Possible Side Effects of Cyclophosphamide, Cytarabine IV or SQ; IT Methotrexate, Mercaptopurine (MP), Vincristine, and PEG L-asparaginase (Table Version Date: August 28, 2014)

COMMON, SOME MAY BE SERIOUS
In 100 people receiving Cyclophosphamide, Cytarabine IV or SQ; IT Methotrexate, Mercaptopurine (MP), Vincristine, and PEG L-asparaginase, more than 20 and up to 100 may have:
  • Hair loss
  • Diarrhea, constipation, nausea, vomiting, loss of appetite
  • Infection, especially when white blood cell count is low
  • Absence of menstrual period which may decrease the ability to have children
  • Blood in urine
  • Blood clot
  • Swelling and sores in the rectum which may cause rectal pain
  • Sores in mouth which may cause difficulty swallowing
  • Anemia which may cause tiredness, or may require blood transfusions
  • Fever
  • Damage to the liver which may cause belly pain, bleeding, yellowing of skin or eyes
  • Fatigue
  • Pain or redness at the site of injection
  • Numbness and tingling of fingers or toes
  • Headache, jaw pain and/or muscle pain
  • Weakness and difficulty walking
  • Chills
  • Pain
  • Swelling of the body
  • Blockage of the airway which may cause cough, wheezing
  • Hives, rash

OCCASIONAL, SOME MAY BE SERIOUS
In 100 people receivingCyclophosphamide, Cytarabine IV or SQ; IT Methotrexate, Mercaptopurine (MP), Vincristine, and PEG L-asparaginase, from 4 to 20 may have:
  • Damage to the bone marrow (irreversible) which may cause infection, bleeding, may require transfusions
  • Loss or absence of sperm which may lead to an inability to father children
  • Stuffy nose
  • Fluid around the heart
  • Bruising, bleeding
  • Allergic reaction which may cause rash, low blood pressure, wheezing, shortness of breath, swelling of the face or throat
  • Numbness and tingling of the arms and legs
  • Severe blood infection
  • Kidney damage which may cause swelling, may require dialysis
  • Chest pain
  • Swelling and redness of the eye
  • Drooping eyelids
  • Sores in stomach
  • Hoarseness
  • Abnormal heart beat
  • Night sweats

RARE, AND SERIOUS
In 100 people receiving Cyclophosphamide, Cytarabine IV or SQ; IT Methotrexate, Mercaptopurine (MP), Vincristine, and PEG L-asparaginase, 3 or fewer may have:
  • Severe skin rash with blisters and peeling which can involve mouth and other parts of the body
  • Damage to the heart or heart failure which may cause shortness of breath, swelling of ankles, cough or tiredness
  • A new cancer including cancer of bone marrow (leukemia) caused by chemotherapy
  • Swelling of the body including the brain which may cause dizziness, confusion
  • of the lungs
  • Damage to the pancreas causing abdominal pain
  • Damage or scarring of the lungs which may result in shortness of breath
  • Seizure

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