BIOGRAPHICAL SKETCH
NAMEIrene Konstantopoulou / POSITION TITLE
Special Scientific Personnel
Molecular Diagnostics Laboratory
National Center of Scientific Research “Demokritos”
EDUCATION/TRAINING
INSTITUTION AND LOCATION / DEGREE
(if applicable) / YEAR(s) / FIELD OF STUDY
Bachelor in Biology, Aristotle University of Thessaloniki, Greece (Prof. S.G. Scouras) / Bachelor / 10/85-2/90 / Biology
Post-graduate fellow (‘Erasmus’ scholarship) in the Cell & Molecular Biology Unit, University Hospital, University of Umea, Sweden (Dr. P. Sideras) / 09/94-12/94 / Molecular Biology
Ph.D. in Biology, Aristotle University of Thessaloniki, Greece (Prof. S.G. Scouras) / PhD / 10/1991-2/1997 / Molecular Biology & Genetics (heat-shock genes, molecular evolution)
Post-doctoral work, Biology Department, Aristotle University of Thessaloniki, Greece (Prof. S.G. Scouras) / 2/1997-5/1998 / Molecular Biology & Genetics (heat-shock genes, molecular evolution)
Post-doctoral fellow, Molecular Diagnostics Lab, NCSR ‘Demokritos’, Athens, Greece (Dr. D. Yannoukakos) / 5/1998-6/2004 / Molecular Genetics (hereditary cancer syndromes)
PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 2 Biographical Sketch Format Page
Principal Investigator/Program Director (Last, First, Middle): PI Name
A. Positions and Employment
03/2007-today: Staff Scientist (Molecular Diagnostics Laboratory, Institute of Radioisotopes and Radiodiagnostic Products, NCSR “Demokritos”)
06/2005-03/2007: Postdoctoral Research Associate (Molecular Diagnostics Laboratory, Institute of Radioisotopes and Radiodiagnostic Products, NCSR “Demokritos”)
06/2004-06/2005: Lab Director of “BioGenomica - Center for Genetic Testing & Analyses S.A.”, a NCSR ‘Demokritos’ spin-off company (Technological Park of Attica “Lefkippos”)
Honors and Awards
03/2003 1st Presentation Award to presentation made at the 8th Panhellenic Congress of the Greek Society of Senology (Thessalonica, Greece, 2003)
11/2001 “Best Presentation” to work presented at the 5th International Congress of the Hellenic Society for Breast Cancer Research – Awarded by the Hellenic Anticancer Society
09/2001 “Best Investigator” Award to presentation made at the 1st Congress of the World Society for Breast Cancer (Istanbul, Turkey, 2001)
05/2000 “Sotiris Papastamatis” Award, Athens Medical Society
1992 – 1997 Special Postgraduate Scholarship (EMY) for PhD thesis, Aristotle University of Thessaloniki, GR
Editor / Reviewer in International Scientific Journals: Editor - ISRN (International Scholarly Research Network) Molecular Biology (http://www.isrn.com/journals/mb/), Reviewer - Hereditary Cancer in Clinical Practice, PLoS ONE, Familial Cancer, International Journal of Medical Sciences, Cancer Investigation, Cancer Biomarkers, European Journal of Obstetrics & Gynecology and Reproductive Biology, Cancer Medicine
Participation in International Consortia
· Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA). Coordinated by Dr Georgia Chenevix-Trench, Queensland Institute of Medical Research, Brisbane, Australia
(http://www.srl.cam.ac.uk/consortia/cimba/index.html)
· Breast Cancer Association Consortium. Coordinated by Prof. Doug Easton, Cambridge University, UK. (http://www.srl.cam.ac.uk/consortia/bcac/)
· Evidence-based Network for the Interpretation of Germline Mutant Alleles – ENIGMA. Coordinated by Prof. A. Monteiro, Univ. S. Florida, Tampa, USA. (http://enigmaconsortium.org/)
· Triple-Negative Breast Cancer Consortium (TNBCC). Coordinated by Prof. F. Couch, Mayo Clinic, Rochester, USA
· Ovarian Cancer Association Consortium – OCAC. Coordinated by Prof. Paul Pharoah, Cambridge University
UK (http://www.srl.cam.ac.uk/consortia/ocac/index.html)
· Collaborative Oncological Gene-environment Study – COGS. Coordinated by Prof. Per Hall, Karolinska Institute, Sweden (http://cogseu.org)
B. Peer-reviewed publications (in chronological order)
1. Konstantopoulou I, Vassilopoulou L, Mavragani-Tsipidou P, Scouras ZG “Insecticidal effects of essential oils. A study of the effects of essential oils extracted from eleven Greek aromatic plants on Drosophila auraria” Experientia (1992) 48: 616-619 - impact factor: 2.072 - (SCI®, 1992)
2. Konstantopoulou I, Ouzounis C, Drosopoulou I, Yiangou M, Sideras P, Sander C, Scouras ZG “A Drosophila hsp70 gene contains long antiparallel coupled open reading frames (LAC ORFs) conserved in homologous loci” Journal of Molecular Evolution (1995) 41: 414-420 - impact factor: 3.519 - (SCI®, 1995)
3. Pardali E, Feggou E, Drosopoulou E, Konstantopoulou I, Scouras ZG, Mavragani-Tsipidou P “The afrotropical Drosophila montium subgroup: Balbiani ring 1, polytene chromosomes, and heat shock response of Drosophila vulcana” Genome (1996) 39: 588-597 - impact factor: 1.792 - (SCI®, 1996)
4. Drosopoulou E, Konstantopoulou I, Scouras ZG “The heat shock genes in the Drosophila montium subgroup. Chromosomal localization and evolutionary implications” Chromosoma (1996) 105: 104-110 - impact factor: 2.633 - (SCI®, 1996)
5. Konstantopoulou I, Drosopoulou I, Scouras ZG “Variations in the heat-induced protein pattern of several Drosophila montium subgroup species (Diptera: Drosophilidae)” Genome (1997) 40: 132-137 - impact factor: 1.876 - (SCI®, 1997)
6. Konstantopoulou I, Scouras ZG “The heat shock gene hsp83 of Drosophila auraria. Genomic organization, nucleotide sequence and long antiparallel coupled ORFs (LAC ORFs)” Journal of Molecular Evolution (1998) 46: 334-343 - impact factor: 3.271 - (SCI®, 1998)
7. Konstantopoulou I, Nikolaidis N, Scouras ZG “Genomic organization of the hsp70 gene of Drosophila auraria (montium subgroup). A single locus with copies in a conserved arrangement” Chromosoma (1998) 107: 577-586 - impact factor: 2.651 - (SCI®, 1998)
8. Konstantopoulou I, Kroupis C, Ladopoulou A, Pantazidis A, Boumba D, Lianidou ES, Petersen MΒ, Florentin L, Chiotellis E, Nounesis G, Efstathiou E, Skarlos D, Tsionou C, Fountzilas G, Yannoukakos D “BRCA1 mutation analysis in breast/ovarian cancer families from Greece” Human Mutation (2000) 16(3): 272-273 - impact factor: 3.666 - (SCI®, 2000)
9. Armakolas A, Ladopoulou Α, Konstantopoulou Ι, Gomatos IP, Kataki A, Konstadoulakis MM, Stathopoulos GP, Markopoulos C, Leandros E, Gogas I, Yannoukakos D, Androulakis G “Mutations in the BRCA2 gene in Greek breast cancer patients: determination of three novel mutations” Human Mutation (2002) 19(1): 81-82 - impact factor: 6.894 - (SCI®, 2002)
10. Ladopoulou Α, Konstantopoulou Ι, Armaou S, Efstathiou E, Mihalatos M, Bardi G, Nasioulas G, Pandis N, Yannoukakos D “A change in the last base of BRCA1 exon 23, 5586G>A, results in abnormal RNA splicing” Cancer Genetics & Cytogenetics (2002) 134(2): 175-177 - impact factor: 1.713 - (SCI®, 2002)
11. Ladopoulou Α, Kroupis C, Konstantopoulou I, Pantazidis A, Armaou S, Tsiagas I, Lianidou E, Efstathiou E, Tsionou C, Panopoulos C, Mihalatos M, Nasioulas G, Fountzilas G, Pandis N, Yannoukakos D “Germ line BRCA1 & BRCA2 mutations in Greek breast/ovarian cancer families. 5382insC is the most frequent mutation observed” Cancer Letters (2002) 185(1): 61-70 - impact factor: 2.346 - (SCI®, 2002)
12. Pampanos A, Economides J, Iliadou V, Neou P, Leotsakos P, Voyiatzis N, Eleftheriades N, Tsakanikos M, Antoniadi T, Hatzaki A, Konstantopoulou I, Yannoukakos D, Gronskov K, Brondum-Nielsen K, Grigoriadou M, Gyftodimou J, Iliades T, Skevas A, Petersen MB “Prevalence of GJB2 mutations in prelingual deafness in the Greek population” International Journal of Pediatric Otorhinolaryngology (2002) 65(2): 101-108 - impact factor: 0.516 - (SCI®, 2002)
13. Tsoli E, Zacharatos P, Dasiou-Plakida D, Peros J, Evangelou C, Zavras AI, Yannoukakos D, Konstantopoulou I, Asimakopoulos PJ, Kittas C, Gorgoulis VG “Growth index is independent of microvessel density in non-small cell lung carcinomas” Human Pathology (2002) 33(8): 812-818 - impact factor: 3.029 - (SCI®, 2002)
14. Iliades T, Eleftheriades N, Iliadou V, Pampanos A, Voyiatzis N, Economides J, Leotsakos P, Neou P, Tsakanikos M, Antoniadi T, Konstantopoulou I, Yannoukakos D, Grigoriadou M, Skevas A, Petersen MB “Prelingual nonsyndromic hearing loss in Greece. Molecular and clinical findings” ORL-Journal for Otorhinolaryngology & its Related Specialties (2002) 64(5):321-323 - impact factor: 0.734 - (SCI®, 2002)
15. Kroupis C, Goutas N, Ladopoulou A, Konstantopoulou I, Pantazidis A, Efstathiou E, Vourlidis N, Tsionou C, Yannoukakos D, Lianidou E “Atypical medullary breast carcinoma in a family carrying the 5382insC BRCA1 mutation” The Breast Journal (2003) 9(3):260-262 - impact factor: 0.469 - (SCI®, 2003)
16. Sevinc A, Yannoukakos D, Konstantopoulou I, Manguoglu E, Luleci G, Colak T, Akyerli C, Colakoglu G, Tez M, Sayek I, Voutsinas G, Nasioulas G, Papadopoulou E, Florentin L, Kontogianni E, Bozkurt B, Aygun Kocabas N, Esat Karakaya A, Yulug IG, Ozcelik T “No association between RNASEL Arg462Gln variant and breast cancer risk” Anticancer Research (2004) 24(4): 2547-2549 - impact factor: 1.395 - (SCI®, 2004)
17. Konstantopoulou I, Jankovic R, Raicevic L, Ladopoulou A, Armaou S, Nikolopoulos G, Pandis N, Nasioulas G, Radulovic S, Yannoukakos D “BRCA1 and BRCA2 genes mutation analysis in patients with a family history of breast and ovarian cancer” Jugoslovenska Medicinska Biohemija (2004) 23(3): 271-277
18. Kaldrymides P, Mytakidis N, Anagnostopoulos T, Vassiliou M, Tertipi A, Zahariou M, Rampias T, Koutsodontis G, Konstantopoulou I, Ladopoulou A, Bei T, Yannoukakos D “A rare RET gene exon 8 mutation is found in two apparently unrelated Greek kindreds with familial medullary thyroid carcinoma: Implications for screening” Clinical Endocrinology (2006) 64: 561-566 - impact factor: 3.358 - (SCI®, 2006)
19. Branković-Magić M, Dobričić J, Janković R, Konstantopoulou I, Yannoukakos D, Radulović S “Identifying and testing for hereditary susceptibility to breast/ovarian cancer in Serbia: Where are we now?” Archive of Oncology (2006) 14(3-4): 131-135
20. Armaou S, Konstantopoulou I, Razis E, Boukovinas I, Xenidis N, Fountzilas G, Yannoukakos D “Genomic rearrangements account for 5% of the BRCA1 mutations in Greek breast/ovarian cancer families; identification of a novel genomic rearrangement in BRCA1 gene involving exon 24 and 3’ UTR” European Journal of Cancer (2007) 43(2): 443-453 - impact factor: 4.454 - (SCI®, 2007)
21. Fostira F, Thodi G, Konstantopoulou I, Sandaltzopoulos R, Yannoukakos D “Hereditary cancer syndromes” Journal of BUON (2007) Suppl 1: S13-S22
22. Konstantopoulou I, Rampias T, Ladopoulou A, Koutsodontis G, Armaou S, Anagnostopoulos T, Nikolopoulos G, Kamakari S, Nounesis G, Stylianakis A, Karanikiotis C, Razis E, Gogas H, Keramopoulos A, Gaki V, Markopoulos C, Skarlos D, Pandis N, Bei T, Arzimanoglou I, Fountzilas G, Yannoukakos D “Greek BRCA1 & BRCA2 mutation spectrum: Two BRCA1 mutations account for half the carriers found among Greek high-risk breast/ovarian cancer patients” Breast Cancer Research & Treatment (2008) 107(3) : 431–441 - impact factor: 5.684 - (SCI®, 2007)
23. Anagnostopoulos T, Pertesi M, Konstantopoulou I, Armaou S, Kamakari S, Nasioulas G, Dobrovic A, Young MA, Mitchell G, Fountzilas G, Yannoukakos D “A novel BRCA1 founder mutation G1738R related to breast-ovarian cancer predisposition, found in Greek patients” Breast Cancer Research & Treatment (2008) 110(2): 377-385 - impact factor: 5.684 - (SCI®, 2008)
24. Armaou S, Pertesi M,Fostira F, Thodi G, Athanasopoulos PS, Kamakari S, Athanasiou A, Gogas H, Yannoukakos D, Fountzilas G, Konstantopoulou I “Contribution of BRCA1 germline mutations to breast cancer in Greece: a hospital-based study of 987 unselected breast cancer cases” British Journal of Cancer (2009) 101(1): 32-37 - impact factor: 4.346 - (SCI®, 2009)
25. Sinilnikova OM, Antoniou AC, Simard J, Healey S, Léoné M, Sinnett D, Spurdle AB, Beesley J, Chen X, kConFab, Greene MH, Loud JT, Lejbkowicz F, Rennert G, Dishon S, Andrulis IL, OCGN, Domchek SM, Nathanson KL, Manoukian S, Radice P, Konstantopoulou I, Blanco I, Laborde AL, Durán M, Osorio A, Benitez J, Hamann U, Hogervorst FBL, van Os TAM, Gille HJP, HEBON, Peock S, Cook M, Luccarini C, Gareth Evans D, Lalloo F, Eeles R, Pichert G, Davidson R, Cole T, Cook J, Paterson J, Brewer C, EMBRACE, Hughes DJ, Coupier I, Giraud S, Coulet F, Colas C, Soubrier F, Rouleau E, Bièche I, Lidereau R, Demange L, Nogues C, Lynch HT, GEMO, Schmutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Sutter C, Deissler H, Schaefer D, Froster UG, GC-HBOC, Aittomäki K, Nevanlinna H, McGuffog L, Easton DF, Chenevix-Trench G, Stoppa-Lyonnet D, on behalf of the Consortium of Investigators of Modifiers of BRCA1/2 “The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers” British Journal of Cancer (2009) 101(8):1456-1460 - impact factor: 4.346 - (SCI®, 2009)
26. Konstantopoulou I, Pertesi M, Fostira F, Grivas A, Yannoukakos D “Hereditary cancer predisposition syndromes and preimplantation genetic diagnosis: where are we now?” Journal of BUON (2009) Suppl 1: S187-192
27. Pertesi M, Konstantopoulou I, Yannoukakos D “Haplotype analysis of two recurrent genomic rearrangements in the BRCA1 gene suggests that they are founder mutations for the Greek population” Clinical Genetics (2010) 80: 375–382 - impact factor: 2.942 - (SCI®, 2010)
28. Engel C, Versmold B, Wappenschmidt B, Simard J, EMBRACE, Easton DF, Peock S, Cook M, Oliver C, Frost D, Mayes R, Gareth Evans D, Eeles R, Paterson J, Brewer C, McGuffog L, Antoniou AC, Stoppa-Lyonnet D, Sinilnikova OM, Barjhoux L, Frenay M, Michel C, Leroux D, Dreyfus H, Toulas C, Gladieff L, Uhrhammer N, Bignon Y-J, Meindl A, Arnold N, Varon-Mateeva R, Niederacher D, Preisler-Adams S, Kast K, Deissler H, Sutter C, Gadzicki D, Chenevix-Trench G, Spurdle AB, Chen X, Beesley J, kConFab, Olsson H, Kristoffersson U, Ehrencrona H, Liljegren A, SWE-BRCA, van der Luijt RB, van Os TA, van Leeuwen FE, HEBON, Domchek SM, Rebbeck TR, Nathanson KL, Osorio A, Ramón y Cajal T, Konstantopoulou I, Benítez J, Friedman E, Kaufman B, Laitman Y, Mai PL, Greene MH, Nevanlinna H, Aittomäki K, Szabo CI, Caldes T, Couch FJ, Andrulis IL, Godwin AK, Hamann U, Schmutzler RK, on behalf of the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) “Association of the variants CASP8 D302H and CASP10 V410I with breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers” Cancer Epidemiology, Biomarkers & Prevention (2010) 9(11):2859-2868 - impact factor: 4.190 - (SCI®, 2010)
29. Hamel N, Feng B-J, Foretova L, Stoppa-Lyonnet D, Narod SA, Imyanitov E, Sinilnikova O, Tihomirova L, Lubinski J, Gronwald J, Gorski B, van Overeem Hansen T, Thomassen M, Yannoukakos D, Konstantopoulou I, Zajac V, Ciernikova S, Couch FJ, Greenwood C, Goldgar DE, Foulkes WD “On the origin and diffusion of BRCA1 c.5266dupC (5382insC) in European populations” European Journal of Human Genetics (2011) 19: 300-306 - impact factor: 4.400 - (SCI®, 2011)
30. Osorio A, Milne RL, Alonso R, Pita G, Peterlongo P, Teulé A, Nathanson KL, Domchek SM, Rebbeck T, Lasa A, Konstantopoulou I, Hogervorst FB, Verhoef S, van Dooren MF, Jager A, Ausems MG, Aalfs CM, van Asperen CJ, Vreeswijk M, Waisfisz Q, Van Roozendaal CE, Ligtenberg MJ; HEBON; EMBRACE, Easton DF, Peock S, Cook M, Oliver CT, Frost D, Curzon B, Evans DG, Lalloo F, Eeles R, Izatt L, Davidson R, Adlard J, Eccles D, Ong KR, Douglas F, Downing S, Brewer C, Walker L, Nevanlinna H, Aittomäki K, Couch FJ, Fredericksen Z, Lindor NM, Godwin A, Isaacs C, Caligo MA, Loman N, Jernström H, Barbany-Bustinza G, Liljegren A, Ehrencrona H, Stenmark-Askmalm M; Sw E-BRCA, Feliubadaló L, Manoukian S, Peissel B, Zaffaroni D, Bonanni B, Fortuzzi S, Johannsson OT, Chenevix-Trench G, Chen XC, Beesley J, Spurdle AB; kConFab, Sinilnikova OM, Healey S, McGuffog L, Antoniou AC, Brunet J, Radice P, Benítez J; on behalf of CIMBA “Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the consortium of investigators of modifiers of BRCA1/BRCA2” British Journal of Cancer (2011) 104(8):1356-1361 - impact factor: 5.042 - (SCI®, 2011)