ShandongUniversitySchool of Medicine

Year 2010 -2011 Semester1 November, 2010

Test Paper ofPharmacology 1 (A)

No. / Part Ⅰ / Part Ⅱ / PartⅢ / Marks / Marker
Points
Part Ⅰ / 1 / 2 / 3 / 4 / 5 / 6 / 7 / 8 / 9 / 10
11 / 12 / 13 / 14 / 15 / 16 / 17 / 18 / 19 / 20
21 / 22 / 23 / 24 / 25

Part Ⅰ Single Choice Questions （50 points）

1. The drugs that can pass across the blood brain barrier are

A. small in molecular weight and ionized drugs

B. small in molecular weight and nonionized drugs

C. large in molecular weight and ionized drugs

D. large in molecular weight and nonionized drugs

E. all of above are not true

2. Which of the following is true for a drug whose elimination from plasma shows first-order kinetics?

A. the half-life of the drug is proportional to the drug concentration in plasma

  1. the amount eliminated per unit time is constant
  2. the rate of elimination is proportional to the plasma concentration

D. elimination involves a rate-limiting enzyme reaction operating at its maximal velocity

E. a plot of drug concentration versus time is a straight line

3. Which of the following drugs has the largest therapeutic index ?

A. Drug A LD50=150mg, ED50=100mg

B. Drug B LD50=100mg, ED50=50mg

C. Drug C LD50=250mg, ED50=100mg

D. Drug D LD50=300mg, ED50=50mg

E. Drug E LD50=300mg, ED50=150mg

4. The maximal effect of a drug is called

A. potency B. efficacy C. affinity D. toxic effect E. margin of safety

5. The mechanism of treating phenobarbital poisoning with bicarbonate sodium is that it

A. neutralizes Phenobarbital

B. stimulates Phenobarbital transference from the brain to the plasma

C. alkalinizes urine fluid, prevents Phenobarbital from reuptaking, and stimulates excretion of drug

D. both B and C are right

E. both A and C are right

6. The study of the time course of absorption, distribution, metabolism and excretion of drugs in the body is called

A. pharmacology B. pharmacokinetics C. pharmacodynamics

D. pharmacy E. pharmaceutics

7. The pharmacological mechanism of side effect is

A. overdose B. low in selectivity C. hypersensitivity

D. administration of drug for a long time E. the sensitivity of the body

8. The bioavailability is

A. the quantity of drug absorbed after oral administration

B. the rate of drug absorbed after oral administration

C. the ratio of AUC(oral)/AUC(intravenous)

C. the ratio of AUC (intravenous)/AUC(oral)

D. the area under curve of oral administration

E. the area under curve of intravenous administration

9. The effect of pilocarpine on eye is

A. miosis, increase intraocular pressure, accommodation of paralysis

B. miosis, decrease intraocular pressure, accommodation of spasm

C. mydriasis, decrease intraocular pressure, accommodation of paralysis

D. mydriasis , increase intraocular pressure, accommodation of spasm

E. mydriasis , increase intraocular pressure, accommodation of paralysis

10. The correct statement about epinephrine is that

A. inhibition of CNS is very strong B. influence on metabolism is weak

C. it can produce tachycardia D. it is only administered by iv

E. it can only activate  agonist

11. Patients with myasthenia gravis are more effectively treated with

A. epinephrine B. Propranolol C. neostigmine

D. atropine E. pilocarpine

12.β-antagonists can NOT be used in the treatment of

A．hypertension B．bronchial asthma C．tachycardia

D．angina pectoris E．hyperthyroidism

13. Which of the following drugs can be used in treatment of glaucoma?

A. neostigmine B. Pilocarpine C. phentolamine

D. norepinephrine E. atropine

14. Which one is NOT the mechanism for epinephrine in the treatment of allergic shock？

A. cardiac stimulation B. vasoconstriction to increase blood pressure

C. reduce the release of allergic substance D. bronchial dilation

E. improve microcirculation

15. Which of the following therapeutic projects would be used in the treatment of patient with serious organophosphate intoxication?

A．atropine + norepinephrine B．atopine+ neostigmine

C．atropine + pralidoxime iodide

D．atropine + epinephrine E．atropine + morphine

16. The elevated blood pressure caused by epinephrine may be reversed by

A．propranolol B．phentolamine C．norepinephrine

D．nicotine E．atropine

17. The major action of norepinephrine is

A. vasoconstriction B. pupillary dilation

C. heart excitation D. smooth muscle dilation

E. CNS stimulation

18. About the action mechanisms of drugs, which one is true?

A. Benzodiazepines increase the efficiency of GABAergic inhibition, mediating inhibitory synaptic response

B. Selegiline is a Dopamine Receptor Agonists

C. Barbiturates decrease the efficiency of GABAergic inhibition, mediating excitatory synaptic response

D. Benzatropine decrease cholinergic function mainly in periphery

E. Chlorpromazine can block 5-HT receptors

19. Which of the followings is not indication of Chlorpromazine?

A. intractable hiccups B. hypothermia anesthesia

C. schizophrenia D. toothache E. artificial hibernation

20. Which of the following statements about Chlorpromazine is not true?

A. It can block DA-R in meso-limbic pathway

B. It can cause extrapyramidal adverse effects

C. It can block β-R

D. It can block DA-R in meso-cortical pathway

E. It can block DA-R in nigrostriatal pathway

21. The main reason for the combination use of L-DOPA with Carbidopa is

A. Carbidopa is MAO inhibitor, which can inhibit levodopa decarboxylation in periphery

B. Carbidopa is AADC inhibitor, which can inhibit levodopa decarboxylation in periphery

C. Carbidopa is COMT inhibitor, which can inhibit levodopa decarboxylation in periphery

D.Carbidopa is DA receptor agonist, which can inhibit levodopa decarboxylation in periphery

E. Carbidopa is anticholinergic drug, which can inhibit levodopa decarboxylation in periphery

22. Which of the followings about antipyretic effect of NSAIDS is not true?

A. inhibiting COX in CNS, decreasing production of PGs

B. making body temperature alter with the environmental temperature

C. no influence on normal temperature

D. effective in rheumatic fever

E. can not be used in artificial hibernation

23. Aspirin can not induce

A. gastrointestinal side effects B. Parkinson’s syndrome

C. Salicylism reaction D. asthma E. Reye’s syndrome

24. Which of the following statements is not true?

A. Respiration depression is the most common cause of death from Morphine acute poisoning

B. Morphine can cause diarrhea C. Naloxone can reverse the opioid effects

D. Morphine can cause pinpoint pupils E. Morphine can cause biliary colic

25. Which of the following statements is not true?

A. Morphine can be used to treat biliary colic alone

B. Morphine canactivate opioid receptor

C. Morphinehas antitussive effect

D. high dosage of Aspirin is unbeneficial for thrombosis inhibition

E. Acetaminophen may be as a substitute for antipyretic effects of aspirin in Children with viral infections

PART Ⅱ Please explain the following pharmacological terms（20 points）

1. Half-life time (t1/2)

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2. Tolerance

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3. First-pass elimination

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4. First-order Elimination Kinetics

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5. Therapeutic index (TI)

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PART Ⅲ Assay questions （30 points）

1. Please describe the clinical uses of epinephrine.

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2. Please compare analgesic effect between Aspirin and Morphine

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