Osteoblast Specific Factor 2

Table 2

Down-regulated genes in rasV12/E1A transformed MEFs

Fold repression

Description / Accession number / Exp #1 / Exp #2 / Average
Transcription Factors
osteoblast specific factor 2 / D13664 / 163.0 / 83.0 / 123.0
p8 protein / AI852641 / 56.0 / 46.2 / 51.1
H19 mRNA / X58196 / 24.1 / 17.9 / 21.0
Early B-cell factor / L12147 / 22.4 / 18.2 / 20.3
Prx2 homeobox / X52875 / 14.5 / 13.9 / 14.2
T-box 15 / AF041822 / 10.7 / 7.7 / 9.2
cardiac ankyrin repeat protein MCARP / AF041847 / 6.8 / 5.2 / 6.0
Engrailed 1 / L12703 / 6.0 / 6.0 / 6.0
Gut enriched Kruppel-like factor / U20344 / 5.6 / 5.8 / 5.7
Paired mesoderm homeobox 1 / U03873 / 5.6 / 4.4 / 5.0
Kruppel-like factor 13 / AW125783 / 4.8 / 3.4 / 4.1
IER5 / AF079528 / 4.5 / 3.7 / 4.1
Eph family ligand ELF-2 precursor / U30244 / 4.4 / 3.8 / 4.1
Snail homolog / M95604 / 3.8 / 4.0 / 3.9
LIM protein FHL2 / AF055889 / 3.8 / 3.8 / 3.8
Kruppel-like factor 7 (ubiquitous) / AI853712 / 3.7 / 3.9 / 3.8
Smad6 / AF010133 / 3.7 / 3.5 / 3.6
Kruppel-like factor 3 (basic) / AI851658 / 3.7 / 3.5 / 3.6
OASIS protein / AB017614 / 3.6 / 3.6 / 3.6
Core binding factor alpha 1 / D14636 / 3.6 / 3.6 / 3.6
Inhibitor of DNA binding 2 / AF077861 / 3.5 / 3.5 / 3.5
forkhead box C2 / AV251191 / 3.5 / 3.5 / 3.5
Slug homolog / U79550 / 3.5 / 3.5 / 3.5
LIM domain transcription factor LMO4 / AF074600 / 3.4 / 3.4 / 3.4
hermes mRNA / AA636171 / 3.3 / 3.3 / 3.3
mesenchyme fork head-1 protein / X74040 / 3.2 / 3.2 / 3.2
ELL-related RNA polymerase II / AI197161 / 3.1 / 3.3 / 3.2
Inhibitor of DNA binding 1 / M31885 / 3.0 / 3.0 / 3.0
forkhead-related transcription factor 1C / AW122985 / 2.9 / 2.9 / 2.9
c-myc / L00039 / 2.8 / 2.6 / 2.7
X-box binding protein processed isoform / AW123880 / 2.8 / 2.6 / 2.7
CCAAT/enhancer binding protein (C/EBP), delta / X61800 / 2.7 / 2.7 / 2.7
nuclear receptor co-repressor 2 / AW121057 / 2.7 / 2.7 / 2.7
RNA-binding protein with multiple splicing / AW123909 / 2.7 / 2.7 / 2.7
High mobility group protein I, isoform C / X99915 / 2.6 / 2.6 / 2.6
NfiX1-protein / Y07688 / 2.6 / 2.6 / 2.6
twist-related bHLH protein Dermo-1 / U36384 / 2.6 / 2.4 / 2.5
Inhibitor of DNA binding 3 / M60523 / 2.6 / 2.4 / 2.5
iroquois homeobox protein 3 / Y15001 / 2.6 / 2.4 / 2.5
Hox-3.1 / X07439 / 2.5 / 2.5 / 2.5
putative transcriptional regulator (MmTbx14) / AF013282 / 2.5 / 2.5 / 2.5
Id4 dominant negative helix-loop-helix / AJ001972 / 2.4 / 2.4 / 2.4
Smad7 / AF015260 / 2.4 / 2.2 / 2.3
Zinc finger protein 63 / L36316 / 2.3 / 2.3 / 2.3
histone deacetylase mHDA1 / AF006602 / 2.3 / 2.1 / 2.2
Structural proteins
smooth muscle calponin / U28932 / 167.1 / 63.5 / 115.3
Transgelin / Z68618 / 39.8 / 59.4 / 49.6
drebrin 1 (Dbn1) / AW124952 / 39.4 / 43.0 / 41.2
p50b (identical to LSP1 and pp52) / D49691 / 36.9 / 34.9 / 35.9
vascular smooth muscle alpha-actin / X13297 / 36.3 / 31.7 / 34.0
Gap junction membrane channel beta 3 / X63099 / 27.9 / 24.5 / 26.2
Actin, alpha 1, skeletal muscle / M12347 / 19.4 / 15.0 / 17.2
Myosin heavy chain 11, smooth muscle / D85923 / 14.0 / 10.6 / 12.3
tenascin C / AV230686 / 12.3 / 12.3 / 12.3
Gelsolin / J04953 / 12.0 / 12.0 / 12.0
h2-calponin / Z19543 / 11.0 / 12.8 / 11.9
microfibrillar associated protein 5 (Mfap5-pending) / AW121179 / 9.0 / 8.6 / 8.8
CYLN2 gene / AJ228865 / 8.5 / 7.3 / 7.9
kinesin family member C3 / AW124084 / 7.4 / 6.4 / 6.9
actinin, alpha 1 / AA867778 / 6.9 / 6.9 / 6.9
Tubulin, beta 2 / M28739 / 6.6 / 6.6 / 6.6
plectin / AW123286 / 6.3 / 6.5 / 6.4
FLI-LRR associated protein-1 / AF045573 / 5.5 / 6.3 / 5.9
Actin, gamma 2, smooth muscle, enteric / U20365 / 5.3 / 5.3 / 5.3
Actin, alpha, cardiac / M15501 / 4.8 / 5.0 / 4.9
plastin 3 precursor; T-plastin / AW125273 / 4.5 / 3.9 / 4.2
filamin B, beta / AI838592 / 4.2 / 4.0 / 4.1
tropomyosin isoform 2 / M22479 / 4.1 / 3.9 / 4.0
kinectin 1 / AV380640 / 4.0 / 3.8 / 3.9
Tubulin alpha1 / M28729 / 4.0 / 3.8 / 3.9
vinculin / AI462105 / 4.0 / 3.8 / 3.9
myosin heavy chain IX / AW125698 / 3.8 / 3.8 / 3.8
Tropomyosin 4 / AI843046 / 3.8 / 3.6 / 3.7
Fascin 1 / L33726 / 3.7 / 3.5 / 3.6
thymosin, beta 10 / AI852553 / 3.7 / 3.5 / 3.6
destrin / AB025406 / 3.6 / 3.6 / 3.6
Vinculin / L18880 / 3.6 / 3.2 / 3.4
Microtubule-associated protein 6 / Y14754 / 3.5 / 3.3 / 3.4
epithelial protein lost in neoplasma / AI836140 / 3.3 / 3.3 / 3.3
Microfibril-associated glycoprotein / L23769 / 3.2 / 3.0 / 3.1
Enabled homolog / U72521 / 2.7 / 3.1 / 2.9
CDCREL-1 homolog / AF033350 / 2.7 / 2.7 / 2.7
transgelin 2 / AI852545 / 2.7 / 2.5 / 2.6
moesin / AI839417 / 2.7 / 2.3 / 2.5
Microtubule-associated protein 4 / M72414 / 2.7 / 2.3 / 2.5
Utrophin / Y12229 / 2.6 / 2.2 / 2.4
Formin / AF094519 / 2.5 / 2.3 / 2.4
Small proline-rich protein 2K / AJ005569 / 2.4 / 2.2 / 2.3
Myosin Ic / U96723 / 2.4 / 2.0 / 2.2
Signaling Factors
Cysteine rich intestinal protein / M13018 / 44.8 / 37.2 / 41.0
ASM-like phosphodiesterase 3a / Y08135 / 38.3 / 24.7 / 31.5
RBP associated molecule RAM14-1 / U41739 / 27.6 / 31.0 / 29.3
Protein tyrosine phosphatase, receptor-type, zeta / AI849305 / 24.3 / 18.9 / 21.6
inositol trisphosphate receptor type 2 / AF031127 / 21.5 / 21.3 / 21.4
cellular retinoic acid binding protein / X15789 / 17.7 / 16.1 / 16.9
G-protein coupled receptor 26 / U13370 / 14.7 / 13.5 / 14.1
Wnt-5a / M89798 / 13.8 / 13.4 / 13.6
S100 calcium-binding protein A4 / M36579 / 12.6 / 11.4 / 12.0
Guanine nucleotide binding protein, alpha inhibiting 1 / U38501 / 12.1 / 11.9 / 12.0
Lipocortin 1 / M69260 / 11.7 / 12.1 / 11.9
Kras oncogene-associated / U02487 / 10.3 / 11.5 / 10.9
dickkopf-3 / AJ243964 / 10.2 / 10.2 / 10.2
annexin A1 / AV003419 / 10.1 / 9.9 / 10.0
PKC-delta binding protein / AW048944 / 9.8 / 9.2 / 9.5
frizzled homolog 2 / AW123618 / 9.1 / 8.9 / 9.0
latent TGF beta binding protein / AF022889 / 8.0 / 9.2 / 8.6
transforming growth factor beta 1 induced transcript 1 / L22482 / 7.4 / 7.0 / 7.2
Annexin VI / X13460 / 7.2 / 6.8 / 7.0
four and half LIM domain protein 1 / AI839950 / 6.8 / 7.0 / 6.9
TC10-like Rho GTPase / AW121127 / 6.8 / 7.0 / 6.9
Guanine Nucleotide-Binding Protein Gamma-11 Subunit / AI854793 / 6.5 / 6.1 / 6.3
Annexin 8 / AJ002390 / 6.4 / 5.8 / 6.1
hippocalcin-like 1 / AI643393 / 6.1 / 6.1 / 6.1
LIM and SH3 protein 1 / AW122780 / 5.3 / 5.3 / 5.3
Myristoylated alanine rich protein kinase C substrate / M60474 / 5.3 / 5.3 / 5.3
SSeCKS / AB020886 / 5.0 / 5.0 / 5.0
Fyn proto-oncogene / M27266 / 4.9 / 4.5 / 4.7
Phosphatidic acid phosphatase / D84376 / 4.9 / 4.7 / 4.8
retinally abundant regulator of G-protein signaling mRGS-r / U94828 / 4.8 / 4.4 / 4.6
Downstream of tyrosine kinase 1 / U78818 / 4.8 / 4.4 / 4.6
LIM-domain protein LMP-1 / AW125223 / 4.7 / 3.9 / 4.3
receptor activity modifying protein 3 / AJ250491 / 4.7 / 3.7 / 4.2
Type I Inositol-1,4,5-Triphosphate 5-Phosphatase / AA762325 / 4.3 / 4.1 / 4.2
mitogen-responsive phosphoprotein p96 / U18869 / 4.2 / 4.2 / 4.2
rhoC / X80638 / 4.0 / 4.2 / 4.1
calcium/calmodulin-dependent protein kinase II delta / AF059029 / 3.7 / 4.3 / 4.0
non-receptor protein tyrosine kinase Ack / AF037260 / 3.7 / 4.1 / 3.9
guanine nucleotide exchange factor homolog GRP1 / AF001871 / 3.6 / 4.2 / 3.9
calcium-dependent phospholipid binding protein / M72394 / 3.5 / 3.9 / 3.7
TNF intracellular domain-interacting protein / AW061307 / 3.5 / 3.5 / 3.5
modular calcium-binding protein 2 / AA980164 / 3.5 / 3.1 / 3.3
protein kinase WNK1 / AV319920 / 3.5 / 3.1 / 3.3
dickkopf-2 / AJ243963 / 3.4 / 3.2 / 3.3
Tyrosine-Protein Kinase-Like 7 Precursor / AI326889 / 3.4 / 3.2 / 3.3
proteasome (prosome, macropain) 26S subunit / AI835520 / 3.3 / 3.3 / 3.3
Rho-guanine nucleotide exchange factor / U73199 / 3.3 / 3.1 / 3.2
M-Ras / AB004879 / 3.3 / 3.1 / 3.2
SH3 domain-containing protein Lasp-1 / U58882 / 3.2 / 2.8 / 3.0
coatomer protein complex, subunit zeta 2 / AI843212 / 3.1 / 2.9 / 3.0
major vault protein / AI874858 / 3.2 / 2.8 / 3.0
Polycystic kidney disease 2 / AF014010 / 3.1 / 2.9 / 3.0
type II phosphatidylinositolphosphate kinase-alpha / AB009615 / 3.1 / 2.7 / 2.9
integrin binding protein kinase / U94479 / 3.1 / 2.7 / 2.9
neural cell expressed developmentally downregulated Nedd9 / AF009366 / 3.1 / 2.7 / 2.9
tubby like protein 4 / AI848591 / 3.0 / 2.6 / 2.8
Sec14-Like Protein 1 / AI852087 / 3.0 / 2.6 / 2.8
p33 protein; suppressor of ras transformation / X63039 / 3.0 / 2.6 / 2.8
guanine nucleotide binding protein, alpha inhibiting activity polypeptide 1 / AI153412 / 3.0 / 2.4 / 2.7
proline-rich protein 48 / AF020313 / 3.0 / 2.4 / 2.7
binder of Rho GTPase 4 / AI844806 / 2.9 / 2.5 / 2.7
protein kinase inhibitor p58 / U28423 / 2.8 / 2.6 / 2.7
Reticulocalbin / D13003 / 2.8 / 2.6 / 2.7
ceramide glucosyltransferase / D89866 / 2.7 / 2.5 / 2.6
SH3-containing protein SH3P2 / U58888 / 2.7 / 2.5 / 2.6
farnesyl diphosphate synthetase / AW045533 / 2.7 / 2.5 / 2.6
r IL-6 signal transducer (gp130) / X62646 / 2.7 / 2.5 / 2.6
Growth factor receptor bound protein 10 / AF022072 / 2.7 / 2.3 / 2.5
pp90 ribosomal protein S6 kinase 3 / AJ131021 / 2.6 / 2.4 / 2.5
FMS-like tyrosine kinase 4 / L07296 / 2.6 / 2.2 / 2.4
protein kinase, lysine deficient 1 / AI835081 / 2.6 / 2.2 / 2.4
Sec23 homolog A / AI843665 / 2.5 / 2.3 / 2.4
c-Cbl associated protein CAP / U58883 / 2.5 / 2.1 / 2.3
GDP-dissociation inhibitor / L07918 / 2.5 / 2.1 / 2.3
growth factor-inducible immediate early gene / X61940 / 2.4 / 2.2 / 2.3
protein kinase inhibitor p58 / U28423 / 2.4 / 2.0 / 2.2
annexin V / D63423 / 2.3 / 2.1 / 2.2
PFTAIRE protein kinase 1 / AF033655 / 2.3 / 2.1 / 2.2
mitogen- and stress-activated protein kinase-2 / AF074714 / 2.3 / 1.9 / 2.1
Secretory proteins
Cholecystokinin / AF019371 / 155.8 / 68.4 / 112.1
Serum amyloid A 3 / X03505 / 105.9 / 64.5 / 85.2
PRDC / AB011030 / 67.9 / 48.5 / 58.2
Insulin-like growth factor binding protein 5 / L12447 / 51.7 / 31.5 / 41.6
gremlin / AF045801 / 38.8 / 33.4 / 36.1
follistatin / Z29532 / 36.6 / 31.2 / 33.9
small inducible cytokine subfamily B, member 14 / AW120786 / 28.7 / 25.7 / 27.2
cytokine (SDF-1-beta) / AV139913 / 23.8 / 23.4 / 23.6
Small inducible cytokine A7 / X70058 / 23.4 / 21.0 / 22.2
connective tissue growth factor related protein WISP-1 / AF100777 / 22.2 / 22.2 / 22.2
cysteine-rich glycoprotein SPARC / X04017 / 19.2 / 18.4 / 18.8
Inhibin beta-A / X69619 / 18.1 / 16.7 / 17.4
Stromal cell derived factor 1 / L12029 / 16.8 / 16.6 / 16.7
Interleukin 6 / X54542 / 16.8 / 16.6 / 16.7
Fibroblast growth factor 7 / Z22703 / 16.8 / 14.4 / 15.6
insulin-like growth factor binding protein-6 / X81584 / 15.5 / 14.5 / 15.0
Insulin-like growth factor 2 / U04710 / 14.9 / 13.3 / 14.1
Adrenomedullin / U77630 / 14.8 / 13.2 / 14.0
Stromal cell derived factor 1 / L12029 / 13.8 / 12.4 / 13.1
Coagulation factor III / M26071 / 13.1 / 13.1 / 13.1
RNase A family 4 / AI840339 / 12.1 / 12.5 / 12.3
Brain derived neurotrophic factor / X55573 / 10.5 / 11.3 / 10.9
Glypican 4 / X83577 / 9.4 / 8.6 / 9.0
insulin-like growth factor binding protein 4 / AI838737 / 9.1 / 8.5 / 8.8
Small inducible cytokine B subfamily, member 5 / U27267 / 8.0 / 8.2 / 8.1
minopontin / X13986 / 7.8 / 8.0 / 7.9
Retinol binding protein 1 / X60367 / 7.5 / 8.3 / 7.9
Transforming growth factor, beta induced, 68 kDa / L19932 / 7.5 / 8.1 / 7.8
Pentaxin related gene / X83601 / 7.1 / 7.7 / 7.4
neuropilin / D50086 / 6.9 / 6.9 / 6.9
type II hair keratin / AV241614 / 6.2 / 6.2 / 6.2
secreted frizzled related protein sFRP-1 / U88566 / 6.0 / 6.4 / 6.2
Latent transforming growth factor beta binding protein 2 / AF004874 / 5.7 / 4.1 / 4.9
Follistatin-like / M91380 / 4.8 / 3.8 / 4.3
Vascular endothelial growth factor C / U73620 / 4.3 / 3.9 / 4.1
amyloid precursor protein / U82624 / 4.0 / 4.0 / 4.0
Secretory protein SEC23 related gene / D12713 / 3.8 / 4.2 / 4.0
connective tissue growth factor related protein WISP-2 / AF100778 / 3.7 / 4.1 / 3.9
beta-galactoside binding lectin / U55060 / 3.7 / 3.5 / 3.6
stanniocalcin / U47815 / 3.5 / 3.3 / 3.4
macrophage colony-stimulating factor / M21952 / 3.5 / 3.1 / 3.3
Transforming growth factor, beta 3 / M32745 / 3.4 / 3.2 / 3.3
Small inducible cytokine A2 / M19681 / 3.2 / 3.0 / 3.1
secreted acidic cysteine rich glycoprotein / AW214439 / 3.2 / 3.0 / 3.1
monoglyceride lipase / AI846600 / 3.0 / 3.0 / 3.0
Fibroblast inducible secreted protein / M70642 / 2.9 / 2.9 / 2.9
lectin lambda / U56734 / 2.9 / 2.3 / 2.6
GAS 6 mRNA associated with growth-arrest / X59846 / 2.7 / 2.5 / 2.6
Complement component 1 inhibitor / AF010254 / 2.5 / 2.5 / 2.5
Calumenin / U81829 / 2.5 / 2.3 / 2.4
beta-galactoside specific lectin / X15986 / 2.5 / 2.3 / 2.4
extracellular superoxide dismutase / U38261 / 2.4 / 2.0 / 2.2
Transforming growth factor, beta 2 / X57413 / 2.3 / 2.1 / 2.2
Endothelin 1 / U35233 / 2.3 / 2.1 / 2.2

Receptors

Integrin alpha 5 / X79003 / 61.6 / 24.6 / 43.1
transient receptor protein 2 / AI842649 / 23.0 / 15.0 / 19.0
retinoic acid receptor alpha / M60909 / 17.7 / 10.7 / 14.2
Chemokine orphan receptor 1 / AF000236 / 12.4 / 11.2 / 11.8
Platelet derived growth factor receptor, beta polypeptide / X04367 / 11.8 / 10.8 / 11.3
insulin receptor substrate 1 / X69722 / 10.5 / 11.7 / 11.1
semaphorin E / X85994 / 9.7 / 8.9 / 9.3
osteoprotegerin / U94331 / 9.5 / 8.5 / 9.0
Lymphocyte antigen 84 / Y07519 / 8.8 / 5.8 / 7.3
Platelet derived growth factor receptor, alpha polypeptide / M57683 / 7.2 / 6.6 / 6.9
interleukin-4 receptor (secreted form) / M27960 / 6.9 / 5.7 / 6.3