News in ageing research
Specialized journals:
Experimental Gerontology
Ageing Research Reviews
Mechanisms of Ageing and Development
Journal of Gerontology
Biogerontology
European journal of ageing
International journal of ageing and later life
The internet journal of geriatrics and gerontology
Neurobiology of ageing
Archives of gerontology and Geriatrics
Psychology and Ageing
July 2007- August 2007
Significantly increased lifespan and improved behavioral performances by rAAV gene delivery in adult mucopolysaccharidosis IIIB mice (abstract)
H Fu, L Kang, J S Jennings, S S Moy, A Perez, J DiRosario, D M McCarty & J Muenzer
Gene Ther 2007 14: 1065-1077
Dispatch: C. elegans Aging: Proteolysis Cuts Both Ways (abstract)
Bruce Bowerman
Current Biology, Vol 17, R514-R516
Body composition by the four-compartment model: validity of the BOD POD for assessing body fat in mexican elderly (abstract)
H Alemán-Mateo, R H Huerta, J Esparza-Romero, R O Méndez, R Urquidez & M E Valencia
Eur J Clin Nutr 2007 61: 830-836
Different antioxidant profiles in Italian centenarians: the Sardinian peculiarity (abstract)
M C Polidori, E Mariani, G Baggio, L Deiana, C Carru, G M Pes, R Cecchetti, C Franceschi, U Senin & P Mecocci
Eur J Clin Nutr 2007 61: 922-924
The human we rner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase Neil1 (abstract)
Aditi Das, Istvan Boldogh, Jae Wan Lee, Jeanine A. Harrigan, Muralidhar L. Hegde, Jason Piotrowski, Nadja de Souza-Pinto, William Ramos, Marc M. Greenberg, Tapas K. Hazra, Sankar Mitra, and Vilhelm A. Bohr
J. Biol. Chem. published 3 July 2007
Randomised phase III trial of carboplatin plus etoposide vs split doses of cisplatin plus etoposide in elderly or poor-risk patients with extensive disease small-cell lung cancer: JCOG 9702 (abstract)
H Okamoto, K Watanabe, H Kunikane, A Yokoyama, S Kudoh, T Asakawa, T Shibata, H Kunitoh, T Tamura & N Saijo on Behalf of the Japan Clinical Oncology Group (JCOG)-Lung Cancer Study Group
British Journal of Cancer (2007) 97, 162-169
Chronic treatment with resveratrol induces redox stress- and ATM- dependent senescence in p53-positive cancer cells (abstract)
Elke H. Heiss, Yvonne D.C. Schilder, and Verena M. Dirsch
J. Biol. Chem. published 11 July 2007
Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids (abstract)
Maria Almeida, Li Han, Marta Martin-Millan, Lilian I. Plotkin, Scott A. Stewart, Paula K. Roberson, Stavroula Kousteni, Charles A. O'Brien, Teresita Bellido, A. Michael Parfitt, Robert S. Weinstein, Robert L. Jilka, and Stavros C. Manolagas
J. Biol. Chem. published 10 July 2007
p53 Mediates Senescence-Like Arrest Induced by Chronic Replicational Stress (abstract)
Andriy Marusyk, Linda J. Wheeler, Christopher K. Mathews, and James DeGregori
Mol. Cell. Biol. 2007;27 5336-5351
Trends in oxidative aging theories (abstract)
Florian L. Muller, Michael S. Lustgarten, Youngmok Jang, Arlan Richardson and Holly Van Remmen
Free Radical Biology and Medicine Volume 43, Issue 4, Pages 477-503
Delayed ageing through damage protection by the Arf/p53 pathway (abstract)
Ander Matheu, Antonio Maraver, Peter Klatt, Ignacio Flores, Isabel Garcia-Cao, Consuelo Borras, Juana M. Flores, Jose Viña, Maria A. Blasco & Manuel Serrano
Nature 448, 375-379
Parametric and Regional Maps of Free Serotonin 5HT1A Receptor Sites in Human Brain as Function of Age in Healthy Humans (abstract)
Mette Møller, Steen Jakobsen & Albert Gjedde
Neuropsychopharmacology 2007 32: 1707-1714
Downregulation of Wnt Signaling Is a Trigger for Formation of Facultative Heterochromatin and Onset of Cell Senescence in Primary Human Cells (abstract)
X. Ye, B. Zerlanko, A. Kennedy, G. Banumathy, R. Zhang, and P.D. Adams
Molecular Cell, Vol 27, 183-196
Myostatin Blockade: A New Way to Enhance Skeletal Muscle Repair in Old Age? (abstract)
Zipora Yablonka-Reuveni
Mol Ther 2007 15: 1407-1409
Antagonism of Myostatin Enhances Muscle Regeneration During Sarcopenia (abstract)
Victoria Siriett, Mônica Senna Salerno, Carole Berry, Gina Nicholas, Rob Bower, Ravi Kambadur & Mridula Sharma
Mol Ther 2007 15: 1463-1470
Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis (abstract)
Akiko Taguchi, Lynn M. Wartschow, Morris F. White
Science 20: Vol. 317. no. 5836, pp. 369 - 372
Research Highlight: Neurodegenerative diseases: Age concerns (abstract)
Katherine Whalley
Nature Reviews Neuroscience 8, 572-573
Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age (abstract)
Alex Soltermann, Stephan Koetzer, Franz Eigenmann & Paul Komminoth
Mod Pathol 2007 20: 878-883
FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization (abstract)
Christian Hafner, Arndt Hartmann, Johanna M M van Oers, Robert Stoehr, Ellen C Zwarthoff, Ferdinand Hofstaedter, Michael Landthaler & Thomas Vogt
Mod Pathol 2007 20: 895-903
Molecular chaperones regulate p53 and suppress senescence programs (abstract)
Michael Sherman, Vladimir Gabai, Cornelia O’Callaghan and Julia Yaglom
FEBS Letters Volume 581, Issue 19, Pages 3711-3715
Cellular Senescence in Cancer and Aging (abstract)
Manuel Collado, Maria A. Blasco, and Manuel Serrano
Cell, Vol 130, 223-233
Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress (abstract)
L. Yan, D.E. Vatner, J.P. O'Connor, A. Ivessa, H. Ge, W. Chen, S. Hirotani, Y. Ishikawa, J. Sadoshima, and S.F. Vatner
Cell, Vol 130, 247-258, 27 July 2007
Mitochondrial Fission and Fusion Mediators, hFis1 and OPA1, Modulate Cellular Senescence (abstract)
Seungmin Lee, Seon-Yong Jeong, Won-Chung Lim, Sujeong Kim, Yong-Yea Park, Xuejun Sun, Richard J. Youle, and Hyeseong Cho
J. Biol. Chem. 2007;282 22977-22983
itochondrial Reactive Oxygen Species Trigger Hypoxia-Inducible Factor-Dependent Extension of the Replicative Life Span during Hypoxia (abstract)
Eric L. Bell, Tatyana A. Klimova, James Eisenbart, Paul T. Schumacker, and Navdeep S. Chandel
Mol. Cell. Biol. 2007;27 5737-5745
Normal or stress-induced fibroblast senescence involves COX-2 activity (abstract)
Stéphanie Zdanov, David Bernard, Florence Debacq-Chainiaux, Sébastien Martien, Karo Gosselin, Chantal Vercamer, Fazia Chelli, Olivier Toussaint and Corinne Abbadie
Experimental Cell Research Volume 313, Issue 14, Pages 3046-3056
Anti-angiogenic therapy of exudative age-related macular degeneration: current progress and emerging concepts (abstract)
Agnès Noël, Maud Jost, Vincent Lambert, Julie Lecomte and Jean-Marie Rakic
Trends in Molecular Medicine Volume 13, Issue 8, Pages 345-352
Inhibitory role of RhoA on senescence-like growth arrest by a mechanism involving modulation of phosphatase activity (abstract)
Chaehwa Park, Inkyoung Lee, Jun Ho Jang and Won Ki Kang
FEBS Letters Volume 581, Issue 20, Pages 3800-3804
Vimentin Is the Specific Target in Skin Glycation: STRUCTURAL PREREQUISITES, FUNCTIONAL CONSEQUENCES, AND ROLE IN SKIN AGING (abstract)
Thomas Kueper, Tilman Grune, Stefanie Prahl, Holger Lenz, Vivienne Welge, Tanja Biernoth, Yvonne Vogt, Gesa-Meike Muhr, Astrid Gaemlich, Tobias Jung, Gerrit Boemke, Hans-Peter Elsässer, Klaus-Peter Wittern, Horst Wenck, Franz Stäb, and Thomas Blatt
J. Biol. Chem. 2007;282 23427-23436
Differential Association of Hemoglobin with Proinflammatory High Density Lipoproteins in Atherogenic/Hyperlipidemic Mice: A NOVEL BIOMARKER OF ATHEROSCLEROSIS (abstract)
Junji Watanabe, Katherine J. Chou, James C. Liao, Yunan Miao, Hsiang-Hui Meng, Helen Ge, Victor Grijalva, Susan Hama, Kathy Kozak, Georgette Buga, Julian P. Whitelegge, Terry D. Lee, Robin Farias-Eisner, Mohamad Navab, Alan M. Fogelman, and Srinivasa T. Reddy
J. Biol. Chem. 2007;282 23698-23707
Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury (abstract)
Patrick C H Hsieh, Vincent F M Segers, Michael E Davis, Catherine MacGillivray, Joseph Gannon, Jeffery D Molkentin, Jeffrey Robbins & Richard T Lee
Nature Medicine 13, 970 - 974
Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging (abstract)
Hongjun Liu, Maria M Fergusson, Rogerio M. Castilho, Jie Liu, Liu Cao, Jichun Chen, Daniela Malide, Ilsa I. Rovira, Daniel Schimel, Calvin J. Kuo, J. Silvio Gutkind, Paul M. Hwang, Toren Finkel
Science 10 Vol. 317. no. 5839, pp. 803 - 806
Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis (abstract)
Andrew S. Brack, Michael J. Conboy, Sudeep Roy, Mark Lee, Calvin J. Kuo, Charles Keller, Thomas A. Rando
Science 10 Vol. 317. no. 5839, pp. 807 - 810
Sirtuins: critical regulators at the crossroads between cancer and aging (abstract)
L R Saunders & E Verdin
Oncogene 2007 26: 5489-5504
Partial uncoupling of oxidative phosphorylation induces premature senescence in human fibroblasts and yeast mother cells (abstract)
Petra Stöckl, Christina Zankl, Eveline Hütter, Hermann Unterluggauer, Peter Laun, Gino Heeren, Edith Bogengruber, Dietmar Herndler-Brandstetter, Michael Breitenbach and Pidder Jansen-Dürr
Free Radical Biology and Medicine Volume 43, Issue 6 Pages 947-958
Age, sex and the risk of grade-specific second primary colorectal cancer: Evidence for the protective effect of female hormone (abstract)
Wenbin Liang
European Journal of Cancer Volume 43, Issue 12, Pages 1856-1861
Translational Research in Late-Life Mood Disorders: Implications for Future Intervention and Prevention Research (abstract)
Gwenn S Smith, Faith M Gunning-Dixon, Francis E Lotrich, Warren D Taylor & Jovier D Evans
Neuropsychopharmacology 2007 32: 1857-1875
Defining Hair Follicles in the Age of Stem Cell Bioengineering (abstract)
Cheng-Ming Chuong, George Cotsarelis & Kurt Stenn
J Invest Dermatol 2007 127: 2098-2100
The common biology of cancer and ageing (abstract)
Toren Finkel, Manuel Serrano and Maria A. Blasco
Nature 448, 767-774
Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age (abstract)
Alex Soltermann, Stephan Koetzer, Franz Eigenmann & Paul Komminoth
Mod Pathol 2007 20: 878-883
FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization (abstract)
Christian Hafner, Arndt Hartmann, Johanna M M van Oers, Robert Stoehr, Ellen C Zwarthoff, Ferdinand Hofstaedter, Michael Landthaler & Thomas Vogt
Mod Pathol 2007 20: 895-903
Blood and marrow transplantation in elderly acute myeloid leukaemia patients – older certainly is not better (abstract)
T L Kiss, W Sabry, H M Lazarus & J H Lipton
Bone Marrow Transplant 2007 40: 405-416
Economics: Age, health and wealth (online)
Frances Cairncross
News and Views: Nature 448, 875-876
Transgenerational response to nutrition, early life circumstances and longevity (abstract)
Gunnar Kaati, Lars Olov Bygren, Marcus Pembrey & Michael Sjöström
Eur J Hum Genet 2007 15: 784-790
Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis (abstract)
Josine L Min, Ingrid Meulenbelt, Margreet Kloppenburg, Cornelia M van Duijn & P Eline Slagboom
Eur J Hum Genet 2007 15: 791-799
Busulphan is safe and efficient treatment in elderly patients with essential thrombocythemia (abstract)
L Shvidel, E Sigler, M Haran, A Klepfish, A Duek, A Berrebi & M Shtalrid
Leukemia 2007 21: 2071-2072
Radiation-induced senescence-like phenotype in proliferating and plateau-phase vascular endothelial cells (abstract)
Kaori Igarashi, Ippei Sakimoto, Keiko Kataoka, Keisuke Ohta and Masahiko Miura
Experimental Cell Research Volume 313, Issue 15, Pages 3326-3336
Research Highlight: Ageing: Getting old and cancer: hand-in-hand? (abstract)
Gemma Alderton
Nature Reviews Cancer 7, 641
Nature Reviews Molecular Cell Biology presents a special Focus that highlights the latest advances in our understanding of ageing at the molecular and cellular level, and how this translates to organismal ageing. In addition, experts Lenny Guarente, Cynthia Kenyon and David Sinclair discuss the promise and the challenges of this fast-moving field in the accompanying Podcast.
To access the Focus content and download the Podcast, visit:
Evidence for the association of the S100bold italic beta gene with low cognitive performance and dementia in the elderly (abstract)
J-C Lambert, S Ferreira, J Gussekloo, L Christiansen, G Brysbaert, E Slagboom, D Cottel, T Petit, J-J Hauw, S T DeKosky, F Richard, C Berr, C Lendon, M Ilyas Kamboh, D Mann, K Christensen, R Westendorp & P Amouyel
Mol Psychiatry 2007 12: 870-880
Properties, regulation and in vivo functions of a novel protein kinase D: C. elegans DKF-2 links diacylglycerol second messenger to the regulation of stress responses and lifespan (abstract)
Hui Feng, Min Ren, Lu Chen, and Charles S. Rubin
J. Biol. Chem. published 29 August 2007