BIOGRAPHICAL SKETCH

Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
WANG, Fan (Audrey) / POSITION TITLE
Assistant Professor of Cell Biology and Neurobiology
eRA COMMONS USER NAME
F.WANG
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION / DEGREE
(if applicable) / YEAR(s) / FIELD OF STUDY
Tsinghua University, China / B.S. / 1993 / Biology
Columbia University, New York / Ph.D. / 1998 / Neurobiology

A. Positions and Employment

1993 – 1998 Graduate Student, Columbia University, New York, Thesis advisor: Dr. Richard Axel

1998 – 2003 Postdoctoral Associate, Howard Hughes Medical Institute, Stanford University,

Stanford, CA. Postdoctoral Mentor: Dr. Marc Tessier-Lavigne

2003 – present Assistant Professor, Department of Cell Biology, Duke University Medical Center,

Durham, NC

2004 – present Assistant Professor, Department of Neurobiology, Duke University Medical Center,

Durham, NC

Professional Memberships

1999 – present Member, American Association for the Advancement of Science (AAAS)

2003 – present Member, Society for Neuroscience

Honors and Awards

1989 – 1993 Outstanding Student Scholarship, Tsinghua University, China

1993 Distinguished Graduate Award, Tshinghua University, China

1998 Distinct Thesis Honor, Columbia University, New York

1998 Postdoctoral Fellowship from Howard Hughes Medical Institute

2004 Alfred P. Sloan Scholar

2004 Klingenstein Fellow in Neuroscience

2004 Whitehall Foundation Award

2007 McKnight Scholar Award

B. Selected peer-review publications (in chronological order)

1. Mombaerts, P. Wang, F., Dulac, C., Vassar, R., Chao, S.K., Nemes, A., Mendelsohn, M., Edmondson, J. and Axel, R. (1996) The molecular biology of olfactory perception. Cold Spring Harbor Symposia on Qualitative Biology, V LXI: 135-145.

2. Mombaerts, P., Wang, F., Dulac, C., Chao, S.K., Nemes, A., Mendelsohn, M., Edmondson, J. and Axel, R. (1996) Visualizing an olfactory sensory map. Cell 87: 675-686.

3. Wang, F., Nemes, A., Mendelsohn, M. and Axel, R. (1998) Odorant receptors govern the formation of a precise topographic map. Cell 93: 47-60.

4. Bulfone, A., Wang, F., Hevnor, R., Anderson, S., Cutforth, T., Chen, S., Meneses, J., Pedersen, R., Axel, R. and Rubenstein, J.L.R. (1998) An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. Neuron 21: 1273- 1282.

5. Lin, D,M., Wang, F., Lowe, G., Gold, G.H., Axel, R., Ngai, J., and Brunet, L. (2000) Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity. Neuron 26: 69-80.

6. Graef, I.A.*, Wang, F.*, Charron, F., Chen L., Neilson, J., Tessier-Lavigne, M., and Crabtree, G.R. (2003).Neurotrophins and netrins require Calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell, 113: 657-670. (*These two authors contributed equally to this work)

7. Grieshammer, U., Ma, L., Plump, A.S., Wang, F., Tessier-Lavigne, M., and Martin, G.R. (2004). Slit-2 mediated ROBO2 signaling restricts kidney induction to a single site. Developmental Cell 6 (5): 709-717.

8. Wang, F. (2004). Steering Growth Cones with a CaMKII/Calcineurin Switch. Neuron 43 (6): 760-762.

9. Zhou, X, Babu, J.R., da Silva, S., Shu, Q., Tani, T., Oliver, T., Tomoda, T., Graef, I.A., Wooten, M.W., and Wang, F. (2007). Ulk1/2-mediated endocytic process regulates filopodia extension and branching of sensory axons. PNAS 104 (14): 5842-5847.

10. Hodge, LK, Klassen, M., Han, B., Yiu, G., Hurrell, J., Howell, A., Rousseau, G., Lemaigre, F., Tessier-Lavigne, M., and Wang, F. (2007) Retrograde regulation of trigeminal sensory neuron identities and face map formation by target derived signals. Neuron 55: 572-586.

11. Hasegawa, H., Abbott, S., Han, B., Qi, Y., and Wang, F. (2007). Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene. J. Neurosci. 27(52): 14404-14.

12. Hasegawa, H., and Wang, F. Visualizing TrkC-expressing touch and proprioceptive sensory endings using HS3ST-2-PLAP mice. (2008). J. Comp. Neurol. 511(4): 543-556. PMCID: PMC2577232

13. Que, J., Wilm, B., Hasegawa, H., Wang, F., Bader, D., and Hogan, BL. Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. (2008). PNAS. 105: 16626-16630. PMCID: PMC2567908

14. Kessler, J., Hasegawa, H., Brun, S.N., Yang, Z.J., Dutton, J.W., Wang, F., and Wechsler Reya, R.J. N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. (2009). Genes & Dev. 23(2): 157-70. PMCID: PMC2648542

Book Chapter

1. Graef I.A., Crabtree, G.R., and Wang, F. (2006). Calcineurin/NFAT signaling in development and function of the nervous system. In Transcription Factors, ed Thiel G., pp353-378.

2. Wang, F. (2008). “Pathfinding:Axon Guidance: Building Pathways with Molecular Cues in Vertebrate Sensory Systems.” The New Encyclopedia of Neuroscience, edited by Larry Squire et al, Elsevier, 2008.

C. Teaching

Cell and Molecular Biology (Neuronal development)

Concepts in Neuroscience (Developmental neurobiology part)

Seminars in Cell Biology (small RNAs: biogenesis and mechanisms of biological functions)

Cell Biology of Nervous Tissue (lectures as part of Medical School course on Cells and Molecules)

D. Research Support:

Active:

5 RO1 DE016550 (PI: Wang) 04/05/2005-02/28/2010

NIH/NIDCR

Trigeminal mechanisms underlie distinct orofacial pain

McKnight Scholar for Neuroscience (PI: Wang) 07/01/2007 – 06/30/2010

Molecular and Genetic Analyses of Mammalian Touch Sensation

5RO1 DE019440 (PI: Wang) 07/01/2009-06/30/2014

NIH/NIDCR

Control of trigeminal touch sensory circuit assembly

5RO1 DA028302 (PI: Wang) 07/01/2009-06/30/2014

NIH/NIDA

Genetically encoded probes for neuronal activity and plasticity

Recently Completed:

Alfred P. Sloan Scholar Award (PI: Wang) 09/16/2004 – 09/15/2006

Whitehall Foundation (PI: Wang) 07/01/2004 – 06/30/2007

Neural circuit development in the mouse trigeminal system

Esther A. and Joseph Klingenstein Fund (PI: Wang) 07/01/2004 – 06/30/2007

Neural circuit formation in mouse trigeminal sensory system