Name: Mohamed Taky El Din Khayyal

Name: Mohamed Taky El Din Khayyal

CURRICULUM VITA

Name: Mohamed Taky El Din Khayyal

Born on: 26 October 1937in Cairo, Egypt

Scientific Degrees: B.Pharm., Alexandria University, 1958

Ph.D. (Pharmacology), LondonUniversity, 1964

Previous Positions:

  • Demonstrator in Pharmacology, Faculty of Medicine, CairoUniversity, from Nov. 58
  • Lecturer in Pharmacology, Faculty of Pharmacy, CairoUniv., from Nov. 65
  • Associate Prof. of Pharmacology, Faculty of Pharmacy, CairoUniv., from Jan. 71
  • Prof. of Pharmacology, Faculty of Pharmacy, CairoUniversity, from 76
  • Head of Pharmacology Dept., Faculty of Pharmacy, CairoUniversity, from Nov.76 to March 79 and from March 87 to March 93
  • Vice-Dean for Student Affairs, Faculty of Pharmacy, CairoUniv., March 81 to Feb.87

Present Posts:

  • Emeritus Professor of Pharmacology, Faculty of Pharmacy, CairoUniversity.
  • Academic Councillor for Pharmacy and Biotechnology, GermanUniversity in Cairo.
  • President, Egyptian Society of Pharmacology and Experimental Therapeutics

Scholarships & Fellowships held:

  • EgyptianState scholarship to study for Ph.D., Oct.1959 - March 1965
  • International Atomic Energy Agency, Vienna, Austria, 1973
  • Alexander von Humboldt Foundation, Germany, 1978
  • Fulbright Fellowship, USA, 1987

Scientific Affiliations:

  • Councillor, Executive Committee of International Union of Pharmacology (IUPHAR) 2002 – 2010.
  • Active member of the British Pharmacological Society
  • Active member of the German Pharmacological Society
  • Active member of Society of Medicinal Plant Research (GA).
  • Active member of German Society for Neurogastroenterology and Motillity.
  • Active member of the Egyptian Pharmaceutical Society
  • Active member of the Egyptian Toxicology Society

Scientific Publications and Interests:

Over 90 scientific publications in national and international journals (see attached list), over 70 of which are cited in Pubmed. The following are the major fields of interest:

# chemotherapy of schistosomiasis.

# inflammation.

# bronchial asthma.

# autonomic pharmacology.

# effects of radiation exposure.

# natural products & herbal medicine

Foreign Languages

Fluent in spoken and written English, German and French, apart from Arabic mother tongue.

Teaching Experience

  • Teaching undergraduate and postgraduate students in Pharmacology for over 45 years at Cairo University.
  • Helping to develop and modernise Pharmacology curricula at the Faculty of Pharmacy, CairoUniversity, as well as in some Arab countries (Aleppo, Syria and Amman, Jordan).
  • Attending international seminars on Pharmacology teaching at IUPHAR Conferences.
  • Changing lecture-based teaching to problem-solving teaching and adapting student evaluation to that effect.

Activities related to IUPHAR

  • Suggested reduction of dues of Third World countries to IUPHAR Conferences. Suggestion was approved and adopted.
  • Helped to organise First IUPHAR Workshop on Clinical Pharmacology in the Arab World. Workshop was successfully held in Alexandria in February 2004-08-27.
  • Actively participated in Executive Committee meetings since joining it in 2002.
  • Is actively involved in promoting IUPHAR objectives in Arab and African countries.
  • Has contributed articles in Pharmacology International related to IUPHAR activities.

Activities in NGOs

  • Active Rotarian since 1985
  • Member of Egyptian Council for Foreign Affairs

LIST OF PUBLICATIONS

M.T.KHAYYAL

  1. Rapid hepatic shift of worms in mice infected with Schistosoma mansoni after a single injection of tartar emetic.

Buttle, G.A.H., Khayyal, M.T.

Nature, 194, 780-781, (1962).

  1. Über die Einwirkung von Antimonverbindungen auf die Würmer von Schistosoma mansoni.

Khayyal, M.T.

Naunyn-Schmied.Arch.exp.Path.Pharmak., 247, 386, (1964)

  1. The effects of antimony uptake on the location and pairing of Schistosoma mansoni.

Khayyal, M.T.

Brit.J.Pharmacol., 22, 343-348, (1964)

4. Significance of worm shifts in experimental schistosomiasis mansoni, with emphasis on the action of anaesthetics.

Khayyal, M.T.

Nature, 205, 1331-1332, (1965)

5. The effects of multiple doses of antimonials in Schistosoma mansoni infection.

Khayyal, M.T.

Bull.Wld.Hlth.Org., 33, 547-551, (1965).

6. Treatment of intestinal bilharziasis with antimonials : The possible use of dimercaprol as an adjuvant to therapy.

Khayyal, M.T.

Bull.Wld.Hlth.Org., 33, 589-591, (1965).

7. The use of penicillamine as an adjuvant to tartar emetic in the treatment of experimentalschistosomiasis.

Khayyal, M.T., Girgis, N.I., McConnell, E.

Bull.Wld.Hlth.Org., 37, 387-392, (1967).

  1. The possible inactivation of antimony by schistosomes.

Khayyal, M.T., Girgis, N.I., McConnell, E.

Ann.trop.Med.Parasit., 62, 74-80, (1968).

  1. The influence of the vehicle on the action of tartar emetic in experimental schistoso-

miasis.

Girgis, N.I., Khayyal, M.T., McConnell, E.

J.Egypt.Publ.Hlth.Assoc., 44, 209-216, (1969).

  1. Comparison of the chemotherapeutic potencies of 4 antimonial drugs.

Khayyal, M.T.

Bull.Wld.Hlth.Org., 40, 959-963, (1969)

  1. Effectiveness of a single dose of hycanthone orally in experimental schistosomiasis in

hamsters.

Khayyal, M.T., Girgis, N.I., Henry,W.

Bull.Wld.Hlth.Org., 40, 963-965, (1969).

12. Activity of antimony dextran glycoside (RL-712) against visceral leishmaniasis in the

hamster.

Mikhail, J.W., Khayyal, M.T., Girgis, N.I.

Bull.Wld.Hlth.Org., 40, 327-328, (1969)

  1. Effect of acetylsalicylic acid and phenylbutazone on glucose absorption in vitro.

Saleh, S., Khayyal, M.T., El-Masri, A.M., Ghazal, M.A.

Metabolism, 18, 599-605, (1969).

  1. Influence of reserpine and guanethidine on the chronotropic effect of sympathomimetics on isolated rat atria.

El-Hawary, M.B., Khayyal, M.T., Abdel-Wahed, S., Helmy, R., Ishaac, Z.

Arch.Intern.Pharmacodyn.Ther., 182, 279-286, (1969).

  1. Penicillamine as an adjuvant to antimonial therapy. Effect on electrocardiographic

changes in dogs.

Girgis, N.I., Khayyal, M.T., McConnell, E., Norton,J.

E.Afr.Med.J., 47, 1-6, (1970).

  1. The value of glucosamine in increasing the efficacy of tartar emetic in experimental

schistosomiasis.

Girgis, N.I., Mansour, N.S., Khayyal, M.T., Henry, W.

J.Egypt.Publ.Hlth., XLVII, 81-87, (1972).

  1. Penicillamine as an adjuvant to antimonial therapy of schistosomiasis : effect on liver

function tests in rabbits and on antischistosomal activity.

Khayyal, M.T., Saleh, S., El-Masri, A.M.

Bull.Wld.Hlth.Org., 48, 415-420, (1973).

  1. Studies on the effect of oral hypoglycaemic agents on hepatic glycogenolysis.

Saleh, S., Abddel-Khalek, A., Sharaf, A.A., Khayyal, M.T., El-Masri, A.M.

Pharmacol.Res.Comm., 6, 539-550, (1974).

  1. A sensitive method for the bioassay of acetylcholine.

Khayyal, M.T., Tolba, H.M., El-Hawary, M.B., Abdel-Wahed, S.

Europ.J.Pharmacol., 25, 287-290, (1974).

  1. Pharmacological study of the effects of some oral contraceptive drugs on certain aspects of carbohydrate metabolism in normal rats.

Khayyal, M.T., El-Sayed, M.E., Ahmed, H.M.S., Ata, M.M.

Egypt.J.Pharm.Sci., 16, 197-203, (1975).

21. Effect of fluphenazine on tissue noradrenaline concentrations and its interaction with

pargyline.

El-Azhary, R., Khayyal, M.T., Saleh, S.

Brit.J.Pharmacol., 53, 593-595, (1975).

22. Leishmania donovani : Therapeutic and prophylactic action of antimony dextran

glycoside (RL-712) in the golden hamster.

Mikhail, J.W., Mansour, N.S., Khayyal, M.T.

Exp.Parasit., 37, 348-352, (1975).

23. Desipramine pargyline interaction.

Saleh, S., Khayyal, M.T., El-Azhary, R.

Egypt.J.Pharm.Sci., 16, 25-34, (1975)

24. Comparative study of the effect of neostigmine, trimetaphan and oxyphenonium on some aspects of 5-hydroxytryptamine metabolism in rats.

Kenawy, S.A., El-Masri, A.M., Saad, S.F., Khayyal, M.T., Abdel-Aziz, M.T.

J.Pharm.Pharmacol., 27, 871-873, (1975).

25. A study into the nature of the autonomic receptors of the human Fallopian tube and thepossible role of pprostaglandins.

Fayad, M., El-Hawary, M.B., Khayyal, M.T., Abdel-Wahed, S.A., Shaban, H.A.

J.Egypt.Soc.Obst.Gyn., 1, 11-17, (1975).

26. The effect of potassium antimonyl tartrate on the gamma amino butyric acid and acetylcholine contents in the cerebral hemispheres of normal and Schistosoma mansoni infected mice.

Samaan, S.S., Galal, E.E., Khayyal, M.T., Saad, S.F.

J.Pharm.Pharmacol., 28, 379-384, (1976).

27. The effect of cysteine on the hepatic toxicity and antischistosomal activity of antimonyl potassium tartrate.

Saleh, S., Khayyal, M.T.

Bull.Wld.Hlth.Org., 53, 379-384, (1976).

28. Adrenergic responses of the rabbit stomach serosal strip and their modifications by mono amine oxidase inhibitors and antiadrenergic drugs.

Khayyal, M.T., Tolba, H., Hawary, M.B.

J.Pharm.Pharmacol., 28, 489-492, (1976)

29. Effect of antischistosomal drugs on some aspects of carbohydrate metabolism in mice.

Saleh, S., Abdel-Aziz, M.T., El-Sayed, H.M., Khayyal, M.T.

Pharmacol.Res.Commun., 8, 359-368, (1976).

30. Effect of niridazole on the lipid pattern of the parasite and host tissues in experimentalschistosomiasis mansoni.

Khayyal, M.T., Mousa, A.H., Saleh, S., Abo-Hashish, M.A., Metwally, A.A.

Egypt.J.Bilh., 4, 89-96, (1977).

31. Effect of oral contraceptives on carbohydrate metabolism in alloxan diabetic rats.

Khayyal, M.T., El-Sayed, M.E., Ahmed, H.M.S., Ata, M.M.

J.Egypt.Med.Assoc., 60, 625-632, (1977).

32. Action of oral contraceptive drugs on protein metabolism in rats.

Khayyal, M.T., El-Sayed, M.E., Ahmed, H.M.S., Ata, M.M.

J.Egypt.Med.Assoc., 60, 633-638, (1977).

33. The effect of gamma irradiation on the biological activity of the local anaesthetic, pri-

locaine hydrochloride.

Saad, S.F., Khayyal, M.T., Roushdy, H.M., Chaban, E.A.

IRCS Med.Sci.Biomed.Techn.Endocr.Syst.Pharmacol., 5, 314, (1977).

34. Changes in biological activity of dexamethasone sodium hemisulphate after irradiation sterilization.

Khayyal, M.T., Saad, S.F., Roushdy, H.M., Abdel-Aziz, A.H.

IRCS Med.Sci.Biomed.Techn.Endocr.Syst.Pharmacol., 5, 315, (1977).

35. The effect of sterilization on the biological activiity of testosterone propionate.

Saad, S.F., Khayyal, M.T., Roushdy, H.M., Amer, A.G.

IRCS Med.Sci.Biomed.Techn.Endocr.Syst.Pharmacol., 5, 316, (1977).

36. The effect of ascorbic acid, inositol hexanicotinate and clofibrate treatment on experi-

mental atherosclerosis in rabbits.

Kheir-El-Din, A.A., Khayyal, M.T., El-Adle, N.M., Farid, F., Abdalla, W.A.

Egypt.J.Pharm.Sci., 18, 115-125, (1977).

37. Penicillamine as an adjuvant to antimonial therapy in schistosomiasis : Effect on the

lipid pattern of parasites and host.

Khayyal, M.T., Saleh, S., Metwally, A.A., Mousa, A.H.

Egypt.J.Bilh., 4, 149-156, (1977).

38. Influence of piperazine diantimonyl tartrate on -amino butyric acid and acetylcholine

contents of the cerebral hemispheres of normal and Schistosoma mansoni infected mice.

Galal, E.E., Khayyal, M.T., Saad, S.F., Samaan, S.S.

J.Drug Res.Egypt, 9, 167-180, (1977).

39. The antagonism of the analgesic effect of dipyrone by l-DOPA and its relation to brain amine concentrations.

Khayyal, M.T., Samaan, H.A., Galal, E.E.

J.Pharm.Pharmacol., 30, 195-196, (1978).

40. Studies on the effect of oral hypoglycaemic agents on amino acid metabolism in the liver.

Abdel-Khalek, A., Saleh, S., Sharaf, A.A., Khayyal, M.T., El-Masri, A.M.

J. Egypt. Med. Assoc. 61, 11-22, (1978)

41. Effect of prolonged administration of oral contraceptives and psychotropic drugs on

some ovarian adrenocortical functions.

Abdel-Aziz, M.T., Kheir-El-Din, A.A., Khayyal, M.T., Saad, S.F., Aly, M.H.M.

J.Egypt.Med.Assoc., 61, 703-709, (1978).

42. Biochemical effects of niridazole. I. In vitro and in vivo effect of niridazole on the rate ofgluconeogenesis and oxidation of pyruvate and some Krebs cycle intermediates in mice.

Sharaf,A.A., Khayyal,M.T., Kheir-El-Din, A.A., Sharaf,A.A., Kassem, F.

Egypt.J.Bilh., 5, 49-57, (1978).

43. Biochemical effects of niridazole. II. In vitro and in vivo effects of niridazole on the rate of gluconeogenesis and oxidation of pyruvate and some Krebs cycle intermediates in

Schistosoma mansoni infected mice.

Sharaf, A.A., Khayyal, M.T., Kheir-El-Din, A.A., Sharaf, A.A., Kassem, F.

Egypt.J.Bilh., 5, 56-69, (1978).

44. Effect of hycanthone and niridazole on cholinesterase levels in experimental schistosomiasis.

Hanna, S.K., Khayyal, M.T., Saleh, S., Farid, F., Abdallah, W.A.

Egypt.J.Bilh., 5, 101-112, (1978).

45. Effect of some antimonial drugs on cholinesterase and serum protein levels in experimental schistosomiasis.

Saleh, S., Khayyal, M.T., Hanna, S.K., Nasr, A.A., Farid, F., Abdallah, W.A.

Arab.J.Lab.Med., 4, 71-83, (1978).

46. Serum glycoprotein, lipoprotein and protein patterns in schistosomiasis mansoni beforeand after therapy.

Saber, M.A., Khayyal, M.T., Saleh, S., Ebeid, F.

Arab.J.Lab.Med., 5, 47-55, (1979).

47. The effect of nicotine on certain aspects of 5-hydroxytryptamine metabolism in rats.

Kenawy, S.A., El-Masry, A.M., Saad, S.F., Khayyal, M.T., Abdel-Aziz, M.T.

J.Drug Res.Egypt, 11, 161-165, (1979).

48. Effect of oxamniquine on host hepatic and plasma lipids in experimental schistoso-

miasis.

Khayyal, M.T., Kheir-El-Din, A.A., Sayed Ahmed, H.M., Saleh, S., Zein El-

Abdin,A., Metwally, A.A.

J.Egypt.Med.Assoc., 63, 41-49, (1980).

49. Effect of oxamniquine on the lipid pattern of female and male S.mansoni worms in vivo.

Khayyal, M.T., Kheir-El-Din, A.A., Saleh, S., Sayed Ahmed, H.M., Zein El-

Abdin, A., Roshdi, M.Z., Metwally, A.A.

J.Egypt.Med.Assoc., 63, 195-204, (1980).

50. A study of the changes in amino acid composition of serum in S.mansoni infected mice before and after treatment with oxamniquine and tartar emetic.

Khayyal, M.T., Saleh, S., Saber, M.A., Ebeid, F.A.

Egypt.J.Bilh., 7, 61-71, (1980).

51. The immunological aspects of praziquantel in unsensitized mice with experimentally

induced schistosome pulmonary granuloma.

Botros, S.S., Metwally, A.A., Khayyal, M.T.

Trans.Roy.Soc.Trop.Med.Hyg., 78, 569-572, (1984).

52. Effect of exposure to radiation on the inflammatory process and its influence by diclofenac.

El-Ghazaly, M., Kenawy, S., Khayyal, M.T., Roushdy, H., Saleh, S.

Br.J.Pharmac., 85, 45-50, (1985).

53. Reversal of hepatic fibrosis after praziquantel therapy of murine schistosomiasis.

Morcos, S.H., Khayyal, M.T., Mansour, M.M., Saleh, S., Ishak, N.I., Girgis, N.I.,

Dunn, M.A.

Amer.J.Trop.Med.Parasit., 34, 314-321, (1985).

54. Study on some immunopharmacological properties of praziquantel in experimental

schistosomiasis mansoni.

Botros, S.S., El-Badrawy, N., Metwally, A.A., Khayyal, M.T.

Ann.Trop.Med.Parasit., 80, 189-196, (1986).

55. The protective value of piroxicam on the enhanced inflammatory response after wholebody irradiation.

El-Ghazaly, M., Saleh, S., Kenawy, S., Roushdy, H.M., Khayyal, M.T.

Pharm.Res.Commun., 18, 563-580, (1986).

56. Effect of praziquantel on the cardiotonic action of cardiac glycosides.

Khayyal, M.T., Saleh, S., Schlieper, P., Tawfik, H.

Arch.Int.Pharmacodyn., 286, 85-96, (1987).

57. Comparative effect of tiaprofenic acid and piroxicam alone and as adjuvants to anti-

bilharzial therapy on pulmonary granuloma in unsensitized mice.

Botros, S.S., Metwally, A.A., Khayyal, M.T.

Int.J.Immunopharmac., 10, 601-607, (1988).

58. Radiation exposure and the effect of piroxicam and diclofenac on mediator release from isolated guinea-pig lung.

Khayyal, M.T., Roushdy, H., Saleh, S., El-Ghazaly, M., Kenawy, S., El-Mazar,

M.A.

Arch.Int.Pharmacodyn.Ther., 298, 247-263, (1989).

59. Effect of schistosomiasis infection on the clearance of phenazone in mice.

Metwally, A.A., Janku, I., Kemper, F., Khayyal, M.T., Ebeid, F.A., Botros, S.S.

Arzneim.-Forsch./Drug Res., 40, 206-209, (1990).

60. Schistosoma mansoni : Angiotensin converting enzyme activity in mice under the in-

fluence of praziquantel and/or captopril.

Khayyal, M.T., Saleh, S., Metwally, A.A., Botros, S.S., Mahmoud, M.R.

Exp.Parasit., 73, 117-126, (1991).

61. Study of the antiinflammatory activity of Populus tremula, Solidago virgaurea and

Fraxinus excelsior.

El-Ghazaly, M., Khayyal, M.T., Okpanyi, S.N., Arens-Correl, M.

Arzneim.-Forsch./Drug Res., 42, 333-336, (1992).

62. Evaluation of hepatic fibrosis after therapy of murine schistosomiasis.

Morcos, S.H., Mansour, M.M., Khayyal, M.T., Saleh, S., Ishak, E.A., Girgis, N.I.

Ann.Trop.Med.Parasit., 86, 511-516, (1992).

63. Hyperthermic potentiation of cisplatin cytotoxicity on solid Ehrlich carcinoma.

Osman, A.M., Sayed Ahmed, M.M., Khayyal, M.T., El-Merzabani, M.M.

Tumori, 79, 268-272, (1993).

64. Flavone derivatives isolated from Artemisia herba alba have affinity to brain benzo-

diazepine receptors and  adrenergic receptors in vitro.

Shen, X., Witt, M.R., Nielsen, M., Bergendorff, O., Sterner, O., Khayyal, M.T.,

El-Alfy, T.S., El-Gohary, H.

Chinese Journal of Pharmacology and Toxicology, 7(4), 305-306, (1993).

65. Inhibition of leukotriene release by mofebutazone : a possible clinical advantage.

Khayyal, M.T., El-Khatib, A.S., El-Ghazaly, M., Hatem, A.

Int.J.Clin.Pharm.Res., XIII, 255-261, (1993).

66. Mechanisms involved in the antiinflammatory effect of propolis extract.

Khayyal, M.T., El-Ghazaly, M.A., El-Khatib, A.S.

Drugs Exptl.Clin.Res., XIX, 197-203, ( 1993).

67. Inhibition of (methyl-3H) diazepam binding to rat brain membranes in vitro by diatin and skrofulein.

Shen, X.L., Nielsen,M., Witt,M.R., Sterner,O., Bergendorff,O., Khayyal,M.T.

Acta Pharmacol. Sinica 15, 385-388, (1994).

68. The use of aqueous propolis extract against radiation-induced damage.

El-Ghazaly, M.A., Khayyal, M.T.

Drugs Exptl.Clin.Res., XXI, 229-236, (1995).

  1. The influence of carbon tetrachloride induced liver damage on the inflammatory reaction elicited by carrageenan and its treatment with diclofenac.

Agha, A.M., El-Khatib, A.S., Kenawy, S.A., Khayyal, M.T.

Pharmacol.Res., 32, 75-84, (1995).

70. Tolerability of mofebutazone in asthmatic patients.

Khayyal, M.T., El-Ghazaly, M.A., El-Khatib, A.S., Hatem, A.

Int.J.Clin.Pharm.Res., XV, 145-151, (1995).

71. The protective effect of aqueous propolis extract on isolated rat hepatocytes against carbon tetrachloride toxicity.

Mahran, L.G., El-Khatib, A.S., Agha, A.M., Khayyal, M.T.

Drugs Exptl.Clin.Res., XXII, 309-316, (1996).

  1. Influence of certain calcium-channel blockers on some aspects of lorazepam-dependence in mice.

Saad, S.F., Khayyal, M.T., Attia, A.S., Saad, E.S.
J.Pharm.Pharmacol. 49, 322-328, (1997).

73. Effect of magnesium pyridoxal 5-phosphate glutamate on vascular reactivity in experimental hypercholestrolaemia.

Khayyal, M.T., Khayyal, M.A., Sharaf, H.M., El-Sherbeeny, M., Okpanyi, S.N.,

Schneider, W.

Drugs Exptl.Clin.Res., XXIV, 29-40, (1998).

74. The possible "chondroprotective" effect of the unsaponifiable constituents of avocado and soya in vivo.

Khayyal, M.T., El-Ghazaly, M.A.

Drugs Exptl.Clin.Res., XXIV, 41-50, (1998).

75. Antiulcerogenic effect of some gastrointestinal acting plant extracts and their combination

Khayyal, M.T., El-Ghazaly, M.A., Kenawy, S.A., Seif-El-Nasr, M., Mahran, L.G.,Kafafi, Y.A.H., Okpanyi, S.N.

Arzneimittel-Forsch., 7, 545 -553, (2001).

76. Prophylactic effect of aqueous propolis extract against acute experimental hepatotoxicity in vivo.

El-Khatib, A.S., Agha, A.M., Mahran, L.G., Khayyal, M.T.

Z.Naturforsch., 57c, 379-385, (2002).

77. The blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats.

Khayyal, M.T., El-Ghazaly, M.A., Abdallah, D.M., Nassar, N.N., Okpanyi, S.N.,

Kreuter,M.H.

Arzneimittel-Forsch., 52, 797-802, (2002).

78. A clinical pharmacological study of the potential beneficial effects of a propolis food

product as an adjuvant in asthmatic patients.

Khayyal, M.T., El-Khatib, A.S., El-Ghazaly, M.A., Hatem, A.M., De Vries,

P.J.F., El-Shafei, S., Khattab, M.M.

Fundamental and Clinical Pharmacology, 17, 93-102, (2003)

79. Mechanisms involved in the anti-inflammatory effect of a standardized willow bark

extract.

Khayyal, M.T., El-Ghazaly, M.A., Abdallah, D.M., Okpanyi, S.N., Kelber,O.,

Weiser, D.

Arzneimittel-Forsch.,55, 677-687, (2005).

80. Mechanisms involved in the gastro-protective effect of STW 5 (Iberogast®) and its components against ulcers and rebound acidity.

Khayyal, M.T., Seif-El-Nasr, M., El-Ghazaly, M.A., Okpanyi, S.N., Kelber, O.,

Weiser, D.

Phytomedicine, 2006;13 Suppl 5:56-66

81. Willow bark extract: the contribution of polyphenols to the overall effect.

Nahrstedt A, Schmidt M, Jäggi R, Metz J, Khayyal MT.

Wien Med Wochenschr. 2007;157(13-14):348-51.

82. Solanum indicum ssp. distichum extract is effective against L-NAME-induced hypertension in rats.

Bahgat A, Abdel-Aziz H, Raafat M, Mahdy A, El-Khatib AS, Ismail A, Khayyal MT.

Fundam Clin Pharmacol. 2008 Dec;22(6):693-9

83. Effect of methimazole treatment on doxorubicin-induced cardiotoxicity in mice.

Osman AM, Nemnem MM, Abou-Bakr AA, Nassier OA, Khayyal MT.

Food Chem Toxicol. 2009 Oct;47(10):2425-30

84. The effects of celecoxib, a COX-2 selective inhibitor, on acute inflammation induced in irradiated rats.

Khayyal MT, El-Ghazaly MA, El-Hazek RM, Nada AS.

Inflammopharmacology. 2009 Oct;17(5):255-66

85. Effect of an herbal preparation, STW 5, in an acute model of reflux oesophagitis in rats.

Abdel-Aziz H, Zaki HF, Neuhuber W, Kelber O, Weiser D, Khayyal MT.

J Pharmacol Sci. 2010;113(2):134-42.

86. Effect of selective COX-2 inhibitor, celecoxib on adjuvant-induced arthritis model in irradiated rats.

El-Ghazaly MA, Nada AS, El-Hazek RM, Khayyal MT.

Int J Radiat Biol. 2010 Dec;86(12):1079-87

87. The influence of irradiation on the potential chondroprotective effect of aqueous extract of propolis in rats.

El-Ghazaly MA, El-Naby DH, Khayyal MT.

Int J Radiat Biol. 2011 Mar;87(3):254-62.

88. Ginkgo biloba extract (EGb 761) normalizes hypertension in 2K, 1C hypertensive rats: role of antioxidant mechanisms, ACE inhibiting activity and improvement of endothelial dysfunction.

Mansour SM, Bahgat AK, El-Khatib AS, Khayyal MT.

Phytomedicine. 2011 Jun 15;18(8-9):641-7.

89. Anti-ulcerogenic effect of aqueous propolis extract and the influence of radiation exposure.

El-Ghazaly MA, Rashed RR, Khayyal MT.

Int J Radiat Biol. 2011 Oct;87(10):1045-51.

90. STW 5 is effective in dextran sulfate sodium-induced colitis in rats.

Wadie W, Abdel-Aziz H, Zaki HF, Kelber O, Weiser D, Khayyal MT.

Int J Colorectal Dis. 2012 Nov;27(11):1445-53.

91. Antidiabetic effects of a standardized Egyptian rice bran extract.

Kaup RM, Khayyal MT, Verspohl EJ.

Phytother Res. 2013 Feb;27(2):264-71.