs only):
Total amount of award (if multi-year) and dates (direct costs only):04/01/09-03/15/12
$100,000
Clinical Trials Activities
Present / Grantor:Title of Project:
Role (Principal Investigator, Co-Investigator):
Past / Grantor:
Title of Project:
Role (Principal Investigator, Co-Investigator):
Teaching Activities
Year(s) / ActivityMedical and graduate school didactic and small group teaching
2009-2012 / Building Working Cells and Tissues (FOM1), lecture on Diabetes and Metabolism (1 hr/yr), 114 students
2008-2012 / Pediatrics Clerkship, lecture on Normal and Abnormal Growth Patterns in Childhood (9 hr/yr)
2008-2012 / Clinical and Translational Research Pathway, Journal Club Course Director
Dissertation committees
Qualifying examination committees
Committees concerned with medical and graduate student education
Graduate student rotations
Medical student rotations
Graduate student trainees
2008-2012 / Advising of Zheni Gjoka (4th year medical student), Sabine Schnyder (third year pediatrics resident), William Zawatski (second year pediatrics resident), Nasim Gorji (first year pediatrics resident)
Postgraduate medical education (graduate & continuing medical education)
Postdoctoral trainees
Invited Lectures
Year(s) / Title / LocationInternational
2005 / Focal lesions of congenital hyperinsulinism localized using [18F]-fluorodopa PET scan. / European Society of Paediatric Endocrinology /Lawson Wilkins Pediatric Endocrine Society. Joint Meeting. Lyon, France.
2006 / Focal lesions of congenital hyperinsulinism localized using [18F]-fluorodopa PET scan. / Lawson Wilkins Pediatric Endocrine Society. Toronto, Canada.
2007 / Focal lesions of congenital hyperinsulinism localized using [18F]-fluorodopa PET scan. / Congenital Hyperinsulinism International Conference, Philadelphia, PA.
National
2005 / Focal lesions of congenital hyperinsulinism localized using [18F]-fluorodopa PET scan. / Endocrine Society 88th Annual Meeting, Boston
2009 / Hypoglycemia in the neonate. / New England Pediatric Nursing Organization, Woodstock, VT
2011 / Role of inflammatory monocytes in adolescent metabolic syndrome. / Pediatric Academic Society,Denver, CO
2011 / Activated innate immunity in childhood: a novel treatment target. / Translational Medicine Conference, Worcester, MA
Regional/Local
Functional genomic analysis of insulin secretion using RNA interference. / Department of Genetics. Postdoctoral Fellow and Graduate Student Research Talk. Philadelphia, PA.
2005 / Localization of focal lesions of congenital hyperinsulinism using 18 f-labeled L-fluoro dopa. / Philadelphia Endocrine Society. Endocrine Fellows Presentation. Philadelphia, PA.
2005 / Fatty acids and insulin secretion: from bedside to bench. / Department of Genetics. Postdoctoral Fellow and Graduate Student Research Talks, Philadelphia, PA.
2006 / Spoonful of sugar helps the medicine go down … hypoglycemia in the neonate. / Pediatric Grand Rounds. University of Massachusetts Medical Center.
2007 / Diabetes … new approaches and equipment. / Pediatric Grand Rounds. Milford Regional Medical Center. Milford, MA.
2008 / Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan. Hyperinsulinemic hypoglycemia following gastric bypass: pathogenesis and treatment symposium. / Joslin Diabetes Center. Boston, MA
2008 / Computational genomics approach to insulin resistance and obesity / Diabetes and Endocrinology Research Center Retreat, Shrewsbury, MA
2009 / Role of the monocyte/macrophage cell lineage in obesity-related insulin resistance. / UMMS 15th Annual Research Retreat,Woods Hole, MA
2010 / Innate immunity and metabolic disease. / Touchstone Diabetes Center Conference, Dallas, TX
2011 / Gestational weight gain impacts child adiposity and metabolic disease. / Community of Scholars, Worcester, MA
2011 / ABCs of Type 1 Diabetes Mellitus Care in the Community. / Diabetes Day for School Nurses, Worcester, MA
Technological and Other Scientific Innovations
InnovationPatent, if any, pending or awarded /If described in print/on web, provide citation
Service to the Community
Year(s) / Role / Organization or institutionMay include a brief, one-sentence description of each role if needed (optional)
Bibliography
Peer-Reviewed Publications (List in chronological order with complete pagination. Authors should be listed in the same order as they appear in the published article.
Original Research Articles
Hardy O, Yan A, Grimberg A. PTU-associated vasculitis in a girl with Turner’s syndrome and Graves disease. Pediatr Emerg Care. 22:52-54 (2006).Peranteau WH, Bathaii SM, Pawel B, Hardy O, Alavi A, Stanley CA, Adzick NS. Multiple ectopic lesions of focal islet adenomatosis identified by positron emission tomography scan in an infant with congenital hyperinsulinism. J Pediatr Surgery. 1:188-192(2007).
Hardy O, Pampaloni M, Suchi M, Ruchelli E, Zhuang H, Ganguly A, Saffer J, Freifelder R, Adzick NS, Alavi A, Stanley C. Diagnosis and localization of focal congenital hyperinsulinism by 18F- fluorodopa PET scan. J Peds. 2:140-145 (2007).
Hardy OT, Hohmeier H, Becker T, Doliba N, Gupta R, White P, Manduchi E, Stoeckert C, Matschinsky F, Newgard C, Kaestner K. Functional genomics of the β-cell: SCHAD regulates insulin secretion independent of K+ currents. Molecular Endocrinology. 3:765-773 (2007).
Gupta R, Gorski R, White P, Hardy OT, Rafiq K, Brestelli J, Chen G, Stoeckert C, Kaestner K. Expansion of adult β -cell mass in response to increased metabolic demand is dependent on HNF-4a. Genes and Development. 7:756-769 (2007).
Hardy OT, Hernandez-Pampaloni M, Saffer JR, Scheuermann JS, Ernst LM, Freifelder R, Zhuang H, MacMullen C, Becker S, Adzick NS, Divgi C, Alavi A, Stanley CA. Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism.J Clin Endocrinol Metab. 12:4706-4711 (2007).
Mohnike K, Blankenstein O, Pfuetzner A, Pötzsch S, Schober E, Steiner S, Hardy OT, Grimberg A, van Waarde WM. Long-term non-surgical therapy of severe persistent congenital hyperinsulinism with glucagon. Hormone Research. Horm Res. 1:59-64 (2008).
Nwosu, BU, Soyka LA, Angelescu A, Hardy OT, Lee MM. Is Multifetal Pregnancy a Risk Factor for Maternal and Neonatal Vitamin D Deficiency? The Endocrinologist. 18:172-175 (2008).
Nwosu BU, Hardy OT, Angelescu A, Soyka L, Lee MM. Do Atypical Antipsychotic Agents Trigger Autoimmune Diabetes in Adolescents? The Endocrinologist. 19:2 (2009).
Fitzgibbons T, Hardy OT, Lessard D, Gore JM, Yarzebski J, Goldberg RJ. Body Mass Index, Treatment Practices, and Mortality in Acute Heart Failure. Archives of Internal Medicine. Coronary Artery Disease. 8:536-543 (2009).
Hardy OT, Perugini RA, Nicoloro SM, Gallagher-Dorval K, Puri V, StraubhaarJ, Czech MP. BMI-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. Surgery for Obesity and Related Disorders. 1:60-67(2011).
Hardy, OT, Wiecha J, Kim A, Salas C, Briceno R, Moody K, Becker J, Glazer G, Ciccarelli C, Shi L, Hayman LL. (2012). Effects of a multicomponent wellness intervention on dyslipidemia among overweight adolescents. J Pediatr Endocrinol Metab. 25(1-2):79-82.
Hardy OT, Czech MP, Corvera S. (2012). What causes the insulin resistance underlying obesity? Curr Opin Endocrinol Diabetes Obes. Apr;19(2):81-7.
Reviews, Chapters, Monographs and Editorials
Books/Textbooks
Hardy O, Kelly A. The 5-Minute Pediatric Consult. Premature Thelarche. Fourth Edition. Lippincott Williams & Wilkins. Philadelphia, PA. (2005).Hardy O, Stanley C. PET for localization of focal forms of hyperinsulinism of infancy. Pediatric PET Imaging. Springer. New York. (2006).
Hardy O, Stanley C. Fetal and Neonatal Physiology. Hypoglycemia. Elsevier. Missouri. In press.
Case Reports
Letters to the Editor
Proceedings of Meetings
Clinical Practice Guidelines
Non-peer reviewed scientific or medical publications/materials in print or other media
Hardy O, Worley G, Lee MM, Chaing S, Mackey J, Crissman B, Kishnani PS. Hypothyroidism in Down syndrome: Screening guidelines and testing methodology. American Journal of Medical Genetics Part A 2003; June 30 (4):436-437.Hardy O, Litman R. Congenital hyperinsulinism. A review of the disorder and a discussion of the anesthetic management. Pediatric Anesthesia. 2007 Jul;17(7):616-21
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