Online appendices to:Primary angioplasty versus thrombolysis for acute ST-elevation myocardial infarction in the UK NHS: an economic analysis of the National Infarct Angioplasty Project.
Appendix 1:Acknowledgements
Principal contacts at NIAP and control sites
LondonChestHospital: Martin Rothman (Interventional cardiologist) Rodney de Palma (Cardiology SpR), Rachel Parke (Cardiac research co-ordinator)
Doncaster Royal Infirmary: Gillian Payne (Consultant cardiologist), Michelle Barratt (Cardiac rehabilitation sister)
DryburnHospital, Durham: MichaelCave (Consultant cardiologist), Julie Close (audit nurse)
HammersmithHospital: Chris Baker (Interventional cardiologist), Irene Arenillas (NIAP audit co-ordinator)
HarefieldHospital: Miles Dalby (Interventional cardiologist), Kylie Rowles (PPCI nurse), Emma Neves (PPCI nurse)
Hull Royal Infirmary: John Caplin (Consultant cardiologist), Lorraine Rowell (cardiology nurse), Marilyn Brown (cardiology nurse)
JamesCookUniversityHospital, Middlesbrough: Jim Hall (Interventional cardiologist), Andrea Moffitt (audit sister), Bob Morley (audit)
KingsCollegeHospital: Martyn Thomas (Interventional cardiologist), Jayne Damm (PPCI nurse)
Leeds General Infirmary: Jim McLenachan (Interventional cardiologist), Claire Priestley (PPCI nurse), Kathryn Somers (PPCI nurse)
Manchester Royal Infirmary: Farzin Fath-Ordoubadi (Interventional cardiologist), Roger Gamon (Primary PCI project manager), Sam Chapman (PPCI nurse)
Northern General hospital, Sheffield. Stephen Campbell (Consultant cardiologist)
Oxford Radcliffe hospitals: Adrian Banning (Interventional cardiologist)
Royal Devon and Exeter hospitals: David Smith (Interventional cardiologist), Sam Tampkins (Research nurse), Cathy Allman (reperfusion nurse)
RoyalLiverpoolUniversity hospital: Mike Fisher (Consultant cardiologist), Rory Cavanagh (cardiology nurse)
Royal Victoria Infirmary, Newcastle: Phil Adams (Consultant cardiologist), Joan Easton (CCU sister)
St Mary’s NHS Trust: Iqbal Malik (Interventional cardiologist), Tina Chan (PPCI nurse), Priscilla Ryder (PPCI nurse)
Wythenshawe hospital: Bernard Prendergast (Interventional cardiologist), Mike Cullen (PPCI nurse), Luke Coleman (audit facilitator)
The following staff for help with providing cost data for the economic evaluation: Rebecca Stevens, Katrina O’Halloran (Doncaster Royal Infirmary), Stephen Stewart (Northern General, Sheffield), Kiki Anne Doran, Caroline Kitchen (Royal Liverpool), Mark Jackson (CTC, Liverpool), Sheila Jamieson (Freeman hospital, Newcastle), Aidan MacDermott, Louise Matthews (Royal Victoria, Newcastle), Colin Evans, Jan Keenan, Alyn Still (John Radcliffe, Oxford), Sarah Bolton (James Cook, Middlesbrough), Claire Priestley (Leeds General Infirmary), Tina Chan, Lee Lewis (St Mary’s, London), Rachel Parke (London chest hospital).
Appendix 2: NIAP hospitals
St Mary’s Hospital, London
HarefieldHospital, London
HammersmithHospital, London
LondonChestHospital (Barts), London
Wythenshawe Hospital, Manchester
Manchester Royal Infirmary, Manchester
Royal Devon and Exeter, Exeter
Leeds General Infirmary, Leeds
JamesCookUniversityHospital, Middlesbrough
Appendix 3: Unit costs
Resource category / Name / Cost / SourceDrugs
Thrombolytic drug / Streptokinase / 81.18 / BNF (2007)
Alteplase / 735 / BNF (2007)
Reteplase / 666.11 / BNF (2007)
Tenecteplase / 612.5 / BNF (2007)
Unfractionated heparin / 4.04 / BNF (2007)
Low molecular weight heparin / Clexane / 21.6 / BNF (2007)
Thienopyridine platelet inhibitor / Clopidogrel / 35.31 / BNF (2007)
Abciximab / Reopro / 781.2 / BNF (2007)
Angiotensin II Receptor Blocker (ARB) / Losartan / 18.09 / BNF (2007)
Bivalirudin / Angiox / 620 / BNF (2007)
Tests
Exercise ECG / 59 / NHS reference costs 2006/7
Echocardiography / 58 / NHS reference costs 2006/7
Radionuclide Study / 312.09 / NHS reference costs 2005/6 inflated by 3% based on price index (Curtis 2007)
Angiography (procedure) / 258.53 / NHS reference costs 2005/6 inflated by 3% based on price index (Curtis 2007)
CABG (episode) / 7976 / NHS reference costs 2006/7
PCI (episode) / 2534 / NHS reference costs 2006/7
Hospital stay
Day on ITU / 990 / NHS reference costs 2006/7
Day on CCU / 450 / NHS reference costs 2006/7
Day on HDU / 657 / NHS reference costs 2006/7
Day on Acute Ward / 223 / NHS reference costs 2006/7 in Curtis (2007)
Day on dialysis / 381 / NHS reference costs 2006/7
Ambulance journeys
Paramedic emergency transfer / 247 / NHS reference costs 2006/7
Staff costs per minute
Cardiologist / 2.53 / Curtis 2007
Nurse / in/out of hours / 0.35/0.52 / Curtis 2007 upgraded by 4.5%
Technician/Radiographer / in/out of hours / 0.42/0.63 / Curtis 2007 upgraded by 4.5%
Catheter lab operating costs per minute / 9.08 / average from NIAPP sites
PPCI consumables
Drug eluting stents / 634.74 / average from NIAP sites
Non drug eluting stents / 216.00 / average from NIAP sites
Diagnostic devices / 659.58 / average from NIAP sites
Procedural devices / 628.59 / average from NIAP sites
Athero-thrombus removal devices / 401.09 / average from NIAP sites
Emboli protection device / 523.11 / average from NIAP sites
Intra-aortic balloon counterpulsation (IABP) / 585.21 / average from NIAP sites
Pacing wire / 92.74 / average from NIAP sites
Arterial puncture management / 55.61 / average from NIAP sites
Sheath / 10.65 / average from NIAP sites
Guide catheter / 21.88 / average from NIAP sites
J wire / 2.25 / average from NIAP sites
Guide wires / 49.50 / average from NIAP sites
Balloon / 73.75 / average from NIAP sites