Partnership for the Advancement of Cancer Research

FredHutchinsonCancerResearchCenter | New MexicoStateUniversity

Partnership for the Advancement of Cancer Research

U54 Collaborative Grant

Statement of Intent

NMSU

Name of NMSU Principal Investigator, Title, Degree:
Address:
Phone number:
Email Address:
Signature:

FHCRC

Name of FHCRC Principal Investigator, Title, Degree:
Address:
Phone number:
Email Address:
Signature:

PROJECT

Title of Project:
Total Amount Requested:
Does the research involve humans?
Does the research involve animals?

Statement of Intent Due Date: March 31, 2011

FredHutchinsonCancerResearchCenter | New MexicoStateUniversity

Partnership for the Advancement of Cancer Research

U54 Collaborative Grant

Statement of Intent

Specific Aims:

New MexicoStateUniversity | FredHutchinsonCancerResearchCenter

Partnership for the Advancement of Cancer Research

U54 Minority Institution (MI)/CancerCenter (CC) Partnership

COVER PAGE

NMSU

Name of NMSU Principal Investigator, Title, Degree:
Address:
Phone number:
Email Address:
Signature:

FHCRC

Name of FHCRC Principal Investigator, Title, Degree:
Address:
Phone number:
Email Address:
Signature:

PROJECT

Title of Project:
Total Amount Requested:
Does the research involve humans?
Does the research involve animals?

PROPOSAL CHECKLIST

Signed Statement of Intent
Signed Cover Page
PHS 398 (06/09) Form Page 2 (Project Summary, Performance Sites, Senior/Key Personnel, Other Significant Contributors, Human Embryonic Stem Cells) (NMSU and FHCRC)
PHS 398 (06/09) Form Page 4 (Budget for Initial Period) (NMSU)
PHS 398 (06/09) Form page 5 (Budget for Entire Proposed Project Period/Justification)(NMSU)
PHS 398 (06/09) Resources Format Page for each investigator(NMSU)
PHS 398 (06/09) Form Page 4 (Budget for Initial Period) (FHCRC)
PHS 398 (06/09) Form page 5 (Budget for Entire Proposed Project Period/Justification)(FHCRC)
PHS 398 Resources Format Page for each investigator(FHCRC)
PHS 398 Biographical Sketch for all key personnel, including mentors of each junior investigator, post-doctoral fellow, graduate students(if applicable). Please place in alphabetical order (NMSU and FHCRC)
Research Plan (PHS 398 Continuation pages) (6 pages for a pilot project and 12 pages for a full project for sections 1-3)
Sustainability
Career Development Plan for each junior investigator, post-doctoral fellow, and/or graduate student (if applicable)
Mentor(s) Letter(s) of Support for each junior investigator, post-doctoral fellow, and graduate student (if applicable)
Environment and Institutional Commitment to Candidate [for each junior investigator, post-doctoral fellow, and/or graduate student (if applicable)]
Targeted/Planned Enrollment Table
Program Director/Principal Investigator (Last, First, Middle):
PROJECT SUMMARY (See instructions):
RELEVANCE (See instructions):
PROJECT/PERFORMANCE SITE(S) (if additional space is needed, use Project/Performance Site Format Page)
Project/Performance Site Primary Location
Organizational Name:
DUNS:
Street 1: / Street 2:
City: / County: / State:
Province: / Country: / Zip/Postal Code:
Project/Performance Site Congressional Districts:
Additional Project/Performance Site Location
Organizational Name:
DUNS:
Street 1: / Street 2:
City: / County: / State:
Province: / Country: / Zip/Postal Code:
Project/Performance Site Congressional Districts:

PHS 398 (Rev. 6/09)Page 2Form Page 2

Program Director/Principal Investigator (Last, First, Middle):
SENIOR/KEY PERSONNEL. See instructions. Use continuation pages as needed to provide the required information in the format shown below.
Start with Program Director(s)/Principal Investigator(s). List all other senior/key personnel in alphabetical order, last name first.
Name / eRA Commons User Name / Organization / Role on Project
OTHER SIGNIFICANT CONTRIBUTORS
Name / Organization / Role on Project
Human Embryonic Stem Cells / No / Yes
If the proposed project involves human embryonic stem cells, list below the registration number of the specific cell line(s) from the following list: Use continuation pages as needed.
If a specific line cannot be referenced at this time, include a statement that one from the Registry will be used.
Cell Line

PHS 398 (Rev. 6/09)Page 3Form Page 2-continued

Number the following pages consecutively throughout
the application. Do not use suffixes such as 4a

Program Director/Principal Investigator (Last, First, Middle):

DETAILED BUDGET FOR INITIAL BUDGET PERIOD

DIRECT COSTS ONLY(NMSU)

/ FROM / THROUGH

List PERSONNEL(Applicant organization only)

UseCal, Acad, or Summer to Enter Months Devoted to Project

Enter Dollar Amounts Requested (omit cents) for Salary Requested and Fringe Benefits

NAME / ROLE ON
PROJECT / Cal.
Mnths / Acad.
Mnths / Summer
Mnths / INST.BASE
SALARY / SALARY
REQUESTED / FRINGE
BENEFITS / TOTAL
PD/PI
SUBTOTALS
CONSULTANT COSTS
EQUIPMENT (Itemize)
SUPPLIES (Itemize by category)
TRAVEL
INPATIENT CARE COSTS
OUTPATIENT CARE COSTS
ALTERATIONS AND RENOVATIONS (Itemize by category)
OTHER EXPENSES (Itemize by category)
CONSORTIUM/CONTRACTUAL COSTS / DIRECT COSTS
SUBTOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD (Item 7a, Face Page) / $
CONSORTIUM/CONTRACTUAL COSTS / FACILITIES AND ADMINISTRATIVE COSTS
TOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD / $

PHS 398 (Rev. 6/09)PageForm Page 4

Program Director/Principal Investigator (Last, First, Middle):

BUDGET FOR ENTIRE PROPOSED PROJECT PERIODDIRECTCOSTSONLY(NMSU)

BUDGET CATEGORY
TOTALS / INITIAL BUDGET
PERIOD
(from Form Page 4) / 2nd ADDITIONAL YEAR OF SUPPORT REQUESTED / 3rd ADDITIONAL YEAR OF SUPPORT REQUESTED / 4th ADDITIONAL YEAR OF SUPPORT REQUESTED / 5th ADDITIONAL YEAR OF SUPPORT REQUESTED
PERSONNEL: Salary and fringe benefits. Applicant organization only.
CONSULTANT COSTS
EQUIPMENT
SUPPLIES
TRAVEL
INPATIENT CARE
COSTS
OUTPATIENT CARE
COSTS
ALTERATIONSAND
RENOVATIONS
OTHEREXPENSES
DIRECT CONSORTIUM/
CONTRACTUAL
COSTS
SUBTOTALDIRECTCOSTS
(Sum = Item 8a, Face Page)
F&A CONSORTIUM/
CONTRACTUAL
COSTS
TOTAL DIRECT COSTS
TOTAL DIRECT COSTS FOR ENTIRE PROPOSED PROJECT PERIOD / $
JUSTIFICATION. Follow the budget justification instructions exactly.
Use continuation pages as needed.

PHS 398 (Rev. 6/09)PageForm Page 5

Program Director/Principal Investigator (Last, First, Middle):

JUSTIFICATION (continued)

PHS 398/2590 (Rev. 06/09)Page Continuation Format Page

Program Director/Principal Investigator (Last, First, Middle):

RESOURCES(NMSU)

Follow the 398 application instructions in Part I, 4.7 Resources.

PHS 398 (Rev. 6/09)PageResources Format Page

Program Director/Principal Investigator (Last, First, Middle):

DETAILED BUDGET FOR INITIAL BUDGET PERIOD

DIRECT COSTS ONLY(FHCRC)

/ FROM / THROUGH

List PERSONNEL(Applicant organization only)

UseCal, Acad, or Summer to Enter Months Devoted to Project

Enter Dollar Amounts Requested (omit cents) for Salary Requested and Fringe Benefits

PHS 398 (Rev. 6/09)PageForm Page 4

Program Director/Principal Investigator (Last, First, Middle):

BUDGET FOR ENTIRE PROPOSED PROJECT PERIODDIRECTCOSTSONLY(FHCRC)

PHS 398 (Rev. 6/09)PageForm

Program Director/Principal Investigator (Last, First, Middle):

JUSTIFICATION (continued)

PHS 398/2590 (Rev. 06/09)Page Continuation Format Page

Program Director/Principal Investigator (Last, First, Middle):

RESOURCES(FHCRC)

Follow the 398 application instructions in Part I, 4.7 Resources.

PHS 398 (Rev. 6/09)PageResources Format Page

Program Director/Principal Investigator (Last, First, Middle):

BIOGRAPHICAL SKETCH(SAMPLE)

Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
Hunt, Virginia Lively / POSITION TITLE
Associate Professor of Psychology
eRA COMMONS USER NAME (credential, e.g., agency login)
huntvl
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)
INSTITUTION AND LOCATION / DEGREE
(if applicable) / MM/YY / FIELD OF STUDY
University of California, Berkeley / B.S. / 05/90 / Psychology
University of Vermont / Ph.D. / 05/96 / Experimental Psychology
University of California, Berkeley / Postdoctoral / 08/98 / Public Health and Epidemiology

A. Personal Statement

The goal of the proposed research is to investigate the interaction between drug abuse and normal aging processes. Specifically, we plan to measure changes in cognitive ability and mental and physical health across a five-year period in a group of older drug users and matched controls. I have the expertise, leadership and motivation necessary to successfully carry out the proposed work. I have a broad background in psychology, with specific training and expertise in key research areas for this application. As a postdoctoral fellow at Berkeley, I carried out ethnographic and survey research and secondary data analysis on psychological aspects of drug addiction. At the Division of Intramural Research at the National Institute on Drug Abuse (NIDA), I expanded my research to include neuropsychological changes associated with addiction. As PI or co-Investigator on several previous university- and NIH-funded grants, I laid the groundwork for the proposed research by developing effective measures of disability, depression, and other psychosocial factors relevant to the aging substance abuser, and by establishing strong ties with community providers that will make it possible to recruit and track participants over time. In addition, I successfully administered the projects (e.g. staffing, research protections, budget), collaborated with other researchers, and produced several peer-reviewed publications from each project. As a result of these previous experiences, I am aware of the importance of frequent communication among project members and of constructing a realistic research plan, timeline, and budget. The current application builds logically on my prior work, and I have chosen co-investigators (Drs. Gryczynski and Newlin) who provide additional expertise in cognition, gerontology and geriatrics. In summary, I have a demonstrated record of successful and productive research projects in an area of high relevance for our aging population, and my expertise and experience have prepared me to lead the proposed project.

B. Positions and Honors

Positions and Employment

1998-2000Fellow, Division of Intramural Research, National Institute of Drug Abuse, Bethesda, MD

2000-2002Lecturer, Department of Psychology, Middlebury College, Middlebury, VT

2001-Consultant, Coastal Psychological Services, San Francisco, CA

2002-2005Assistant Professor, Department of Psychology, Washington University, St. Louis, MO

2005- Associate Professor, Department of Psychology, Washington University, St. Louis, MO

Other Experience and Professional Memberships

1995-Member, American Psychological Association

1998-Member, Gerontological Society of America

1998-Member, American Geriatrics Society

2000-Associate Editor, Psychology and Aging

2003-Board of Advisors, Senior Services of Eastern Missouri

2003-04NIH Peer Review Committee: Psychobiology of Aging, ad hoc reviewer

2005-09NIH Risk, Adult Addictions Study Section, member

Honors

2003Outstanding Young Faculty Award, Washington University, St. Louis, MO

2005Excellence in Teaching, Washington University, St. Louis, MO

2008Award for Best in Interdisciplinary Ethnography, International Ethnographic Society

C. Selected Peer-reviewed Publications (Selected from 42 peer-reviewed publications)

Most relevant to the current application

Merryle, R.J. & Hunt, V.L. (2004). Independent living, physical disability and substance abuse among the elderly. Psychology and Aging, 23(4), 10-22.
Hunt, V.L, Jensen, J.L. & Crenshaw, W. (2007). Substance abuse and mental health among community-dwelling elderly. International Journal of Geriatric Psychiatry, 24(9), 1124-1135.
Hunt, V.L, Wiechelt, S.A. & Merryle, R. (2008). Predicting the substance-abuse treatment needs of an aging population. American Journal of Public Health, 45(2), 236-245. PMCID: PMC9162292
Hunt, V.L., Newlin, D.B. & Fishbein, D. (2009). Brain imaging in methamphetamine abusers across the life-span. Gerontology, 46(3), 122-145.
Hunt, V.L. & Sher, K.A. (2009). Successful intervention models for older drug-abusers: Research across the life-span. American Psychologist, in press. NIHMSID: NIHMS99135

Additional recent publications of importance to the field (in chronological order)

Gryczynski, J., Shaft, B.M., Merryle, R., & Hunt, V.L. (2002). Community based participatory research with late-life addicts. American Journal of Alcohol and Drug Abuse, 15(3), 222-238.
Shaft, B.M., Hunt, V.L., Merryle, R., & Venturi, R. (2003). Policy implications of genetic transmission of alcohol and drug abuse in female nonusers. International Journal of Drug Policy, 30(5), 46-58.
Hunt, V. L., Marks, A.E., Shaft, B.M., Merryle, R., & Jensen, J.L. (2004). Early-life family and community characteristics and late-life substance abuse. Journal of Applied Gerontology, 28(2),26-37.
Hunt, V.L., Merryle, R. & Jensen, J.L. (2005). The effect of social support networks on morbidity among elderly substance abusers. Journal of the American Geriatrics Society, 57(4), 15-23.
Hunt, V.L., Pour, B., Marks, A.E., Merryle, R. & Jensen, J.L. (2005). Aging out of methadone treatment. American Journal of Alcohol and Drug Abuse, 15(6), 134-149.
Hunt, V.L, Marks, A.E., Venturi, R., Crenshaw, W. & Ratonian, A. (2006). Community-based intervention strategies for reducing alcohol and drug abuse in the elderly. Addiction, 104(9), 1436-1606. PMCID: PMC9000292
Merryle, R. & Hunt, V.L. (2006). Randomized clinical trial of cotinine in older nicotine addicts. Age and Ageing, 38(2), 9-23. PMCID: PMC9002364
Hunt, V.L., Jensen, J.L. & Merryle, R. (2008). The aging addict: ethnographic profiles of the elderly drug user. NY, NY: W. W. Norton & Company.
Hunt, V.L. (2009). Contrasting ethnicity with race in the older alcoholic. TheJournals of Gerontology Series B: Psychological Sciences and Social Sciences, in press. PMCID: PMC Journal – In Process.
Hunt, V.L. (2009). Intervening successfully with the older methadone patient. Journal of Applied Gerontology, 13(4), 67-79.

D. Research Support

Ongoing Research Support

R01 DA942367-03Hunt (PI)09/01/07-08/31/12

Health trajectories and behavioral interventions among older substance abusers

The goal of this study is to compare the effects of two substance abuse interventions on health outcomes in an urban population of older opiate addicts.

Role: PI

R01 MH922731-05Merryle (PI)07/15/05-06/30/10

Physical disability, depression and substance abuse in the elderly

The goal of this study is to identify disability and depression trajectories and demographic factors associated with substance abuse in an independently-living elderly population.

Role: Co-Investigator

Faculty Resources Grant, Washington University08/15/09-08/14/11

Opiate Addiction Database

The goal of this project is to create an integrated database of demographic, social and biomedical information for homeless opiate abusers in two urban Missouri locations, using a number of state and local data sources.

Completed Research Support

K02 AG442898Hunt (PI)09/01/06-08/31/09

Drug Abuse in the Elderly

Independent Scientist Award: to develop a drug addiction research program with a focus on substance abuse among the elderly.

Role: PI

R21 AA998075Hunt (PI)01/01/04-12/31/06

Community-based intervention for alcohol abuse

The goal of this project was to assess a community-based strategy for reducing alcohol abuse among older individuals.

Role: PI

BIOGRAPHICAL SKETCH

Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME / POSITION TITLE
eRA COMMONS USER NAME (credential, e.g., agency login)
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)
INSTITUTION AND LOCATION / DEGREE
(if applicable) / MM/YY / FIELD OF STUDY

Please refer to the application instructions in order to complete sections A, B, C, and D of the Biographical Sketch.

PHS 398/2590 (Rev. 06/09)Page Continuation page

Program Director/Principal Investigator (Last, First, Middle):

Research Plan

Sections 1 - 3 should not exceed 6 pages (pilot) or 12 pages (full).

Please see full RFA for instructions regarding the specific research plan requirements for pilot and full proposals at: IV. Application and Submission Information, Sub-header 6. Other Submission Requirements and Information, item 3.C.1 Proposed Pilot Projects/Programs and 3.C.2 Proposed Full Projects/Programs).

1. INTRODUCTION TO APPLICATION (RESUBMISSION OR REVISION APPLICATIONS ONLY) N/A

2. SPECIFIC AIMS(up to 1 page)

3. RESEARCH STRATEGY (SIGNIFICANCE, INNOVATION AND APPROACH)(up to 6 pages for a pilot project and up to 12 pages for a full project).

A. Significance

B. Innovation

C. Preliminary Studies (encouraged, but not required for pilot projects)

D. Approach

Sections 4- 15 (outside page limits):

4. INCLUSION ENROLLMENT REPORT (RENEWAL OR REVISION APPLICATIONS ONLY) N/A

5. BIBLIOGRAPHY AND REFERENCES CITED

6. PROTECTION OF HUMAN SUBJECTS

7. INCLUSION OF WOMEN AND MINORITIES

8. TARGETED/PLANNED ENROLLMENT TABLE(please use imbedded template)

9. INCLUSION OF CHILDREN

10. VERTEBRATE ANIMALS

11. SELECT AGENT RESEARCH(if applicable)

12. MULTIPLE PD/PI LEADERSHIP PLAN N/A

13. CONSORTIUM/CONTRACTUAL ARRANGEMENTS(if applicable)

14. LETTERS OF SUPPORT (E.G., CONSULTANTS) (if applicable)

15. RESOURCE SHARING PLAN(S) N/A

SUSTAINABILITY

The funding agency (NCI) requires evidence of sustainability. That is, the NCI wants to know that the work of the grant can eventually lead to other external funding (e.g. RO1, R21) and high-quality publications. To demonstrate that your work can be sustained, please provide a grant or PAR/RFA number as an example of where you would apply next for external funding;

Career Development Plan (if applicable,up to 12 pages)

A career development plan is required for eachjunior investigator, post-doctoral fellow, and graduate student. Mentors may be individuals who are on the project and/or senior faculty at either NMSU or the FHCRC. According to RFA-CA-11-001( IV. Application and Submission Information, Sub-header 6. Other Submission Requirements and Information, item 3.D. Career Development and Mentoring Plan), a career development plan must include the following: