NUTRICIAMetabolicsResearch Fund

encouraging nutrition-relatedresearchininbornerrorsofmetabolism

Application must be written in English, using font type Calibri, size 12, single line spacing.

APPLICATIONFOR RESEARCHGRANT

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PROJECTTITLE:

1.PRINCIPAL APPLICANT

Name(last, first):

ageplease tick 35years,35yearsandabove

Position, title:

Institution:

Mailingaddress:

e-mailaddress:

Telephone/fax number: /

Mobilephone:

Names andaddresses ofcollaborators(ifany):

SIGNATURES

Principalapplicant/investigatorHeadofmetabolic centre/institution

I certify that the research proposal is my original work

Name(first/last)

date/locationdate/location

2.ShortCVofAPPLICANT -education, degree, pastand presentposition (max.1 page):

Please presentany data thatcansupportthe fact thatyouhaveenoughknowledge/

experienceandtheenvironmentto performthestudy and/orleadthe project

Listofpublicationsby theapplicantfrom thelast5yearsandrelevantto the topic (max. 10 key publications):

3.RESEARCHPLAN-executivesummary(max.halfa page):

4.RESEARCHPLAN-in detail(pleasecover the followingaspects-max. 3pages):

- Projecttitle

- Hypothesis(includingliteraturebackground)

- Aim

- Study/experimentdesign

including: study population,samplesize,inclusion/exclusioncriteria, intervention, duration,primary andsecondaryreadoutmeasures, statisticalanalysis andpowercalculation

- Ifanimal testingis necessary clarify themotivation

- Timetableincludingmilestones

- Scientific valueofthe proposal

describe theoriginality, thesignificanceandinnovativeelements ofthe proposal, why this projectisworthfinancingetc.

- Literaturereferences

5. BUDGETESTIMATES forcomplete project

BudgetCategory Totals(gross value–indicatecurrency)

Personnel

Outsidecontracts/

consultantcosts

Equipment

Supplies

Publications

Otherexpenses

Total budget:

Please indicateBudgetrequested from NutriciaMetabolicsResearchFund:

20.000Euro50.000Euroother

5.1.STATEMENTABOUTFUNDINGFROM OTHERPARTIES

-Didyouorwillyouapply for thirdparties for fullor partial fundingofthisproject?

NOYES

-Ifyes,whoaretheseothersourcesandwhichamounts have beenrequestedand/

committed.

pleasespecify:source/s

amount/s

-Ifotherfunds areorwillbeavailable, whatis theadditionalminimumamountof budgetrequired togetthe projectstarted?

NUTRICIAMetabolics Research Fund

Toencouragenutrition-relatedresearchin inbornerrorsofmetabolism

TERMSANDCONDITIONSAPPLICABLETOIEM RESEARCHGRANT

1.IEMResearchGrant

1.1DanoneMedicalTradingB.V.,hereinafterreferredto as“NutriciaMetabolics”,makesavailablean amount of€170.000,00forsevenresearchgrantsinthefieldofinbornerrorsofmetabolism(IEM), consistingofonegrantof€50.000,00 andsixgrantsof€20.000,00.

1.2Dependingonthenumber andqualityofthe proposalsreceived,NutriciaMetabolicstakesthe libertyto adjustthe number ofgrantsandtheamountsset out aboveunder 1.1, providedthatthemaximumgrant

amountshall notexceed€ 170.000,00.

2.Eligibilitycriteria anddecision mechanism

2.1In ordertobeeligibleforoneoftheIEMResearchGrants,aproposalmustbe related to nutrition and/or dietarymanagement in the field of inheritedmetabolic diseases.It should clearly pointoutwhat medical needwillberesearchedandwhatwill beitsanticipatedcontributiontothefield ofIEM.

2.2A groupofseniorNutriciametabolicexpertswillevaluate ifandtowhat extent anapplication meetsthe eligibilitycriterionsetoutin 2.1.Onthebasisofthisevaluation,takingintoaccounttheconditionssetout

belowin 4,thewinner(s)willbe elected.

2.3The safereceiptofeachandanyapplicationwillbeconfirmed andeveryapplicantwillreceive personal feed-backregardinghisapplication.Apartfromthat,NutriciaMetabolicsshallnothaveany correspondencewithapplicants.

3.Who canapplyandhow?

3.1Eachprofessional,includingbut notlimitedtodieticians, nutritionists,cliniciansandpostdocs,workingwith an institutionorcompanyactiveinthefield ofIEMcan participate inthisIEMgrant application. NutriciaMetabolicsawardsresearchgrantswiththe expressunderstandingthat suchresearch grantsdonot allowthefundstobeusedforresearchprojectswhoseprincipalinvestigator'sotheractivitieswould identifiedasareal,potential orapparentconflict ofinterestwithoutexpresswrittenpermissionfrom NutriciaMetabolics.

3.2Participationismade byusingthe presentelectronic version (Word-file)andreturningthisto ynolaterthan15July 2017.

3.3Decisionsregardingthewinner(s) ofthegrantshallbecommunicatedbynolaterthan 30November

2017.

4.Applicable conditions

4.1Anyapplicationmustbesignedforapprovalbytheheadofdepartmentoftheinstitutionofwhichthe applicantisanemployee.

4.2The approvalsetoutin4.1impliesthatthecompany/institutionmakesavailabletherequired labspace andtimeandtakesfullresponsibilityfortheproper executionoftheintendedresearch.BecauseNutriciawillwantthewinningproposalstofly, itissuggestedthatlabspaceshouldbe available byno laterthan6

monthsafterthe grantdecision, assetoutin3.3.

4.3In caseethical approvalisrequired,theapplicantshallinclude thepositiveadvicefromthe medical ethicalcommitteeatstake.

4.4The applicantshallspendtheNutricia grantfunding exclusivelyonthefundedresearchand itshallmake

availabletoNutriciaMetabolicsanextendedsummaryoftheresearchundertaken.

4.5Whereappropriate,theapplicantshall includeintheresearch summarypower andsamplesize calculationsinfullanditshallseeksupportfromstatisticianswhen neededin ordertotranslatethe researchresultsintotheresearchsummary.

4.5In anypotentialpublicationsonthefundedresearch,NutriciaMetabolicsshallbementionedasa sponsor,asfollows:“Thisresearchwasenabledonthe basisofagrantreceivedfromtheDanoneMedicalTradingB.V.which encompasses NutriciaMetabolics.”

4.6 Any applications shall be dealt with confidentially. However, the winning applicant(s) grant(s) NutriciaMetabolics the right to publish a high-level summary of the sponsored research onDanone's digital platforms, including

5Applicablelawand competentCourt

5.1Thisresearch grantapplication issubjecttothelawoftheNetherlands.

5.2AnydisputesfollowingfromorrelatedtothisIEMgrant applicationthatcannotbesolvedamicably, shall be exclusivelysubmittedtothecompetentCourt incentralNetherlands(“RechtbankMidden-Nederland”).