Curriculum Vitae

Page 6

Constantine E. Anagnostopoulos, M.D.

45 East 89th Street
New York, NY 10128
(212) 523-1611
(212) 289-8654
(917) 287-4673 Cel
email: / 7 The Courtyard
Locust Valley, NY 11560
(516)-671-7679 Phone
(516) 676-3000 Fax
(646) 879-2736 Cel
(212) 523-2828 … 8173… Pager

Date of birth: November 9, 1940

Place of birth: Salonica, Greece

Came to the U.S. in 1958 after my father became Commercial Counselor of the Greek Embassy, Washington, DC

Citizenship: United States and Hellenic

Married, 1983: Madelaine Low Reese (after my first wife, Dr. Marilyn Hruby, died in 1980)

Children: Anne-Marie Anagnostopoulos, Dr. Peter Reese, Dr. Annie Reese

Grammar and High School (Gymnasium)

1946-1958 Athens, Greece - Psychiko and Anavryta National School (honors June 1958)

Academic Training:

Georgetown University, Washington, D.C.

A.B. with honors, September 1959

M.D. with honors, May 1963

University of Athens, Greece, School of Medicine, Equivalence Examinations, June 1963

Doctor of Science, University of Athens, Athens Greece-with honors, 1967

Medical Licensure -

1965 Athens, Greece

1965 State of Washington

1969 State of Illinois #036-042707

1982 State of New York #152539

Traineeship:

1963-1964 Columbia University, Columbia Presbyterian Medical Center, New York, New York; Surgery

1964-1969 Yale University, School of Medicine,

General and Thoracic Surgery

1964-1965 Yale University School of Medicine, U.S.P.H.S.

Fellow, Cardiovascular Surgery

Board Certification:

1964 National Board of Medical Examiners

1970 American Board of Surgery

1970 American Board of Thoracic Surgery

1970 General and Thoracic Surgery Certification in Greece

Military Service:

Registered for U.S. and Hellenic Selective Service 1-A to 1972

Professional Organizations and Societies:

1965 American Heart Association, Cardiovascular Surgery Member

1965 Sigma Xi Honor Scientific Society

Athens Medical Society

1970 Association for Academic Surgery

1970 Fellow, American College of Cardiology

1972 Fellow, American College of Surgeons

1972 International Cardiovascular Society

1973 Chicago Surgical Society

1974 American Association for Thoracic Surgery

1975 European Society for Surgical Research

1976 Chicago Heart Association Committee on Cardiovascular Surgery

1980 Society for Vascular Surgery

1983 American Medical Association

1984 International Society for Heart Transplantation

1989 Suffolk County Medical Society

1992 New York County Medical Society

1991 New York Society for Thoracic Surgeons

1993 The New York State Society of Surgeons, Inc.

1995 Hellenic Society for Cardiothoracic Surgery

1996 The Yale Surgical Society

1996 The University of Chicago Surgical Society

Academic and Hospital Appointments:

Yale University School of Medicine

1967-1969 Instructor in Surgery

The University of Chicago

1969-1973 Assistant Professor of Surgery Thoracic and Cardiovascular Surgery

1973-1979 Associate Professor of Surgery Thoracic and Cardiovascular Surgery

1979-1983 Professor of Surgery

State University of NY at Stony Brook

1982 - 1991 Chief, Division of Cardiothoracic Surgery

1982 - 1993 Professor and Attending in Surgery

St. Luke's/Roosevelt Hospital Center, NY, NY

A University Hospital of Columbia University

College of Physicians & Surgeons 1991 - 1998 Sr. Attending, Chair and Chief, Division of Cardiothoracic Surgery

Professor of Surgery

1998-Present Sr. Attending, Division of Cardiothoracic Surgery

Professor of Surgery

Consulting and Other Appointments

Jul - Aug Massachusetts General Hospital, Harvard University, Boston, Mass.

1973 Sabbatical Visit

1975 Michael Reese & St. Elizabeth's Hospital., Chicago

Visiting Consultant

1976 Christ Hospital Oak Lawn, Chicago

Visiting Consultant

1985 Veterans Administration Medical Center, Northport, NY

Visiting Consultant

1992-Present Harlem Hospital Center, New York, NY

Affiliated with Columbia University

College of Physicians & Surgeons

Consultant, Cardiac Surgery and Cardiology

Chief, Cardiothoracic Surgery - 1998

1993-1998 Onassis Heart Surgery Center, Athens, Greece

Honorary Chair Surgery and Pediatric Cardiac Surgery

1997-Present University of Ioannina, Professor of Cardiac Surgery

Ioannina, Greece

1997-Present Euroclinic Medical Center, Consulting Scientific Director

Athens, Greece

1998-Present North General Hospital

Honors and Awards:

A.B., M.D. and Sc. D. with honors

Alpha Omega Alpha Honor Medical Society, 1961

Established Investigator, American Heart Association, 1971-76

Teaching Award, Medical Class of 1978. Univ. of Chicago

Who's Who in America, 1978

"Paul Harris Fellow" - Rotary Club International, 1987

1988 Graduating Chief Residents in Surgery - Appreciation Plaque, University Hospital at Stony Brook

St. Paul's Medal - Archdiocese of North and South America of the Greek Orthodox Church, Glen Cove, NY, 1989

“KRIKOS” Scientific Organization - Honored guest and Lecturer, New York, NY 1991

Hellenic Medical Society of New York - Honored Guest and Lecturer, New York, NY 1993

Harvard Medical School Dean’s Council, 1996-1999

Fellowship, Research, Fundraising, and Support for Clinical Projects (as principal investigator):

1971-1973 American Heart Association

"Rectus Sheath Cardiovascular Grafts"

1971-1976 American Heart Association, $75,000 Established Investigator award

1973-1975 U.S.P.H.S. (NIH), $80,000, American Heart $30,000 "Animal Model Transposition of Great Vessels I and II"

1973-1975 U.S.P.H. (NIH) $45,000 "Rectus Sheath, Vascular Grafts"

1975-1977 U.S.P.H.S. (NIH) $45,000 "S.C.O.R. - Retrograde Coronary Venous Perfusion"

1983-1984 GRS Support - S.U.N.Y. at Stony Brook "Rectus Sheath Aortic Valve"

1984-1986 CPMP Support - S.U.N.Y. at Stony Brook "Growing Vascular Grafts"

1986-1989 Stony Brook Foundation - S.U.N.Y. at Stony Brook - "International Children's Program"

1986-1989 University Hospital at Stony Brook "Teaching Case Support" International Children's Program

1987-1989 Greek Orthodox Church at Pt. Jefferson and Glen Cove, New York - $35,000 for Transport Needs, International Children's Program

1987 Rotary Club International "Gift of Life"

1987 "Heal The Children Program"

1989 "Vascucare Company" Research use of $40,000 Angioscopy equipment

1990 GRS Support-Autologous Grafts and Growth (Co-Investigator) $12,000

1991 Variety Club International Program

1991 Sphinx Pharmaceuticals Grant in Aid $32,000 Protein Kinase Inhibitor and Cardiac Cross Clamp Injury - canine model

1992 - 1994 Sphinx Pharmaceuticals Grant in Aid $64,000 Protein Kinase Inhibitor and Cardiac Cross Clamp Injury - canine and isolated heart models

1993 - 1996 Onassis Cardiac Surgery Center, Athens, Greece. Clinical Affilliation $250,000

Departmental and University Committees:

St. Luke's-Roosevelt Hospital Center:

Heart Center Advisory Committee - 1995

Invasive Procedures Quality Assurance Subcommittee - Chair, 1992

Executive Committee of the Department of Surgery, 1991

SUNY and University of Chicago

Credentials Committee

Operating Room Committee

Curriculum Vitae

Page 7

Teaching:

· Weekly 3rd year medical student surgery course (U of Chicago and SUNY)

· Daily clinical operative teaching and rounds in intensive care unit with attending surgeons, residents, and students (3rd and 4th year elective) - St. Luke's/Roosevelt, (Columbia University) State University of New York at Stony Brook and the Univ. of Chicago

· Cardiac Anatomy and Embryology Course - The Univ. of Chicago

· Weekly Cardiac Surgery Conference, Journal Club (SLRHC), Weekly Cath Conference, (HHC)

Cardiac Surgery Course, University of Ioannina.

Editorial Boards and National Committees:

1985 Cardiology Board Review

1992 Journal of Cardiovascular Surgery

1995 Video Journal of Cardiothoracic Surgery

1997 Society of Thoracic Surgeons Committee on Nomenclature and Coding

1998 Joint Committee on Nomenclature and Coding, American Association of Thoracic Surgery/Society of Thoracic Surgery

Original, Peer Reviewed Articles

1. Holcomb WG, Anagnostopoulos CE, Glenn WWL. A New Method of Determining Tissue Resistance by the Reflectometer Principle, for Use With Implanted RF Pacemakers; Laboratory and Clinical Observation on Cardiac, Bladder, and Phrenic Nerve pacemakers. Trans NY Acad Sci; Ser. II, 27:894-908, 1965.

2. Anagnostopoulos CE*, Glenn WWL, Holcomb WG, Van Heeckeren DW. Epicardial Radiofrequency Cardiac Pacamaker Implant. Cardiovasc Surg 1965: Suppl. I to Circulation Vols. XXXIII and XXXIV: I 99-l06, l966.

3. Anagnostopoulos CE*, Glenn WWL. Electronic Pacemakers of the Heart, Gastrointestinal Tract, Phrenic Nerve, Bladder, and Carotid Sinus: Current Status. Surgery; 60: 480-494, 1966.

4. Anagnostopoulos CE*, Holcomb WG, Glenn WWL. Pacemaker Synchronization. Science; 153:1636-1637, 1966.

5. Anagnostopoulos CE*, Patel B, Fenn JE, Stansel HC. Transvenous Coronary Sinus Pacemaker: A New Primary Approach to Heart Block in Patients with Tricuspid Prostheses. Ann Thorac Surg; 9:76-80, 1970.

6. Anagnostopoulos CE*, Athanasuleas CL, Kittle CF. The Autologous Rectus Sheath Valve, II: Pulmonary Valve and Artery Replacement in the Calf. J Thorac Cardiovasc Surg; 63:665-673, 1972.

7. Anagnostopoulos CE.* The Autologous Rectus Sheath Cardiac Valve Graft. Surgical Forum; 23:164-166, 1972.

8. Athanasuleas CL, Anagnostopoulos CE*, Kittle CF. The Autologous Rectus Sheath Valve, III Design and Physical Properties. J Thorac Cardiovas Surg; 65:118-123, 1973.

9. Anagnostopoulos CE*, Kittle CF. Penetrating Wounds of the Heart and Great Vessels. Thorax; 28: 142-146, 1973.

10. Anagnostopoulos, CE.* A Proposed New Technique for Correction of Transposition of the Great Arteries. Ann Thorac Surg; l5:565-569, l973.

11. Campbell DP, Anagnostopoulos CE, Glenn WWL. Selection of Patients with Portal Hypertension for Splendorenal Shunt. Ann Surg; 178:70-74, 1973.

12. Anagnostopoulos CE*, Athanasuleas CL, Arcilla RA. Toward a Rational Operation for Transposition of the Great Arteries. Ann Thorac Surg; 16:458-463, 1973.

13. Campbell DP, Parker D, Anagnostopoulos CE.* Survival Prediction in Portacaval Shunts: A Computerized Statistical Analysis. Am J Surg; 126:748-751, 1973.

14. Balderman SC, Athanasuleas CL, Anagnostopoulos CE.* Coronary Artery Anatomy in Transposition of the Great Vessels in Relation to Anatomic Surgical Correction. J Thorac Cardiovas Surg; 67:208-212, 1974.

15. Resnekov L, Anagnostopoulos CE, et al. Unstable Angina Pectoris: National Cooperative Study Group to Compare Surgical and Medical Therapy, I. Report of Protocol and Patient Population. Am J Cardiol; 37:896-902, 1976.

16. Toscano M, Demos SS, Athanasuleas CL, Moraldi A, Anagnostopoulos CE. Treatment of Experimental Acute Myocardial Ischemia by Arterialization of the Coronary Veins. Il Policlinico: Sezione Chirurgica; 83(1-2)385-390, 1976.

17. Balderman SC, Bates RJ, Anagnostopoulos CE.* Cardiac Valve Replacement: Improved Survival Related to Air Exclusion and Myocardial Protection. Illonois Med J; 2:113-116, 1977.

18. Kolff J, Bates RJ, Balderman SC, Shenkoya K, Anagnostopoulos CE.* Acute Aortic Arch Dissections: Reevaluation of the Indications for Medical and Surgical Therapy. Am J Cardiol; 39:727-733, 1977.

19. Schraut W, Lamberti JJ, Kampman K, Anagnostopoulos CE, Replogle RL, Glasgov S. Does Local Cardiac Hypothermia During Cardiopulmonary Bypass Protect the Myocardium from Long-Term Morphological and Functional Injury? Ann Thorac Surg; 24:315-322, 1977.

20. Lamberti JJ, Lin C-Y, Cutiletta A, Anagnostopoulos CE, Arcilla RT, Replogle RL. Clinical Effects of Surface Cooling (20 Degrees Celsius) and Circulatory Arrest in Infants Undergoing Cardiac Surgery: Results in a Ventricular Septal Defect. Complete Atrio-ventricular Canal, and Total Anomalous Pulmonary Venous Connection. Arch Surg; 113:822-826, 1978.

21. Resnekov L, ...Anagnostopoulos CE et al. Unstable Angina Pectoris; National Cooperative Study Group to Compare Surgical and Medical Therapy, II. In-hospital Experience and Initial Follow-up Results in Patients with One, Two, and Three Vessel Disease. Am J Cardiol; 42:839-848, 1978.

22. Kapelanski DP, Al-Sadir J, Lamberti JJ, Anagnostopoulos CE.* Ventriculographic Features Predictive of Surgical Outcome for Left Ventricular Aneurysm. Circulation; 58:1167-1174, 1978.

23. Lyon RT, Levett JM, Sheridan JM, Glasgov S, Anagnostopoulos, CE.* Myocardial Rupture, III. Chamber Pressure, Rate of Distention and Ventricular Disruption in Isolated Hearts. Ann Thorac Surg; 27(6): 554-558, 1979.

24. Muster AJ, Bharati S, Aziz KU, Idriss FS, Paul MH, Lev M, Carr I, DeBoer A, Anagnostopoulos CE. Taussig-Bing Anomaly with Straddling Mitral Valve. J Thorac Cardiovasc Surg; 77(6):832-842, 1979.

25. Fennell WH, Chua KG, Cohen L, Morgan J, Karunaratne HB, Resnekov L, A-Sadir J, Lin C-Y, Lamberti JJ, Anagnostopoulos CE.* Detection, Prediction and Significance of Perioperative Myocardial Infarction Following Aorto-coronary Bypass. J Thorac Cardiovasc Surg; 78(2):244-253, 1979.

26. Anagnostopoulos CE,* Beere PA, Athanasuleas CL. Autologous Rectus Sheath Grafts, V. Growth in Aortic Grafts. J Thorac Cardiovas Surg; 78:784-791, 1979.

27. Lamberti JJ, Campbell C, Replogle RL, Anagnostopoulos CE. The Prosthetic (teflon) Central Aorto-pulmonary Shunt for Cyanotic Infants Less Than Three Weeks of Age: Results and Long-term Follow-up. Ann Thorac Surg; 28:568-577, 1979.

28. Schraut W, Kampman K, Lamberti J, Freeburger M, Anagnostopoulos CE, Glagov S, with technical assistance of Andersen J.,B.S.: Myocardial Protection from Permanent Injury During Aortic Cross-clamping: Effectiveness of Pharmacological Cardiac Arrest Combined with Topical Cardiac Hypothermia. Ann Thorac Surg; 31(3): 224-232, 1981

29. Sanderson CJ, Rich S, Beere PA, Anagnostopoulos CE*, Levett JM, Lawrence JM. Clotted False Lumen - A Reapprasial of Indications for Medical Management of Acute Aortic Dissection. Thorax; 36(3):194-199, 1981.

30. Sanderson CJ, Anagnostopoulos CE*, Brunner MC, et al. Growth in Coronary to Subclavian Anastomoses: Long-term Clinical Confirmation After Treatment of Anomalous Left Main Coronary Artery. J Thorac Cardiovasc Surg; 82(2):293-296, 1981.

31. Bilfinger TV, Lin C-Y, Anagnostopoulos CE.* In Vitro Determination of Accuracy of Cardiac Output Measurements by Thermal Dilution. J Surg Research; 33(5):409-414, 1982.

32. Bilfinger TV, Beere PA, Sanderson C, Glagov S, Anagnostopoulos CE.* Parallel Growth of Rectus Sheath Grafts and Recipient Aorta: Critical Role of Graft Tissue Preservation. J Thorac Cardiovasc Surg; 86(2):294-299, 1983.

33. Liu KJ, Rubin JM, Potel MJ, Aisen A, MacKay SA, Sayre RE, Anagnostopoulos CE.* Left Ventricular Wall Motion: Its Dynamic Transmural Characteristics. J Surg Research; 36:25-34, 1984.

34. Little AG, Lin C-Y, Wernly JA, Langmuir VK, Bilfinger, TV, Levett JM, Anagnostopoulos CE.* Use of the Pulmonary Artery for Left Ventricular Venting During Cardiac Operations. J Thor Cardiovasc Surg; 87(4):532-538, 1984.

35. Seifert FC, Banker M, Lane B, Bagge U, Anagnostopoulos CE. An Evaluation of Resting Arterial Ischemic Models in the Rat Hind Limb. J Cardiovasc Surg; 26:502-508, 1985.

36. Lawson WE, Seifert FC, Anagnostopoulos CE, Hills DJ, Swinford RD, Cohn PF. Effect of Coronary Artery Bypass Grafting on Left Ventricular Diastolic Function: American Journal of Cardiology; 6l:283-287, 1988.

37. Hartman AR, Hood RM, Anagnostopoulos CE. Phenomenon of Heparin-Induced Thrombocytopenia Associated with Paradoxical Thrombosis. J Vasc Surg 1988;7(6):781-784.

38. Hartman AR, Mawulawde KI, Dervan JP, Anagnostopoulos CE. Myocardial Revascularization with the Lateral Costal Artery. Annals of Thoracic Surgery; 49:816-818, 1990.

39. Hartman AR, Vlay SC, Dervan JP, Lawson WE, Mannisi J, Anagnostopoulos CE. Emergency Coronary Revascularization Using Polytetratfluorethylene Conduits in a Patient in Cardiogenic Shock. Clinical Cardiology; 14:75-78, 1991.

40. Zelen J, Bilfinger, TV, Anagnostopoulos CE.* Coronary Artery Bypass Grafting: The Relationship of Surgical Volume, Hospital Location, and Outcome. New York State Journal of Medicine, 91:290-292, 1991.

41. Kvilekval KH, Mason RA, Newton B, Anagnostopoulos CE*, Vlay SC, Giron F. Complications of Percutaneous Intra-Aortic Balloon Pump Use in Patients with Peripheral Vascular Disease. Archives of Surgery, 126:621-623, 1991.