Part of Plasmodium Sequence Trimmed

Figure 1S

Alignment of amino acid sequences from ODC homologs. Initially the alignment was built with ClustalW and subsequently manually refined. Some N- and C-terminal regions were removed for conciseness. Two internal bulging regions of Plasmodium ODCs were also trimmed. The positions of the 20 key amino acids used for evaluation of the biochemical properties of the proteins are shown on the bottom of the alignment. Alterations of the 20 key amino acids are highlighted in light blue. Species and homolog names are given on the left side. Homologs with at least one alteration of a key amino acid are shown in red letters. Conserved key amino acids are highlighted in red. Gaps are indicated by “-“. Incomplete sequences are marked by “*” following the name.

Caenorhabditis_briggsae_ODC2/AZIF AGESEWSRETFGEQSVAVLSGGYRNPIEMARHVAARCGSHQPFFVMDVAAIERRLEVLRSTLPLIRPNYS--IACNADPVLARVLSNNLDVNFEVATSGELELTCLHS------EPSRIIFCSQLLTRKGIKNAVQAGCGTFVVE------NEKQMN---DVMNASADAQMFLAVCLP-----YSS-----GEVPFGCSID--ELVEILDMAHLLGANLTGIYLELGVRAT--LDDYITAIHDARSIIDTASTKF------LDLRHISLGNLVIPT-GT----DGSVNNNSISFCETINRAVSELFDD------HIDFSANIGRFLVTNAFTLCTNVIGKRALNAKYITNDDFDDG------VGYLYQTNDGIYGSFGCKLMDINPQCKPLNGEET------FDGSNQLYLGAVLGPILDGCDVAQRLTRCRQ--LRVGEWLVWEKMGAFTIPVDGEHHVPPVYYYSGKECWQKLIHKDEQRRSPSPSV

Caenorhabditis_elegans_ODC2/AZIF AGEPEWSREMFGEQSIAVLSGAYRNPIEMARHVAARCGSYQPFFVMDVAAIERRLEALRVMLPRVRPNYA--VACNADPVLARVLSNNIDVNFEVSNTAELELVRMNV------EPSRAVFCSQLMTRKAIKNAVLAGCSTFVVE------SEKQVT---DVMNASPEAEIILAVCLP-----YST-----GEVPFGCSVD--EIEEILDMAHLLGANVTGIYLELGLRAT--LEDYITSVHDARSIFETADQKF------LTLRRVCFGNLSVPT-GA----DGAVNNEFMSFCNSLNNVIDDLFES------NIDFSASIGRFLVTNAFTLCTNVIGKRAMDAKFITNDDFDDG------VGFVYQTNDGVYGSFGCKQMDIKPLCKPLDVE------NDSEEQLHFGTILGPTLDGTDVAQRLMKSRQ--LRVGEWLVWEQMGAFTIPVDSEHSVPPVYYYSGKECWQKLIHKDEQRRSPSPSV

Ancylostoma_ceylanicum_ODC2/AZIF ------LHSFS---TRNARILLAISMNGHRGD-----NDS-----LSAQKGADPE--EIEGLLMTAFELRAKVVGISFDLGSATS--ACTYYKALHEVHELFMFANRIG------LELDTINLGGGFPAS-NV----DKAQR--FPEMCDVINAGLDQLFWSREF--PQLKVVATPGRYFAAAAFVLCTNVIGKQALEARYITKDDFDDG------IGFVYQTNDSVYGSFGCVLMNSQPECIPLDDV------ADAPQHFGTVLGASLQPGDVAQSLIRCRQ--LGVRDWLLWRDAGAYTMPLDAEHAVPPVYYFAGSDKWERIIGIHNKATSAYASG

Heterodera_glycines_ODC2/AZIF LREGGTITVFRDVANDEFRRRRPSEFAAQIAESKSAKDDCRPFFVMNIDCAVALLELWAQFLPRVQPFYA--LNCNADPMLLRLMASHQSVGFSCSSGAEMLNALHYVS------ADRVFGAFPCWTRSALRQAETCGVYTLCFD------SERDLD---RILANHSNARLLLRICVDPCATDANA-----LFGAPLDEAVELLKLCVQLGLNCIGISLSTGPSTDDNCNLSSSSLFHFSSVYAFAIECSARLFRIAIDLGLRMDVLNIGDAFACPWSSXSTETDESLAHFAEFCTEFNRSFDVHFPSDGIG-HGLRIMATPGQFFARSPFSLVTNVIGKRSTDASAVTNNDFDAG------KTAFHYQTNESYYGTFGCRMMVNTEPRCAPLFNDFD------MDTEQNQCFYYGTVFGQSGFDDGSDTDIVQSVCHFRQ--LNIGDWLIWSNMGAYSFGNCGSLDDEINDDDDSDGNEFDTLKTPPIFYFASQ--

Aedes_aegypti_ODC2/AZIE1 ----MCFLKEDYRGDFTLLQSKGSVRQVVDELLKSPVRE-DPFHVLDLDDVVQKHLTWLRQMPRVRPFYA--VKCNDDPYILETLACLGTG-FDCASKAEIRKVLNLG------VEPDRIIFAHPVKSNEALLFAKEKRVTKMTFD------SELELE---KIAQFYPEAELVLRFRHDSATVLISLGK------KFGCNAQEEGPELIRKAKKLG-LNVVGVSFHVGCGSK-DVDCYYDAIKSAKSLFDFASSVG------YKFKLLDIGGGFPGD------SDKKIDGYAEVINQALDKFFPTQSG----IEVIAEPGRYYVGSAVRLFTTIHGKKFVKTDDGEN------HVMYYINDGVFGTLFDWVSLRAVQDLARVIPSIT------SDKHDKPLLKTTIWGPTCDSTDIVCE-DVEFPEHDIG-EYMLFENIGAYGITFATSFNGFPSPTIRVYVKEQTWSALTNLKCIKWTDK

Culex_pipiens_ODC2/AZIE1 -MSTATKLPSGDRSSFNLLDETESVEAVLEQVLAAPAEE-NPFHLLDLDDVVRKHLNWLRELPRVKPFYA--VKCNDDESIVKTLALLGTG-FDCASKGEISQVLGLG------VGAERIIYAHPIKAKESLVFARNNGVGKVTFD------NECELK---KVAKYYPEAELVLRIRHDSDKVLISLGK------KFGCDARLDGPELIRKAQELG-LNVIGVSFHVGCGSL-DADCFYNAIKSAKFLFEFADTVG------YRFSLLDIGGGFPGD------VDKPIGEFATAINRALDEFFPNLDG----IQVIAEPGRYYVGSAVRLLATINGKKIIRDPADSSRIL------QVMYYINDGVFGTLFDWVSLRAINDLSRAIPIIT------KQKREKVQFKTTVWGPTCDSTDIVCE-DVDFPEHDIG-EYLLFENIGAYGITFATNFNGFPKPTIQIYVKKQTWNALAALDGIKWQDK

Anopheles_gambiae_ODC2/AZIE1 MDTRQDTHLAKLNNVTIRPASAGSLEEEISRIIEDEPRE-HPLHLLDLDDLVGKHLVWLRSMPRVTPFYA--VKCNDDPAILATLAALGTG-FDCASEAEMRTILALG------VTPDRIIFAHPIKSVQALAFAKAHGIRRMTFD------NECELE---KVAREYPEAELVLRIRHDSDRVLIALGK------KFGCDARGDGRVLLARAQALG-VAVIGVSFHVGCGSL-DADCFYHAIASARSVFDYAKDELG-----MRLWLLDVGGGFPGD------NDKPIDQYAEAVSRALQEFFPPEQDE--EVYVLGEPGRFYVGSAATLLTTVQGKKIVRDDAGQIQ------QMMYYINDGVFGTLFDWLSLREIKDLKRAVPLVR------REREHEPAFPTTIWGPTCDSTDIVCE-DVPYPEHHIG-DYIVFENLGAYGMTFATNFNGFPKPTVQVYVKEHTW------

Aedes_aegypti_ODC3/AZIE10 ------MHNIRYNLVEGEFSLDDAVHSIVARGPQD-SPVHILNLDDVVAKHRNWREKLPRVEPFYA--VKCNDDPAIIRTLVALGAG-FDCASKKEIEMVLKLG------GNADKIIYAHTAKSMDSITYAKTCGISMMTFD------GEIELD---KIKKLHPEASLVLRIRYDSPDAAVSLGK------KFGCDPEHEAPHLLKYAKSLG-LSVVGISFHVGSGNK-NAECFYGAIKTTRTLFNLASELD------FDLSLLDIGGGFPGD------HDKPIDTFVKAINLALQRYFPIKSG----VRVIAEPGTYYVASAVNLVANVQSKRIIRS--GPQATI------SEIMYYLNDGMFGSFDWLNPRCY--PPVVIPGNP------QIVRSRDQFLTTLWGPTCDSTDLIAS-GWMMEELQIG-DFLVFNDMGAYGSVLSTNFNGFAKPKMMVYVSRTTYDQLKLGRNDRRLKR

Culex_pipiens_ODC3/AZIE10 RVSGRDDSVTMRKIRYNLLEDDASVKDVIELVVSQGPKD-EPVHILDLDDVVAKHQNWRRKLPRVDPFYA--VKCNDDPAIVQTLIALGAG-FDCASKAEIELVLQRG------GDPSRIIYAHTAKSIDSLVYAKACGINLMTFD------GEIELD---KINQVHPEASLVLRIHYDSANAQVSLGK------KFGCDPEHEAPQLLRYAKSLG-LSVVGISFHVGSGNS-DHECFYGAIKAAKKLFDYAQSLG------YDLRLLDIGGGYPGD------HDKPIDPYATTINGALQRFFPLKTN----VRVIAEPGTYYVASAVTLIANVQSKRIVR---TPQGTV------RELMYYLNDGLFGSFDWLNPRKY--PPQVIPGNR------QLVRSRELFLTTLWGPTCDSTDLILS-GMAMEELQIG-DFLVFDDMGAYGTVLATNFNGFAKPKVMVYISRRSWEQLELEKRNRRTKR

Anopheles_gambiae_ODC3/AZIE8 ------MSVLECPSDLTLISDDMSIGDVIRDVVRMGPHE-EPLHVLDLDDVVRKHYGWCAQMPRVKPYYA--VKCNDDPRILQTLMTLGTG-FDCASKGEMERMLGYG------VKPESIIFAQPAKSIPSLLYARSKQVSVMTFD------GAVELE---KIHQYYPEARLVLRMRHDSLKVRCSLGK------KFGCDPIAEAPELLRYAATLR-MNVIGISFHVGSDCD-EHEVYYEAVKIAKGLFEYAKTIG------YEFSLLDIGGGFPGD------NDKPIDRYAQAVNVAIDQFFPAESD----IRIIAEPGRYYVSSAVTLVSFVDSKRVMKEKQPDGTEK------TRMYYYLNDGIFGTFYCTAHEAQ--PAIPIVER------KTGAKDFPTSVWGPTCDVMDLILP-DVMLPELNVG-DSVVFENCGAYGQVLACRFNGFPLPKVIAYLREGTW------

Anopheles_gambiae_ODC5/AZIE9 ------MSVLECPSDLTLISDDMSIGDVIRDVVRMGPHE-EPLHVLDLDDVVRKHYGWCAQMPRVKPYYA--VKCNDDPRILQTLMTLGTG-FDCASKGEMERMLGYG------VKPESIIFAQPAKSIPSLLYARSKQVSVMTFD------GAVELE---KIHQYYPEARLVLRMRHDSLKVRCSLGK------KFGCDPIAEAPELLRYAATLR-MNVIGISFHVGSDCD-EHEVYYEAVKIAKGLFEYAKTIG------YEFSLLDIGGGFPGD------NDKPIDRYVQAVNVAIDQFFPAESD----IRIIAEPGRYYVSSAVTLVSFVDSKRVMKEKQPDGTEK------TRMYYYLNDGIFGTFYCTALEGQ--QVVPIVR------SKLTKRYDTTLWGPTCHVVDKIA--EARLPELDVG-DSVVFENVGAYGMVLANQFNGFPLPKVRAYLREGTW------

Anopheles_gambiae_ODC6/AZIE4 ------MDPGYILIDEHSSVDELIRLIAKRVTTVGEPLNVLNLDDIVAKHRNWQAKLPTVAPFYA--VKCNSHPTILRLLAALGCG-FDCASRAELDSVLELG------VTPDRIVYAHPNKSIGSIVHAKKLGVKRMTFD------GSDELE---KLARHYPEAELILRVRHDAAAAQLSLGR------KFGCDQVRDARPLLERARELG-LSVIGVSFHVGSGSM-DAECFYGGIRKAIEIFRVGSTLG------MKMELLDVGGGYPGA------NGALFDRCAYYINKALKELVPTPVA------VIAEPGKYYVESAVTALVNVVSKSYEKDVDGAVVR------VRYYVDDGLYDTFDWCDDQGS------GPLLQ------EDKRGAPCVRSVIYGRTMCEHDVIRE-EISLPEHEIG-DCLVFPNRGAYAKLLGRGHNGFRPTGTKVCLTRATLNYMCAEAVKAVRG-

Aedes_aegypti_ODC5/AZIE5 ----MSLLSVLKNRVEIVDDSVSSRDLVNRLVTQGP--QEEPLHLTEVDTLVKRHYEWLQHLPRVKPYYA--VKSNDEASLVEATVLMGLG-YDCASMAEVRRMLELG------VERERIIFAQPQKTIVSLQYARKHKIL-TVFD------SECELR---KIHQHYPEAEVLIRYRFDSKKSKVNLGS------KFGCETENESKSLLHVAKQLG-IKVVGWCFNVGSGCT-DADVFYAAIKKGREIHDYATSIG------FKFRMIDLGGGFMGD------KGCGIEEYAVHINRALEECYPASED----IFIFAEPGRYYCAAAVTSISPVHGKRILCNENDPLKIE------QVFYYFNDGMYGTFYSPRYRNQT---LYPIVWK------SGGNLGTTYKTTLFGPTCDGNDFFAK-DIDLPELEVS-DFVVFENQGAYARVHSCRFNGFCLPKVINYMRKSTWELLEKASKSLNPTQ

Culex_pipiens_ODC5/AZIE5 ----MDLLSVLKCRLEVVDDEVSSRDLVNRLVALGP--QEEPLHLIELDTLMKRHYQWLRHLPRVRPFYA--IKSNDDAALVETAILLGCG-FDCASKAEVHRVLGFG------VDRERIIFAQPAKTIESLRYAREKNIR-TVFD------SEFELR---KLHEHYPEAEVLIRYRFDSRNARVNLGN------KFGCDPGQEARVLLQLAKDLG-IKVVGWCFNVGSACS-DAEIFYDAIRKGREISDYAATLG------FHFNYIDLGGGFSGD------KDVSIEKYSVHINKALDEFYPDDKG----LTIIAEPGRYYSAAAVTSVIPVHGKRVFRDATDQNKID------KVFYYFNDGIYGTFISAKYRNQP---VNPIIWK------KRGDCGPAYSSTLFGPTCDGSDFFAS-DIQLPELDIS-DFVVFENQGAYARVHSCRFNGFCLPKGVIFIRRSAMDLLYEVFDVDNPDQ

Aedes_aegypti_ODC4/AZIE6 ----MDILSVLKSRLEIVDDAVTSKELVDRLVARGP--LEESLHLTELDTLVKRHYQWLKHLPRVRPFYA--IKSNDEPSIVETTILLGCG-YDCASTGELKRILGFR------VEPERIMFGQPMKTIESLELAKKMKLR-TVFD------SEDELR---KIHQHYPEADVVIRFRLETAEDPMNLGI------KFGCEADVEARELLDLAKELG-INVIGWCFNLGHACI-NPKNFYIGIKKGKELTDYAESLG------FKFNLIDLGGGFSGD------KDVSIEQYAEQINKGLDEFFPAELG----YTIVAEPGRYYSAAAVTAVVPIHGKRFIRSKDNPNDIE------KVFYYFNDGIYGTFYSAKYRGKA---VKPIVWK------QPSECGPTRKTTLYGPTCDGIDFFAK-DIEIPELNVA-DFVVFENQGAYSRVHACRFNGFSPPKPVIFVRQSVWALLEEASEGDATKK

Culex_pipiens_ODC4/AZIE7 ---MDHLLANLKNRLEIVPDSETSKNLVDRLVALGP--QEEPLHLIELDNLIKQHYAWLRHLPRVNPFYA--IKSNDEPTIVATSVLLGIG-YDCASKSELKRVLAHG------VNSEKIIFAQPAKTIEALKFARESKVR-TVFD------SEFELK---KIQQYYPEAELLIRYKFDSKNSRATLGT------KFGCNPDTEAPHLLQIAKELG-LNVVGWCFNVGSACS-DADIFYHAIKKGRQLCDLAAALG------FHFKFFDLGGGFAG------DIERYAVHINAALDEFFAIDEE----CTVIAEPGRYYCAATTINVVSIHGKKVLYNAEVPTQIE------HIYYYLNDGLSGTFYGVRSDNDP---VNPIAWK------KINNSQPRYKTTFFGPTCDNGDRFGT-GIELPELDIS-DRLVFPNHGAYTRVYATTFNGFCLPKTVIFIRQSSWKLLEQLSICHNPSE

Aedes_aegypti_ODC6/AZIE2 ----MDLLTVLKCRLEIIDDSITTKQLIDELVSFGP--LEAPVHLTELDNVVKRHYQWVRHLSAVHPFYT--VRTNNDLRILGTTVLLDCG-YVCSSKIEVMQVLELG------VDPEWILLKSAADSDDLLKFAQRKRLL-LSFS------TERELR---NIHHVYSEAELLICFGYE------LDP------DAEHQSQIETHDLLNLAKELE-MDVIGWSYEPSSVHL-DHTTLHDAIRKGREITDFAMIVG------FNFNFINIGNGLSIH------KDHDISQYAAQVNRSLQDFFPDRGN----FTIVAESGPFHCAAAVTAISTINGKRVFWHPEFPSQIE------RVSYYLN------HDFGDESSR---FEPIIWK------SPKDCGTVCRSSLYAS---SNECLID-NLALPEVNEM-DCMVFENQG---ASTSDLAEMPVLPITLAFVRKSMWNFLKALSTSDNPRR

Culex_pipiens_ODC6/AZIE2 ----MEILNVLKCRLEIVDDTVSSQQLVDQLICDAPRTEEPLLHLTELDCVVKRHYDWLRNLPRVRPYYT--VGSNDDVRIIGTTALLDCG-YVCSSKAEVLKVLEFR------VDPGVVLLERVGGNAELLRFARRKDVR-VVFD------SEEELR---MIHQYFPEAEVLIRFRLS------EDV------QPGCQADGEARDLLNLAKELN-MDVIGWCFNAGSSCC-DPAIFYTAISKGREITDHATIVG------FNFKFINLGVGVCGQ------KDVQGQRYASYINRALEDYFPERRG----WTIAAEVGSFHSAAAVTAITAIRGKRIFWNQRHPSRID------QVFYYVSGRVERTSHSLIHASDP---VCPIVWK------DRDECGVECRTTLYEAG--SDECICK-DLLLPELNEN-DFMVFESQGNLTRRISKSAEGVSCPITLVYVRRSMWEFLKYLSESRFPRE

Anopheles_gambiae_ODC4/AZIE3 ------MESPPEPLSVFATTKALLLKRFVAQGHTETSLNILDLDEIVHSHHRAMARFGSFATPYYP--PGVNNHPAALTILSKLGLG-FSCASIAEMGTVLGTG------VPPQRIILAHPVKSPDTILYAKQQDIQRIVCD------SVQEIT---KVQRLYPMAKIILRLRMC------VTQ------KFGCCPYNDVEEILHYIKSAQTVTIEGIHIALLQTPS-APSLLGETLQKAIHIAQDVFNLA------HALGCPDIPELILS------GMDNVPPAELQQIPTAFYHDPT----LRIIIETDRQLVESAVTLLASVQSKRVIRLGGTDGPVL------EIMYFINDGRYGSFEWWNAVDKR---PAVIRSDG------TVLHAGLTYPSSLWGQSCDSADIICE-RIELPELEIG-DYLVFSGMGAYGVTLASRFNGFPIPETVVCAGQSTTKALIESTGTRWLS-

Aspergillus_clavatus_ODC2/AZIM ------MDSTERLIDLAIQTRLFSLSSR-GWGIADEPFFVADLGQVIRQHRRWRVNLPDVHPFFA--VKCNPDPNLLKLLADLGTG-FDCASIEELRTVLSLG------VDPSRIIFANPCKSASSLVFAARTGVTRTTFD------NLDELD---SIRTFLPNAQLVLRIFASDSDALINLGE------KFGAS-VEASLPLLQRARELG-LGVCGVSFHVGTGAS-NASAYVNAIQHAKIVFGYGKSLGFD------MNFLDIGGGFQ------DCNLEDIACSLR--PMLKEEFPSG----VRLIAEPGRYYARSAYTLACKILSRRRHLGTDDHDKPD------MLYQNDGVYGSFMNVLIEKEIVRPSLVAYNWPS------HSHSNDTRQKLEEHRYTIWGPTCDSVDCVAK-DVPMSSEIRIGDWLKYKNMGAYTTATATQFNGFSNKHDVIYINTESMDYQVMHWTALANLH

Neosartorya_fischeri_ODC2/AZIM1 ------MDSTERLIDLAIQTRLFSLSSRDGWGIADEPFFVADLGQVIRQHRRWRVNLPDVHPFYA--VKCNPDPNLLKLLANLGTG-FDCASIEELRTVLSLG------VDPCRIIFANPCKSASSLVFAARTGVTRTTFD------NLDELD---TIRTFLPNAELVLRIYASDSDALIDLGE------KFGAT-VEASLPLLQRARELG-LDVCGVSFHVGTGAS-NASAYVNAIRHAKIVFGYGKSLGFD------MNLLDIGGGFQ------DCNLEDIACTLR--PMLKEEFPSG----VRLLAEPGRYYVRSAYTLACKILSRRRHIGTDDHDRPD------MLYQNDGVYGNFMNVLIEKETVRPSLVAYTWPF------HSHGNDTRRKLEEHRYTIWGPTCDSMDCVAK-DVPMTSEIRIGDWLKYKNMGAYTTATATQFNGFSNQYDVIYINTESMDHQVMHRKSVGKSI

Neosartorya_fischeri_ODC3/AZIM2 SLTSDWHKARMTDPIDRLIYLTIQTRLSSMGNY-EFGITDEPFFVADLGQILRQHRRWQSNLPNVHPFYA--VKCNPDPTLLRLLAELGTG-FDCASTEELRVVLNLG------VDPSRIIFANPCKSASSLLFAARTGVTLTTFD------NLDELE---TIQTFLPTARLMLRIYACDDDALIKLGE------KFGAP-IKSSFVLLQRAQELG-LEVCGVSFHVGTGAS-NVSAYVNAIRHAHMVFELGKSLGYD------MDLLDIGGGYQ------DSNFEKIAQSIR--GTLMEAFPSR----TQIIAEPGRYYARSAYTLVCKILSRRCHIAEAAQDRPD------MLYQNDGVYGSFMNVLFEKEVVHPSLIPCSSPY------HLRN--TKRVRGPHHYSIWGPTCDSVDCVAR-ESTLEAEVRVGDWLKYSNMGAYTMATSTQFNGFSNKHDIIYINTESRNSDQMHFKPSWDVH

Aspergillus_terreus_ODC2/AZIM ------MPNPVDLAIESHLASFNQSELNAVQEDPFFVMDLGEVIRQHQRWRRHLPNVHPFYA--VKCNSDPTLLRLLAEQGTG-FDCASIGEMRSVLSLG------VDPSRIIFANPCKSALSLVFAQMSGVNLATFD------NLDELD---SIKTYHPDCRLVLRIFACDDDALLNLSQ------KFGAP-EGSLLRLLERARELD-LNVTGVSFHVGTGAC-NAAPYVMAIQNAKVVFEQAKRLGYD------MNLLDIGGGFQ------DHNFEQIACHVA--VALNDGLPRD----IRIIAEPGRYYVRTAYTLVCKVISRRRQISDPANLEPD------MLYQNDGVYGSFMNVLIEKERLQPSLIPGSRHL------HQHAS--KRRSGQHCYSIWGPTCDSIDCVTK-QTVFDSEVNVGDWLKYSNMGAYTLATATQFNGFPIPQVAIHINSESQGQTKEFVSSGFAQP

Botryotinia_fuckeliana_ODC2/AZIM SDLTTSTFRESPESAEQLLNNTIYQHVAHIEQFPHIIGFNDPFFVVDIEAIRRQHDLWVSHLPFVRPFYA--VKCNTNTVMLRILMQLGVG-FDCASVEEMHTVLSLG------ADPGSIIFANPCKAPEALAFAYNVGVRRTTFD------NLDELD---SINKYMPNAQLMLRIFANDNSALVALGD------KYGAP-LESTQALLVRAKRLG-MNVVGTSFHIGSGAS-DPAVIRKAVEHSRVVWDIAESLGFS------LRIVDIGGGFQS------TESAFEKMAVAVSS-AISEAAFPEQ----TTFIAEPGRFYARSAFTLVCKIIARRVSTTIESSKTLE------MLYQNDGIYGNFMNGLIEKEEFMPTLIR------SKLNTTMARKTGNHTYKIWGPTCDSTDCVSR-STTFGCEVKIGDFLVYKNMGAYTSVTATNFNGFSNQTGTIYICSSPQDFTQIEESSSEEGT

Coccidioides_immitis_ODC2/AZIP ---MPVVNQKGIPPACAGGVIPSTVHKVIQEHLQTGIRHKESFFVGDEPFIHNQLKLWESKLSDVEPFYA--VKCNDNLRFLRILAEHGLG-FDCASQSEMQRILNLG------VEPHRILYAAPFKSEDGILYAKEHGVTQTMFD------TEDELR---KLADYFPNAELYLRLWADDPSSRVRLGS------KYGVQ-LPQAKELLVLAQELN-MKVIGLCFHVGSSAA-DFDAYRQAIAFTREVYDFNQSLRED--QRHPIRTIDIGGGFS------LGNFESAATAIRTSIRQYFGDEKH----LRWFAEPGRYFAEEAFYLVCRVLGTRPRACLGNGIGADEKLP------VGDIHINDGIYHNFLNALTEQVVPQPILLDCT------GTPYVSAA--DNGDPYTVWGQTCDSFDKIAT-NCVLPRRAKVGDWLCFPFMGAYTHVTGSDFNGFPKLKKTIWISNSPEDVSIAASSPLRTLR

Uncinocarpus_reesii_ODC2/AZIP ---MSSVHETGVPPGYGMHTIPPTVHAAIRKHLQTGPSHKESFYVVDEEFIHSQLRMWASKFGHVQPFYA--VKCNDNPRLLSILAKHGTG-FDCASQSEIKRILDLG------VKPDRILYAAPIKSEDHILYAKEHGVVQTMFD------SEDELR---KLVKLFPPAQLYLRLWADDPTSRVRLCD------KFGVQ-LPQAKRLLTLARELN-MTVVGLCFHVGSSAS-DCDAYRRAIALSREVYDYNESFGAD--KRHPIRTIDVGGGFS------RGNFDNAVRAINEGIQEHFGADNQ----LRWVAEPGRYFPDEAFHLVCRVIGTRPRPSLSDEPPPGEAFP------VGDVYINDGIYRNFLNAITEQVVPPARLLDCT------GSPYVRGD--DTEDTYVLWGQTCDSFDKINS-SCVLPRRAKVGDWVYFPSMGAYTHVTANDFNGFPKDTQTIWIPNSTEESKNAVSAPFRTLK

Aspergillus_fumigatus_ODC2/AZIP ------MSTPSDLGLSSATTFPYSVAVAVQNHLKDHGKDRQSFFVGNLDSVLDRLEEWRRELPFVQPFYA--VKCNDNKTLLTLLSRAGTG-FDCASKKEMQQILQLG------VNPERIIFAAPRKAEDYINYAHEHGIDKIVVD------SEDELR---KLAEIVPSAMIFLRLRADDPTSRVRLSE------KFGSD-LLEARGILQVAVDLS-VKVTGICFHVGSAAL-DPGAYVRAIAMAREVYDYNETLSS----KHPILIIDIGGGFT------ESNFRLLAPAVRSAADMYFGGETG----IQWVAEPGRFIVSEAFYLVCRVLGTRKRLVEYVDGPNQNHYF------HAELFVNDGIYQNFLNALVEGYIPTPVPLDPS------GRPYGLPEREDKSYSYTVWGQTCCGADKIKS-NCRLRCEMQAGDLLCFPSMGAYTHVTASGFNGFTARAMTVWTSSVRGREKLKEANRVGSWW

Nasonia_vitripennis_ODC1 ------MKVTNLDERIHVLDNNSSLMTVIKDIANSGLQEEAFYVLDVGDIVQKHQIWKEKLPRVDPFYA--VKCNDSLTVLEVLASLGVG-FDCASKNEINKVLDIG------VDSSRIIFANPAKPASHIRHAAAVGVDLMTVD------NESELH---KIKKLFPTAKVVLRIRCD-SEVAQCQLG-----MKFGCDPTFEAPSLLR-LARLLDIDVVGISFHVGSGCQ-DPPVFNRAICHAKNLFDLAVDIGF---K---PYLLDLGGGYP------GNKGSSIEKIADVINHALDEYFP-TD----DVHIIAEPGRFYVASAFTLATAIHSKRSVRADGNSP------GNVTHTMYYINDGVYGSFNCLLYDHQHVTPIPLRPG------HG-KMIPSSIWGPTCDGLDQVVENVLMHE--MELGDWIIFENMGAYTLPVASPFNGFPIPKVHVVADESIWLLLKDALPLTEEHF

Nasonia_vitripennis_ODC2/AZIJ ------MIELKLDEVKIFDDDLSEFEILRKVIDEKEG-EEPIHMLDVGDIIRKHQLWMEKMPRVVPYYA--VKCNPDSTVIKVLAALGGH-FDCASKQEIIQTMSQG------VSADRIIYANPMKFSSHIEYARKVGVAMMTAD------CEDELK---KIKDVYPDAKIVIRIRCD-TEVTTACLG-----EKFGCDPSSDAVQLIK-ATLDLGLTLHGFSFHVGSPCG-EPMAICRGILWCKNLIDTAKAMGC---R--DVSLIDIGGGIP------GERNFILDEFSELINDALENIDSSIE------IISEPGRYYVTSAFTSAAYVFGKKTLMKEN------QKTFMYYVSDGVYGSFIEELLHIKARHPVRLTNS------TSITNDEKYLSTVWGPTCDSYDVLLKNHMLPE--FNVGDWLAWSDIGSYSTCLSTEFNGFQAPKIHPIIRRKDWNYLWAEVKNRQQLK

Apis_mellifera_ODC ------MKVTNLDERIHVLDSASNVTTVIKDIALSGLQEEAFYVLDIGDVVRKHQIWKEKMPRVSPYYA--VKCNDNLIVIEVLAALGIG-FDCASKSEINKVLSVG------VDPSRIIFANPAKPASHIRHSAVVGVDVMTAD------NESELH---KIKKLHPTAKVVIRIRCD-AEVAQCQLG-----MKFGCDPIFEAPNLLR-LSRVLGLNIIGISFHVGSGCQ-DPPVFYRAIRHSKILFDLATDLGF---K---PYLLDIGGGYP------GNKGSSIDRIADVVNEALDEYFN-TD----AVHVIAEPGRFYVASAFTLATSIHSKRSVRGDENSP------NTITHNMYYINDGVYGSFNCLLYDHQHVIPIPLKKG------CG-KMIPSSIWGPTCDGLDQVVENVLLHE--MDLGDWIIFENMGAYTLPVASPFNGFPVPKVHIVADENIWHLLKDALPLTEEHF

Tribolium_castaneum_ODC ------MKFTNTDERVHVLDAQSNVWSVIMDIADSGVQEEAFYVCDVGDIVRKHKTWKAFLPRVQPHYA--VKCNDSLTVLEVLAALGTG-FDCASKGEINKVLSLG------VSPDRIIFANPAKPSSHIRHAAATNVSTMTFD------NETELH---KIKNFHPDSKLVIRIRCD-ATDSQCPLG-----MKFGCDPVLEAPRLLQ-TARSLNLNVIGVSFHVGSGCR-EPSVFKRAIAMSREVFDLGQALGY---N---FTLLDIGGGFP------GDRGTSLDEIAQVVNSALDDYFP-DP----SVEIIAEPGRFYVSSAYTLICNIHSIRDVISEDE------TTRHRMYYINDGVYGSFNCILYDHQRVVPLPLHEV------PGSKYYSSSIWGPTCDGLDQVVEEVLLPE--MGLGDWLVFENMGAYTLPVASPFNGFPVAKVHVVADESIWVLLKDIMPLTEEHF

Acyrthosiphon_pisum_ODC ------MRICGLEEQIHVIDNKVTVEEIIKDIVRTKEISDPFYIFDVGDLVHKARIWQQKLPRVKPFYA--VKCNDNSLVLETLAAFGTN-FDCASKAEIKKVLDLG------VNPSRIIFANPAKMTSHIKYAMSQCVDLTTFD------NELELY---KIKSIHPSCNLVIRIRCD-ATETQCPLG-----IKYGCDPLTEAPALMS-LARDLGLSIVGVSFHVGSGCN-EPAAFRRAIAASAAIFRLAQQLGF---MN--MYLLNIGGGFP------GNKSTSLDKIADIVNDALNEWFPPNN----GVTIIAEPGRFFVASAFTLSTKIHSIKKRSNDEN------HIMYFINDGVYGSFNSILYDHSVVVPKPLNDY------PMSPACQSSIWGPTCDGLDQVVDLVNLPL--MGMGDWITFDDMGAYTIPVASTFNGFPLPKVFAVANRRIWQKLKNLMPISEDHF

Anopheles_gambiae_ODC1 ------MKFLENESDKIEIVDGEVEVPAIIDQLAEQLPTDNPFYVMDIGDIVRKHQQWIEKMPRVVPHYA--VKCNDTDLVCATLAALGAS-FDCASKGEIAKILSLG------VAPERIIFANPMKPASHVRYAASNAVKTMTYD------SDTELH---KIKQYCPDAKLVIRIRCE-AEKAQCPLG-----KKFGCDPVEEAPRLIK-IARSLGLEVIGVSFHVGSGCA-DFPIYYKAISYARDLFDYAAQLGY---S---FSLLDIGGGFP------GDTGTSIDEVAMIVNAALDTFFP-DK----AVRVISEPGRYYVSSAFTLVTNVQSKRVCLNARTG------TIDRMMYYLNDGVYASFNSILYDHQVPQPKLIGGQ------AG-KQYKSTLWGPTCDALDQLIETIALPE--LQIDDWVVFENMGAYTIPVASPFNGFELPKVYCYISRKHW------

Culex_pipiens_ODC1 ------MKFFSPDCERVQIVDGQVNVPAIIDELTGTLSNEEPFYVMDIGDIVRKHQNWIEKMPRVVPHYA--VKCNDAEVVCSTLAALGAS-FDCASKGEISKILGLG------VAPERIIFANPMKPSSHLRYANANNVKTMTFD------SDTELH---KIRKLCPDAKLVLRIRCE-AEKAQCPLG-----KKFGCDPVEEAPRLIK-IVRSLDMDLVGISFHVGSGCA-DFPVYYKAISYARDLFDYAATLGY---E---LNLLDIGGGFP------GDVGTSIDEVAMIVNSALDKFFP-DK----SVRVISEPGRYYVASAFTLITCVQSKRVCLNAKTG------TIDRMMYYLNDGVYASFNSILYDHQHPQPKLIGQQ------GG-KVYDSTIWGPTCDALDQLIETIRMPE--LQIDDWVVFENMGAYTIPVASPFNGFPLPKIYCYISKDTWEMLNNMYPLEEENF

Aedes_aegypti_ODC1 -----MKFLSQNETELVQVVDGPVDVPAIIDQLTNELSTEEPFYVMDIDDIVRKHQAWIEKMPRVVPHYA--VKCNDTEVVCATLATLGAS-FDCASKGEIAKILALG------VSPDRIIFANPMKPSSHLRYASANNVKTMTFD------SEIELH---KIRKFCPDAKLVLRIRCE-AEKATCPLG-----KKFGCDPVDEAPSLIR-IARSMNLDVIGISFHVGSGCS-DFPIYYKAISIARDLFDYAKQLGY---E---FNLLDIGGGFP------GSHGTSIDEVALIINTALDKFFA-DK----SVRIISEPGRYYVASAFTLLTNVQSKRACLDPATG------TIDRMMYYLNDGVYASFNCILFDHQYPQPRLIGQQ------SG-KTYKSTIWGPSCDALDQVVETINLPE--LQIEDWVVFDNMGAYTIPIASPFNGFPLPKVFCYISKNTLEMMEHLTTLADESL

Bombyx_mori_ODC ------MKVVEEQRIRVMEGSWSPVSVIREIVESGVQEDPFYVMDLGEVVARYQQWKELLPRVEPFNA--VKCNDDKLLLTTLAALGTG-FDCASKAEIELVTSLG------VPPERIIFANPAKMASHIRYASAVGVDVMTFD------SEIELM---KIKQYMPHAQLLIRIRCD-AASAQCPLG-----IKFGCDPVTEAPRLLK-LASVLGLDVAGVSFHVGSGAA-EAAVFGRGVQLARSLFSAARDLGL---R---PRLLDLGGGYPGI------AAHTHFMLEIAEVVNAALDSHFP-ER----SVRVVAEPGRYFAAAAYTLAAMVHSKREIPAKEGE------DADTHTMYFINDGVYGSFNCVLYDHQIVSAEPLHDR------AD-ALLPCSVWGPSCDALDCVMESALLPP--LDAGDWLVFRDMGAYTIPIASPFNGFPVPRVRPWWTPGCGPGACARPGRPWTRS

Drosophila_melanogaster_ODC1 ------MAAATPEIQFYERELNIRRVIEECDLQR-LDQALNICDLSSVERKLRLWQKLLPRIKPFYA--VKCNDDPMVVRLLAQLGAG-FDCASKNEVKLVLGFD------VSPERIIFANPCRPVSHLEYAKEHQVSNGTVD------NEFEVY---KLHTHYPNSNLIVRFKSE-AKEAQCPLG-----DKFGCDADVDAAALML-LAKSLELKVTGTSFHVGSGCS-ELQAYDRAIKKAKNLFKFGALLGY---D---MDFLDIGGGFP------GSDDVKFEKIAESVNTSVQRHFP-DE----RVHIIAEPGRFFVAAACTLVCKIHAKREIRNE------AGKLDTVMYYLNDGVYGSFNCILYDHQVVIAEHYLDN------AESLPHLKSLIWGPSCDALDKISEDLHLPN--LNRGDLLGFRNMGAYTMPIASAFNGFEVPKTLYFQAI------

Drosophila_melanogaster_ODC2/AZIH ------MVNGDLRIQYYDEELNIRKVIEQADLEH-LDQALNICDLSSLERKLRLWHKLMPRIEPHYA--VKCNDDPVVVKFLADLGTG-FDCASKNELKLVLGLG------VSPERIIFAHPCRPASHLRYAKEQQVVNGTVD------NEYEIY---KLRKHYPDSNLIVRFKSE-AKKALCPLG-----DKYGCDAEADAAALML-LAKALGLKVTGTSFHVGSGCS-EVEAYDRAIEKAENIFKVGEMIGH---K---MELLDVGGGFP------GIDDEMFEEIAQSVNTSVELRFP-DK----RIRIISEPGRFFVEAAYTLICKVHAKREVRSK------DGKLDTMMYYLNDGIFGAFAGMFYYPEEVAPELYLDE------AESLPKLKSVIWGPSCDAMDKISD-LLLPN--LNPGDLLGFRNMGAYTMPIASPFNGFDVPETRFFKAK------

Glossina_morsitans_ODC ------MFKGENEINYYSAELPLKTVIQTFDFKN-TDEALFICDLTKIKEKYVTWQKYMPRVKPYYA--IKCNNDDLVIKTLADLGTG-FDCASKNEIKQILDIG------VQGERIIFANPCKLTSHIKYARSNQVLNGTVD------NEFEMY---KLHKYYPQSNLIIRFRCE-AEEVQCPLG-----EKFGCDAEQDASALML-LAKSLQLNVIGISFHVGSGCK-DFPAYDRAINIAKKLFKFGALLGY---D---MNLLDIGGGFP------GSSDENFKVIAAIVNKSLNRHFP-DR----KVNVIAEPGRFFVAAAYTLICKIHAKREAEPGRFFVAAAYTLICKIHAKREVR------SPNNNKLLRKMYYLNDGVYGSFNCILYDHQHVTVEHFLDT------DSYLPSFKTLIWGPTCDALDKIIEDTELPD--LCCGDLLAFPNMGAYTIPIASPFNGFMSPKTLYFLQNQK------

Musca_domestica_ODC ------MFKENEINFYENEIDLKQVIAGQNLQS-ADEALFVCDLTRLKEKYDMWTKYMPRVKPYYA--VKCNDDGHIVKTLAELGTN-FDCASKGEIKQVLDLG------VHPDRIIFAQPCKPISHLEYAKEMGVMTSTVD------TEFEIH---KLHKHFPESNLVIRFRCE-AKEAQCPLG-----DKFGCDAENEATSLML-LAKSLNLKVIGTSFHVGSGCN-DLPAYDRAITIAKNLFKFGALLGY---E---MNLLDIGGGFP------GSDNKKFEKIAEIVNKSLMRHFP-DD----KVNIIAEPGRFFVASAYTLICKIHAKGEARLP------NGKLLTKMYYLNDGVYGSFNCILYDHQHAEVQHFVDEE------NAEVPKFNSLIWGPTCDALDKIAEDLQLPD--LKCGDFLAFPNMGAYTIPIASPFNGFMLPKILYFHKAKI------

Caenorhabditis_briggsae_ODC1 -MISQFELIGDDKVGVLPKQVNQLEMCREIAAQKDMQENDSSFMLVDLDKIIERFNLWKRELPMIEPFYA--VKCNTDVVLIRVLASLGCG-FDCASREEIDIVMETG------VSADRLIYANPCKTRSFIVHALERDVRMMTFD------NAEELI---KIGKLHPNAEMILRIAVS-DPTATCPLN-----LKFGADPVLAAPQLLK-LAHEEGVNVVGISFHVGSGCN-DATAYRTALSHAKNLCEIGEGYGF---K---MDIIDMGGGFPGA------EHAHNPFEKIAETIRDALDEFFPET-----DKRLIAEPGRFFAAEPFSLVANIIHATEVPASKITK------DPKDSAEHGYMYYINEGVYGSFNCILFDHAHPIGGPLFDVD------RN--EKYMSTIWGPTCDSLDLVEDKKLMVK--MEIGEWMYYPDMGAYTLAAATTFNGFAKPVPMYVMSEEMWANIKDSNHI-----

Caenorhabditis_elegans_ODC1 -MISQFEIIGDNKIGVLPKQVDQLQMCRDIAASKDLQENDSSFMLVDLDKIIERFQLWKRELPMIEPFYA--VKCNTDLVLIRILASLGCG-FDCASKDEIDIVMGTG------VSAERIIYANPCKTRSFIAHAMDRDVKMMTFD------NPEELL---KIAKLHPNAEMILRIAVS-DPTATCPLN-----LKFGADPIIAAPQLLK-TASEEGINVVGISFHVGSGCN-DASAYRNALQHAKNLCEIGEGLGF---K---MDIIDMGGGFPGA------EHHN-PFEKIAETIRDALDEFFPDT-----NKRLIAEPGRFFAAGPFSLVANIIHATEVPASKITK------DPKDCADHGYMYYINDGVYGSFNCILFDHAHPIGSPLFDTD------RN--EKFMSTIWGPTCDSLDLVEDKKLMPK--MNVGEWLYYPDMGAYTLAAATTFNGFSKPVPMYVMSEEMWESIRDSTHV-----

Haemonchus_contortus_ODC1 TMITQMELIGDSKVGIADGEVDALSMCRQIARNYDK--DNIDEALCWSTDVVSTDSFVKRELPMIEPFYA--VKCNTDRVLVRTLAALGTG-FDCASREEIDIVMDLG------VSAERIVYANPCKTRSFITHAKERNVSMMTFD------SAEELA---KVAQLHPQAKMILRIAVS-DPTARCPLN-----LKFGADPVKMAPQLLV-HAQELGVDVIGISFHVGSGCN-DPTAYREALAHARHLIELGRGLGL---D---MTLVDLGGGYPGT------PQQTSFEDIAAVIRSAVDEYLPPEF-----GVRLIAEPGRFFAAAPFTLVCNIIHATEVSAEKITK------RPEDVEERGFMYYVNDGVYGSFNCILFDHVQPVGTPLFDEI------A---QEYPSTIWGPTCDSLDKIEDQKLMRM--MSVGEWIVYRNMGAYTCSASTTFNGFQRPNAIYMINRKNWARISTSPNV-----

Panagrellus_redivivus_ODC GCVDYYEIIAGTKVAVCRNAIDNKTVATAIAATRTVNGNDDPFVVMNVSTIMAKVIQWQRTMPRVAPCYA--VKCNDDKVLLRTLADLGMG-FDCASKAEIEKVIG-L------VGPEKIVYANPCKTRGFIAHAEAAGVKRMTFD------SVEELT---KIKQNHADPSLILRISVS-DPTAQCQLG-----IKFGCDPETVAPKLLR-KAADMGMNVIGISFHVGSGCN-EPATFRTALEYARGLFDLGISLGL---S---MTLLDIGGGFPGV------DTAHISLDACAAVINPALEELFPLDSCP--DVEVIAEPGRYFACAAVSVTTNVIASVKVPASRITE------KADDVNRDGYMYYMNDGVYGSFNCKLFDHYQPRGMPLAEHD------ADE-PRFPVCVWGPTCDGLDQVEESSVMPR--LYEGDWLYYPDMGAYTSVAASTFNGFDKPKTYYFIDEATLGSIVRKADSAPRG-

Ixodes_scapularis_ODC ------MKSYPTCDVVNPMG-AIGMVDSITSDPDNDQPFFVVDVADIVYKIKLWKLKIPRVEPFYA--VKCNSDAAVLELMAGLGLG-FDCASKAEIDVVRSLG------VSPSRIIYANPCKTKSFIKHAAAQGVDLMTFD------NEQELY---KVKELFPLARLVIRIRVD-DSGSVCQLG-----LKFGCEVS-DAQHLLT-IAKSLGLSVVGVSFHVGSNSR-EPMSFARAIESARLVFDQGLAMGF---P---MELLDIGGGYPGD------RGFQKLFDKITQTINGSLALHFPEET----GVRVISEPGRFFVASAFTLYTTVIAKREVLLPGSAL------PRAMYYLNDGVYGSFNCTVFDHAEPVPFALRGG------GPLRPCSLWGPTCDSMDQILEEALLPD--LGVGDWVVFENMGAYTLCASSNFNGFQVPEVKYALTYASIAYLREFPFWEHLSR

Rhipicephalus_appendiculatus_ODC ------MKTCEVVDPMVGSVSMVRSITSNPDNDQPFFVVDVGDILYKVKLWKLKIPRVEPFYA--VKCNGDPAVLELLAGLGLG-FDCASKAEIDTIRALG------VASNRIIYANPCKTRSFIKHAASVGVDLMTFD------NELELY---KVRELYPVARLVLRLRVD-DSGSVCKLG-----LKFGCELD-DAPHLLS-VARKLGLSVVGVSFHVGSNSH-EPQSFARAIESARQVFDQGLALGF---P---MTLLDIGGGYPGD------RGFQKLFDQIAYTINTSLAEHFPEES----GVRVISEPGRFFVSSAFTLYTTVIAKRESGD------RLMYYLNDGVYGSFNCTVFDHAEPVPFALNSSD------GPRRLCSLWGPTCDSMDLVLEDALLPE--LQTGDWVVFENMGAYTLCAASNFNGFQSPEVKYTLTYPTMVQLQGMSFWNNLAR

Aplysia_californica_ODC ---MKTSPQNESCVETLADAPNVAALVKEKIEELDAQGCDEAFFIADLGDVVGKFVKWKELLPRVEPFYA--VKCNQDETVVKLLAELGMG-FDCASKAEISQVVKMG------VSPSRIIYANPCKQKSFLKYAHKQSVDLMTFD------NEAELI---KIKALYPSARLVLRLLPTSHFKVQCELG-----NKFGCHPD-NVGKLLA-QAQELDLNVMGISFHVGSGVE-EAAAFSCAVKQAYEAWNMAQAYGF---E---MTLLDIGGGFPGQ------KSAPVTFEEIASVLNQALDMYFPKGSG----VRIIAEPGRYFVASAFTLAVNIIAKRTVARDISDNGGASVDG------HHQQNVTRNDEPSHMYYVNDGVYGSFNSLMYDHAQVEASVLE------DPD-APQFSSSVWGPTCDGLDCILEDCHLPE--MEVGQWMYFRDMGAYTMCAGSTFNGMPRPACFYFCRSSVWREVNGEPVAKRRCE

Crassostrea_virginica_ODCx ---MKKYLGNNCTVQMITYERSIKSLVQEKAALHDHEQREEAFFIGDLGDIVTKYQVWKDTLPRVTPFYA--VKCNDDYAVLKLLADMGTN-FDCASKAEIMKVLDLG------VDPSRIIYANPCKQNSFIKYAAKKNVAMMTFD------NEDELH---KVKALFPDAKLVLRILPTSNFKVQCELG-----NKYGCHPD-KARHLLE-AARNLGLNVMGVSFHVGSGCE-EAEAFAVAIQQARTVFDLALDMGF---N---MTLLDIGGGFPGQ------QSAPIPFSEIAHVVSEALDQYFPASEG----VDIIAEPGRYFVASAFTLTVNIIAKRVVTKEKTND------DDPMNNQGPAMMYYVNDGVYGSFNCLLFDHAKVEVSTLQ------ESE-ERPYSSSVWGPTCDGLDCILEDCPLPE--LRVGQWLFFRDMGAYTM------

Lottia_gigantea_ODC MMLAMSKINNFIELIPHCTSNIIRSLVEKKTACYDVELKEDAFFIGDLGDIISKYKTWCELLPRIEPFYA--VKCNPDPVILQLLAHLGTS-FDCASKDEIESVLKLG------VSPTRIVYANPCKQKSFIRYAAKHKVKMMTFD------NEVELD---KIKLLYPDAHLIIRILPPSNFKVQCDLG-----LKFGCHPN-KAIDLLE-KAKFLGLNVKGVSFHVGSGAE-EVEAFSAAVKEAYNVFQMGLELGH---D---MTILDVGGGFPGQ------KTAPICFEEVAMVLNEALDEYFPPESG----VRIIAEPGRYFVASAFTLTANVIAKRMVSRDNKNADG------CVEQCVGKDDEPAYMYYLNDGVYGSFNCLLFDHSHVAPSLLK------TTRNKIEFTSSVWGPTCDSIDLILEDYLLPE--LHVGEWIYFEDMGAYTMCASSTFNGMPKPKCFFYCQEDQWLNTGLQIELEAVPK

Helobdella_robusta_ODC SSASSSSSPVINETMYTNFDNDLSEVVCDKIKITETEDNFDAFYVADMGDIVRKHKIWKALLPRVQPFYA--VPCNDNAEVLKVLAKLGTG-FDCASKGEIQKVLDLG------VSSDRIIYANPCKQSSHIKYAARHHVEFMTFD------NETELL---KVKEYHPNAKLVVRILPPASDKCQCELG-----MKFGCHPK-HVAKLLQ-LAKKLELDVIGVSFHVGSGCY-DSNAYLSAVKSAHEVFSVAHSEGF---Q---FNLLDIGGGFPGQ------PNAKLSFNEIVDVLKPALDALFPEESG----VQIIAEPGRFFVASAFTLAVSVISSRQVPSEIQG------GEPSYMHYVNDGVYGSFNCILFDHAEVEALLPEL------KKYEDQPLYQCSLWGPTCDGLDCIIKDCRLPC--LTTGDWLVFKDMGAYTMSAASCFNGMPKPKCYYFMKNVVMELLNGDVHDIVCCS

Tubifex_tubifex_ODC ------MNNKVNARGRIDKHDAFFVGDMGDVVKKYKTWIAQLPRVEPFYA--VKCNDDPAVLAVLAQLGTG-FDCASKAEIQKVLDLK------VEPSRIIYANPCKQSSFIQYAAKHDVELMTFD------NETELH---KVKANHPNAKMVVRILPPVTDKCIAPLG-----MKFGCHPK-QVPRLLQ-VAKELDVDVVGVSFHVGSGCY-DASAYSAAVMSARVVFDMAEKEGF---H---FDLLDIGGGFPGQ------TSVKLSFDEIVDVLRPALDLYFPEQSG----VRIIAEPGRFFVASAFTVAVNIIATRTVTVEPNPEEFD------ADSDVGEQMFMYYVNDGVYGSFNCILFDHMPVTATLLEP------ERMVNEPQYKCSIWGPTCDGLDCIVKECLMPR--LETSEWMIFRDMGAYTMSAASCFNGMPKPKCYYVIQEHDWHILNNTVNQALPPM

Capitella_ODC ---MKQNLKNTKLNVELTKDIINENFISAKINSRGREDKDDAFFIADLSDIVRKYKTWKRELPRVEPFYA--VKCNDNAGVLSVLAELGTG-FDCASKAEVSKIMGLK------VSPSRVIYANPCKQSSHIRYAAKNDVALMTFD------NISELH---KVKANHPNAKLVVRILPPDGTKAQCELG-----MKFGAHPK-DVPKLLK-TAKDLGLNVVGVSFHVGSGCY-DPTAFPAAVASARAVFDMGETAGF---H---FDLLDIGGGFPGQ------KSAKISFEAICGPLRSALDAYFPESKG----VRIIAEPGRFFVASAFTLAVNIIAKRAVVGEEIADDYT------SSGD-VEPKFMYYVNDGVYGSFNCLLFDHAEVVPQLVHA------EEYADEPLFTCSIWGPTCDGIDCISDETQLPE--MFSGDWLIFRDMGAYTMCAASSFNGMPKPRSYYVMQDSAWVQMQQHMNDVEMRP

Branchiostoma_floridae_ODC1 --MKTHIMNKDLSMEVLRDGLTARDVLTNKVNSGGRDDKDDAFFVCDLGDVVNKYKKWVSCLPRVEPFYA--VKCNDSPHVLQVLANLGTG-FDCASKTEVQTVLNLG------VAPDRIVYANPCKQTSHIRYAMKNSVDLMTFD------NEDELH---KIKNYFPDARLLLRILPP-AAEAQCQLG-----MKFGCHPS-QAPKLLE-VAAQLDLNVVGVSFHVGSGCL-EASAFARGVESAKRIFNIADQYGF---D---FDMLDIGGGFPGQ------ESAAISFDEIVADLGPALDEHFPPASG----VRIIAEPGRYFVASAFTVAVNIVAKRMVARDIQEFKDEEAEDAV------MNSVAPSMCEEPAFMYYVNDGVYGSFNCLLYDHAAVTPSLMR------DVDKEEALFSTSVWGPTCDGLDRIMEHCLLPE--LQVGDWILFEDMGAYTMAAASTFNGFSKPSCYYVVDANMWSSNNHAFIQSECYT

Paracentrotus_lividus_ODC -MESLNVESFKTELIDSSKVTLKDVIVSKINDPSLREDADDAFFIGDLGDVIQKHRKWLRNLPRVEPHYA--VKCNPDPHVLKLLAGLNIG-FDCASKNEIQQVLQIG------VCPSRIIFANPCKQRSHLKYAAQSDVRLMTFD------NESELL---KVKKTFPEAKLVLRILTD-DSTAQCQLG-----LKFGCHPL-HAPALLR-TAQDLGLDVVGVSFHVGSGCR-DPMTYIESIRNAKEIFDFGQELGF---K---MNLLDIGGGFPGQ------DSAPIKFEEFATVINQALSEHFPVGCG----VRVIAEPGRFYVASAFTLVVNITAKRMVARDIPTFKVPESEDIV------ANTVAPSKCDEPAYMYYVNDGVYGSFNCLLFDHAEVQPTLLK------ERDSDVQMYSTSVWGPSCDGIDRILENSLLPE--LEVGEWIIFQDMGAYTMCASSEFNGFKRPLGYFIISKEYLPIVERITGPPKP-R

Strongylocentrotus_purpuratus_ODC1 -MEQLSADSFRTELYDSSEMTLKDIIESKIKDPTMREDADDAFFIGDLGDIIQKHRKWLRNLPRVEPHYA--VKCNPDLHVLKLLSGLNLG-FDCASKNEIQQVLKIG------VSPSRIIFANPCKQRSHLKYAADNDVRLMTID------NEAELI---KIKKIFPHAKLVLRILTD-DSTAQCQLG-----LKFGCHPR-HAPALLR-FAQDLELDVVGVSFHVGSGCR-DPMTYVDSIRNSKELFDFGNDLGF---K---MNLLDIGGGFPGQ------ESAPIKFEEFATVINQALAENFPVGCG----VRVIAEPGRFYVASAFTLAVNITAKRMVARDVPTYQVPESKDLV------ANTVAPSKCDEPAFMYYVNDGVYGSFNCLLFDHAEVEAQLLK------ERDGDVQMYSTSVWGPSCDGIDRIIENHLMPE--LEVGEWLIFQDMGAYTMCASSEFNGFKRSIGYFIISKEYLSIVEQITGKPKPPR

Saccoglossus_kowalevskii_ODC MFTKMNVIGKDIVVDVVDDCTKPCDVISKIAVIHDLEEKDDAFFVMDFGDIVNKFEKWEALLPRVHPFYA--VKCNENPAVLRLLAALGTG-FDCASKSEIKEITDMG------VSPSRIVYANPCKPNSHLKFAAQRKVSLMTFD------NEMELQ---KIRKIYPDAELVLRILTD-DSTAQCQLG-----LKYGCHPQ-HAPSLLR-VAKELGLNVVGVSFHVGSGCR-DASAFSDAIQSSRMVFDYGSALGF---D---FQLLDIGGGYPGQ------SSAAISFEEMAGCINQALDVHFPEGCG----VRIISEPGRYFVASAFTLTLNVIAKRAVARDIQTFHVPGSEDLV------ANTVAPSQCDEPAYMYYCNDGVYGSFNCLLFDHATVQPSLLK------KMLLGEPKFASSLWGPSCDGLDRIMENCLLPE--LHVGDWIVFEDMGAYTMCAASTFNGFPKPICYYMANESTWNFLKRIMPCPVEME

Nematostella_vectensis --MMKQSIGTDLAIEIVKDGLSHRDVITEKIDSLGREEKDDAFYIVDLADVVLKHKKWVQLLPRVEPFYA--MKCNNDPAVLKLLAGLGLG-FDCASKGEIQTILGLG------VSPKKIVYANPCKQASHIKYASQHDVAMTTFD------NEMELH---KIKKLYPDAQLILRIRTD-DSKSLCQLG-----IKFGAPLK-QCRHLLK-VAQDLGLNVVGVSFHVGSGCF-DASAYATAVIAARSVFNLAVQFGF---N---CTLLDIGGGFPGD------PNAAITFEEICTTINPLLEEHFPPSSG----VRIIAEPGRYYSSSSFTLAVNVYSRREVQSSSVLAEDVT------APENNGNQGFMYYVNDGVYGSFNCLIFDHATVEAIPVK------ESSGQPLYQTSIWGPTCDSMDCITKNMMLPK--VEVGEWLFFKYMGAYTQSAASTFNGFKKPTKFYLCTEELWPVLKQVIDPCHIEY

Hydra_magnipapillata_ODC1 TMKLS-TVHKDSVINVCNDDFNMRDLLRLKTNSSGREYKDDPFYICNLDDVVRKYWKFQEHLPQVQPFFA--VKCNPDPVIIALLAYLGVN-FDCASKGEIKAVLDLG------VDPERIIFANPCKQNSFIKYANEKNVKKMTFD------NEAELY---KIKQHFPDAELVIRLKVD-DSKSSCQFG-----IKFGATLE-SAEKLLN-IAKELGLNVIGVSFHVGSGCY-DASLYYDAVKLSATVFEQAENLGF---N---FTLLDIGGGFPGV------EGGKISFELTASQLNLGIEKFFPPERN----VRIIAEPGRYFVASAFTLTCNVTSIREVSTNKNS------PPGFMYYLNDGVYGSFNCILFDHQSPTPLTLH------ETDHCPRYKCSLWGPTCDSMDCISKDSYLPK--LMIGDWLYFENMGAYTIAPSIKFNGFKPPVVFYMCTQSMYEESMSPSDVVASVK

Hydra_magnipapillata_ODC2/AZIK SLKLSNDFLSESYIDICNDNFNMKQYIRFKVNANDREYNDDPFYVCDIDDIVKKHWMFQNLLPQIKPFYA--IKCNPDPVVIALLAHLGVN-FDCASKCEIKAVLDLG------VDPDRIIFANPCKQASYIKYANEKNVKKMTFD------NEAELY---KIKEHFPGAELVIRIKVD-DSKSIYKLG-----RKFGASLE-STQKLLH-IAKDLDLNVIGVSFHVGTGCY-DASLFYSAVKSAAAVFNQGEILGY---N---FTLLDIGGGFPGV------KNGKISMDNIAAQLNLSIAEFFPPEMN----LSIIAEPGKYFVESAFTLCCNVTSVRKVVDDKK------TEFMYYLNDGVYNSFLCVLFSEKFKP-LPLN------DSKTHLLFKSSVWGPTCDSCDCISEETYLPK--LSIGGWLYFENMGAYATCLATKFNGFNPPIIYYACTESIYKDLSNGKANLMQCR

Ciona_intestinalis_ODC1 ---MKQDCSVETSAVEIYPTINTSEIIASKILNDGREDHDNGFFICDLGDVMKKYIRWQKNFPRVIPHYA--IKCNPDEILLKMLIGLGTG-FDCASKSEIRQMLALG------ARPEQIIFANPCKQASHVRYARDNNVKRIVFD------NVEELI---KMKKNFPTADLVLRIQTD-DSQSICRFS-----MKYGAHPD-VCKQLLD-TAHKMNLNVVGISFHVGSGCQ-DVQAFVKALQNARVLFDYAECIGY---K---LNLLDIGGGFPGT------EDVNLKFEEIASVVNMTLKELFPMEEFP--HVDVIAEPGRYFAASAYTLASNIIAKREVMRDVTEETVCEQTGHTDTIENRSSPTRCD------EPAYMYYINDGLYGSFNCLFYDHAHVTPKLLK------EPSEIDMLYSSSVWGPTCDGLDRICELVQLPQ--LDVGNWILWEDMGAYTMAAGSSFNGFKTSKVYYVISDLENNLLQDQIAKKELPG

Monosiga_ovata_ODC -----MKKACSVPYIPTHGTDKESIKKSIQRIVDKNVTQNEPFLIVDLGNVYRKHKQWQRMLPRAQPFYA--VKCCNEPRIVEALVSLGLS-FDCASKGEIEQVMKLG------VPASKIIFANPAKSISHIRYAREVGVDLMTFD------NEIELL---KIKEHHPDARMVLRILAD-DPTAVCQFG-----IKFGIAPS-QAFGVLQ-SAKAMGINVVGVSFHVGSGCQ-NPDAFHDAVAAARRVFNEAATLGF---E---FSLLDVGGGFPGH------DNARISFKDITTVLNAALDKYFPEESG----VQIIGEPGRYYVASAGTLVTHIVAKRAVNRDG------ERHIMYYVNDGAYGSFNCLLYDHATVTPIALN------EPSDSSTLVRSSFWGPTCDSLDLLVKSIDFPE--VHIGDWIIWDDMGAYTIAAGSCFNGFQRPMPIYTFSSTEFFDDSEVPEDYPVTP

Batrachochytrium_dendrobatidis_ODC FKAINKLGTNATPAVTTDTRSISEIIQSRVTLDKSHPDSENPFFVADLGDVVRQHQQWKALLPRVEPFYA--IKCNPDPAILQTLAALGTG-FDCASKAEIDMVLEQG------VDPSRIIYANPCKQASHIRHAGACNVKVMTFD------NADELY---KIKQAMPSAKMVLRILTD-DSRSVCRFG-----IKFGASLA-AVPSLLR-TARELDIDVIGISFHVGSGCY-DASAFSEAVLLARKAFDIGQALDF---N---FTLLDIGGGFPGR------STEGIQFTDVARLLRPVIDDNFPETVR------VIAEPGRYFASSAFTLAVNIFARRVVLRDTIESTTASSEFGKDSPTTVSSQLSLDSECNPTNANEHPSYMYYINDGMYGSFNCLTFDHAVVKAIPLVRQGE------YLFDSPEVSDSMPQFSCSIWGPTCDSIDCIGRECLLPM--MKIGDWLYFSNMGAYTMAAASAFNGFEKSTVLYTTTN------

Coccidioides_immitis_ODC1 HGG--PELSHAREASKELILDILQKKAASIDVQNCCPGEEDPFYVADLGEVYRQHIRWKMNLGRVKPFY--AVKCNPDPQVLRLMAHLGNG-FDCASKAEIDYVLAAG------VDPSRIIYAHPCKTKSYLRYAAQQGVKQMTFD------NADELY---KIKTMCPDAELFLRILTD-DSASLCRLS-----MKFGASLT-VTRSLLE-LAKDLGLNVVGVSFHVGSGAE-DPTAFVKAVEDARFVFDQASDIG------HDLKVLDVGGGFCD------ETFERFAAALSDALDTYFPPH------IRVIAEPGRYYVASAFTLAANVIARRDVSPAASDSDSATG------PAEMYMIYLNDGVYGNFSNIVFDHQHPVAQILT------KDD------MASTH------PVEYSIWGPTCDGIDVISKRVTLNG-VLGVGNWLYFENMGAYTQCSATRFNGFTDKHDIIYISTEPSAAALMGY------

Coccidioides_posadasii_ODC1 HGG--PELSHAREASKELILDILQKKAASIDVQNCCPGEEDPFYVADLGEVYRQHIRWKMNLGRVKPFY--AVKCNPDPQVLRLMAHLGNG-FDCASKAEIDYVLAAG------VDPSRIIYAHPCKTKSYLRYAAQQGVKQMTFD------NADELY---KIKTMCPDAELFLRILTD-DSASLCRLS-----MKFGASLT-VTRSLLE-LAKDLGLNVVGVSFHVGSGAE-DPTAFVKAVEDARFVFDQASDIG------HDLKVLDVGGGFCD------ETFERFAAALSDALDTYFPPH------IRVIAEPGRYYVASAFTLAANVIARRDVSPAASDSDSASG------PAEMYMIYLNDGVYGNFSNIVFDHQHPVAQILT------KDD------MASTH------PVEYSIWGPTCDGIDVISKRVTLNG-VLGVGNWLYFENMGAYTQCSATRFNGFTDKHDIIYISTEPSAAALMGY------

Uncinocarpus_reesii_ODC1 HGG--LELLHAREASKELILNILRNKAASIDVQNCCPGEEDPFYVADLGEIYRQHVRWKMNLGRVKPFY--AVKCNPDPQVLRLMAHLGNG-FDCASKAEIDYALDAG------VDPSRIIYAHPCKTKSYLRYAAQQGVKQMTFD------NADELY---KIKAMCPDAELFLRILTD-DSASLCRLS-----MKFGASLT-VTRSLLE-LAKELDLNVVGVSFHVGSGAE-DPKAFVKAVEDARFVFDQASDIG------HDLKVLDVGGGFCD------ETFEHFAAALSDALDTYFPPH------IRVIAEPGRYYVASAFTLAANVIARRDVSPSASDSDSSTG------PAEMYMIYLNDGVYGNFSNIVFDHQHPVAQILT------KDD------ITSTH------PVEYSIWGPTCDGIDVISERITLNG-VLGVGNWLYFENMGAYTRCSATRFNGFADNHDIIYISTEPSAAALLGY------

Ajellomyces_capsulatus_ODC1 HGG--FDLFQAREASKDLIFEILKEKVAKIDIHNCHPGEEDPFYIADLGQVYRQHVRWKKNLGRVKPFY--AVKCNPDPQVLRLMANLGNG-FDCASKAEIDCALGAG------VDPSRIIYAQPCKTKSYLRYASQVGVKQMTFD------NSDELY---KIKEMCPEAELYLRILTD-DSASLCRLS-----MKFGASLS-ITRSLLE-LAKELKLNVIGVSFHVGSGAE-DPRSFVKAVEDSRYVFDQAAEVG------FDLKVLDVGGGFSE------DTFERFASTLGDALDEHFPPH------IRVIAEPGRYYVASAFTLAANVIARRDVSLEMSDSDSTSS------ATEAYMIYLNDGVYGNFSNIIFDHQHPVPQILT------MES------PVCTP------IEYSIWGPTCDGIDLITQRITLPG-ALDIGNWLYFENMGAYTKCSATCFNGFTDKHEVIYISTEPSATALLGYSD-----

Aspergillus_fumigatus_ODC HGG--DDLSQSRLAAKNLVLDVLKKRAAEVDVDRCGPGEEDAFYVADMGEIYRQHLRWKMNLGRVKPFY--AVKCNPDPEILRLMAKLGNG-FDCASKAEIDLALETG------IDPSRIIYAQPCKTKSYLRYAAKVGVKQMTFD------NADELY---KIKACYPDAELYLRILTD-DSTSLCRLS-----MKFGASLD-IARQLLE-LAHELELKVVGVSFHVGSGAE-DPRAFLKAVQDARLVFDQAAEVG------HELHTLDVGGGFCQ------DTFEKFAGILSEALDTYFPPH------IRVIAEPGRYYVASAFTLAANVIARRDVRDPKDP------ANDTYMLYLNDGVYGNFSNIIFDHQHPVAKILTCSGE---TQP-SALN------AATSE------GIAYSIWGPTCDGIDVITQRIVLPG-LLDVGDWLYFEEMGAYTKCSATRFNGFSDNHEVIYISSEAGATALLEY------

Neosartorya_fischeri_ODC1 HGG--DDLSQSRLAAKNLVLDVLRKRAAEVDVDRCGPGEEDAFYVADMGEIYRQHLRWKMNLGRVKPFY--AVKCNPDPEILRLMAKLGNG-FDCASKAEIDLALETG------IDPSRIIYAQPCKTKSYLRYAAKVGVKQMTFD------NADELY---KIKACYPDAELYLRILTD-DSTSLCRLS-----MKFGASLD-IARQLLE-LAHELELKVVGVSFHVGSGAE-DPRAFLKAVQDARLVFDQAAEVG------HELHTLDVGGGFCQ------DTFEKFAGILSEALDTYFPPH------IRVIAEPGRYYVASAFTLAANVIARRDVRDPEDP------ANDAYMLYLNDGVYGNFSNIIFDHQHPVAKILTCSGE---TQP-SALN------AATSE------GIAYSIWGPTCDGIDVITQRIVLPG-LLDVGDWLYFEEMGAYTKCSATRFNGFSDNHEVIYISSEAGATALLEY------

Aspergillus_clavatus_ODC1 HGE--DDLSQSRLAAKDMVLDILKKRAVEVDVDRCEPGEEDAFYVADMGEIYRQHLRWKMNLSRVKPFY--AVKCNPDPEILRLMAKLGNG-FDCASKSEIDLALETG------IDPSRIIYAQPCKTKSYLRYAAQVGVRQMTFD------NADELY---KIKACFPDAELYLRILTD-DSTSLCRLS-----MKFGASLD-IARQLLE-LAAELELKVVGVSFHVGSGAE-DPRAFLKAVQDARLVFDQAAEVG------HELHTLDVGGGFSQ------DTFETFAGILGEALDTYFPPH------IRIIAEPGRYYVASALTLAANVIARRDLRDPEDP------ANDAYMLYLNDGVYGNFSNIIFDHQHPVAKILTRSGG---PQP-IAPN------AATSE------GIAYSIWGPTCDGIDVITQRIVLPG-LLDVGDWLYFEEMGAYTKCSATRFNGFSDNHEVIYISSEPGATALLEY------

Aspergillus_flavus_ODC1 GG---DDLSQSRLAAKDLVMDVLKKRAGEVNTDRCAPGDEDAFYVADMGEVYRQHLRWKMNLSRVRPFY--AVKCNPDPEILRLMAKLGNG-FDCASKAEIDMALDTG------IDPSRIIYAQPCKTKSYLRYAAQMGVKQMTFD------NADELY---KIKACFPDAELYLRILTD-DSTSLCRLS-----MKFGASLD-IARQLLE-LAHELELKVVGVSFHVGSGAE-DPTAFVKAVQDARMVFDQAAEIG------HELHTLDVGGGFSG------DTFEKFAGVLSEALDTYFPPH------IRVIAEPGRYYVATAFTLAANVIARRDVRDPEDP------ANDAYMIYLNDGVYGNFSNIIFDHQHPVAQILTCAN------ASN------AATSA------GIAYSIWGPTCDGIDVISQRITLPG-LLDVGDWLFFEEMGAYTKCSATRFNGFSDNHEVIYISSEAGASALLEY------

Aspergillus_terreus_ODC1 GE---DDLSQSTLAAKDLVLNVLKKRAAEVNVDQCGPGEEDAFYVADMGEVYRQHMRWKMNLGRVRPFY--AVKCNPDPEILRLMAKLGNG-FDCASKAEIDLALATG------VDPARIIYAQPCKTKSYLRYAAQKGVKQMTFD------NADELY---KIKACFPDAELYLRILTD-DSTSLCRLS-----MKFGASLD-VAHQLLE-LARDLELKVVGVSFHVGSGAE-DPSAFLKAVQDARLVFDQAADLG------HELHTLDVGGGFTG------ETFEKFAGVLSEALDTYFPPH------VRIIAEPGRYYVASAFTLAANVIARRDVRDPEDP------NNDAYMIYLNDGVYGNFSNIIFDHQHPVAQILTCAN------GPN------AATSG------IAYSIWGPTCDGIDVITQRITLPG-LLDVGDWLFFEEMGAYTRCSATRFNGFSDNHEVIYISSEAGASALLEY------

Aspergillus_nidulans_ODC1 HGA--DDLSQSRLAAKDLVLNVLKKRAAEVDTDRCAPGEEDAFYVADMGEVYRQHLRWKMNLSRVRPFYELAVKCNPDPEVLRLMAKLGNG-FDCASKAEIDMALSTG------VDPSRIIYAQPCKTKSYLRHAAKVGVKQMTFD------NADELY---KIKACYPEAELYLRILTD-DSNSLCQFS-----MKFGASLD-VARQLLE-LAHQLELKIVGVSFHVGSGAE-DPKAFLKAVQDARLVFDQAAEIG------HELHTLDVGGGFTG------ETFEKFAAVLDSALETYFPPN------IRIIAEPGRYYVGGAFTLAANIIARRGVQDPENP------SKDAYMIYLNDGVYGNFSNIIFDHQHPEARILSCAS------EING------RPVSE------DVTYSIWGPTCDGIDVISQRSVLPG-LLDVGDWLYFEEMGAYTRCSATRFNGFSDNHEVIYISSEAGASALLEY------

Penicillium_marneffei_ODC1 HGINDALVLRGHSSPKEMILGELKKRIDSIDIAGCEPGEEDAFYVADMGEVYRQHMRWKMNLGRIKPFY--AVKCNPDPEVLRLMAKLGLG-FDCASKTEIDLALKTG------IDSSRIIYAQPCKTRSYLRYARQKGVKQMTFD------NTDELY---KIKNDFPDAELYLRILTD-DSTSLCRLS-----MKFGASLD-TARPLLD-LAKKLELNVVGVSFHVGSGAE-DPGAFLKAAQDARWVFDQAAEVG------YELHTLDVGGGFCD------NTFEKFAAILSKAVDDLFPAH------VRIIAEPGRYYVAAAFTLAANVIARRDVFDPQN------SSGSYMIYLNDGVYGNFSNIIFDHQHPVAQILTCSST---PDPSAGDS------PCAPA------GVEYSIWGPTCDGIDVISQQIVLPG-LVDVGDWLYFEDMGAYTRCSATRFNGFPDNHNVIYISSESGASALLEY------

Talaromyces_stipitatus_ODC1 HGVNDALVLRGHSSPKEMILSELKKRVSRIDIAGCEPGEEDAFYVADMGEVYRQHMRWKLNLGRVKPFY--AVKCNPDPEVLRLMAQLGNG-FDCASKTEIDLALKTG------IDPSRIIYAQPCKTRSYLRYARQKGVKQMTFD------NADELY---KIKNDFPDAELYLRILTD-DSTSLCRLS-----MKFGASLD-TARPLLD-LAKKLELNVVGVSFHVGSGAE-DPGAFLKAAQDARWVFDQAAEVG------YELHTLDVGGGFCD------ETFEKFAAILSKAVDDLFPPN------IRIIAEPGRYYVAAAFTLAANVIARRDVLDPQA------SSGSYMIYLNDGVYGNFSNIIFDHQHPVAQILTYTVF---RRWFPMRI------SRRNR------IQHLGTNL------

Botryotinia_fuckeliana_ODC1 ---DSYIEVNGVNPAKTIIGNALKQRVENIDNDVCEADDEDAFFVADLGEVYRQHMRWKKNLPRVKPFYA--VKCNPDPQVIRLLAELGTG-FDCASKGEIEQVLKAG------IDPTRIIYAQPCKTNSYVRYAEKNGVKQMTFD------NSDELY---KIKKLFPGAELFLRISTD-DSSSLCRLS-----LKFGAAMD-ATNNLLA-LARELDLNVVGVSFHVGSGAS-DPLAFRKAVQDAHTVFEQARNFG------YYMHTLDVGGGFC-T------ETFEVMASVLSDALEEYMPKN------IKIIGEPGRYYVANAFTLACNVIARRTVEDPESLEKS------YMLYLNDGLYGNFSSIMFDHQNPIAQVLQTGNRSYFNTLES-CA------TLEG------TEYSIWGPTCDGIDRISASIRFNH-NLDVGDWLYFESMGAYTKCSATRFNGFTDSHDVIYVSSEPGVNALLEM------

Sclerotinia_sclerotiorum_ODC ---DAYIDLNGVNTPKNIIGNALKQRVENIDNDACEAGDEDAFFVADLGEVYRQHMRWKRNLPRVKPFYA--VKCNPDPQVIRLLAELGTG-FDCASKGEIEQILKTG------IDPARIIYAQPCKTNSYVRYAAKQGVKQMTFD------NSDELH---KIKKLFPGAELFLRISTD-DSSSLCQLS-----LKFGATMD-TTSDLLA-LARELDLNVVGVSFHVGSGAS-DPLAFREAVQDAHTVFEQARTYG------YYMHTLDVGGGFC-S------ETFEKMAAALNDALEEYMPKN------IKIIGEPGRYYVANAFTLACNVIARRTVEDPVSTEKS------YMLYLNDGLYGNFSSIMFDHQNPIAQVLRTGKRSYFDTLAS-QA------TLGG------TEYSIWGPTCDGIDRISASIRFDH-NLDVGDWLYFEGMGAYTKCSATRFNGFTDSHDVIHVSSEPGVNALLGM------

Botryotinia_fuckeliana_ODC3 ---GSYIELNGANISKNVIGNALKQRVESIDHNICEAGEEDSFFVVDLGEVYRQHMRWKKNLPRVKPFYA--VKCNPDPQVIRLLAELGTG-FDCASKGEIEQVLKMG------IDPNYIIYAQPCKTSSYIRYAADQGIKQMTFD------NGDELY---KIKKLFPDAELFLRISTD-DSSSLSPLS-----LKFGAAMN-ATNDLLA-LAKSLGLNIVGVSFHVGSGAS-DPLAFRKAVQDAHSVFEQALTHG------YHLHTLDIGGGFC-T------EIFELMTDTLSKALDEFMPSH------INIIGEPGRYYVSKAFTLACNIIARRTIKDPVSSDKS------YMLYLNDGLYGNFSGIVFDHRNPVARVLRAGSFTCFDSLTN-QE------TVDG------IQYSIWGPTCDGIDRISANICFDH-NLDVGDWLYFEDMGAYTKCCVTRFNGFTDNHDVIYVSSEPGTRALLGI------

Oculimacula_yallundae_ODC1 SFVEPEVNNHGVNNPKKLIGDALKERIENIDQDACEPGDEDAFFVADLGEVYRQHMRWKLNLPRVKPFYA--VKCNPDNRVIQLLAALGTG-FDCASKAEIEQVIKAD------VDPSRIIYAQPCKTNSYVRYAANHNVKQMTFD------NADELH---KVKKLFPGAELFLRISTD-DSSSLCRLS-----LKFGAAMD-TTDGLLA-LAKELDLNVVGVSFHVGSGAS-DPLAYMRAVQDARLVFDQAAAHG------FSLHTLDIGGGFV-S------ESFEAMASVLCEALDTYMPSH------INIIGEPGRYYVSSAFSVACHIIARRTIVEPASSEKS------YMIYLNDGLYGNFSSIMFDHQNPIAQVLRTGDRTYFNNIAA-QD------SVDG------TEYSIWGPTCDGIDRISESIRFDH-TLDVGDWLYFEEMGAYTKCSATRFNGFSDAHEVIYVASEPGARALLGMN------

Phaeosphaeria_nodorum_ODC1 -QTLGSVENHGAWKSKQLIGSALKSRVEAIDHDSCDVGDEDAFFIADLGEVYRQHLRWKKNLARVKPHYA--VKCNPDTQVLRLMSELGMG-FDCASKNEIETVLKLG------VDPARIIYAQPCKTKSYVRYAANSGVKQMTFD------NADELY---KTKQLFPDAELYLRILTD-DSGSLCRLS-----QKFGASLD-TTAELLE-LAHKLELNVVGVAFHVGSGAS-DPKAFIKAVQDARFVFDQAAAFG------FDMHTLDVGGGFTGD------ITFEPMAAVLSASLDEYFPPH------IRVIGEPGRYYVSTAFTIACHVIARRTVADATLGTTS------YMLYLNDGVYGNFSSIIFDHQHPVPRVLKSGNDVLYDVRTSGYD------TPSQ------VEYSIWGPTCDGIDIISSSCSFPE-LLDVGDWLYFEDMGAYTKCSATKFNGFTDSHDVVYVCSEPGAKALMGM------

Pyrenophora_tritici_ODC1 -YSASSVDNHGACYSKQLIGDALKSRVEAIDSDTCNVGEEDAFFIADLGEVYRQHLRWKTNLSRVKPHYA--VKCNPDPQVLRLMTALGLG-FDCASKNEIETVLNLG------VDPSRIIYAQPCKTKSYVRYAAQSGVKQMTFD------NADELY---KTKQLFPDAELYLRILTD-DSASLCRLS-----QKFGASLD-TTAELLE-LAKKLELNVVGVAFHVGSGAS-DPKAFIKAVQDARFVFDQAAALG------FNMHTLDVGGGFTGD------VTFEPMAAVLSAALDEYFPPH------IRVIGEPGRYYVSTAFTLACHVIARRTVNDATLGTTS------YMLYMNDGVYGNFSSIIFDHQHPVPRVLKNGNDVLYDVRRSGYD------TPSQ------VEYSIWGPTCDGIDVISSSCTFPE-LLDVGDWLYFEEMGAYTKCSATRFNGFSDSHDVVYVCSEAGAAALMGM------

Chaetomium_globosum_ODC1 GHHDDGDRLN---SAKQLIGDALRERVENVDHEFCEPGEEDTFFVADLGEVYRQHLRWKLNLPRVRPFYA--VKCNPDTRLLELLSALGTG-FDCASKSEIEQVLNLG------VDPSRIIYAQPCKTNSYVRYVAQKGVRQMTFD------NADELH---KIARLYPDAELFLRILTD-DSSSLCRLS-----LKFGASLD-STDSLLA-LASELGLNVVGVSFHVGSGAS-DPGAFLKAVRDAHEVFQQAASHG------FSLQTLDVGGGFCSD------NTFEQMAGVLRAALDEYFPAHL----GINLIAEPGRYYASTAFTLACNVIARRTIEDMSAAS------YMVYVNDGLYGNFSSIMFDHQHPIAKVLRSGGRTMYNTPAADAT------DDG------IEYSIWGPTCDGIDRITESIRFPR-LLDVGDWLYFEDMGAYTKCSATTFNGFTNSHDVIYVCSEPGAKALLGLD------

Podospora_anserina_ODC1 GEHHHHHEGP---TAKELIGNALRQRVESIDHEDCEPGEEDTFFVADLGEVYRQHLRWKMNLPRVKPFYA--VKCNPDPMLLKLLAALGNG-FDCASKAEIEQVLRMG------VDPSRIIYAQPCKTNSYVRYVAQQGVRAMTFD------NADELR---KIARFYPEAELYLRILTD-DTSSLCRLS-----MKFGASLD-STDGLLA-LARDLNLNVVGVSFHVGSGAS-DPSAFLKAVRDSHMVFQQAASYG------FSLKTLDVGGGFCAD------NTFEQMAGVLREALDEYFPAHS----GINLIAEPGRFYASAAYTLACNVIARRTIQDTALINNGTTT------PDPSYMLYVNDGLYGNFSSIMFDHQHPEAKVLRAGGQTLYDTPAANGM------DDRS------GVEYSIWGPTCDGIDRITESIRFPV-VLDVGDWLYFEDMGAYTKCSATTFNGFSNEHDVIYVCSEPGAKALLDL------

Neurospora_crassa_ODC1 HDDYLHGLANGKLVAKQMIGDALRQRVESIDSEFCEPGDEDTFFVADLGEVYRQHLRWKLNLPRVKPFYA--VKCHPDERLLQLLAALGTG-FDCASKAEIEQVLRMG------VDPSRIIYAQPCKTNSYLRYVAQQGVRQMTFD------NADELR---KIARLYPDAELFLRILTD-DSSSLCRFS-----MKFGASLD-STDGLLG-LARQLGLNVVGVSFHVGSGAS-DPTAFLKAVQDAHVVFQQAAAYG------YSLKTLDVGGGFCSD------DSFEQMANVLRAALDEYFPAHT----GVNLIAEPGRYYASSAFTLACNIIARRTIQDGSAVSVSDSSSMSDD------GSVNNGDARYMVYVNDGLYGNFSSIMFDHQHPVAKILRAGGRTMYNSVAAHES------SAED------AIEYSIWGPTCDGIDRITESIRFRE-ILDVGDWLYFEDMGAYTKCSATTFNGFSNEHDVIYVCSEPGAMALLGL------

Magnaporthe_grisea_ODC1 TPGFLDHHHNGELVSKAMIGGALRHRVESIDPEFCDAGDEDTFFVADLGHVYRQHLRWKKNLPRVKPFYA--VKCNPDPKVLRLLAELGNG-FDCASKTEIKQVLDMG------VDPSRIIYAQPCKTNSYVRYVAAEGVRQMTFD------NADELY---KIAKLFPEAELYLRILTD-DSSSLCRLS-----LKFGASLD-ATDGLLA-LARELGLNVVGVSFHVGSGAS-DPLAFLKAVRDANFVFEQAAAHG------FDMKTLDVGGGFCSD------DTFEAMAGVLRDALDEYFPPHR----GVSLIAEPGRYFVSAAFTIACNVIARRTVEDPNGSVNGSLAAAP------SYMVYVNDGLYGNFSSIMFDHQHPVAKVLRSSGNFFYNTTDADSP------ESPSE------GIEYSIWGPTCDGIDRISESVRFSQ-TIDVGDWLYFEDMGAYTKCSATRFNGFSDAHDVIYVCSEPAARAMMLNYI-----

Fusarium_oxysporum_ODC1 PLLQEPLEQYGVITPKQLIGQALHQRVEAIDHEMCEPGDEDTFFVADLGEVYRQHLRWKKNLPRVRPFYA--VKCNPDPQIIKLLSELGTG-FDCASKTEIEQVLSAG------LSPDRIIYAQPCKTNSYVRYVKSVGVKQMTFD------NADELY---KIAKLYPGAELFLRIMTD-DSESLCRFS-----MKFGAAMD-TTEGLLA-LAKDLGLNVVGVSFHVGSGAS-DPLAFYKAVRDAHTVFQLAHEFG------FNMRTLDVGGGFSG------DTFETMAAVLGDALDEFFPPHS----NIEIIAEPGRYYVATAFTIACNIIARRTVEDPTLDGKG------YMLYVNDGVYGNFSNIMFDHQQPIAKVLRASGKTLFETTAAHPT------PEGE------GFEYSVWGPTCDGIDRITESTRFDS-ILDVGDWLYFEDMGAYTKCSATQFNGFSNAHDVIYVCSEPGAKALLGL------

Gibberella_moniliformis_ODC1 PLLQESLEQYGVITPKQLIGQALHQRVEAIDHEMCEPGDEDTFFVADLGEVYRQHLRWKKNLPRVRPFYAPAVKCNPDPQIIKLLSELGTG-FDCASKTEIEQVLSAG------LSPDRIIYAQPCKTNSYVRYVKSVGVKQMTFD------NADELY---KIAKLYPGAELFLRIMTD-DSESLCRFS-----MKFGAAMD-TTEGLLA-LAKDLGLNVVGVSFHVGSGAS-DPLAFYKAVRDAHTVFQLAHEFG------FNMRTLDVGGGFSG------DTFETMAAVLGGALDEFFPPHS----NIEIIAEPGRYYVATAFTIACNIIARRTVEDPTLDGKG------YMLYVNDGVYGNFSNIMFDHQQPIAKVLRASGKTLFETTAAHPT------PEGE------GFEYSVWGPTCDGIDRITESTRFDS-ILDVGDWLYFEDMGAYTKCSATQFNGFSNAHDVIYVCSEPGAKALLGL------

Gibberella_zeae_ODC1 PIIRDSIEQHDVITPKQLIGQALHQRVEAIDHEMCEPGDEDTFFVADLGEVYRQHLRWKKNLPRVRPFYA--VKCNPDPQIIKLLSELGTG-FDCASKTEIEQVLSAG------LSPDRIIYAQPCKTNSYVRYVKSVGVKQMTFD------NADELY---KIAKLYPGAELFLRIMTD-DSESLCRFS-----MKFGAAMD-TTEGLLA-LAKDLGLNVVGVSFHVGSGAS-DPLAFFKAVRDAHTVFQQARDFG------FAMRTLDVGGGFCG------DTFEAMANVLRGALDEFFPPHS----GVEIIAEPGRYYVATAFTIACNIIARRTVEDPTLDGKG------YMLYVNDGVYGNFSNIMFDHQQPTAKILRTSGKTLFETAAAEPT------PVGE------GFEYSIWGPTCDGIDRITDSTRFDP-ILDVGDWLYFEDMGAYTKCSATQFNGFSNAHDVIYVCSEPGAKALLGL------

Trichoderma_reesei_ODC1 PQYLGALQHNVAVDPKQLIGEAFHQRVGAVNHELCDPGEEDTFFVADLGEVYRQHLRWKKNLPRIKPFYA--VKCNPDPKVLQLLAALGTG-FDCASKGEIEQVLGLG------VSPDHIIYAQPCKTNSYVRYVKSVGVKQMTFD------NADELH---KIAKLFPGAELFLRIMTD-DTSSLCRLS-----MKFGAPMD-TTESLLA-LAKELGLNIVGVSFHVGSGAS-DPAAFRKAVVDAHTVFQQALTYG------YHLRVLDVGGGFSG------ETFETMAGVLDDALAEYFPSGC----GVDIIAEPGRFYVATAFTIACNIIARRTVDDPSAQTTS------YMAYINDGVYGNFSSIMFDHQHPVAKILHAGGQTLYNTYAAEPC------PGDE------GVEYSIWGPTCDGIDLISQSTRFNR-ILDVGDWLYFENMGAYTKCSATQFNGFPNAHDTIYVYSESGAKALLDL------

Trichoderma_virens_ODC1 PQYLGALQNNVAIDPKQLIGEAFHQRVGAVDHELCDPGEEDTFFVADLGEVYRQHLRWKKNLPRIKPFYA--VKCNPDPRVLQLLAALGTG-FDCASKGEIEQVLGLG------TSPDHIIYAQPCKTNSYVRYVKSVGVKQMTFD------NADELH---KIAKLFPGAELFLRIMTD-DTSSLCRLS-----MKFGAPMD-TTESLLA-LAKELGLNVVGVSFHVGSGAS-DPAAFYKAVLDAHTVFQQARTYG------FHLRVLDVGGGFSG------ETFEKMAGVLDSALTEYFPSGC----GVDIIAEPGRFYVATAFTIACNIIARRTVDDPSVQTTS------YMAYINDGVYGNFSSIMFDHQHPVAKILHSGGQTLYDTYAAEPC------SPGD------GVEYSIWGPTCDGIDQISQSTHFQR-ILNVGDWLYFENMGAYTKCSATQFNGFPNSHDTIYVCSEPGAKALLDL------

Trichoderma_atroviride_ODC1 PQYLGALQNNVALDPKQLIGEAFRQRVGAVNHELCDPGEEDTFFVADLGEVYRQHLRWKRNLPRIKPFYA--VKCNPDPKVLQLLAALGTG-FDCASKGEIEQVLGLG------ASPDHIIYAQPCKTNSYVRYVKSVGVKQMTFD------NADELH---KIAKLFPGAELFLRIMTD-DTSSLCRLS-----MKFGAPMD-TTEGLLA-LAKELGLNVVGVSFHVGSGAS-DPSAFRKAVVDAHTVFQQARAYD------FHLKVLDVGGGFSG------DTFETMAAVLDNALTEYFPAGC----GVDIIAEPGRFYVATAFTIACNIIARRTVDDPAAQATS------YMAYINDGVYGNFSSIMFDHQHPVAKILHSSGQTLYNSYAAEQC------SVGN------GIEYSIWGPTCDGIDLISQSAFFPC-TLNVGDWLYFEDMGAYTKCSATQFNGFPNSHDTIYVCSEPGAKALMDL------

Ascosphaera_apis_ODC1 ADSKWKSDGSKSDLGERLVLSTMKERAARINTMTCQPGDEDPFYVADLGDVYRQYVRWIENLPRVRPYYA--VKCNPDKLVIGLLARLGIG-FDCASKNEVELALSTG------IDPSRIIYAQPCKTPSFLRYATEKGVLQMTFD------NIDELH---KIKDVCPDAQLFLRIFTD-DSAAACRLS-----VKFGAALS-ATSFLLK-TAHELGLNVVGVSFHVGSGAA-DPGAYLEAIQDARKVFDEARAIG------FQMKILDIGGGFSA------ETFDRFGKLISQALDTYFAPE------VEVIAEPGRYFVASAFTLAVNVIARRDPSPGMEHAEK------GQVMLYLNDGVYGNFSNIIFDHQMPVPRVLITR------ETEAT------PTEYSLWGPTCDGIDIVNKSVTLPV-RISVGDWLYFKDMGAYTACSRTKFNGFADNHEVIYISSEPINLGGGISRFIS---

Yarrowia_lipolytica_ODC VDEVSASIDQGLSESEKLIANAMKTRIEAIDLETCSPGSEDSFFVADLGIVYSQFMRWSNCLPRVTPFYA--MKCNGDPKVLQLLAALGTG-FDCASRNEIQTILDLG------VSQDRIIYAHPCKVASYIRYASSVGVEKMVFD------NAEELY---KCAKYHPTAKLFLRIVTD-DSQSLCQFS-----VKYGAALE-NTQSLLQ-LAKDLGLNVAGVSFHVGSGAG-DPNAFLDAVRNAKRVFDQGAAIG------MHLNTLDVGGGFSD------DSFESSAAVLGDALDKYFPEES----GVNLMAEPGRFFVSEAFTIASHVIARRIIENQNK------AMLYLNDGVYGNMNCILFDHQEPVPKVLTYQGKFMYG----ERY------QKQKS------SQDVSVWGPTCDGIDCISKSCQLPV-LLDVGDWMYFTSFGAYTVAASTTFNGFNSDCETLYVCSKKEVEQYIKL------

Saccharomyces_cerevisiae_ODC KNNQD-LELLPHEQAHPKIFQALKARIGRINNETCDPGEENSFFICDLGEVKRLFNNWVKELPRIKPFYA--VKCNPDTKVLSLLAELGVN-FDCASKVEIDRVLSMN------ISPDRIVYANPCKVASFIRYAASKNVMKSTFD------NVEELH---KIKKFHPESQLLLRIATD-DSTAQCRLS-----TKYGCEME-NVDVLLK-AIKELGLNLAGVSFHVGSGAS-DFTSLYKAVRDARTVFDKAANEYG---LP-PLKILDVGGGFQF------ESFKESTAVLRLALEEFFPV----GCGVDIIAEPGRYFVATAFTLASHVIAKRKLSEN------EAMIYTNDGVYGNMNCILFDHQEPHPRTLYHNLEFHYDDFESTTA------VLDSINKT-----RSEYPYKVSIWGPTCDGLDCIAKEYYMKH-DVIVGDWFYFPALGAYTSSAATQFNGFEQTADIVYIDSELD------

Saccharomyces_mikatae_ODC KNNPG-LKKLPHVQAHSAIFQALKSRIGKINNETCDPGEENSFFICDLGEIKRLFNNWMKELPRIKPFYA--VKCNPNAKILSLLAELGVN-FDCASKVEIDRVLSMN------ISPDRIIYANPCKVASFIRYAASKSVMKSTFD------NVEELY---KIKKFHPESQLLLRIATD-DSTAQCRLS-----TKYGCQMD-KVDSLLK-GIKELGLNLVGVSFHVGSGAS-DFTSLYKAVRDARTVFDKAANKYD---LP-PLKILDIGGGFQF------ESFKESTAILRLALEKYFPI----GCGVDIIAEPGRYFVATAFTLASHVIAKRRLSEN------EAMIYTNDGVYGNMNCILFDHQEPHPKTLYHGSQFHYNDFESTTA------TLDSINKT-----RAEYPYKVSIWGPTCDGLDCISKEYYMKH-DVVVGDWFYFPDLGAYTSSAATQFNGFDQTADILYIDSEFD------

Saccharomyces_bayanus_ODC KNNPD-SGILPHDQSHAEIFQALKTRIGKINNETCDPGEESSFFICDLGEIKRLYYNWVKELPRIKPFYA--VKCNPNPEVLSLLAELGAN-FDCASKVEIDRALAIG------ISPDRIIYANPCKVASFIRYAASRNVMKSTFD------NVEELY---KIKQFHPESQLLLRIATD-DSTAQCRLS-----AKYGCEMD-KVDSLLE-CIKELGLNLAGVSFHVGSGAS-DFTSLYKAVRDARTVFEKAANKYN---LP-PLNILDIGGGFQF------ESFKESTAVLRLALDEFFPV----GCGVDLIAEPGRYFVATAFTLATHIIAKRKLSEK------EAMIYTNDGVYGNMNCILFDHQAPHPRTLYHDSKFYYDDFESTSA------DLDPVNKT-----RATYPYKVSIWGPTCDGLDCIAKEYYMKH-DVVVGDWFYFPNLGAYTSSAATQFNGFDQTADIVYINSESD------

Candida_glabrata_ODC KNDPE-ISKLPHNEAHLEIYNALKKRVDDINNETCEPGEENSFFVCDLGEIERLYANWWKELPRVQPFYA--VKCNPDLKIIRKLADLGAN-FDCASKLEIDKVLSMD------VNPERIIYANPCKAASFIRYAATNKVMKSTFD------NVEELH---KIKKFHPESQLFLRIATD-DSTAQCRLS-----TKYGCEME-RVDSLLE-CIKTLGLNLVGVSFHVGSGAS-DFSSLYKAVRDARIVFDKAVNDYG---LP-ELKTLDVGGGFQL------ESFKESSAVLRLALDEYFPE----SSKVDIIAEPGRYLVASAFTLSANVIAKRKLNEA------ESMIYVNDGVYGNMNCILFDHQEPTPRTLWHDNNYHYDDFDSTSP------NPITT------CPYKVSMWGPTCDGLDCITKEYYMKH-DLVVGDWLYFPRLGAYTSSAATPFNGFDQTADIIYINSENHDNI------

Saccharomyces_castellii_ODC KADPK-IAELPHDQAHPQISKALQERVRSVNEDTCDPGEENSFFVCDLNEIRNLHKNWQKELPRIQPYYA--VKCNPNPLILRLLADMGVN-FDCASKLEIETILKLG------VSPERIIYANPCKVSSFIRFAAKQEVKKSTFD------NVEELY---KIKKFHPESELFLRIATD-DSTAQCRLS-----TKYGCDLE-NVDELLA-KVKELDLNLVGVSFHVGSGAS-DFSSLYKAVKDAKFVFNKVVDEYQ---LP-KLKILDVGGGFQF------ETFAESSAVLRMALDEFFPE----GCGVDLIAEPGRYFVATAFTLAAHVIAKRTVNNNK------EECMLYINDGVYGNMNCILFDHQEPNPRVLYHDNKFHYEDFHSSSP------KPECP------YKVSMWGPTCDGLDCITKEYYLKY-DLVVGDWLYFPNLGAYTSSAATPFNGFDQTADIIYINKEEPL------

Vanderwaltozyma_polyspora_ODC NSNTK-SYKLPYEPAHEFIFNSLKKRIESINEDTCAPGEENSFFVCDLGELEKLYKNWKLELPNVQPFYA--VKCNPNEKILQTLDQLGIN-FDCASKSEIDKVLSMN------VDPERIIYANPCKASSFIRYAQTKNVLKSTFD------NVEELH---KIKKFHPNSELFIRIATD-DSTAQCRLS-----TKYGCELS-DVENLLQ-AVKDLDLNLVGVAFHVGSGAS-DFTSLYQAVKDSRYVFDKCIEMG----LP-ELKILDIGGGFQF------ESFHESSKVVRVALEEYFP-----GDKVKFMAEPGRYFVSTALTLASNVIAKRTISNN------EAMLYINDGVYGNMNCILFDHQEPIPRILYHNNEFHYYDFESSTN------MLKKND------VSKYPQKVSIWGPTCDGLDCITKEYYLKH-DLEVGDWFYFPNLGAYTSTAATPFNGFQQHSDTLYINSLKDAL------

Kluyveromyces_waltii_ODC KLQFEGLKTSNNAVAHEHICNALKTRVESVNQEICEAGDENSFFVCDLGEVQRLYELWRCKLPRVHPFYA--VKSNPNAQVLKTLAELGVN-FDCASKSEIEAVLEMG------VDPARIIYANPCKASSFIRFAKNCDVKKSTFD------NVEELA---KIKKYHPDSELLLRIATD-DSTAQCRLS-----TKYGCEME-RVASLLA-KVKELDLNLVGVSFHVGSGAS-EFSAFHKAVQDAREVFDLASNQYG---LQ-NMRILDIGGGFQL------ESFDEATAVLNTALEEYFPV----ECGVDIIAEPGRFFAASPFTLACHVIAKRAHDEN------ESMLYINDGVYGNMNCILFDHQEPTPRVLYHNGQLHYWDFESSSL------KSNGKCG------HKVSIWGPTCDGLDCITKEYYLKH-DLVVGDWLYFPSLGAYTSSAATQFNGFEQSADVIYINSATA------

Kluyveromyces_lactis_ODC GLPLSKQGQLPHQQSHHKIFAALKEKIDSINHETCDAGDENSFFVCDLGEISRLRNYWTQILPRVTPFYA--VKCNPNIEIIKRLASMSTN-FDCASKSEIEKVLACG------VDPERIIYANPCKASSFIRFAAKNGVKKSTFD------NIDELY---KIKKYHPESELLLRIVTD-DSSAQCRLS-----TKYGCELD-DVPVLLE-TVKELGLNLIGVSFHVGSGAS-DFSTVTQAVKDGRKVFDMAESRG----LP-ALKMLDVGGGYQF------DTITEVADVLNAALDYFFPQET--HSDVSFIAEPGRYFVATAFTLAATVIGKRNNSDS------ESMIYINDGVYGNMNCILFDHQEPSPRVLYHKNRFHYMDINSSSK------AKCDACN------YKVSIWGPTCDGLDCVSKEYYMKY-DLDIGDWVHFDNIGAYTCSAATPFNGFEQTVDIIFIDSAL------

Ashbya_gossypii_ODC ATDPTTQKTGAHEQAHQAVFQAMKEHVERVNKDTCDAGEENSFFVCDLGEVERLLRYWRRELPRVQPYYA--VKCNPDVRVLERLASLGVN-FDCASKAEIERVLQLG------VAPERIIYANPCKVCSVIRFAAARAVRQSTFD------NVQELY---KIARFHPESQVLLRISTD-DSTAQCQLS-----AKYGCSPD-EVDPLLA-KVAELGLNLVGVSFHIGSGAS-DFSSLTQAVVDARRVFDRAAHFG----LP-ALRVLDVGGGFQF------DTFHQSSAILNAALDTHFPP----GSGVELIAEPGRFLVATAFTLSSHVIAKLRLPER------GSMLYINDGIYANMNCILFDHYQPTPRVLYHAAAFHYFDTTSSKS------RTAACP------HRTSIWGPTCDGLDCITDEYYLRY-DLAVGDWLYFANFGAYTSSAATPFNGFEAAVEVIYIDTA------

Candida_albicans_ODC TTTTTTLNVNKTLKAIDLIETSIKNHILTIDHENCLPNDEDSFFVCDLGEIINSVNQWQQILPMVQPYYA--VKCNSNPQILTTLSELGVN-FDCASKNEIDLVLSLGI------HQAHERIIYANPCKTNSFIRHAADENVNLTTVD------NVHELY---KLAKFHPHCKILIRLITD-DSTAQCQLS-----TKFGCDLNTAIGEILP-KAKELGLQVHGVAFHVGSGAK-DFSSIYQAIKDSRILFDEMLSMGF---T---PKLLDIGGGFER------ETFPQLSQMVKFALEKFFPIEFSQSNEIKFIAEPGRFMVANAFTLITHIIARRDLPTGGNN-NNNDM------TPSAMLYINDGVYGNLNCILFDHQTPKVYVLTNENQLFYKQEMMRSL------LVNNNNNN----NNKTDGFKFSIWGPTCDGLDCVSSLAKLSK-NVQVGDWLFFENVGAYTSCASTKFNGLSSGETKTLYVNSNEE------

Lodderomyces_elongisporus_ODC IDIESRQFKNFFKGENKLIEKALIDHINEVDHEECEPGDEDSFFVCDLNQVYKSVQLWKQQLPRVQAHYA--VKCNTNMKVVEFLADKGVN-FDCASKNEIDAVLQLG------VAAERIVYANPCKTNSFIRHARDNQVNLTTVD------NVNELV---KLSKFHPECGILVRIITD-DESSQCRLS-----TKFGCSVETAVKEILP-TAKNLGLPVVGVAFHVGSGAK-DFQAIYQAIRDSRIVFDYGIDLGF---K---MKILDIGGGFEF------DTFVESSKMVNVSIDKFFPDLFVKENGISFIAEPGRFMVANAFTLATHVIAKRDING------SAKAMLYINDGVYGNLNCILFDHQEPTARILKSGGQFHYGEKDQR------RFEYSIWGPTCDGLDCVSASSHLNC-NVAVGDWLYFPNLGAYTSCAKTQFNGFKN-DTEVIYIPVQE------

Debaryomyces_hansenii KSSGVKATG--PEFSANLIGEALATHISNIDHEVCEAGEEDSFFVVDLGEVYRSYMKWKETLPNVHAHYA--VKCNTDLSVIKLLGQLGAN-FDCASKNEIDIVLGLG------FSPDRIVYANPCKTNSYIRYANDSNVNLTTVD------NPQELY---KLHKYHPECGILLRIATD-DETAQCRLS-----TKFGCSVDTAVNELLP-LAAKLGLNVRGVAFHVGSGAK-DFDSIHEAVRDSRFIFDKGIDEYG---YGKTMNILDIGGGFEM------ETFDKSSAMVKLSLEKYFSSDYCSSQNIKFIAEPGRLMVSKAFTLAAHIIARRDLPRSLKESND------IEAMLYINDGVYGNMNCILFDHQNPVPHVLTHKNSLYYNEQVS------DRTTKHQFSIWGPTCDGLDCVSNRSALYH-NVEVGDWLYFPDLGAYTSAATTSFNGFKNKAQVIRVASEDFSELEL------

Pichia_stipitis_ODC AEISSSSSSSKDQLARELINRALVNHISGIDHEECEAGDEDSFFVCDLGEVYRSFGVWQQKLPQVQPHYA--VKCNTNLEVIKLLASLGVN-FDCASKNEIDTILNLG------ISPDRIVYANPCKTNSFIRHASKANVNLTTVD------NAQELH---KLKKFHPDCGILIRLATD-DETAQCRLS-----TKFGCTLSAAINELLP-LAKELGLNVRGVAFHVGSGAK-DFDSIYKAIRDSRDVFNRAITEYG---F--EMSILDIGGGFEL------ETFDESSSMVCSSLNKFFPADFVSQNGIKFIAEPGRFMVSNAFTLAAHIIARRDLDLKATFVSEEDK------QVSAMVYINDGVYGNMNCILFDHQNPQAHVLQHKNKFFYHQDEESD------DQKLID----DDAKGEHHFSIWGPTCDGLDCVASKCTLSH-DVEVGDWLYFPNLGAYTSAATTAFNGLGGNSHIIYVCSEDL------

Pichia_guilliermondii_ODC LKNQPIPKRLQNFETKSVVASGLRSKIANIDHDSCEAGDEDSFFVADIGAVVRNYRLWQQELPQVQPHYA--VKCNTDMRVIEALARMGCN-FDCASKTEIDQVLLLG------VDPGRIVYANPCKTNSYVRHAKDVGVNLTTVD------NVHELQ---KIKRFHPECGILIRIMTD-DESAQCRLS-----TKFGCSVKTAVEELFP-LAKELNLRVRGVAFHVGLGAT-DLDSIYKAVQDSRILFDCGIDQFG---FK-EMNLLDIGGGFQE------LTFGESSAMVRMSLDKFFSSAYRELHPVEFIAEPGRFMVANAFTLAVHVIARRDVR------EAES------EVQAMLYVNDGVYGNLNCILFDHQVPLASLLTHKGQFVYGSEPD------PELSFSIWGPTCDGLDCISGKCQLAF-NVEVGDWLYFPNLGAYTSAATTSFNGFKGTAEVVYVNSEK------

Clavispora_lusitaniae_ODC SGSVTSGHKRSSLASSDLVRSALVDQVNQIDHDVCAAGDEDSFFVADLGQVFRSFQLWKETLPRVQPFYA--VKCNTDPHVVLLLGRMGAN-FDCASKTEIDTVLGLG------FTPDRIIYANPCKTNSFIRHACEKNVNLTTVD------NANELY---KLKRFHPRTRILIRIVTD-DESAQCRLS-----TKFGCTVEVAVNQLLP-LCRELDLDVAGVAFHVGSGAT-CFDSFFHAIKDARRIFDAGEQLGL---R---LTILDIGGGFEP------CSFDAATQVVNRALDTFFPTTYAQQHGMQFIAEPGRFMVANAFTLATHIIARRDLD------SNS------GMEAMLYINDGVYGNLNCVLFDHQHPEAKVLKHAGKMFPGEMDG------ETQSQHYNFSIWGPTCDGLDCVSSKTALPA-NVGVGDWLYFPELGAYTSAATTSFNGFSGCAKVNYVCSVDLGEYGY------

Coprinopsis_cinerea_ODC1 SGDVIFPSLPPLHQGHPDIHMRNGVMASFAAAADHEPDAEKAFFVADLSQVYRQHQRWITCLP--EIQPFYAVKCNPDPYVIRLLAALGAG-FDCASLNEISSVLNVGG------IDPSRIIFANPCKAVSFIRNASRMGVDTMTFD------NADELY---KVARSHPKAKLVVRILTD-DSKSLCAFG-----IKFGAPLN-VVPSLLA-KAKELNLDVVGVSFHVGSGCY-DPSVYTDAIMRSRTVFDMAKEAG------YDFTLLDIGGGFED------ALFEKAATVLREAIDRYFPDR----KHIKMIAEPGRFYVSTAFKLAAHIIARRAPLEKDAAPATSG------TAEEPDQPKVMYYINDGVYGAFNCILFDHQVIHPYVLSMGG--SFHVAESEP------KHVSSVWGPTCDSIDCVSPKTVLPV-NLQVGDWLGFNNMGAYTVCAASQFNGFAVSNVIYTAGVAHANEVRMALKAFAAEG

Phanerochaete_chrysosporium_ODC1 EGFTAVPGLPPLHVGHPDTHLRNGVMRAAELAADGEPDAEKAFFVADLSYVYHQHMRWKRMLP--EIEPFYAVKCNPDPYVLRLLAALGTG-FDCASNGEISQVLSLG------VSPSRVIFANPCKPTSFVRQSAKAGVDMMTFD------NTDELY---KVARTHPNAKLVVRILTD-DSKSLCRLG-----LKYGAPLV-TVPALLA-KARELNLNVIGVSFHVGSGCY-DTAAYSDAIARARAAFDMGKAAG------YDFTLLDVGGGFED------ATFERAADTLREAIDLHFPSR----ENIRIIAEPGRYYVAKAFTIAVNVIARRAPPAIEGSEADD------VDPEQPSVMYYINDGVYGAFNCIMFDHQTPEPYVLCLNG--SFHVPASVG------TCASSVWGPTCDSIDVVCPVTQLPR-TLSVGDWLAFENMGAYTRCAASQFNGFQVSNVVYTSGQGVASAEVRRLLRGSGGG

Rhizopus_oryzae_ODC1 NLIKSVPS-PDVCINNSPVEQIAREKIQSISNQKWESDQENAFFVGDLGEVFRQHLRWKALLP--RIEPFFAVKCNPDPMVIKLLASLGLG-FDCASKAEIQQVLNSG------VEPNRIIYANPCKQASFIRYAAQQNVSRMTFD------NSEELH---KIKKLYPDAELVLRILTD-DSNSLCQLG-----LKFGAPLE-NVENLLK-TAKELELNVIGVSFHVGSGCL-DESAFGDAVMRARKVFDQAEQIG------FHFTLLDVGGGFPGN------DVKDGITFEKVAAILGPMVDSLFP------PEIRVIAEPGRYYVASAFTICANVIGRRTIAPKAEGEKQ------QFMYYINDGMYGSFNCILFDHQIVHPKVLVKDENFVYGQQLQEE------HFECSVWGPTCDSIDCLNKSTQLP--ILEAGDWLYYENMGAYTICAASQFNGFRKSQVYYTNTFN------

Rhizopus_oryzae_ODC2 NLIKSVPSSPDIRVHDRSVEEIALEKIQSNSNQKWDTDQENAFFIGDLGEVFRQHLRWKALLP--RIEPFFAVKCNPDPMVVKLLASLGLG-FDCASKSEIQQVLDTG------VEPSRIIYANPCKQASFIRYAAQQNVSRMTFD------NAEELY---KIKKLYPDAELVLRILTD-DSNSLCQLG-----LKFGAPLD-TVESLLK-TAKELDLNVVGVSFHVGSGCL-DASAFGDAILRARRVFDQGEQMG------FNFTLLDVGGGFPGN------DVKDGITFEKIAAILGPMVDTLFP------PEIRVIAEPGRYYVASAFTICANVIGRRTIAPKSEHERQ------QFMYYINDGMYGSFNCILFDHQVVYPKVLVKNDSFVYGQQIQEE------HFECSVWGPTCDSIDCLNKSTKLP--MLEAGDWIYYENMGAYTICAASQFNGFRKSDVIYTNTFN------

Mucor_circinelloides_ODC1 ALFKSAPSSPDISVHNRSVSEVFQQRLESITNQKWESDQENAFFVGDLGEVVRQHIRWKSLLP--RIEPFYAIKCNPDPMVVQLLASLGCG-FDCASKQEIQQVLDVG------VDPSRIIYANPCKQASFIRYSAQQNVSRMTFD------NAEELF---KIKKYYPDAELVLRILTD-DSMSLCQLG-----LKFGAPLH-TVQHLLQ-LAKELNLNVIGVSFHVGSGCL-DENAFGDAVVRAKNVFDQAKAMG------YDFKFLDVGGGFPGA------DVKNGITFEKVAAVLGPIVDRLFP------KDVRVIAEPGRYYVASAFNLAVNVIGRRTNMAHQDQTDAS------PEYMYYVNDGMYGSFNCIIFDHQVVHPKVLMKNELFAYGQDLPEA------QYESSVWGPTCDSIDCLNKSARLP--KLEPGDWLYFENMGAYTICAASQFNGFRKSEVLYTNTFC------

Ustilago_maydis_ODC1 ELDHIKPFDGHKPIYHGDFDSQLRRVLNDIDIHGCEANGENAFFVADLSEVYRQHLRWMRALP--RIVPFYAVKCNPDPYVLQLLGALGTG-FDCASNGEIEAVLKLG------INPARIIYANPCKAASFVRHAAAHNVGLTTFD------NMDELE---KMKRYHPSCKLVVRILTD-DSKSACQLG-----LKFGAPLA-SVPRLLE-RARELELDVVGVSFHVGSGCY-DPDSFRDAVYRARCAFEMGKQAG------FSFDLLDVGGGFGH----DNFEMVAGVLGPAIDAYFPDEDFAPGGKEVVGKVNGLRIIAEPGRFYVHSAFALATNIIAVRRGEPSAAMDH------VEATAPKAQVMYYQNDGLYGSFNCVIFDHVKVHPKVLTLGHEYVYEPTIGSPG------VRAVSAADSRLQQEAMTLESCSVWGPTCDSIDCVRDHVELPKG-LQVGDWLVYENMGAYTICAASTFNGIRRSEIRYTLGHGQDADIVRQLMLQ----

Ustilago_maydis_ODC2 SSITLSRLMVTSPSITATLTRSVGVFSTTLTYHGCEANGENAFFVADLSEVYRQHLRWMRALP--RIVPFYAVKCNPDPYVLQLLGALGTG-FDCASNGEIEAVLKLG------INPARIIYANPSKAASFVRHAAGHNVGLTTFD------NMDELE---KMKRYHPSCKLVVRILTD-DSKSACQLG-----LKFGAPIA-SVPRLLE-RARELELDVVGVSFHVGSGCY-DPDSFRDAVYRA-CAFEMGKQAG------FSFDLLDVGGGFGH----DNFEMVAGVLGPAIDAYFPDEDFAPGGKEVVGKVNGLRIIAEPGRFYVHSAFALATNIIAVRRGEPSAAMDH------VEATP-KAQVMYYQNDGLYGSFNCVIFDHVKFIQSSDAG-PRVRVRADDWVAR------GASGECGRLALQQEAMTLESCSVWGPTCDSIDCVRDHVELPKG-LQVGDWLVYENMGAYTICAASTFNGIRRSEIRYTLGHGQDADIVRQLMLQ----

Puccinia_graminis_ODC PIVTEQQQDPLPSIHSNPTINVFRSILTEIDTSKCEENGENAFYVCDLAYVYRQYLRWQEALGN-RVEPFFAVKCNPDSLVLKLLAQLGTG-FDCASHAEIEMVLKLG------VEPSRIIYANPCKAGSFVRHAHAKGVQMMTFD------NQDELE---KVAKFHPNARMVLRILTD-DSGSLCRLG-----EKFGAPLE-NVRGLLE-RAKELDVAVIGVAFHVGSGCS-NPLLYTDAVGRAKWTFELGQELG------FHFDFLDVGGGFGD------DNFDLLAEGLLVGLDKYFPVG----CGVRVIAEPGRYFVTRAFELATNIIARRKAPTPPPSSLFLSMMAGAS------QLTPDCLVRLSDYINDGVYGAFNCIIFDHQVVEPKVLTLGGVFYGDGFTETG------YPTFLVDELELCKIFGPSCDSIDLVSPATLLPTNRLLVGDWLRWPNMGAYTICAASQFNGFKISQVVYTIGDPSVDEKVRHILRSSSSS

Cryptococcus_neoformans_ODC THSIISNDEEHPALAPVVDIPVHQLVQQTIAASTGVDIDESAFFAADLSAVYQAVQMWRASPIGSRVEIFYAVKCNPSPAVLHLLSLMGTS-FDCASSSEINQVLSLPS------APSGDRIIFANPCKPASFIRTAAQRGVSMMTFD------NVDELY---KVKRICPNAKLVLRMLTD-DSKSLCRLG-----LKFGAPVD-SCPGLLK-VARQLGLNVVGVSFHVGSGCK-DPMQFADAVWRARKVFDMGKEAG------YNFDLLDIGGGFER------ETFAEMTQVLKDSFDLYFPED----SGVRIIAEPGRFLVSSAFTLATSIIASRRAPKAEASQQVQAAT------QEDTKSADVMYYINDGVYGSFNCIMFDHQIVHPHPLTIGHKLAIAAPPFPPP------PNVQLEVDLPVQMGYKDVEKVSVWGPTCDSIDCVRQLVDLPK-GMDVGDWIGWGEMGAYTLCAASTFNGFDRSPVLWTTGGNTEDARMVRAILDSFAA

Schizosaccharomyces_japonicus_ODC AESVSTWSSCGKSREAIRELLEQKISESEVNSATGEMRDADAFFVADLAEVYRQLVRWHTNLP--RVQPFYAVKCNPDPRVLALLVKFGTG-FDCASKGELQQILSLG------VSPERIVYANPCKAINYIRYARNNNVDFMTFD------NTEELY---KCKQHHPNARLLLRISTN-DENSICRLS-----LKFGAPMS-ETEELLR-VAKTLDLNVVGVSFHVGSGNL-DPASFIDAICRSRVVFDQGERYG------FHFNTLDIGGGFMS------DSFEQTAAILREQLDTHFPAN------VRIIAEPGRFFVATAFTLAVNVVAKRRIPEEN------KVMYYVNDGVYGSLNCILFDHQHPVARVLKHAGRMCYNQYVGTG------DHVCSIWGPTCDSLDVIASDARLPF-ELEVGDWIYFDDAGAYTVAAASSFNGFQTSKVEYVSTDLV------

Schizosaccharomyces_pombe_ODC IDSVVTWSSPGSSRQAIGEAFKNTIEEIERAAVRGEPADSDAFFVADLNGVYRQLLRWHAKLP--RVQPFYAVKCNPDPKVLALLNKFGTG-FDCASKGELEQILGLG------VSPDRIVYANPCKAITYVRYAASKGINLMTFD------NADELY---KVKQHHPNSRLLLRISTD-DSNSLCRLS-----LKFGASLD-DTGKLLD-IAKSLELNVVGVSFHVGSGSY-DPSAFLDAIQRSRQVFDQGLERG------FNFDLLDIGGGFMN------DSFDGVADLIRSALDTYFDPS------IRVISEPGRFFVSSSFTLAVNVIAKRKLDDEE------KVMYYVNDGVYGSLNCILFDHQHPVARVLKCGSRFVYNDLVGTG------QHRCFIWGPTCDSLDVIANDAHLPY-ELNVGDWIYFEDAGAYTVAAASCFNGFKTSRIVYLDTDILD------

Xenopus_laevis_ODC1_1 MNSFSNDDFDFSFLEEG-FSARDIVEQKINEVSL--SDDKDAFYVADFGDIVKKHVRWFKALPRVTPFYA--VKCNDGKAIVKTLSILGAG-FDCASKTEIQLVQSIG------VSPERIIYANPCKQVSQIKYAASCGVEKMTFD------SEVELM---KVARNHPNAKLVLRIATD-DSKAVCRLS-----VKFGATLKTSRLLLER-AK-ELNVDIIGVSFHVGSGCT-DPQTYVQAVSDARCVFDMGA------ELGFNMHLLDIGGGFPGS-ED----VKLKFEEITS---VINPALDKYFPADSG----VKIIAEPGRYYVASSFTLAVNIIAKKVMVNEQSGSDD------EEDAANDKTLMYYVNDGVYGSFNCILFDHAHVKPVLTKK------PKPDEKFYSSSIWGPTCDGLDRIVE-RFELP-ELQVGDWMLFENMGAYTVAAASTFN-GFQRPTLYYVMSRPHWQLMHDIKEHGILP

Xenopus_tropicalis_ODC1 MNSFSNDDFDFSFLEEG-FCARDIVEQKINEVSL--SDDKDAFYVADLGDIVKKHVRWFKALPRVTPFYA--VKCNDSKAIVKTLSLLGAG-FDCASKTEIQLVQSIG------VSSERIIYANPCKQVSQIKYAASCGVEKMTFD------SEVELM---KVARNHPNAKLVLRIATD-DSKAVCRLS-----VKFGATLKTSRLLLER-AK-ELNVDIIGVSFHVGSGCT-DPQTYVQAVSDARCVFDMGA------ELGFNMHLLDIGGGFPGS-ED----VKLKFEEITS---VINPALDKYFPVDSG----VTIIAEPGRYYVASAFTLAVNIIAKKVMVNEQSGSDD------EEDAANDKTLMYYVNDGVYGSFNCILFDHAHVKPVLTKK------PKPDESFYSSSIWGPTCDGLDRIVE-RFDLP-ELQVGDWMLFENMGAYTVAASSTFN-GFQRPTLYYVMSRPHWQLMHDIKEHGILP

Xenopus_laevis_ODC1_2 MNGFSNDDFDFSFLEEG-FCARDIVEQKINEVSL--SDDKDAFYVADLGDIVKKHLRWFKALPRVAPFYA--VKCNDSKAVVKTLSILGAG-FDCASKTEIQLVQSIG------VSPERIIYANPCKQVSQIKYAASCGVEKMTFD------SEVELM---KVARNHPNAKLVLRIATD-DSKAVCRLS-----VKFGATLKTSRLLLER-AK-ELNVDIIGVSFHVGSGCT-DPHTYVQAVSDARCVFDMGA------ELGFNMYLLDIGGGFPGS-ED----VKLKFEEITS---VINPALDKYFPTDSA----VKIIAEPGRYYVASAFTLAVNIIAKKVMVNEQSGSDD------EEDAANDKTLMYYVNDGVYGSFNCILFDHAHVKPVLTKK------PKPDEKFYSSSIWGPTCDGLDRIVE-RFELP-ELQVGDWMLYENMGAYTVAASSTFN-GFQRPTLHYVMSRPHWQLMQDIKEHGILP

Ambystoma_mexicanum_ODC1 MQNFSNDEFDFSFIEEG-FSARDILEQKINEVSS--SDDKDAFYVADLGDIIKKHLRWFKALPRVTPFYA--VKCNDSKAIVQTLAALGSG-FDCASKTEIQIVQNIG------VSPERIIYANPCKQVSQIKYAANSGVKMMTFD------SEVELM---KVARNHPHAKLVLRIATD-DSKAVCRLS-----VKFGATLKTSRILLER-AR-ELNIDIIGVSFHVGSGCT-DPFTYVQAVSDARVVFDMGA------ELGFSMHLLDIGGGFPGS-ED----VKLKFEEITA---VINPALDKYFPAGSG----VKIIAEPGRYYVASSFTLAVNIIAKKVMFNELLGSDE------EDGGSDDKTLMYYVNDGVYGSFNCILYDHAHVNPVLQKR------PKPEERHYCSSIWGPTCDGLDRIVE-RTDLP-ELYVGDWMIFENMGAYTVAAASTFN-GFQRPTLYYVMSRPAWQLMEQIKEHGVPD

Homo_sapiens_ODC MNNFGNEEFDCHFLDEG-FTAKDILDQKINEVSS--SDDKDAFYVADLGDILKKHLRWLKALPRVTPFYA--VKCNDSKAIVKTLAATGTG-FDCASKTEIQLVQSLG------VPPERIIYANPCKQVSQIKYAANNGVQMMTFD------SEVELM---KVARAHPKAKLVLRIATD-DSKAVCRLS-----VKFGATLRTSRLLLER-AK-ELNIDVVGVSFHVGSGCT-DPETFVQAISDARCVFDMGA------EVGFSMYLLDIGGGFPGS-ED----VKLKFEEITG---VINPALDKYFPSDSG----VRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDD------EDE-SSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKR------PKPDEKYYSSSIWGPTCDGLDRIVE-RCDLP-EMHVGDWMLFENMGAYTVAAASTFN-GFQRPTIYYVMSGPAWQLMQQFQNPDFPP

Macaca_mulatta_ODC MNNFGNEEFDCHFLDEG-FTAKDILDQKINEVSF--SDDKDAFYVADLGDILKKHLRWLKALPRVTPFYA--VKCNDSKAIVKTLAAVGTG-FDCASKTEIQLVQNLG------VPPERIIYANPCKQVSQIKYAANNGVQMMTFD------SEVELM---KVTRAHPKAKLVLRIATD-DSKAVCRLS-----VKFGATLRNSRLLLER-AK-ELNIDVVGVSFHVGSGCT-DPETFVQAISDARCVFDMGA------EVGFSMYLLDIGGGFPGS-EE----VKLKFEEITN---VINPALDKYFPADSG----VRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDD------EDE-SSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKR------PKPDEKYYSSSIWGPTCDGLDRIVE-RCDLP-EMHVGDWMLFENMGAYTVAAASTFN-GFQRPTIYYVMSGPAWQLMQQFQNPDFPP

Canis_familiaris_ODC MNNFNNAEFDCHFLDEG-FTAKDILDQKINEVSS--SDDKDAFYVADLGDILKKHLRWLKALPRVTPFYA--VKCNDSRTIVKTLAAIGTG-FDCASKTEIQLVQSLG------VPPERIIYANPCKQVSQIKYASNNGVQMMTFD------SEVELM---KVARAHPKAKLVLRIATD-DSKAVCRLS-----VKFGATLKTSRLLLER-AR-ELNIDVIGVSFHVGSGCT-DPETFVQAISDARCVFDMGA------EVGFNMYLLDIGGGFPGS-ED----VKLKFEEITS---VINPALDKYFPADSG----VRVIAEPGRYYVASAFTLAVNIIAKKLVLKEQTGSDD------EDE-SSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKR------PKPDEKYYSTSIWGPTCDGLDRIVE-RCDLP-EIHVGDWMLFENMGAYTVAAASTFN-GFQRPTIYYVMSGPTWQLMQQIQNHDFPP

Bos_taurus_ODC MNSFSNEEFDCHFLDEG-FTAKDILDQKINEVSY--SDDKDAFYVADLGDILKKHLRWLKALPRVTPFYA--VKCNDSRTIVKTLAAIGTG-FDCASKTEIQLVQSLG------VPPERIIYANPCKQVSQIKYAANNGVQMMTFD------SEVELM---KVARAHPKAKLVLRIATD-DSKAVCRLS-----VKFGATLKTSRLLLER-AK-ELDIDVIGVSFHVGSGCT-DPETFVQAISDARCVFDMGA------EVGFNMYLLDIGGGFPGS-ED----VKLKFEEITS---VINPALDKYFPSDSG----VRIIAEPGRYYVASAFTLAVNIIAKKLVLKEQTGSDD------EEE-STDRTFMYYVNDGVYGSFNCILYDHAHVKPLLQKR------PKPDEKYYSSSIWGPTCDGLDRIVE-RCNLP-EMHVGDWMLFENMGAYTVAAASTFN-GFQRPTIYYVMSGPTWQLMQQIRTQDFPP

Mus_musculus_ODC MSSFTKDEFDCHILDEG-FTAKDILDQKINEVSS--SDDKDAFYVADLGDILKKHLRWLKALPRVTPFYA--VKCNDSRAIVSTLAAIGTG-FDCASKTEIQLVQGLG------VPAERVIYANPCKQVSQIKYAASNGVQMMTFD------SEIELM---KVARAHPKAKLVLRIATD-DSKAVCRLS-----VKFGATLKTSRLLLER-AK-ELNIDVIGVSFHVGSGCT-DPETFVQAVSDARCVFDMAT------EVGFSMHLLDIGGGFPGS-ED----TKLKFEEITS---VINPALDKYFPSDSG----VRIIAEPGRYYVASAFTLAVNIIAKKTVWKEQPGSDD------EDE-SNEQTFMYYVNDGVYGSFNCILYDHAHVKALLQKR------PKPDEKYYSSSIWGPTCDGLDRIVE-RCNLP-EMHVGDWMLFENMGAYTVAAASTFN-GFQRPNIYYVMSRPMWQLMKQIQSHGFPP

Rattus_norvegicus_ODC MGSFTKEEFDCHILDEG-FTAKDILDQKINEVSS--SDDKDAFYVADLGDVLKKHLRWLKALPRVTPFYA--VKCNDSRAIVSTLAAIGTG-FDCASKTEIQLVQGLG------VPPERIIYANPCKQVSQIKYAASNGVQMMTFD------SEIELM---KVARAHPKAKLVLRIATD-DSKAVCRLS-----VKFGATLKTSRLLLER-AK-ELNIDVIGVSFHVGSGCT-DPETFVQAVSDARCVFDMGT------EVGFSMYLLDIGGGFPGS-ED----TKLKFEEITS---VINPALDKYFPSDSG----VRIIAEPGRYYVASAFTLAVNIIAKKTVWKEQTGSDD------EDE-SNEQTLMYYVNDGVYGSFNCILYDHAHVKALLQKR------PKPDEKYYSSSIWGPTCDGLDRIVE-RCSLP-EMHVGDWMLFENMGAYTVAAASTFN-GFQRPNIYYVMSRSMWQLMKQIQSHGFPP

Monodelphis_domestica_ODC MNSFSNDEFDFNFLDEG-FTAKDILDQKINEVSS--SDDKDAFYVADLGDILKKHLRWYKALPRVTPFYA--VKCNDSRAILKTLAAVGAG-FDCASKTEIQLVQSLG------VPPERIIYANPCKQVSQIKYAANNGVQMMTFD------SEVELM---KVARAHPKAKLVLRIATD-DSKAVCRLS-----VKFGATLKTSRLLLER-AK-ELNIDVIGVSFHVGSGCT-DPETFVQAVSDARCVFDMGA------EFGFNMYLLDIGGGFPGS-ED----VKLKFEEISS---VINPALDKYFPPDSG----VRIIAEPGRYYVASAFTLAVNIIAKKLVLKEQTGSDD------EDE-ANDQTFMYYVNDGVYGSFNCILFDHAHVKPLLQKR------PKPDEKYYSSSIWGPTCDGLDRIVE-RCDLP-EMHVGDWMLFENMGAYTVAAASTFN-GFQRPTIYYVMSGPAWQCMQQIKNQGFPA

Ornithorhynchus_anatinus_ODC MNNFSNDEFDFTFLDEG-FTAKDILDQKINEVSS--SDDKDAFYVADLGDVLKKHLRWYKALPRVTPFYA--VKCNDSKAIVKTLAALGAG-FDCASKTEIQLVQSIG------VSPERIIYANPCKQVSQIKYAANSGVQMMTFD------SEVELM---KVNRAHPKAKLVLRIATD-DSKAVCRLS-----VKFGATLKTSRLLLER-AK-ELNIDVIGVSFHVGSGCT-DPDTFVQAVTDARCVFDMGA------ELGFDMYLLDIGGGFPGS-ED----VKLKFEEITS---VINPALEKYFPSDSG----VRIIAEPGRYYVASAFTLAVNIIAKKVVLKEQTGSDD------EDD-VNDKTIMYYVNDGVYGSFNCILYDHAHVKPILQKR------PKPDESYYSCSIWGPTCDGLDRIVE-RCDMP-ELQVGDWMLFENMGAYTVAAASTFN-GFQRPTIYYVMSGPAWQRMQQINERGFPA

Gallus_gallus_ODC MGSFSKEELEFTFLDEG-FTAKDILDQKINEVSS--SDDKDAFYVADLGDIVKKHMRWHKALPRVTPFYA--VKCNDSEAVVKTLAVLGAG-FDCASKTEIQLVQSIG------VPPERIIYANPCKQLSQIKHAANSGVRMMTFD------SEVELM---KIARAHPKAKLVLRITTD-DSKAVCRLS-----VKFGATLKTSRLLLER-AK-ELDLAIVGVSFHVGSGCT-DPETFVQAISDARCVFDMGA------ELGFNMYLLDIGGGFPGS-ED----VKLKFEEITS---VINPALDKYFPLDSE----VTIIAEPGRYYVASAFTLAVNIIAKKIVSKEQTGSDD------EDD-VNDKTLMYYVNDGVYGSFNCILYDHAHVKPVLQKR------PKPDDGCYSCSIWGPTCDGLDRIVE-RCNMP-ELQVGDWILFENMGAYTVAAASTFN-GFQRPTIHYVMSRPAWQLMQQIKEQEFLA

Fugu_rubripes_ODC1 ----MNTEMEFSFLEEG-FSAKDIVEQKIKESSV--TDDRDAFYVCDLGDVLKKHVRWMRALPRITPFYA--VKCNDSLSVLKTLASLGTG-FDCASKTEIQLVQSLG------VDPSKIIYANPCKQVSQIKYASAHGVKMMTFD------SEVELM---KVARCHDNAKLVLRIATD-DSKAVCRLS-----VKFGVPVKACRGLLER-AK-KLGLDVIGVSFHVGSGCT-DPKAYIQAIADARCVFDIGN------ELGFKMDLLDIGGGFPGS-DD----AELQFEEITA---VINPTLEKYFPADSD----VKIIAEPGRFYVASAYTLVVNIIAKKVILDED--SDE------EDERTNEKTVMYYVNDGVYGSFNCILYDHAHCMPTLHKK------RKPDEVRYPSSIWGPTCDGLDRIVE-LCSLP-DLQVGDWLVFENMGAYTVAASSTFN-GFQKPDLHYIMSRPAWQSVQQISQGMLPP

Tetraodon_nigroviridis_ODC1x ----MNAEMEFSFLEEG-FSAKDIVEQKIKESSL--TVT------TEIQLVQSLG------VDAGRIIYANPCKQASQIKYAAAHGVQMMTFD------SEVELM---KVARCHDNAKLVLRIATD-DSKAVCRLS-----VKFGVPVKACRGLLER-AR-ELGLDVIGVSFHVGSGCT-DPNAYTQAIADARCVFDIGN------ELGFKMDLLDIGGGFPGS-DD----AALQFEEITA---VINPALDKYFPADTE----VKVIAEPGRFYVASAYTLVVNIIAKKVIEDED--EDE------EDERSGEKTVMYYVNDGVYGSFNCILYDHAHCMPTLHKK------RKPDEVRYPSSIWGPTCDGLDRIVE-LCSLP-DLQVGDWLVFENMGAYTVAASSTFN-GFQKPDLHYIMSRRAWCVRAAAGQRGRSS

Gasterosteus_aculeatus_ODC1 MNTSTSTEFDFSFLEEG-FSARDIVEQKINESST--TDDRDAFYVCDLGDVLKKHLRWVRALPRVTPFYA--VKCNNSRAVVMTLASLGAG-FDCASKNEIHLVQSLG------VDPSRIIYANPCKQVSQIKYASAHGVRMMTFD------SEVELM---KVARCHENAKLVLRIATD-DSKAVCRLS-----VKFGAPLKACRGLLEC-AK-KLQLDVIGVSFHVGSGCT-DPQTYSQAIADARCVFDMGD------ELGFNMDLLDIGGGFPGS-DE----AELKFEEITG---VISPALDKFFPADTG----IKVIAEPGRFYVASAYTLVVNIIAKKAIVDDESASDE------EDEGTNDTTLMYYVNDGVYGSFNCILYDHAHCLPTLLKK------PKPDEAMYTCSIWGPTCDGLDRIVE-QCDLP-DLQVGDWLVFDNMGAYTVAASSTFN-GFQKPDIYYVMSRTAWQQVQRICSQGLPP

Danio_rerio_ODC1 MTACTGSDFDFAFLEEG-FCARDIVEQKINESSL--SDDKDAFYVADLGDVLKKHLRWLRVLPRITPFYA--VKCNDSRAVVTTLASLGAG-FDCASKTEIQIVQSVG------VDPSRIIYANPCKQVSQIKYASAHGVQMMTFD------SEVELM---KVARSHENAKLVLRIATD-DSKAVCRLS-----VKFGATLKSSRLLLER-AK-ELGLDVIGVSFHVGSGCT-DPETYSQAISDARYVFDIGA------ELGYNMSLLDIGGGFPGS-ED----TKLKFEEIAA---VINPALDKYFPVDSG----VRIIAEPGRYYVASAYTLAVNIIAKKVIMKEQSASDE------EEDVSNDRTLMYYVNDGVYGSFNCILYDHAHVLPTLHKK------PKPDERMYPCSIWGPTCDGLDRIVE-QCSLP-DMQVGDWLLFENMGAYTVAASSTFN-GFQKPDIYYIMSRTAWQCMQQIRAQGIPA

Anolis_carolinensis_ODCp -MTRCLDESDIVMVEEG-FTTKDVLENLLLEVDQ--TGNREPFFVADLEEVVKKHLRLLKALPRIKPFYA--LKCNRSKGVVQTLAGLGAG-FSCANKTEMALVKSVG------VPAERIICASPCKQLSLIKYAASQGVQLMTFD------NEVELG---KVARSHPSARMLLCLATD-DSRSSTHLS-----IKFGATLKTCRHLLET-AK-EMKVEVVGISFHLGSSCP-DPQIFTQSIADARLVFEMGA------EVGYKMHLLDIGGGFPAF-EE----SRGRFEEARITSAVVNSALDLYFPEGCG----VEIMAELGRYYVDSAFTLAVNIVAKKEVTLDQVSSED------EDP-GGKKSFVYHLNDGVYGSFGSVIFNNACPIPILHQK------PSPDQRLHSSSFWGPTGDGLDRLAE-GVDLP-ELHVGDWLVFENMGAYAVPPSASLS-SGPPARIHYAMSRVAWEAVQLLWGKLLHT

Gallus_gallus_ODCp -MNGYLNESNFMMVEEG-FTSRDLLESTLVELCR--TGDQQAFFVADLGDIVKKHLHFLKALPRVKPYFP--VKCNSSGGVIRLLAELGAG-FACANKTEIAEVQSIG------VPADKIFYSSPCKQIAHIKYAASHGVQLMTFD------NLVELS---KVARSHPQARMLLGIAAD-SS-PSAHPS-----MTFGATLKSCRCLLES-AK-EQDVEVVGISFHLGRHSL-EPQVFAQAVAEAQLAFDMGA------ELGYRMHLLDIGGGFPGT-ED----TRAQFEEI---AAVINSALDMYFPEGCG----VEIIATPGRYYVTSAFTFAASITSKEDVPVEQPGSDG------EES-GSKRSFVYHLSNGIYGTFSCVLFDGPCPKPLLHKK------PCSEQLLCSSSLRGPLGHAEDQITD-DVELP-ELQDGDWLIFQDMGAYSIATSSLCG-GCPQPHVTYAMSRLAWKALQLLQGKPPPA

Bos_taurus_ODCp -MAGYLRETDFVMVEEG-FSTRDLLEELTLGASQATTEEVAAFFVADLGAVVRKHFCFLKCLPRVRSFYA--VKCNSSPGVLKVLAELGLG-FSCANKAEMELVQHIG------VPASKIIYANPCKQIAHIKYAAKHGVRLLSFD------NEMELA---KVVKSHPSAKMVLCVATE-DSHSLSRLS-----LKFGASLKSCRHLLEN-AK-RDHVEVVGVSFHIGSDCP-DPQAYAQSIADARVVFEMGA------ELGHRMHILDLGGGFPGV-ED----AKVRFEEI---ASVINSALDLYFPEGCG----VDILAKLGRYYVTSAFTLAVSIIAKKEVLLDQPGREE------ETS-SSPKSVVYHLGEGVYGVFNSVLFDSACPAPILQKK------PSTEQPLYSSSLWGPVASGCDCVAE-GLWLP-QLHVGDWLVFENMGAYTVGVGSLLR-GAQTCRITYAMSRVAWEALQGQLLPAEQD

Canis_familiaris_ODCp -MAGYLSETDFVMVEEG-FSTRDLLEELTLGASQATAGDVAAFFVADLGAVVRKHFCLLKCLPRVRPFYT--VKCNSSPGVLKVLAELGLG-FSCANKAEMELVQRIG------VPASKIVYANPCKQIAQIKYAAKHGVRLLSFD------NEVELA---KVVKSHPSAKMVLCIATD-DSHSLSHLS-----FKFGASLKSCRHLLEN-AK-RSHVEVVGVSFHVGSGCP-DLHAYTQSIADARLVFEMGA------ELGHRMHILDLGGGFPGL-EG----AKVRFEEI---ATVINSALDLYFPEGCG----VDILARLGRYYVTSAFTLAVSIIAKKEVLLDQPGREE------ETG-STPKTIVYHLGEGVYGIFNSVLFDNTCPTPILQKK------SSTEQPLYSSSLWGPVADGSDCVAE-GLWLP-QLHVGDWLVFENMGAYTVGMGSLFG-GTQTCRVTYAMSRVAWEALRGQLLPAEQD

Homo_sapiens_ODCp -MAGYLSESDFVMVEEG-FSTRDLLKELTLGASQATTDEVAAFFVADLGAIVRKHFCFLKCLPRVRPFYA--VKCNSSPGVLKVLAQLGLG-FSCANKAEMELVQHIG------IPASKIICANPCKQIAQIKYAAKHGIQLLSFD------NEMELA---KVVKSHPSAKMVLCIATD-DSHSLSCLS-----LKFGVSLKSCRHLLENAK--KHHVEVVGVSFHIGSGCP-DPQAYAQSIADARLVFEMGT------ELGHKMHVLDLGGGFPGT-EG----AKVRFEEI---ASVINSALDLYFPEGCG----VDIFAELGRYYVTSAFTVAVSIIAKKEVLLDQPGREE------ENG-STSKTIVYHLDEGVYGIFNSVLFDNICPTPILQKK------PSTEQPLYSSSLWGPAVDGCDCVAE-GLWLP-QLHVGDWLVFDNMGAYTVGMGSPFW-GTQACHITYAMSRVAWEALRRQLMAAEQE

Macaca_mulatta_ODCp -MAGYLSESDFVMVEEG-FSTRDLLKELTLGASEATTDEVAAFFVADLGAIVRKHFCFLKCLPRVRPFYA--VKCNSSPGVLKVLAQLGLG-FSCANKAEMELVQHIG------VPASKIIYANPCKQIAQIKYAAKHGIQLLSFD------NEMELA---KVVKSHPSAKMVLCIATD-DSHSLSRLS-----LKFGVSLKSCRHLLENAK--KSHVEVVGVSFHIGSGCP-DPQAYAQSIADVRLVFEMGT------ELGHKMHVLDLGGGFPGT-EG----AKVRFEEI---ASVINSALDLYFPEGCG----VDILAELGRYYVTSAFTVAVSIIAKKEVLLDQPGKEE------ENG-STTKTVVYHLDEGVYGIFNSVLFDNICPTPILQKK------PSTEQPLYSSSLWGPAVDGCDCVAE-GLWLP-QLHVGDWLVFDNMGAYTVGMGSPFG-GTQACHITYAMSRVAWEALRRQLMAAEQE

Procavia_capensis_ODCp* ------GKVAAFFVADLGAIVWKHFGFLKCLPRVRPFYA--VKCNSSPGVLKALAELGLG-FSCANKAEMELVQQIG------IPASKIMYSNPCKQIAHIKYAAKHGVRLLSFD------NETEMA---KVARSHPSARMVLCITTN-DSHSLTHLS-----MKFGASLKSCRHLLEDAK--KSHVEVVGVSFHIGSGCP-DPQAYAQSIADARLVFEMGA------ELGHKMRILDLGGGFPGV-EG----AQVRFEEI---ASVINSALDLYFPEGCG----VDILAELGRYYVTSAFTLAINIIAKKEVLIDQPTKEE------ETG-LTPKTIVYHLEEGVYGIFSSVLFDNACPTPTLQKK------LSAEQPLYSSSLWGPAVDGCDCVAE-GLWLP-QLHVGDWLVFENMGAYTVGVGSFLG-GTQSCHVTYAMSRVAWEMLHGHLLPAEQD

Mus_musculus_ODCp -MAGYLSESDFVMVEEG-FSTRDLLEELTLGASQATSGKVAAFFVADLGAVVRKHFCFLKHLPRVRPFYA--VGCNSSLGVLKVLAELGLG-FSCANKAEMELVQHIG------VPASKIICANPCKQVAQIKYAAKHGVRLLSFD------NEVELA---KVVKSHPSAKMVLCIATQ-DSHSLNHLS-----LRFGASLKSCRHLLENAK--KSHVEVVGVSFHIGSGCP-DPQAYAQSIADARLVFQMGE------ELGHTMNILDLGGGFPGL-EG----AKVRFEEM---ASVINSALDLYFPEGCG----VDILAELGRYYVTSAFTVAVSIVAKREVLD-QASREE------QTG-AAPKSIVYYLDEGVYGVFNSVLFDNTCPTPALQKK------PSADQPLYSSSLWGPAVEGCDCVAE-GLWLP-QLQVGDWLVFDNMGAYTVDTKSLLG-GTQARRVTYAMSRLAWEALRGQLLPAEED

Rattus_norvegicus_ODCp -MAGYLSESDFVMVEEG-FSTRDLLEELTLGASQATTGKVAAFFVADLGAVVRKHFCFLKYLPRVRPFYA--VRCNSSLGVLKVLAELGLG-FSCASKAEMELVQHIG------VPASKIICANPCKQVAQIKYAAKHGVRLLSFD------NEVELA---KVVKSHPSAKMVLCIATQ-DSHSLNHLS-----LRFGASLKSCRHLLENAK--QSHVEVVGVSFHIGSGCP-DPQAYAQSIADARLVFQMGA------ELGHTMNILDLGGGFPGL-EG----AKVRFEEM---ASVINSALDLYFPEGCG----VDILAELGRYYVTSAFTVAVSIVAKKEVLD-QPSREE------QTG-AAPKSIVYHLDEGVYGVFNSVLFDNTCPTPALQKK------PSADQPLYSSSLWGPAVDGCDCVAE-GLWLP-QLQVGDWLVFDNMGAYTVDTKSLLG-GKPFKGSCCLQKKTRTPRVCANLCPAAGR

Monodelphis_domestica_ODCp -MAGYLSESDFVMVEEG-FTTRDLLEELTLGGPQVGKEKKASFFVADLGDVVKKHLRFLKNLPRVRPFYV--VKCNSSPGVLRALAELGLG-FSCANKAEMELLRHIG------VPAHKIIYTSPCKQAAQVKQAARLGIRMLSFD------NEVELA---KVARSHPTARMVLRIATD-DSCSPARLS-----MKLGATLKSCRHLLETAK--KMNMEVVGVSFHVGSGCSSDPQAFTQSIADARLVFEMGT------ELGYRMHILDLGGGFPGT-ED----SKVRFEEM---ASVINSALDMYFPEGCG----VDILAEPGRYYVASAFTLAVRIVAKKEVPSDQTGLDE------EDG-ASPKSIVYHISEGVYGAFNCVFFDNACPMPILQKK------PSPDQRVYSSSLWGPTCDDLDHVAE-GLCLP-ELQLGDWLIFENMGAYTVGTTASCS-GQQTCQTTYAMSRVTWEAVRGRLLPPE--

Ornithorhynchus_anatinus_ODCp -MAGYLQESDFVMVEEGDLATRDLLESLTLEGSRGRSGDVAAFFVADLGDVVRKHLRFLKALPRVQPFYA--VKCNGSRGVVKTLAELGTG-FDCASKKEIELVQSIG------VPGHKIIYANPCKQISHIKYAARHGVQVMTFD------NEVELA---KVAKRYPGARMVLSIATD-EFKSPAHLN-----IKFGATLKSCRHLLETAK--KMNVEVIGISFHVGSACC-DPQAFTQAIADARLVFEMGA------ELGYRMHLLDLGGGFPGP-EN----STVRFEEL---ASVINSALDLYFPEGCG----VEIIAEPGRYYVASSFTLAVNIIAKEHIPSEHLGSDG------AGG-VAPKSIKYRVNDGVYGAFNSVLFDNTCPAPVLQKE------PHPGQPLYSSSLWGPACDGPEPIAE-GLRLP-DLQVGDWLTFENMGAYTAGPASPFS-AARPRRIVYTMSRVPWEALQRKLLQAE--

Xenopus_laevis_ODC2 -MQGYIQESDFTLVEEG-FLARDLMEEIINEVSQ--TEDRDAFFVADLGDVVRKHLRFLKALPRVKPFYA--VKCNSSKGVVKILAELGAG-FDCASKTEIELVQDIG------VAPERIIYANPCKQISQIKYAAKNGVQMMTFD------NEVELS---KVSRSHPNARMVLRIATD-DSKSSARLS-----VKFGAPLKSCRRLLEMAK--NLSVDVIGVSFHVGSGCT-DSKAYTQAISDARLVFEMAS------EFGYKMWLLDIGGGFPGT-ED----SKIRFEEIAG---VINPALDMYFPESSD----VQIIAEPGRYYVASAFSLAVNVIAKKEVEHSVS--DD------EEN-ESSKSIMYYVNDGVYGSFNCLVFDHAHPKPILHKK------PSPDQPLYTSSLWGPTCDGLDQIAE-RVQLP-ELHVGDWLLFENMGAYTIAASSNFN-GFQQSPVHYAMPRAAWKAVQLLQRGLQQT

Xenopus_tropicalis_ODC2 -MQGYIQESDFTLVEEG-FMARDLMEEIINEVSQ--TEDRDAFFVADLGDVVKKHLRFLKALPRVKPFYA--VKCNSSRGVVKILAELGAG-FDCASKTEIELVQDIG------VTPERIIYANPCKQISQIKFAAKTGVQMMTFD------NEVELS---KVSRNHPNARMVLRIATD-DSKSSARLS-----VKFGAPLKSCRRLLEMAK--NLSVDVIGVSFHVGSGCT-DSKAYTQAIADARLVFEMAS------EFGYNMWLLDIGGGFPGT-ED----SKIRFEEMAG---VINPALDLYFPEGSD----VQIIAEPGRYYVASAFSLAVNIIAKKEVLMEHSGSDD------EEN-GPNKNIMYYVNDGVYGSFNCLVFDHAHPKPILHKK------PSPDQSLYTSSLWGPTCDGLDQIAE-NLLLP-ELDVGDWLLFENMGAYTIAASSNFN-GFQQSPVHYAMPRAAWKAVELLQRGLQRT

Petromyzon_marinus_ODC1 -MSGLETSELKLTPLEDDVSLHDMLEARIQEMRT---DEKDAFYVVDLGDIVRKHLRWLCSLPRVRPFYA--IKCNSTQTIVHTLATLGAG-FDCASKAEIALVQSLG------VSADRIIYANPCKQASHVRYAAEHGVNLMTFD------NDAELH---KAARINPNAKMVLRIVTD-DSKSICRFS-----MKFGASLKASRHLLETAR--NLGVDVVGVSFHVGSGCQ-DAQTYAQSIADARVLFNIAA------EMGFNMNLLDIGGGFPGSDTN----AKLTFDEIAA---VVNPALDLYFPKGCG----VNIIAEPGRYYVTSAFTLAVNIIAKKTFSKASANGGE------E------PVHMYYVNDGVYGSFNCILFDHVQPDPIVYKH------VEPEEPVFESSLWGPTCDGLDRVVE-RMQLP-ELHVGDWLLFRNMGAYTMAAASNFN-GFPKPPLHYVIRNADWIAIHELHRSLSEM

Petromyzon_marinus_ODC2 MKGFKEQDMPYFSLLSDGISTRDFLDETIRGLVFS--DEKNAFYVADLGDVVQKHARWLEHLPLVSPFYA--VKCNDELPVLRALAAMGAG-FDCASKNEMALVLGLG------VPAERIIYANPCKQVSHIKYAARHGVHTMTFD------NEAELE---KVARNHPHARLVLRIMAD-DSKAVCRLS-----VKFGASLKSCRHLLERAR--QLGVDVIGVSFHVGSGCM-EAETFALAIADARCVFDMAV------DFGYCLSLLDIGGGFPGS-PD----AKVTFEEIAG---VLNGALERYFPAESG----VRVIAEPGRFYVASAFMLAVGIIAKKAVVQNSLDNEE------ASR-DDQPAYMYYVNDGVYGSFNCILFDHANVLPLAHRK------VDLDEPLFETSVWGPTCDGLDCVLE-CVQLP-ELHLGDWLIFQHMGAYTLAAASTFN-GFQKPVVHYVMSSEDRLLMQELLSGMEEV

Homo_sapiens_AZIA1 MKGFIDDAN-YSVGLLDEGTNLGNVIDNYVYEHTLTG--KNAFFVGDLGKIVKKHSQWQNVVAQIKPFYT--VKCNSAPAVLEILAALGTG-FACSSKNEMALVQELG------VPPENIIYISPCKQVSQIKYAAKVGVNILTCD------NEIELK---KIARNHPNAKVLLHIATE-DNIGGEEGN-----MKFGTTLKNCRHLLECAK--ELDVQIIGVKFHVSSACKES-QVYVHALSDARCVFDMAG------EIGFTMNMLDIGGGFTGT------E--FQLEEVNHVISPLLDIYFPEGSG----VKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSG------VEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKK------YKEDEPLFTSSLWGPSCDELDQIVE-SCLLP-ELNVGDWLIFDNMGADSFHEPSAFN-DFQRPAIYYMMSFSDWYEMQDAGITSDSM

Macaca_mulatta_AZIA1 MKGFIDDAN-YSVGLLDEGTNLGNVIDNYVYEHTLTG--KNAFFVGDLGKIVKKHSQWQNVVAQIKPFYT--VKCNSAPAVLEILAALGTG-FACSSKNEMALVQELG------VSPENIIYISPCKQVSQIKYAAKVGVNIMTCD------NEIELK---KIARNHPNAKVLLHIATE-DNIGGEEGN-----MKFGTTLKNCKHLLECAK--ELDVQIIGVKFHVSSACKES-QVYVHALSDARCVFDMAG------EIGFTMNMLDIGGGFTGT------E--FQLEEVNHVISPLLDIYFPEGSG----VKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSG------VEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKK------YKEDEPLFTSSLWGPSCDELDQIVE-SCLLP-ELNVGDWLIFDNMGADSFHEPSAFN-DFQRPAIYYMMSFSDWYEMQDAGITSDSM

Canis_familiaris_AZIA1 MKGFLDDAN-YSVGLLDEGTNLGNVIDNYVYEHTLTG--KNAFFVGDLGKIVKKHSQWQNIVAQIKPFYT--VKCNSTPAVLEILAALGTG-FACSSKTEMALVQELG------VSPENIIYISPCKQVSQIKYAAKIGVNTMTCD------NEVELK---KIARNHPNAKVLLHIATE-DNIGGEEGN-----MKFGTTLKNCRHLLECAK--ELDVQIIGVKFHVSSACKES-QVYVHALSDARCVFDMAG------EFGFTMNMLDIGGGFTGT------E--FQLEEVNHVISPLLDVYFPEGSG----IKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSG------VEKTGSDEPAFMYYMNDGIYGSFASKLSEDLNTIPEVHKK------YKKDEPLFTSSLWGPSCDELDQIVE-SCLLP-ELNVGDWLIFDNMGADSLHEPSAFN-DFQRPAIYYMMSFSDWYEMQDAGLTSDTM

Bos_taurus_AZIZ1 MKGFIDDAN-YSVGLLDEGTNLGNVIDNYVYEHTLTG--KNAFFVGDLGKIVKKHSQWQNIVAQIKPFYT--VKCNSTPAVLEILAALGTG-FACSSKTEMALVQELG------VSPENIIYISPCKQVSQIKYAAKVGVNIMTCD------NEVELK---KIARNHPNAKVLLHIATE-DSIGGGEGN-----MKFGTTLKNCRHLLECAK--ELDVQIIGVKFHVSSACKES-QVYVHALSDARCVFDMAG------EFGFTMNMLDIGGGFTGT------E--FQLEEVNHVISPLLDVYFPEGSG----IKIISEPGSYFVSSAFTLAVNIVAKKVVENDKFSSG------VGKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKK------YKADEPLFTSSLWGPSCDELDQIVE-NCLLP-ELNVGDWLIFDNMGADSVHEPSAFN-DFQRPAIYYMMSYSDWYEMQDAGATSDTT

Mus_musculus_AZIA1 MKGFIDDAN-YSVGLLDEGTNLGNVIDNYVYEHTLTG--KNAFFVGDLGKIVKKHSQWQTVVAQIKPFYT--VKCNSTPAVLEILAALGTG-FACSSKNEMALVQELG------VSPENIIFTSPCKQVSQIKYAAKVGVNIMTCD------NEIELK---KIARNHPNAKVLLHIATE-DNIGGEDGN-----MKFGTTLKNCRHLLECAK--ELDVQIIGVKFHVSSACKEY-QVYVHALSDARCVFDMAG------EFGFTMNMLDIGGGFTGT------E--IQLEEVNHVISPLLDIYFPEGSG----IQIISEPGSYYVSSAFTLAVNIIAKKVVENDKFSSG------VEKNGSDEPAFVYYMNDGVYGSFASKLSEDLNTIPEVHKK------YKEDEPLFTSSLWGPSCDELDQIVE-GCLLP-ELNVGDWLIFDNMGADSFHEPSAFN-DFQRPAIYFMMSFSDWYEMQDAGITSDAM

Rattus_norvegicus_AZIA1 MKGFIDDAN-YSVGLLDEGTNLGNVIDNYVYEHTLTG--KNAFFVGDLGKIVKKHSQWQNVVAQIKPFYM--VKCNSTPAVLEILAALGTG-FACSTKNEMALVQELG------VSPENIIYTSPCKQASQIKYAAKVGVNIMTCD------NEVELK---KIARNHPNAKVLLHIATE-DNIGGEDGN-----MKFGTTLKNCRHLLECAK--ELDVQIIGVKFHISSACKEY-QVYVHALSDARCVFDMAG------EFGFTMNMLDIGGGFTGT------E--IQLEEVNHVISPLLDIYFPEGSG----IQIISEPGSYYVSSAFTLAVNIIAKKVVENDKLSSG------VEKNGSDEPAFVYYMNDGVYGSFASKLSEDLNTVPEVHKK------YKEDEPLFTSSLWGPSCDELDQIVE-SCLLP-ELSVGDWLIFDNMGADSLHGPSAFS-DTQRPAIYFMMSLSDWYEMQDAGITSDAM

Monodelphis_domestica_AZIA1 MKGFIEDAN-YSVGLLDEGTHLGNVIDNYVYEHTLTG--KKAFFVGDLGKIVKKHSQWQNVVAQIKPFYT--VKCNSAPAVLEILAALGTG-FACSSKNEMALVQELG------VSPENIIDISPCKQSSQIKYAAKTGVNIMSCD------NEIELK---KIARNHPNAKLLLHIATE-DISGDEESN-----MKFGTTLKNCRHLLECAK--ELDVQIVGVKFHVSSSCKEP-QVYIHALSDARCVFDMAG------EFGFKMTILDIGGGFTGS------E--FQLQEVNHVISPLLDVYFPEGSG----IKVISEPGSYYVSSAFTLAVNIIAKKVVENDVVSSG------VGKTGSNEPAFMYYMNDGVYGSFASKLSENLNTIPEVHKK------YKKDAPLFTSSLWGPSCDELDQIVE-NCLLP-ELNVGDWLIFDNMGADTLHEPSAFN-DFQRPTIYYMMSFSDWYEMQDAGITSDTM

Ornithorhynchus_anatinus_AZIA1 MKGFIEDAN-YSIGLLDEGTNFGDVIDNYVYEHTLTG--KDAFFVGDLGKIVKKNSQWQNIVAQIKPFYT--VKCNSTPAVLEILAALGTG-FACSSKSEIALVQELG------VPPENIIYVSPSKQTSQIKFAAKAGVNIMTCD------NEMELK---KIALNHPNAKLLLHIATE-DISGDEEMS-----MKFGTTLKNCRHLLECAK--ELQVQIVGVKFHVSSSCKEP-QVYIHALSDARCVFDMAG------EFGFKMNILDIGGGFTGS------E--FQLEEVNHVIRPLLDIYFPEGSG----IKVIAEPGSYYVSSAFTLAVNIIAKKVVENDHLSSG------VEKTRNSEPAFMYYMNDGVYGSFASNLAKSLNTVPEVHKK------YKKDDPLFTSSLWGPSCDELDQIVE-SCLLP-ELNVGDWLVFDNMGADTLREQSTFN-DFQRPAIYYMMTLSDWYEMQDAGVTSDTL

Gallus_gallus_AZIA1 MKGFLEDAN-YSIGLLDEGATLADVIDNCIYEHTHTG--KRAFYVGDLGKLVKKNIQWQNVMAPIKPFYT--VRCNSTPGVLEILGTLGIG-FACSSKSEMALVQGLG------ISPENIIYTNPCKQASQIKYAAKAGINIMTCD------SDIELK---KIARNHPNAKLLLHIATE-DITADEEMN-----MKFGTTLKNCRHLMECAK--EFGVQIVGVKFHVSGSCKEL-QTYIHAISDARCVFDMAE------EFGFKMNMLDIGGGFTGS------E--LQLEEVNHVIRPLLDVYFPKESG----IQVIAEPGCYYVSSAFTLAVNVIAKKAVDCDKLLPSGV------EQARNDDEPVFTYYINDGVYGSFASKLSEKLYTNPEVHKK------YKEDEPLFASSLWGPSCDELDQIVE-NCLLP-ELSVGDWLIFDNMGSGTLGEQSTFN-DYQRPLIYYMMSFSDWDEMQDAGIASDTL

Xenopus_laevis_AZIA1 MKGFIEDTN-YSIGLLDDSATPRDVVDNYIYEHTLMG--KNAFFVADLGKIVKKHFKWKNIMGHIKPFYT--VRCNSSPAVLEILAALGMG-FACANKNEMSLVYDLG------ISMENVVYTNPCKQASQIKHAAKIGVNLMTCE------SETELK---KIVRNHLNAKLLLHIATE-GISGEEEMN-----MTFGTTLKNCRHLLDCAK--ELSVEVVGVKFHVSSSSNNP-QTYIHALSDARCVFDMAK------ELGFKMNILDIGG-ISEN------E--AQLEEVYQAVSPLLDVYFPEGSG----TRIIAEPGSFYVSSAFTLAVNVIAKEATEHDQHLSS------AGKPNSNKPAFIYCMKEGVYGSFARKLSEKLNTAPEVHKK------YKDNEPLFASSLLGPSYDELDVIVE-HCLLP-ELEVGDWIVFDNMGCGSVNETSPFT-DFDKPSLYNFMTFSDWYEIQDTGNTSESL

Xenopus_tropicalis_AZIA1 MKGFIEDTN-YSIGLLDDTATPRDVIDNYIYEHTLMG--KNAFFVADLGKIVKKHFKWKNIMGRVNPFYT--VRCNSSPAVLEILAALSMG-FACANKNEMSLVYDLG------IPMENAVYTNPCKQASQIKHAAKIGVNLMTCD------SETELK---KIARNHFNAKLLLHIATE-GISGEEDMN-----MTFGTTLKNCRHLLECAK--ELSVEVVGVKFHVSSS-NNP-QTYIHALSDARCVFDMAE------ELGFKMNILDIGG-ISEN------E--AQLEELYQAVSPLLDVYFPEGSG----TRIIAEPGSFYVSSAFTLAVNVMAKNVIEHDQHLPS------AGKQISNKPAFIYCMNEGVYGSFARKLSEKLNTAPEVHKK------YKDDEPLFASSLLGPSYDELDVIVE-HCLLP-ELEVGDWVVFENMGCGSLNEQSPFA-DFEKPSLYNFMSFSDWYEIQDTGNTSESL

Xenopus_laevis_AZIA2 MKGFIDDTN-YSIGLLEDTATPRDVVDHYIYDHTLMG--KNAFFVADLGKIVKKHFKWKNIMGHIKPFYT--VRCNSSPAVLEILAALGMG-FACANKNEMSLVYDLG------ISMENVVYTNPCKQASQIKHAAKIGVNLMTCD------SETELK---KIARNHLNAKLLLHVATE-GMSGEEEMS-----MTFGTTLKNCRHLLDCAK--ELSVEVVGVKFHVSNS-SNQ-QTYNHALSDARCVFDMAE------ELGFKMNILDIGG-IPEN------E--AQLEELYQAVGPLLDVYFPEGSG----TRIIAEPGSFYVSSAFTLAVNVIAKETIEHDHHLSS------AGKPISNKLAFVYCLNEGVYGSFARKLFEKLDTTPEVHKK------YKDGEPLFTSSLLGASYDELDVIVD-HCVLP-ELEVGDWIVFENMGCGSLNENSPFA-DFEKPSLYNFMSFNDWYGIQDTGNISESL

Squalus_acanthias_AZIA1 MKGFVELEESYPFDLLEEKTTLNDVIDNHIREHTLEQTERNAFFVADLGNVVKKNIRWQNVMTHVKPFYT--VKCNSSQSVIEVLAALGTG-FACANKNEITLVQSLG------VTSXNIIYTNPCKQVSQIKYAAXKGINVMSCD------NDAELL---KIARNHPSAKLLVDIATA-DSSEENEMS-----MKFGATLKDCRHLLESAK--ELGVQVVGVRFHVSSSNSNM-EAYLHALADARCVFDMAE------EFGFNMNLLDIGGGFSGT------DGELQLEKVFDAINPLLDIYFPSESG----IKIIAEPGSYYVNSAFTLAVNIVAKKAVARDSQDQSGV------VVSSMNDEPFFIYYISDGVYGSFANNLYGTVNAIPILHKK------PNSGEPVFASSLWGPSCDGLDQVVE-HCLLP-EL------

Fugu_rubripes_AZIA1 MKGLTDKPN-YTIELLEGGVTLEDVIDGHICEQTLVD--KTAFVVGDLGALMRQHVCWQSVSPLLQPYFP--VKCNSSPAVIEVLASLGLG-FVCVNKAEMSLVLEHG------VPPEAIILSGVCKQQAHIKYAAKNNIQHLVCE------NKAELI---KISRLHPNAKLLLQLSTQ-AH--AAETS-----MTFGFSLKSARHLLEAAK--ELELQVVGVSFHIPSSCQDLQEAYTHVLSDARCVFDMGVCQQIGVDLGFNMNLLDIGSGFTGS------E--FQLRQVESALKPLLDAYFSPLSG----VQVLAQPGNFYVASAFCLAIAVIGKKMVN--HHWDNL------AQGENNEGTEFLYYMNEGVYGPFSCKLLGNSISAPSVHKHV------LSAEEALYPSSLWGPSLDQLDHVVE-RCLLP-ELSVGDWLLFPNMGACGLEDFN-----SLQLPVYYTVSTSDWFEMQEAGVALDNA

Tetraodon_nigroviridis_AZIA1 MKGLADKPS-YTIELLEGGVTLEDVIDGHICEQTLVD--KTAFVVGDLGALMRQHVRWQSISPRLQPYFP--VKCNSSPAVIEVMASLGLG-FVCVNKAEMSLVLEHG------VPPEAVILSGVCKQQAHIKYAAKNNIQNLVCE------NEAELF---KISRLHPNAKLLLQLSTQ-AH--AAETS-----MTFGFSLKSSRHLLEAAK--QLGLQVVGVSFHIPSSCQDLQEAYTHALSDARCVFDMG------VESALKPLLDTYFSPLSG----VQVLAQPGNFYVASAFCLAVTIMGKKLVN--PRWDNL------AQGEDNEGTEFLYYMNEGIYGPFSCKLLGNSISAPSVHKHA------LCAEEAMYPSSLWGPSLDQLDQVVE-RCLLP-ELSVGDWLLFPNMGACGLEDFG-----SLQLPVYYTVSTSDWFEMQEAGVALDNA

Gasterosteus_aculeatus_AZIA1 MKGLVDKPS-YIIELLEGGVTLEDIIDGHICEQTLVE--KSAFVVGDLGALMRQHVCWQSAAPRLQPYYP--VKCNSSPAVIEVLASLGLG-FICANKTEVSLVLDHG------VPPENIILSGVCKQLAHIKHAAKNNIQHLVCE------NEAELS---KISRLHPGAKLLLQLNTE-SH--AAETS-----MAFGFSLKSCRHLLEAAK--ELGVQVVGVTFHIPSSCQDLQQAYTHALSDARCVFDMG------VDLGFNMNILDIGGGFTGS------E--GQLNQVESAVRPLLDAYFPPMSG----VQVLAQPGSFYVASAFSLAVNVIGKKVMN--RHWDSL------TQGVNNEDTEFLYYMNEGVYGPFSRKLLGNCIAAPSVHKHV------LCAEEEVFPSSLWGPSLDQLDQVVE-RCLLP-ELSVGDWLCFSNMGVCGLEEFSCLSS-SPQLPVYYTVSTCDWYEMQEAGVALDSA

Danio_rerio_AZIA1 MKGFVDAPN-YFIELLEGGTTLENVIDNHIYEQNLAE--KNAFVVADLGALMRQHVVWKTTMPLVRPFYP--VSCNSSPVVIELLSALGVG-FVCANKAETTLVLSHD------VPPENIILSGVCKQLLLIKHAAKTGINFLLCE------NEAELR---KIARAHPEAKLLLQVSTE-AQ--IEEAS-----VTIGCSLKGCRHLLELAK--ELNVSVAGVTFQVPASCKDP-QAYTHALSDARCIFDMG------KELGFDMNILDIGGGFSGS------E--FQLKQVHSVIRPLLEAYFPSESG----VSIIAEPGNFFVFSCFTLAVNVIGKKAAYRDLHTSTH------DKLTSSEAPEFVYYMNDGVYGSFMGRLFGNIISTPSVHKMS------LTLDEPVFSSSLWGPSCDPLDQVVE-RCLLP-ELAVGDWLVFINMGASGQEGPATFSD-TDQPPVYYTISTDDWFEMQEAGISLDDT

Fugu_rubripes_AZIA2 MKELTNELQ-HSVSLLEGNASLCDVIDNHIYEQTLAG--KNAFFIADLGVVMRQHVRWRTHMAQIRPYYS--VRCNSRPTVIDILAALGTG-FICTNKTELELVQSRG------VPSEDIIFSGVSKQLSQLKYAAKNGIDLLVCD------NEVELC---KISRCHPSAKLLLQVSTE-AFCQDNDLV-----MTFGCSLKDCRHLLERAK--ELGVQVVGVRFNISSSCEDP-QLYAHAMSDARCVFDMG------EEIGFNMNILDIGGGFNGC------E--TQLELVNNTVMSMVDLYFPPSSG----VCIIAEPGSFFVSSAFTLAVNVISKEVVARDSHDQAH------DEPSPNDEPAFQYFMKEGVYGSFASKLCETQIVAPSVHKS------SCLDAALFSSSLWGPSGDDMDQVVE-HCLLP-ELNIGDWLIFSQAGAYSLGQPLCSTDDSPPPHVCYVMSSADWFEMQDIGITYEGT

Tetraodon_nigroviridis_AZIA2 MKEITNELQ-YSVGLLEGNTTLCDVIDNHIYEQTLAE--KNAFFVADLGVVMRQHVRWRTHMAQIRPYYS--VRCNSSPTVIDVLAALGTG-FICTNKTELELVQRRG------VPPEDIIFSGVSKQLSQMKYAAKNGVDLLVCD------NEVELC---KISRCHPNAKLLLQVATE-AISPDNGMA-----MTFGCSLKDCRHLLERAK--ELGVQVVGVRFHIPGSCEDS-QVYVHAVSDARCVFDMG------EEIGFSMKILDIGGGFNGC------E--TQLELVNNAVVSMVDLYFPPSSG----VCIIAEPGSFFVSSAFTLAVNVISKEMVARDSLDQAH------DEPSPNDEPAFQYYMKEGVYGSFASKLCEDQIFVPSVHKN------TCLNAAVFSSSLRGPSGDDMDQVVE-HCLLP-ELDIGDWLIFSQAGAYSLGQPRCSTTDAPAPHVYYVVSSADWFEMQDAGVTYL--

Gasterosteus_aculeatus_AZIA2 MKGIADEPQ-YSVGLLEAGTALCDVINQHIDEQTLSE--KNAFFVADLGVVMRQHVRWRTHMPQIRPYYP--VRCNSSPAVIEVLAVLGAG-FICTNKSELELVQSHG------VPSEDIIYSGICKQVSQIKYAAKNGIDLLVCD------NEAELR---KISRCHPNAKLLLQVSTE-ASIQGDEMS-----MAFGCSLKDCRHLLEKAK--ELGVQVVGVRCHISSACEDD-QVYVHAISDARCVFDMG------EDIGFDMTILDIGGGFSGS------E--NQLEVINKAVMSMADLYFPPSTG----VSIIGEPGSFFVSSAFTLVVNVISKEVVARDRQDQAR------DDPSPNDEPEFQYHLSEGVYGPFASKLSETLIATPSVYK------PPQDAPLFSCSLWGPSGDDLDQVVE-HCLLP-ELNAGDWLLFTHAGAYSTGHPLCTATDSPPPPEYYIISSTDWFEMQDIGVAHEAT

Danio_rerio_AZIA2 MKGSLDELH-YSVELLEGSAALRDVIDKHIYDQTFAQ--KSAFFAADLGVIVQQQARWRNKMDQIRPFYT--VKSNSSPVVVELLASLGTG-FICSNKHELDLVKGFG------VSSQDIILGGTCKQLSHIKYAAKHNIPLLVCD------NEAEMR---KIARCHPKAKVLLLLTSE-SCCEKEEMA-----IPFGSTLKDCRRLLECAA-GELNLQVTGVKFNIPSCCQEV-EKFSRAVSEARCVFDMG------EELGFEMNILDIGGGFDGS------E--EQLDKVNQMLKPMLDMYFPRSTG----LSIIAEPGAYYVSSAFTLAVNIIDKKTVARDCSAQPH------DALSANDEPEFLYHINDGVYGSFASKLLCEDSIATPLAHKH------VSADEPLFSSSLWGPSEDDLDLVME-RCLLP-ELSVGDWLLFRNAGASALGSAFSHGDQHKPPVFYSITEYDWQEIHNSGVTVDVR

Trypanosoma_brucei_ODC QTEKSMDIVVNDDLSCRFLEGFNTRDALCKKISMNTCDEGDPFFVADLGDIVRKHETWKKCLPRVTPFYA--VKCNDDWRVLGTLAALGTG-FDCASNTEIQRVRGIG------VPPEKIIYANPCKQNSHIRYARDSGVDVMTFD------CVDELE---KVAKTHPKAKMVLRISTD-DSLARCRLS-----VKFGAKVEDCRFILEQAK--KLNIDVTGVSFHVGSGST-DASTFAQAISDSRFVFDMGT------ELGFNMHILDIGGGFPGT------RDAPLKFEEIAGVINNALEKHFPPDLK----LTIVAEPGRYYVASAFTLAVNVIAKKVTPGVQTDVGA------HAESNAQSFMYYVNDGVYGSFNCILYDHAVVRPLPQRE------PIPNEKLYPSSVWGPTCDGLDQIVE-RYYLP-EMQVGEWLLFEDMGAYTVVGTSSFN-GFQSPTIYYVVSGLPDHVVRELKSQKS--

Bos_taurus_ODC2/AZID KESPGSTWPKDIIALEPGETAWDVVLKKIKELSVSWRDCRHAFMVADLDVLASRHQVFRQALPRVSPFYV--VKCNSSPWMLRVLAALGTS-FDCSSQGELEQVLDLG------VAPSRIVYANACKPVSHIRFASLHGVKLLVFN------SEEELI---KVAQHHPGARLVLWWTQ--DSDSIFPLS-----SKFGARLEVCEHLLESAR--DLGLAVVGTSFHVGSRCQ-TPRNFMKAIVDCRRVFEMGS------SIGHDMSLLDIRGGFSREE------GSDPEFEEVAGVINAALAQDFPEGSG----VEVIAEPGRFYATFVCTTAVNIIAK------KA------VLEPRGRRKLLYYLNDGHYGTFRIFPRESE--PRMPIMVKE------LSPKLSLFPCTLFGPTCDAFDKLFLKEVQLP-ELDVGDWLVFPFMGAYTSVLSSTFS-GLSPTSICYAVGPELRSLLETTP------

Macaca_mulatta_ODC2/AZID KEAHGRPWPKELIALGPEESAQQMVLRRIQELSD--SDQQDPFMLADLDMLASRHQAFCQALPQVSPFYA--VKCNSSPWVLRVLAALGTG-FDCASQVELEQVLGLG------VAPSRIIYANPCKPASHIRYAARHGVQLLTFD------SEEELT---KVAQHHPGARLLLRLRTQ-DSQSTFPLS-----TKFGASLEACGHLLTSAR--DMGLAVVGASFHVGSNCQ-TPQSFTQAIADCRCVFEMGR------GAGHDMSCLDIGGGFPGTE------DSGPKFEEMARVISAALAQDFPEERG----VKVIAEPGRFYMESVCTAAVNIIAK------KA------VLEPGGSRKLMYYLNDGHYGSFRLGHREPV--PRVPIVVKE------FCSEPPLFPCTLYGPTCDASDRLFLEDVRLP-ELDVGDWLVFPSMGAYTSSMSCSFN-GFLPATICYTMGPQLRSLLEAEPEPRVG-

Mus_musculus_ODC2/AZID LGVAEHLRPSEPITLGPGASAWQLVLKKIKELSIS--GRQDAFMVADLDVLVSRHRTFLQALPRVQPFYA--VKCNSNPWVLLVLAALGTG-FDCASQGELEQVLGLG------VAPSRIIFANPCKAVSHIQFAARCGVQLLTFD------NEEELI---KLARYHPRARLVLRIQTL-DSQSTFPLH-----TKFGAHLEACGHLLQVAR--ELGLAVVGASFHVGSDCH-TPESYRQAIADCHRVFEMGC------KAGHHMSLLDLGGGFPGVK------GSEAKFEEVARVINTALAQYFPEETG----IEVIAEPGRFYAGSVCTAAVNIIVK------KS------SLDPGGHRKLAYYLNEGHYGVFRLFLRDPV--PRIPIVVKE------FPSEPPLFPCTLYGPTCDAYDRLFSTEVQLP-ELDVGDWLIFPDMGAYSSSMSSTFN-GFPIATVYDAMSPQLRSLLETVP------

Rattus_norvegicus_ODC2/AZID LGVTESLWPSEPITLGPETSARQLVLKKIQDLSIS--GHQDPFMVADLDVLASRHQTFLQALPRVWPFYA--VKCNNRPSLLLVLAALGTG-FDCASQGELEQVLGLG------VAPSRIIFANPCKAVSHIQYAARCGVQLLTFD------SEEELT---KLARHHPGARLILRIQTL-GGRSTFPLH-----TKFGARLLACGRLLQVAR--ELGLAVVGASFHVGSDCH-TPQSYRQAIADCHRVFEMGC------KAGHQMSLLDLGGGFPGIE------GSEAKFEEMARVVNAALAQYFPEGTG----VEVIAEPGRFYAESVCTAAVNIIAK------KA------SLEPGGHRKLAYYLNEGHYGAFRIFLRDPV--PRIPIVVKE------LPSDPHLFPCTLYGPTCDAFDRLFSTEVQLP-ELDVGDWLVFPDMGAYRSTMSSTFN-GFPITTVYDAMSPQLRSLLETVP------

Monodelphis_domestica_ODC2/AZID ------MLLETGTSAWKILQEKIRELSDS--DERDAFMVADLGVLAEQHKTFQQMLPRVTPFFA--VKCNNSSSVLRVLANLGTG-FDCASRGELEQVLRMG------IAPTRIIYANTCKQISHLQYAASHGVQLMTFD------CEEEIA---KIAKFHPTARLVLRLWTQ-DSESLFPLS-----TKFGAPLDQCGHLLTLAK--DLGVIVVGACFHVGSGCQ-TPQSFNKAIADARHVFDLGL------QIGHPMSLLDIGGGFPGKK------NFVPTFEEMAAVINIALDQYFPEGSG----VEIIAEPGRFYGTKVCTSALNIIGK------KD------VVEQGG-RKLMYYLNDGFYTSFAAIRREKE--TRIPHVVKK------FNCKPLLYPSTLWGPTCDAFDRLGPTDVLLP-ELHVGDWLIFEDMGAYTYTISSNFN-GFSRPELSFTIPSELSHPLLIFLTQIDHQ

Ornithorhynchus_anatinus_ODC2/AZID CPADTREEREPLHVLEPGDSSWKVLQRKIGDLSCS--EQRDPFLVADLGELVRKHQAFLQALPGVMPFYS--VKCNNSPWVLQILKSLGTG-FDCASQAELEQVLGLG------VPATRIIYANPCKQTSHIQYAASQGVQLMTFD------SEGELT---KVAKFHPGARMVLRIRTE-DSKSLHPLS-----TKFGASLEQSRRLLAVAR--NLNIAVIGVCFHVGSACQ-RVQNYEEAIADAHRVFEMGR------QEGHEMHFLDIGGGFPGTE------SFVPTFEEMAEGIRTALAHYFPEGCG----TEIIAEPGRYYATSVYVSALNIIAK------KA------TVEKGGCRKMMYYLNDGCYGLFQMSSMEDP--KLKPVVMKT------FSSEPPLYPCILWGPTCDAMDKISQEDILLP-ELEVGDWLVFKNMGSYSLTMFSSFN-GFPMPSVHYTLSQHLREPPSLVDTPDAHS

Fugu_rubripes_ODC2/AZIC TMNDVWPDKCGVYILDNESTATRFIDKKIKELDSMD--SEEPFQVLNLDTLIQMHLKWLSYLPRVKPFYA--VKCNSTETVLRTLNALGTG-FDCASKGEISQVLSLG------VKPENIIYAHTTKPQSHIKYACAQGVNLMTFD------DEEELQ---KVSRCHPKAKLVLRIAVD-DSSSFYRLS-----SKFGAGLSTTGRLLECAA--ELGLEVVGVSFHIGSKCS-QSLAFRQAIADARSVFDTAK------LLGFQFSLLDIGGGFSGK------DFPVTLQEFSEVINGALDEYFPFESG----VQVIAEPGRYYAESTFTLAANVIAKRVIMEDMRTEGE------KESP--EKLMMYYLSDGVFGSLNSVLKFTDKNEVTPYLHRV------SITKNH------

Tetraodon_nigroviridis_ODC2/AZIC ------KEGDIYILDNGRTAKDFMDKKIKEFDSMG--GEGPFFVVDLDTLVQKHLKWLSNLPRVKPFYA--VKCNSTPTVLKTLSALGTG-FDCASKGEISQVLALG------VKPEDIIYAHTTKPQSHIKYACTHGINLMTFD------SEDELR---KISFHHPKAN------SGAGLGTAGRLLERAA-QLGLEVVGVSFHVGSKCS-QNSTFRKAIADARQVFDTAN------LLGFQLSVLDIGGGLPGK------DIPVTFQECSDVINEALDEYFPLDGG----VQIIAEPGRYYVESIFTLAANVIAKRAVMDDVTKDEG------REST--ERLMMYYLNEGVYGSLNWLLTDPDYIEIKPYLHG------

Gasterosteus_aculeatus_ODC2/AZIC VVHVLSRDVCGIDILGHVTTVRDFLDHKIKEFVLAE--KEEPFYVANLDSIFERHLRWRTNLPRVKPFYA--VKCNHDAAVLRMMRALDAG-FDCASKVEMQMVLSLG------VKPDRIIYAHTTKPLSHIKYACTHGVDTMTFD------SEDELL---KISLCHAKAKLVLRIAVD-DSASKIRLS-----LKFGARLE-SVGKLLGRAA-ELGLEVIGVSFHVGSGCT-GSLAFKQAIGDARRVFDIAK------SLGLQMSLLDIGGGVSGRE------DCRVTFEEFSVVINGALEEFFPPGSG----VQIIAEPGRYFVDSAFTLAANVIAKRVIEEHKDEHND------TVNNGLDRIMMYYLNDGVYGSLSCLINDAAHTQVEPYLNRV------VESGEQRYRSVLWGPTCDSIDKVAG-VCWIP-ELRVGDWLLVDNMGAYSICSSTDFN-GFERAHVYPVVTAKTWHTLNLSDFFNLHQ

Branchiostoma_floridae_ODC2x DFNPRTYGLRSDETVTVFKKDTTWRQIAQVYKKIFRDSD-DALLILDLSVLHDKFTEWQKFMPNILPHYA--VKANDTPVIVKFLSCLGVG-FDCASKAEIDHVLGLPG------VS-GSDIIYGNPSKSKSHILHAKKMNVKKMTFD------SVCELE---KIKVVFPKAKVVLRLRVD-DSGATSQLE-----KKFGANPE--DCDALFETCKRLNLNLIGISFHVGSGQK-NADAHVKALQLVREMFDLAKEKYG-----IEMNFLDIGGGFPGYDDD----K-----AYIRFERIATGIVECVSEL----FPTTEVVAEPGRYFSSACMTAVTKVITKKSIVLEDGS------KRFKYYLNDGIYGSFNNIKNDSAEPEPQYLREQYLHPETPTY------PSTVYGPTCDSIDVMLTDIMMPE--LQIDDYLYFENMGAYTSSASSTFNGFPHASIQYIYCGNAFSPDEEE------

Dictyostelium_discoideum_ODC LLSRCEKLDIVRKELDVKPWDQGKVTIQELITSLLDKTDRDAFFVADVGVIIKQWQKWVKNLPNVKPYYA--VKCNPTVGVLRVLDALGTN-YDCASRTEIESVLNLG------VD-PSRIIYANPCKQISALKFARAHNVKLMTFD------NLSELE---KIEKFFPEAELVLRIAPD-DSKSVMRFG-----SKFGVHID--DCNDLLEMAKEMNLKVVGVSFHVGSGCQ-SGDSYADALIMVKSVFDMAKKLN------MELTLVDVGGGFTGSDDE----K-----FNAFTKVIREKTAELFS------PNVKIIAEPGRYFAAQSHTLAVTVISKRSIKQEDNRQHP------RRTSNNMRQYNYYLADGVYGSFNNTKFDYAKVEPLLLKPSTKQPT------PCTLFGPTCDSIDVVLKDTQIPE--LKIGDWLYFQDMGAYTIASSSSFNGFCPPPVYYYNSIPEEELKNL------

Leishmania_donovani_ODC RRLSNLYTQKGVKDAASAADAAATTATNGAVPAAPAYEPEDPFYIIDLGRVVEQMARWRHELPMVRPYFA--VKSNPQPAVLEVLSALGAG-FDCASKEEIHMVLGRQL------VASPDDIIFANPCKQLGDLREAQACGVTYVTVD------NPLEME---KISRLMPSAHAIIRIKTN-DSKAQCSFS-----TKFGAPLE--DVEGLLEAARQFNVTVCGVSFHVGSGND-DQSAYVSAVRDAYQVFQQAVQYG------FKCTILDIGGGFPGTEVV----EGSGNTSFEAIARTIRPVLAELFG-----GGDVTIISEPGRYFTAASHALLMNVFASRTLRLSDVEVSR------QAFQSVVSMDEPEEYQYYVNDGLYHSFNCILFDHAHPTLLLLNDGDGADGVESGTE---AAAVCSEEEGETSLSGPLANDPLFMSAWDRRRSFARRPLRITTIFGPTCDSMDCILKKQPFPE--MKLGDWLLVPDMGSYTTAAAGFFNGFATRRLEWVSSVDLCARPRPVYTREGNTL

Leishmania_infantum_ODC RRLSNLYTQKGVKDAASAADAAATTATNGAVPAAPAYEPEDPFYIIDLGRVVEQMARWRHELPMVRPYFA--VKSNPQPAVLEVLSALGAG-FDCASKEEIHMVLGRQL------VASPDDIIFANPCKQLGDLREAQACGVTYVTVD------NPLEME---KISRLMPSAHAIIRIKTN-DSKAQCSFS-----TKFGAPLE--DVEGLLEAARQFNVTVCGVSFHVGSGND-DQSAYVSAVRDAYQVFQQAVQYG------FKCTILDIGGGFPGTEVV----EGSGNTSFEAIARTIRPVLAELFG-----GGDVTIISEPGRYFTAASHALLMNVFASRTLRLSDVEVSR------QAFQSVVSMDEPEEYQYYVNDGLYHSFNCILFDHAHPTLLLLNDGDGADGVESGTE---AAAVCSEEEGETSLSGPLANDALFMSAWDRRRSFARRPLRITTIFGPTCDSMDCILKKQPFPE--MKLGDWLLVPDMGSYTTAAAGFFNGFATRRLEWVSSVDLCARPRPVYTREGNTL

Leishmania_tarentolae_ODC RRLANLYIQKGVKAASSAAHNAATTVTNGAVPVAPTCDPEDPFYIIDLGRVVEQMARWRHELPMVRPYFA--VKSNPQAAVLEVLSALGAG-FDCASREEIQMVLRNNL------VATPDDIIFANPCKQLSDMREAQACGVTYVTVD------NPLEME---KISRVMPSARAIIRIKTN-DSKAQCSFS-----TKFGASLE--DVEGLLQVARQFNVAVCGVSFHVGSGNY-DESAYVSAVRDAYQVFQQAAKYG------FHCTILDIGGGFPGTEAV----EGSGSASFESIARRIRPVLVELFG-----GGEVTIISEPGRYFTAASHALLMNGFASRTLPLSEVEVSR------QAFQSVVSMQEPREHQYYVNDGLYHSFNCILFDHAHPKLLLLNDGDGADEVQSGTE---AAAAYSDEEGGKSPSGPLANDSLFMSAWDRRRNLTSRPLRITTIFGPTCDSMDCILKKQPFPE--MKLGDWLLVPDMGSYTTAAAGVFNGFATRRLEFVSSADLSARSRAVHAHEGNTF

Leishmania_braziliensis_ODC RRLSNVYIEKGVKAAAATAAATTTPTN-CTISGVPRHEPEDPFYIIDLGRVVEQMARWRHELPMVRPYFA--VKSNPQLALLEVLGALGSG-FDCASKGEIQTVLDNHL------VASPDDIIFANPCKQPGDMREAQARGVTYVTVD------NLLEIE---KISRLMPSARAVIRIKTN-DSKAKCAFS-----TKFGVPLN--DVESLLQAARQFKVDVYGVSFHVGSSNS-DPATYVSAVRDAYHVFQQASQYG------FNCTLLDIGGGFPSVETN----TASGEATFEDIARAIRPVLEELFG-----GGDVTIISEPGRYFTASTHALLVNVFASRKLRMSDVEKASS------QALQSVVPMDEPEEYQYYVNDGLYHSFNCIIFDHAHPTLLLLNDGDGADAVEG------NKEEGETSLS------SRTRRPLRITTIFGPTCDSLDCILRKQPFPE--MKLGDWILVPDMGSYTTAAAAPFNGFSTHRFEWVSSIAL------

Crithidia_fasciculata_ODC RRLSNVYIQKGVKATMAAAANPTGSNK------PAYEAEDPFYMIDLGRVVEQMARWRHELPMVRPHFA--VKCNPNLAIMEVLGALGAG-FDCASKDEIHLVLDNHL------VDSPDDIVFANPCKQLGDLREARACGVTYVTVD------NVPEME---KIGRMLPSARAIIRIKTN-DAAAKCAFS-----TKFGAGMD--DVESLLQAARQHNVEVYGVSFHVGSGNG-DQSAYVSALRDSYRVFQLAAGYG------FNCTVLDIGGGYPGTEPI----PGSGETSFETIARAMRPVLEELFG-----GGDVTIISEPGRYFTAATHALAMNVFATRTLRLSDVEKENC------QAFQNVVNMDEPEEYQYYVNDGLYHSFNCIVFDHAHPTLLLLNDGDGADDTAEGVANAAVDDVDSEEEGEPTVDGAPTNDSLFVSAWDRRRNLTRRPLRITTIFGPTCDSMDCILKKQPFPE--MKLGDWLLAPDMGSYTTAAGCPFNGFATRRREWVSSVAL------

Phytophthora_ramorum_ODC1 ASTNAKPPP-ELQRLQLSSAILTQLQTQIQSLGDGPGSQRDAFYVVDTAAVDERFKLWNEFLPEVRPYYA--VKCNPDPALIEGLARLGAG-FDCASQTEIRSVLGNGV------A--PSDIIYANPCKQGSQIAYAQAHGVDTMTFD------SQDELS---KIHTINPNAKLVLRVYVD-DSNSICRLG-----TKFGAMVH--DVPDILAHAKALNLDVMGVSFHVGSGCF-NVEAYSNAVARARKVFDMGHAIG------YNFSLLDIGGGFPGTENA----P----IRFEDCARELKKSLATHFPN----GSGVQVISEPGRFFAASTHTLAVNVIGRKVAPTFDVPGQPP------VLASAAAAAGQVPNYMYFVNDGLYASFNCMVYDHPSIQPVVLSDAASPDATPMHTA------SLWGPTCDGMDCIMKEVQMPL--MDIGQWILFPSMGAYTCAAGSDFNGFQRPQKIYFDSNFVADDQQQFVH------

Phytophthora_sojae_ODC ASTNAKPPPELLQRLQLSVPMLAQLQTQIQSLGTAPGSQRDAFYVVDTAAVDERFKLWHQYLPEVRPYYA--VKCNPDPALIEGLARLGAG-FDCASQTEISSVLGNGV------P--ASDIIYANPCKQGSQIAYAQAHGVDTMTFD------SQDELT---KIHSINPNAKLVLRVYVD-DSNSICRLG-----TKFGAMVH--DCPDILAHAKALNLDVIGVSFHVGSGCF-NVEAYSNAVARARKVFDMGHALG------FNFNLLDIGGGFPGSESA----P----IRFEDCARELKKALAEHFPQ----GSGVQVISEPGRFFAASTHTLAVNVIGRKVAPTFDVPGQPP------VLASAAAATGQVPNYMYFVNDGLYASFNCMVYDHPSIQPVILSDAASPDATPMHKA------SIWGPTCDGMDCIMKEVQLPL--MDIGQWILFPSMGAYTCAAGSDFNGFQRPQKIYFDSNFVADDQQQFVH------

Phytophthora_infestans_ODC1 ASTNAKPPP-ELQRLQLNAAILTQLQTQIQSLGNAPGSQRDAFYVVDTAAVEDRFKLWNQYLPEVRPYYA--VKCNPDPALIEGLARLGAG-FDCASQTEISSVLGNGV------S--ASDIIYANPCKQGSQITYAHANGVDMMTFD------SQEELT---KIHSINPSAKLVLRLYVD-DSNSICRLG-----TKFGAMVH--DVPDILNHAKALNLDVVGVSFHVGSGCF-NVEAYSDAVALARKVFDIGHSQG------FNFSLLDIGGGFPGTENA----P----IRFEDCALELKKSLAVHFPR----SSNVKVISEPGRFFAASTHTLAVNVIGRKVAPTFDIPGQPP------VLASAAGPT---PNYMYFVNDGLYASFNCMVYDHPSIQPVIMSDTASPSATQMFKA------SLWGPTCDGMDCIMKEVEMPL--MDIGQWILFPSMGAYTCAAGSDFNGFQRPQKIYFDSNFVADDQQQFVH------

Phytophthora_ramorum_ODC2 ------MTTATMDERVLTASRAHIESLG---DAAEDAFYTIDLQHVANQYRRMVTQLPRVLPFYT--VKCHPDTRVLGLLAKLGAG-VDCASQSEVALSLSHGV------P--PERIIFANTMKQRSHLRFAREHNVPLMTFD------SSDELG---KIHREFPEARLVLRLQVD-DSKARHQFG-----PKFGTPMA--TVPALLETAKRLELNVVGVCFHVGVGVL-EASAFVDAIVRAKEAFAMGLEAG------YHFTLLNLGGGFAGDDLG----P----VKFEDAAKAINEVLDDLFPE----DSGVRIISEPGRYFVSACATLTVNVVGRKVDPELTER------THSAANELNSELPRYMYIVNDGKHGSFS--TPHLCVVSPPVVLKAANADASKPVPC------SVWGPTMDGKDAITRETALPV--LQVGDWITFPRMGAYSFATGSTFNGFSLPSRIYIKDE------

Datura_stramonium_ODC APAAEND----HTRKVVPLSRDALQDFMVSIITQKLQDEKQPFYVLDLGEVVSLMDQWNAGLPNIRPFYA--VKCNPEPSFLSMLSAMGSN-FDCASRAEIEYVLSLG------ISPDRIVFANPCKPESDIIFAAKVGVNLTTFD------SEDEVY---KIRKHHPKCELLLRIKPMDDGNARCPMG-----PKYGALPE--EVEPLLRTAQAARLTVSGVSFHIGSGDA-DSKAYLGAIAAAKGVFETAARFGMSK-----MTVLDIGGGFT------SGHQFTTASAAVRSALEQHFHDEQ----ELTIIAEPGRFFAETAFTLATTIIGKRVRGELR------EYWINDGLYGSMNCVLYDHATVNATPLACMSNRSN------LNCGGSKTFPSTVFGPTCDALDTVLRDYQLPE--LQVNDWLIFPNMGAYTKAAGSNFNGFNTSAIVTHLAYAYPS------

Solanum_lycopersicum_ODC AAAAENG----HTRKVVPLSKDALQDFMVSIITQKLQDDKQPFYVLDLGEVVSLMEQWNSALPNIRPFYA--VKCNPEPSFLSMLSAMGSN-FDCASRAEIEYVLSHG------ISPDRIVFANPCKPESDIIFAEKIGVNLTTYD------SEDEVY---KIRKHHPKCELLLRIKPMTDGNARCPMG-----PKYGALPE--EIEPLLRTAQAARLTVSGVSFHIGSGDA-DSNAYLGAIAAAKQVFETAAQLGMPK-----MTVLDIGGGFT------SGHQFTTAAPAVKSALETHFHDFP----ELTIIAEPGRFFAETAFTLATTIIGKRVRGELK------EYWINDGLYGSMNCVLYDHATVTATPLACMSNRNN------LNCGGSKTFPSTVFGPTCDALDTVLRDYQLPE--LQVNDWLIFPNMGAYTKAAGSNFNGFNTSAIVTHLAYAYPN------

Capsicum_annuum_ODC STAAAAAENGDTTRKVVPLSKDALQDFMVSIITQKLQGKKKPFYVLDLGEVVSLMDQWNVALPNVHPFYA--VKCNPEPSFLSMLAAMGSN-FDCASRAEIEYVLSLG------ISPERIVFANPCKPESDIIFAEKVGVNLTTYD------SEDEVY---KIKKHHPKCELLLRIKPMNDGNARCPMG-----PKYGALPE--EIEPLLRIAQASRLTVSGVSFHIGSGDA-DSNAYLGAIAAAKQVFETAAKFGMSK-----MNVLDIGGGFT------SGHQFTTAATAVKSALQQHFSNEP----ELTIIAEPGRFFAETAFTLATTIIGKRVRGDLR------EYWINDGLYGSMNCVLYDHATVTATPLACMSNRVN------LNCSGSKMFPSTIFGPTCDALDTVLRDYQLPE--LQVNDWLIFPNMGAYTKAAGSNFNGFNTSAIVTHLAYAYPS------

Nicotiana_tabacum_ODC PTAAAAAEN--GTRKVIPLSRDALQDFMLSIITQKLQDEKQPFYVLDLGEVVSLMDQWKSALPNIRPFYA--VKCNPEPSFLSILSAMGSN-FDCASRAEIEYVLSLG------ISPDRIVFANPCKPESDIIFAAKVGVNLTTYD------SEDEVY---KIRKHHPKSELLLRIKPMLDGNARCPMG-----PKYGALPE--EVDPLLRAAQAARLTVSGVSFHIGSGDA-DSNAYLGAIAAAKEVFETAAKLGMSK-----MTVLDVGGGFT------SGHQFTTAAVAVKSALKQHFDDEP----ELTIIAEPGRFFAETAFTLATTIIGKRVRGELR------EYWINDGLYGSMNCVLYDHATVNATPLAVLSNRSN------VTCGGSKTFPTTVFGPTCDALDTVLRDYQLPE--LQVNDWLVFPNMGAYTKAAGSNFNGFNTSAIVTHLAYSYPS------

Theobroma_cacao_ODC TLQAIVGAPGVRGKKVAALSKDGLTAFIQSIVSTKQ-EMKEPFYVLDLGVVMALFDKWARNLPMAQPFYA--VKCNPNPALLGALATLGSG-FDCASKAEIESVLSLG------VSPGRIIFANPCKAESHIKYAATVGVNLTTFD------SKEELE---KIKKWHPKCALLIRVKAPDDGGARCPLG-----PKYGALPE--EVTPLLQAAQTARLTVTGVSFHIGSGAM-QFRAYREAIAAAKTVFETAARLGMPK-----MHVLNIGGGFT------AGPQFAEAASTVKAALQAYFPNEP----SLTVIAEPGRFFAESAFTLATNIIGKRVRGDLR------EYWINDGIYGSMNCILYDHAVVTCMPLARASSP------RCKGARTYDSTVFGPTCDALDTVLKVYPLPE--LQVNDWLVFPNMGAYTAAAGSNFNGFNTSAILTYLAYSNPN------

Glycine_max_ODC LKPIFCASGIKGKRVTALSAEKNGLTDFIQRIIADKPDIDTPFSVLDLGVVMGLMDQWACKLPTVQPFYA--VKCNPNLSLIGALAALGSS-FDCASKAEIESVLSLG------VSPDRIIYANPCKSESHIRYAASVGVNVTTYD------SIDEVE---KIRKCHPTCELLLRIKPPQDSGARTSLG-----LKYGALPE--EVDELLQAAHEAGLKVTGVSFHIGSGGA-DTRAYHGAISAAKNVFESASRLGLPR-----MGVLDIGGGFT------SGPSFEAAALKINAAIEGSFGKEE----GLVVIGEPGRYFAETAFTLATRVIGKRVRGDVR------EYWIDDGIYGTLNNIVFDYATVTCMPLACTSKPENPTC------CRDLNLKTYPSTVFGPTCDSIDTVLRDYQLPE--LQVNDWLVFPNMGAYTTSSGTNFNGFSSSAKSIFLACSSPEHTMF------

Lotus_japonicus_ODC LNPIFSASGVKGKRVTALTKECD-MSHLIESIIADKPDMDSSFSVLDLGVVMELMDKWVTKFPTVQPFYA--VKCNPDISLIGALAALGSS-FDCASKAEIQIVLSLG------ISPDRIVYANPCKSESDIKYAATVGVNLATYD------SVYEVD---KVQKWHPKCELLLRIKYDSE-GALASLG-----VKYGALPE--EVPELLKAAEAAGVNVTGVSFHIGSGGA-DPLALSGAIEAAKSVFEMASHFGMSR-----MSILDIGGGFT------CGPELDVAATKVKAAILAHFGDHQ----GLVVIAEPGRYFTETAFTLVSRVIGKRVRGELR------EYWINDGVYGSISNIIYDHATIRCAPLRQKN------LTCVDAKTYPTTVFGPTCDCIDIVLKDYQLPE--LQVNDWLVFPNMGAYTISSGTNFNGFTSAVKHVYLACSEQS------

Oryza_sativa_ODC1 VLVAPGVKGKKVLAFKRDGLKKNEAVTGLIHDIVASSSARSAFHVLDLAKVVDLYAGWRRALPGVRPFYA--VKCNPDTALLGALAALGAG-FDCASRAEIEAVLALG------VPPAAIVYANPCKPGAHVAFAAEAGVNVTTYD------SEEEVA---KVKRCHPSCELLLRIKAPDCGGVKVDLG-----LKYGANPD--EVLPLLRAARRAGLGVAGVSFHVGSGAS-RAAVYRGAIEAARAAFDAAAGLGMPP-----MRVLNIGGGFV------AGAAFGDAAAVINRALGRYFGDLLP---TVELIGEPGRYFAETAFTLAARVIGKRRRGDVR------EYWIDDGVYGSLNCILLDSYVPRPRPLAGARPGEE------THASTVFGPTCDSIDTVVTGYQLPE--MSVDDWLVFDDMGAYTTAAGSSFNGFATSAINTYLAYSS------

Oryza_sativa_ODC2 VLMAPGVKDKKVLAFKRGKGKDADAGVTALIRDIVAGGARSAFHVFDLAKVVDLHRGWRRALPDVRPCYA--VKCNPDGAMLAALAALGAG-FDCASRAEIEAVLALG------VRPATIVYANPCKPEAHLEYAAEVGVNLTTYD------SEEEVA---KVRRCHPRCELLLRIKAPDSGDAKVDLG-----LKYGANPD--EVLPLLRAAQREGVAVAGVSFHVGSGAS-RADVYRGAIEAAREAFDAAAALGMPP-----MRVLDIGGGFM------AGRTFDEAAAVINRALERHFGDLP----CVEVIGEPGRYFAETAFTLAARVIGKRTRGELR------EYWIDDGLYGSLNCILMDHYVPRPRPLAAAAAGEDT------TAATTHASTVFGPTCDSLDTVVTGYQLPE--MSVGDWLVFDDMGAYTTAAGSNFNGFATSAIKIHLAYSS------

Chlamydomonas_reinhardtii_ODC TGKLATAQVLVDVKAEHIKAGGPMGMKQEAIKHILRHKPDDTFYVVDLANVQRMFKAWRAAMPRVVPFYA--VKCNPEPGILKLLNALGAG-FDCASKGELDMMLRMG------VSPNRIIFAHPCKRASDIRYAREHNVQYTTFD------TVSELH---KIAQMNPDFKCVLRIRADDP-DARVPLG-----LKYGAEVS--EADVLLRTAKELGLQVVGVSFHVGSACQ-NLSTFSGAIENARKVFDEAGALGFN------MELLDIGGGFTGH--F----DEMGNVMFGEIANTINAALATNFPPEM----GVRVIAEPGRYFAETSSTLLTPVYGQRDRVAADGSVKK------DYWLTDGLYGSFNCILYDGQNPGYKVVRSPLMADS------TDSRTFLSTLWGPTCDSADCVYKDVTLPV--LRNGDWLMWNNAGAYTVAGACDFNGIEFTTPGKLYVWSDSAVDAAEEGADEQVM

Dugesia_japonica_ODC -MPKVCNKKSQRINEIELVHYPSTTESNLLMIKQRIMDSDAPFYQINLGNIFHQFMRWKNLLPRIQPFYA--VKCQPDPKVISFLGKLGAG-FDCASKQEIKTVIDT------MSYNTTQAATNIIFANPFKFKKDILYASRTGVNTVTFD------TESELI---KLSQEWPAVQLVLRLSPQRVYDATCILG-----NKFGADAD--EVPFLLQRAKELSMNVVGVSFHVGSGCN-EMDAFPETVNYCSQVMELARKIG------FKPTILDIGGGFPGLSSV----NGDLSK--QLKFEEMCVKLNHVLDKYFPEENGYKIIAEPGRYFVHGAYTLVTQVIGVHSLDLNNPMANINNIACHKS------NYETYDSIETSSQGSIAEYLLDSMSDILEISNTESRKPDKHQIKYNHLIEKGYRYVINDGVYNSFNCIVFDHAKPVPFGIFDNEGYFKEVACETETFVSTIYGPTCDGFDCLIQQEPLPK--MDVGYWIVWPNMGAYTIAASSCFNGIPMADVHYFMYQDDALELEKVLSCTLGG-

Dugesia_ryukyuensis_ODC ------MRWKNLLPRIQPFYA--VKCQPDPKVISFLGKLGAG-FDCASKQEIKTVIDS------MSYNTTQAATNIIFANPFKFKKDILYASRTGVNTVTFD------TESELI---KLSQEWPAVQLVLRLSPQRVYDATCILG-----NKFGADAD--EVPFLLQRAKELSMNVVGVSFHVGSGCN-EMDAFPETVIYCSQVMELARKIG------FKPTILDIGGGFPGLSSV----NGDLSK--QLKFEEMCVKLNHVLDTYFPEENGYKIIAEPGRYFVHGAYTLVTQVIGVHSLDLSNPIANINNIACHKS------NYETYDSIETSSQGSIAEYLMDSMSDISEFSNAELRKPDKHQLKYNHLIEKGYRYVINDGVYNSFNCIVFDHAKPAPFGIFDNEGYFKEVACETETFVSTIYGPTCDGFDCLIQQEPLPK--MDVGNWIVWPNMGAYTIAASSCFNGIPMADVHYFMYQDDALELDKVLSCTLGGG

Schmidtea_mediterranea_ODC1 ------MDAFPETVIYCSQVMELARKIG------FNPTILDIGGGFPGLSSI----NGDLAK--QMQFEEMCTKLNHVLDTYFPEEDNYRIIAEPGRYFVYGAYTLVTQVIGLRSLDVTNPISNVNNIACHKD------NYEAYDNVETSSQGSMPEYLLDSMSDVSEISSSDSRK--NSKPKYNQIIEKGYRYVINDGVYNSFNCIVFDHAKPVPFGIFDNEGYFREMACETEMYVSTIYGPTCDGFDCIMQQEPLPK--MEIGNWIVWPNMGAYTIAASSCFNGIPMAETHYFMYQEDALELDKVLSCEVGK-

Schmidtea_mediterranea_ODC2/AZIL1* ------VFHFHSAMASSLKIISKIQSKVKEAGHGFFKVDLGYIVHQHLRWKKLFPRVEPYFS--VKCQPDQQVINILNRLGVN-FDCASQAEIEMVLN------TIPSHEKHRIIFTNPFKFRKDMMYASNVGIELTSFD------SVGELD---RLKQMWPQAKLMLRIAASNTKEQQRALSN---TEKFGAQFH--KIPVLLEKALSMKFDVVGISFHAGIMCD-DWSAWSKAVEKSYQVKKLMENYG------FDPKIINIGGGFHGKSVI----SNECTRKEEILYEEICSDLNNNLEKYYPEENGYKIIATPGRHYIIGAYTLA------

Schmidtea_mediterranea_ODC3/AZIL2* EKIFVGFSKNGVRTYSKQFNLNREPLRNLLAVQSQIIDSQQTFFEVNLGHIVKQFLRWRKLLPRVRPFYA--VKCQPDPKVLELLASLGAG-FDCASQEEMELAINNCRKAYNSINIDIETSNKIIADNIIFANPFKFKQDMVFAGSYGIQKTTFD------SEGELY---RLKRYWPSAKLLIRVSTRKKFSAKCQLG-----DKFGVNSN--NIEKLLKKAKELEFDIAGVSFHVGNMCE-DFSAWPDTVEYCAEVMDLITKLG------YNPTLLDIGGGYPGLSSV----ITDFEVKLQEDFEKMCIELNSALDTYYSDR--FTIISEPGTFFVHGAYTLATEVIGKRQIEESEYSQEFYIDQSIPS------QDRTVKIGSLDAVMFENPSNLHSIKVLDEPVDDFKRY-IYILDDGVYGSFNVLQFMEFKFLLIGILNPNASIKNFISDEKCYVSKLYGPTCDTLDCISPASNLPE--MDVGDWLVWVDMGAYTNGSRSDFNGITKPNSYYYISNE------

Plasmodium_falciparum_ODC NDVSLENNMEKNYKEEIWNYYTKNKVEVKTLEKVLNENIDTSVVCINLQKILAQYVRFKKNLPHVTPFYS--VKSNNDEVVIKFLYGLNCN-FDCASIGEISKVIK------LLPNLSRDRIIFANTIKSINSLIYARKENINLCTFD------NLDELK---KIYKYHPKCSLILRINVDFKNYKSYMSS------KYGANEY--EWEEMLLYAKKHNLNIVGVSFHVGSNTK-NLFDFCLAIKLCRDVFDMSSNMG------FNFYIINLGGGYPEELEYNEETFLKTKYGYYSFEKISLAINMSIDHYFSHMKDNLRVICEPGRYMVAASSTLAVKIIGKRRPTFQGIMLKDLKDHYDPLNFAKLGNITNIKKKVVNINDNRYNYFSYYVSDSIYGCFSGIIFDEYNRCPIYVIKNKNN------PNQNFMNFNLYLANVFGQSCDGLDMINSITYLPE--CYINDWLLYEYAGAYTFVSSSNFNGFKKCKKVYIFPESKPSLK------

Plasmodium_vivax_ODC TQTNEEECPEKKHQKEMLNYYRKNKIEMFTLRKILSEDIDTSVVCINLQKILAQYIRFKKNLPSVTPFYS--VKSNNDDVVIKFLYGLNCN-FDCASVGEVKKLTT------LLPELNRERIIYANTIKSINSLIFARNEHINLCTFD------NIEELR---KILKYHPKCSLLLRINVDFKNYKSYMSS------KYGANEH--EWENILSFGRKHNLNIVGVSFHVGSNTK-NLFDYCQAIKLSRDVWNISNKMG------YQFEILNLGGGFPEELEYNEKSVMKTKYNFYNFEKIALAINMSIEHYFKDIKSKLRIICEPGRYMVAASSTLAVKVIGKRHPTFQGLRLRDMRG-VNPLDFAKLGNITNIKRKVVSINDNRYNYYSYYVSDSIYGCFSGIIFDEYNRSPVFVIRNQVDGST------AGDDVASSPLYLANIFGQSCDGLDMITSITYLPE--CYINDWIIYEYAGAYTFVSSSNFNGFKKCQKVYIFPKKSFPFL------

Ciona_intestinalis_ODC2/AZIG1* LEPHTSLKSPVYGVAGGDGRKELAKTFVCSQ--KKLNEWDSSFYIGDLGQVVRNLQLWTKHLPQIRPYYA--MKCNPSQPVVQLLASLGVG-FDCASKFEIESALKCG------VKPDDILFAVPCKMSSHIEYACRTGVRAMTFD------NVDELH---KIKRIHPTGKLLLRLNVTDFEKGVKFGD------KFGASMS--EARKLTLLCKELNLNLVGICFHPGSGSD-SSEATRNCLHQCKELYDFATSNEIH------LKIIDIGGGFVCGEN------FIEISEQVTATVGKLFPPETG----VTVIAEPGRFFVKNAFGFVTPLHGKAIVGDR------AKYYIGAGVFSTFCMTLFEKFERIPENLSR------KAEKCDLYSSTVYGPTCAGVDVVLNNILLPE--AQIGDWWFFDNMGAYSSLVSLGFNGYMVLKTGFYISQDIWNEISEKLDPDCPLF

Ciona_intestinalis_ODC5/AZIG4* LKPHISLEPPVYGVAEGDSRKKLAKTFVCSQ--NKLKEWDSSFYIGDLGQIVRNLQLWTKHMPQIRPYYA--MKCNPSQPVVQLLASLGVG-FDCASKFEIESALKCG------VKPDDIIFAVPCKMSSHIEYACRSGVRTMTFD------NADELH---KIKRIHSTGRLLMRLDVTEFERGIKFGD------KFGASMP--EARKLILLCKQLDLNLVGICFHPGSGSD-SSEATRNCLQKCKKLYDFATSNEVH------LKIIDIGGGFVCGEN------FIEISETVTATVDKLFPPQTG----VTVIAEPGRFFVKNAFAFVTSVHGKALVNDR------AKYYIGAGVFSTFCMTLFEEFERIPESLSR------KAENCEVYASNVYGPTGAGVDIVLNNIMLPE--ARIGDWWFFDNMGAYSSLVSIGFNGYMVLKTGFYIAQDIWNDIADKLDPKSPLF

Ciona_intestinalis_ODC3/AZIG2 LEPSKPLKPPVYGVRKGKSRKEFAKVFVNSQ--RNLKEWDSSFYLGDLGQVVRNLQMWTKHMPKIRPYYA--MKCNPSQPVVQLLASLGVG-FDCASKFEIETALKCG------VKPEDILFAVPCKMSSHIEYACQTGVQVMTVD------NADELH---KIKRIHPTGKLLLRLNVCEFEEGVRMGD------KFGASMS--DAKKLVLLCKSLNLNLNGICYHPGSGVE-SFECIMSCLQQCKELYDFAASNGVD------LKTIDIGGGFLCGEN------FIKISKQVAATIDRLFPPETG----LTVIAEPGRFLVENAFAFVTSVHGKAIVNDV------AKYYIGAGIFTTFWLTTFDHSQKIPESLS------RPNNDKSYVSMVYGPTCAGFDIVLNSAMLPE--AQIDDWWYFDNMGAYSALIVLGFNGYLVTKAAFFISEDIWNEIAEKIDPKSPLF

Ciona_intestinalis_ODC6/AZIG5* LETHIALKPPVYGVKNDANKKEFAKEFVNSQ--QNSKEWDSSFYLADLGQVVRNLQLWTKHMPKIRPYYA--MKCNPSQPVVQLLASLGVG-FDCASKFEIETALKCG------VKPEDILFAVPCKMSSHIEYACQTGVQVMTVD------NADELH---KIKRIHPTGKLLLRLNVKYCGNGIKMGD------KFGVTMS--EARELILLCKELELDLIGVCFHPGSGSN-SFETIRDSLQRCRELYDFAKLIGND------FKIVDIGGGFVCGDN------FIKISKQVNATIDRLFPPETG----LTVIAEPGRFFVENAFAFVTSVHGKAIRGDS------AKYYIGSGVFAAFCLKYFEKFIRIPESLSR------QADKCKCYASTVYGPTGAGDDIVLCDSMLPE--AQIDDWWLFDNMGAYSPLLSLGFNGYMVTKAGFFISQDTWNEIADKLNPNSPLF

Ciona_intestinalis_ODC4/AZIG3* TAYSYINDQSIYIINDGTDGHSFAATMADNQTLSQTKSWDGSFYIGDLNRVFLRHQQWKEVLPRVELFYA--IKCCPLMPVIRLLAALGTG-FDCASQNEIESVISIG------VDPAKIIYALPCKPASQLQHARTRKVSLMTFD------NEDELH---KIQKYFPDARLVLRLLPDETGATFKMGS------KFGCTLE--EGKKLLVHAKKLDLNVIGLSFFVGDDCK-SSIGMRLNLENSRKMFDFASSIGIN------MDLIDIGGGFPGNDKD------QKLFLQIANDTRDTLDKLFPSECG----VRIIAEPGRYFVESSFSIATSIVGKKQSEGI------WCRIVFNAETK------RFSDKAVHDTIIYGTTCDGTDIIAQNVALPE--LDLEDWLIWDDMGAYTVLCKFGFNGVMTTKAFYFVQEGAWKTIQGACCRKDFLP

Tetrahymena_thermophila_ODC STNAQSTSANTYFLKGLDSRILNAEQREELVSFVNQDPFGQSFLVYNSHEALRKLNAWRSKLSWIQPFYA--LKSNPIDPLVEDLCSNGAG-LDVASQGEIKKGLEMG------ISASNMIYSNPVKEEKDILYAAQNNVLYTTAD------TFDEIV---KIHTLAPNMKILWRISITEDNSQQLATVFSN-KFGDDITSLEDAHQKFKFIAQELGVRLHGIHFHCGSGKN-GSSSFLKAVNMARKCIEIGRQYG------HAMEILDLGGGYPSG------DLNDKFIANLKDTCNDPLG----YRVIAEPGRHFSSQTCYLFTRILAKRSKQGK------TCFHVNDSLYHSFNCVLMDGVSFENDNDQFYSVVNNNTL------EQSEINKNSMINSSVFGMTCDGADVIARNVGFCG-DAKVGDWLCFSGMGSYTFGPKSAFNGMESTTRVFKWSSPIGVPESPKKAAETSEE

Paramecium_tetraurelia_ODC LN--NNSAFRLYFLKGCDNRQLNLSQQKEFLNYVKIDPYGHSFMIYNSNELKNKVNQWKQALPWITPYYA--IKSNPIDPILKVIVDGPYGTFDCASKGEISTVIKSG------VPGSKIVYSNPVKEEKDIQYAKSMGVEITSAD------TIDELI---KIQKIAPEMKILWRISIVEENPEQMATVFSG-KFGDDIPDLDAAHKRFQQIQQMG-IQLHGIHFHCGSAVQ-GSSSFGKAIDLAKECMKIGRLYG------HKMILLDVGGGFPTG------NIQENIINALKKTENDPLG----YEVIAEPGRHFSANTCYLLFRIMTKRIKHGR------LCYHVNESLYHSFNCVLMDGITFENENDQLYSVFNSDGS------QNTQNSD--HSNVSIFGMTCDGHDALAKNITLPS-DMQVGDWLCMSGMGSYTIGPKSRFNGMKSTSKIYQWSSQIEEQI------

Fusarium_oxysporum_ODC3/AZIR -MPIMDSPMPVVYPPNMSPGIQATFTKHNALPLSEREKPLFVIDVATVKDTVREFMASMPSTPNIDVVHFGAVKACAAKPVTDVYDQLRCG-FDCASKGEAKPLVDRG------VNPARISLGNCNLPSNELEWGIDVGIQYYAVDSTSQVYRVLEAADRVVKRKGCELATILADIKPFCRLVSSGKGSDKPFS--AKFGVDPE--MAFTIIEEAQAHGLTFIGLSGHPGTQNL-ATDAFVQFAQLFRGVFDRVKN-ELG----ITMTLANIGGGWAGIS------TKTAPLFVDYNKPTIDIFSSVFADWPVKLIMMTEPGRAFISKAGWLQTHVINVSKHTASAS------VSRVFLSVGTLHGLNEANKISFQWHTSSPSEKT------KSCVLYGASCDSSDIILGKDANGKEKTVDLPDVLAPDHLVWVYGPAAYGPDYSTSFNGVPPPKVVYINSKEDIAY-----

Gibberella_moniliformis_ODC3/AZIR FLPIMARSTPIIYPTKMSPSIQATFKHHNALPLLDREKPLFVIDVATVKDTVRDFIASMPSTANIDVVHFGAVKACAAKPVTDVYDQLRCG-FDCASKGEAKPLVDQG------INPARISLGNCNLPTNELEWGIDVGIQYFAVDSTSQVHRMLEAAGRVAKRKGCGVATILANIKPFCRLLCSGKGSDKPFS--AKFGVDPE--MAFTIIEEAQAHGLTFIGLSGHPGTHNL-ATDAFVQFAQLFRGIFDRVKT-ELG----ITMTLANIGGGWAGIS------TKTAPSFADYNKPTIDIFSSVFADWPVKLIMMTEPGRAFISKAGWLQTHVINVSKHTASAS------VSRVFLSVGTLHGLNEANKISFEWHTSVPSEKT------KSCVLYGASCDSSDIILGKDANGREKTVDLPDDLAPDHLVWVYGPAAYGPDYSTSFNGVPPPKVVYINSKEGITYSTRQA

Pseudomonas_aeruginosa_DAPDC ------MDTFSYRDAELFAEGVALSRIAERFGTPTYVYSRAHIEAQYRAYADALAGMPH--LVCFAVKANSNLGVLNVLARLGAG-FDIVSRGELERVLAAG------GDPAKVVFSGVGKTRDDMRRALEVGVHCFN------VESGEELERLQRVAAELGVKAPVSLRVNPDVDAQTHPYISTGLKENKFGIAIDEAE-AVYARAAELDHLEVIGVDCHIGSQLTQLEPFLDALERLLGLV-DRLAGKGIG------IRHLDLGGGLGVR--Y----RDEQPPLAGDYIRAIRERLHGRDLTLV------FEPGRSIVANAGVLLTRVEYLKHTE------HKDFAIVDAAMNDLIRPALYQAWMDVQAV------RPRDAAPRRYDLVGPICETGDFLAK--DRDLALAEG-DLLAVRSAGAYGFVMSSNYNTRGRAAEVLVDGEQTHEVRRRETVQELYAG

Wolinella_succinogenes_DAPDC ------MDFSSLASRYGTPLYVYDFDQIKSQFLQLKEAFAGRKS--LIAYAIKANSNLSVIQHLGKLESG-ADCVSIGEVKRALKAG------IPPYKIIFSGVGKRDEEILEALSLEILMIN------VESEAELLRVESLAKSLGKVARISIRVNPDIDPKTHPYISTGLSENKFGVDIESAK-RLYILCAKSESLHPVGIHFHIGSQLTELEPLLESAKKVADLT-RSLLALKIE------IKFFDVGGGLGIR--Y----KDETPINLYDYAQGILAALHGLDVTIV------CEPGRFIVGNAGCFLTRVLYEKQNE------KKRFVIVDGAMNDLLRPSLYKAYHEAFAP------KGGESFS-EADIVGPVCESGDWLAK--GVMLPPLEHGDLIVIKSAGAYGFSMSSQYNSRARAAEVALEGGESRLIRAREEIESLWQN

Methanothermobacter_thermautotrophicus_DAPDC ------MFPDIEVNDKGHLLIGGADAVELADEYGTPLYVIDEMRIRENYRRLYRAFSGEYSRFQVFYACKANTNLAVMRILEEEGSG-IDAVSPGEIYTALMAG------FDPDRILYTGNNVRDDELQFALDSGVRIN------VDSRSQLLRLSEIAPEG---LRISFRVNPLVGAGHHEHCITGGEMSKFGVMEREAP-EVYRMAMDLG-FEPVGIHAHIGSGILDPEPFMLAVETLMDIAGRVHEATGVE------FEFIDFGGGLGIP--Y----TPEEEPLDIDEFASKITGLFKDKLSEYGLGRPM-MCLEPGRYIVGDASYLLTRVNTIKES------YRKFAGVDAGFNTLLRPAMYGSYHHILVAE------RPLDEPSEKMDVAGNVCESGDLFAR--DRQLPEINEGDVLAIMNAGAYSFSMSSQYNSRPRPAEVLVREGKVDVVRERETFSDLLRG

Branchiostoma_floridae_ODC3/DAPDC APLKNCFHRDGAGFLWCEGVRVKSLQEDLSRRLPRPSCSPFYLYSLSQVRHNVSRYKEALKTLPNPHVLGYSLKANGNLEILKTLRAMGCG-AVTVSGNEIRLALTAG------FSPDSIVYNGNGKQDWELELAVRVNCLIN------VDSDFDLRHVRSAADTVRQRARVLIRINPDIDPRVHPYNSTGLASSKFGLECSQLPGLLEKVRRWPAQLQLVGLHCHLGSTITDVSLFRDVVSVVSAEMESVRSQGFHD------LRYLNMGGGLGID--Y----LRQQDSTNPSPADLVSSIRDALTDKNIC------LILEPGRSIIGDAAILVTKVIGVKGNG------KKRFVVTDGSMTEVIRPSLYSAYHHIQLTEPS------QAEDPTEQEYDVVGPVCECGDFLGK--DRTIPTPHEGCGLVVFDVGAYCSSMASNYNMRIRPAEVLVDGATWRFIRRPETLEDMTRC

Phytophthora_infestans_ODC4 ------MPLPPPTSALERLDALAETYGTPLQIYDEQLIRDNARRLLTAFRAHFPDFQQFYAVKALPNPAILKLLHQEGCG-MDCSSSAELHIVKELG------VPGDQVIFTSNFTAKNDLGTAFDQGVIMN------LDDVSLVDSLVAVRGKCPELMSFRLNPGIGRTDSETKSNVLGGPDAKFGVPPFQIVEAYRKAQQAGAKGFGIHMMTGSCVMNQEYWRETVTVLFNTIVQLKKELGIE------FEFMNIGGGLGIP--Y----REDQEPVNVEAIAKMLREVFDEAVKEHGLQTLPRLCMENGRFMTGPFGWLVTRCEAIKET------YGRYYGVDACMAHLMRPGMYGAFHHISIP------ARANEEVSPSHVVGTLCENNDWFAK--DRPLPKAQVGDLFVIHDTGAHSHSMGFQYNGKLRAPEVLLRADGSDSLMYVSLNML----

Phytophthora_ramorum_ODC4 ------MPLPLPTSVERLDALAANYGTPLQIYDEQLIRDNARRLLAAFRAHFPDFQQFYAVKALPNPAILKLLHQEGCG-MDCSSSAELHICKELG------VAGEKVIFTSNFTAKKDLATAFDQGVIMN------LDDVSLVDSLVAVRGKCPELMSFRLNPGIGRTDSETKSNVLGGPDAKFGVPPFQIVEAYRKAQQAGATRFGIHMMTGSCVMNQEYWRETVTVLFSTIVQLKKELGIE------FEFMNIGGGLGIP--Y----RKDQEPVNVEAIAKMLREVFDEAMQEHGLETLPRLCMENGRFMTGPFGWLVTRCEAIKET------YGRYYGVDACMAHLMRPGMYGAYHEISIP------ARENEEVSPSHVVGTLCENNDWFAK--DRPLPKAQVGDLFVIHDTGAHSHSMGFQYNGKLRAPEVLLRADGSDSLMYVSTCLNWPMV

Phytophthora_infestans_ODC3 VEQQKKEGAAVAHAHHHQRSATITRVVESAIAQKILHDDSPLTNLFNWDAFQKRLANLHTAFPEPQFNHALAVKTNPTRGLLRGACAKGFG-AECASIAEAKHALSLG------FEPRKVVYDSPCKTIGELREMLMAGVYINLDNEEEIRKVNEIFTELGDSEQTKNKHAEQLGLRINPVVGGGTIDATSTATVTSKFGLPLTAET-KSRLLEIFKQNSWLQGVHVHVGSQGCPLDLLTAGAKRAVAFALEVNAYVGHK-----QVSVLDIGGGMLT---V----YDGGESEAYDFNEYADVVRRQVPELFTSG--FSSIITEFGRSVFVKPGVTVSKVEAIKDWA------GQHIAVVHVGADQFPRTAYLPEQWSHCITVLDSHGRTK------TNPSSDYVRQDIAGPLCFSGDFLAK--QLLLPPIQVGDFVVIHDTGGYTMSMHSKYNSRQVSSYFAYSAVGDKVNFSMLKERETTEE

Phytophthora_ramorum_ODC3 LEQQQREDSAVAFDHHQQRCAAVTRVVEAAVSQKLLHDESPLINLFSWDAFQKRLANLHAAFPEPEFNHALAVKTNPTRGLLRGARAKGFG-AECASIAEAKHALSLG------FEPRKVVYDSPCKTLGELREMLLAGVYINLDNEEEIRKVNEIFAELGLSEETKRKHAAQIGLRINPVVGGGTIDATSTATVTSKFGLPLTAET-KPRLFAIFKQNSWLQGVHVHVGSQGCPLDLLAAGAKKAVAFALEVNAHVGNK-----QVSVLDIGGGMPT---V----YDGGEREAYDFQEYADAVREQVPELFTSG--FSSIITEFGRSIFVKPGITVSKVEAVKDWA------GQHIAVIHVGADQFPRTAYLPELWSHCISVLDGHGRPK------THPSGSYVRQDIAGPLCFSGDFLAK--QLLLPPIEVGDFVVIHDSGGYTMSMHSKYNSRQVSSNFAYSSSASDVNFSLLKERETTEE

Prochlorococcus_marinus_ADC PQGKEGNSLELTHLLEELK------GRNLNTPLLLRFDDILEDRLKKLHQAFENAINQYGYNNDYQGVFP--IKCNQQRHVVEEIVTIGRKWHFGLEAGSKAELLIALALVNDPK------AFLICNGYKDNRYIETTILARQLGRQPIVVIE------QSDEVGRIIKASQKLGAAPLIGIRAKLSN-QSSGRWGNSVGEKSKFGLSIPEILKAVQELTAAGLLNELILLHFHVGSQIN-DIAILKNALQEASQIYVELNRLGAP------MGHLDVGGGLGVDYDGSRT-ATSASTNYSLQNYANDVVATIQECCKAKKVKVPKLISESGRFLSSHFSILIFNVLGTSSVPTQIAIETSNECLSVKNLRETLMILHQICEEKKIDVSKLQEAWNDALKFKEDALNAFRLGFIDLTERATAEQLTWACAKQIAAHLPNDLKIP-KELLAINKGLTETYYANISIFRSAPDTWAIQQLFPLLPIHRLQEKPDQLGHFADLTCDSDGKLARFIN-NGQEKFLLELHTVKANENYWIGMFLGGAYQEVMGNLHNLFGSTN

Pseudomonas_aeruginosa_ADC PQGADSTPIDLYELVGQLR------EAGLSLPLLVRFPDILQDRVRKLTGAFDANIERLEYQSRYTALYP--IKVNQQEAVVENIIAT-ENVSIGLEAGSKPELMAVLALAPKG------GTIVCNGYKDREFIKLALMGQKLGHNVFIVIE------KESEVQLVIEEAANVGVQPQVGLRVRLSS-LASSKWADTGGEKAKFGLSAAQLLSVVERFRQAGLDQGVRLLHFHMGSQIA-NLADYQHGFKEAIRYYGELRALGLP------VDHIDVGGGLGVDYDGTHS-RNASSINYDIDDYAGVVVGMLKEFCDAQGLPHPHIFSESGRALTAHHAVLITQVT-----DVERHNDDVPKIVDLDEQPEIVRWLAELLG--PTDAEMVTETYWRATHYIGDAAAQYADGKISLAQKALAEQCYFAICRRLHNQLKARQRSHRQVLDELNDKLADKYICNFSVFQSLPDTWAIGQVLPILPLHRLGEEPDRRAVLQDLTCDSDGKITQYVD-EQSIETSLPVHEVKEGEDYLIGVFLVGAYQEILGDMHNLFGDTD

Arabidopsis_thaliana_ADC1 PHGSNTLPHQDIDLMKVVKKVTDPSGLGLQLPLIVRFPDVLKNRLECLQSAFDYAIQSQGYDSHYQGVYP--VKCNQDRFIIEDIVEFGSGFRFGLEAGSKPEILLAMSCLCKGNP------EAFLVCNGFKDSEYISLALFGRKLELNTVIVLE------QEEELDLVIDLSQKMNVRPVIGLRAKLRT-KHSGHFGSTSGEKGKFGLTTVQILRVVRKLSQVGMLDCLQLLHFHIGSQIP-STALLSDGVAEAAQLYCELVRLGAH------MKVIDIGGGLGIDYDGSKSGESDLSVAYSLEEYAAAVVASVRFVCDQKSVKHPVICSESGRAIVSHHSVLIFEAVS----AGQQHETPTDHQFMLEGYSEEVRGDYENLYG-AAMRGDRESCLLYVDQLKQRCVEGFKEGSLGIEQLAGVDGLCEWVIKAIG------ASDPVLTYHVNLSVFTSIPDFWGIDQLFPIVPIHKLDQRPAARGILSDLTCDSDGKINKFIGGESSLPLHEMDNNGCSGGRYYLGMFLGGAYEEALGGVHNLFGGPS

K69 D88 E94 R154 K169 G171 H197 S200 G235-G237 E274 R277 D332 C360D361D364 G387 Y389 F 397