SUPPLEMENTAL TABLE 1 Example of the tabulation of a study result

Reference / (Zemel & Sun, 2008) 1
Subject category / MET
Target indication / Oxidative stress and inflammation
Target population / Obese subjects
Fat content / Low-fat
Fermentation / Fermented
Test product / Yoghurt
Control product / Sugar-free, calcium-free gelatin dessert
Test subjects / 13 F, 5 M / 39±10 y / obese
Control subjects / 14 F, 2 M / 42±6 y / obese
Diet / 3x6 oz yoghurt, including a caloric deficit of 500 kcal/d / 12 weeks
Controlled dairy test / Yes
Randomization / Randomized
Time factor / Longitudinal
Study results / 1Yoghurt (high Ca) vs control (low Ca): CRP ↓; adiponectin ↑
Net change in IM / 2
Sustainibility of effect over time / Not discussed
Dose-response / No
Bioavailibility data / Not discussed
Biological plausibility / Discussed - Ca signaling, ROS, angiotensin-converting enzyme, fat oxidation, energy utilisation
Bioactive components / Investigated - calcium
Clinical evidence / Yes - yoghurt improves fat loss
Financing of research / Private
Grading criteria / Anti, 1, 2, 3, 4, 5, 6, 7, 10, 11
IS / 10

Initial grading Anti (+1)

Incremental grading

(1)  Controlled study with dairy as test product: Yes (+1)

(2)  Randomized study: Yes (+1)

(3)  Longitudinal study: Yes (+1)

(4)  The dairy product is not solely measured as part of a dietary pattern: Yes (+1)

(5)  More than two IM changed: Yes (+1)

(6)  At least one IM was measured in vivo (and not ex vivo): Yes (+1)

(7)  The change in IM was measured over more than 12h, e.g. not postprandially: Yes (+1)

(8)  The effect is still measured after a washout period of at least one week: No

(9)  A dose-response is demonstrated with the dairy product: No

(10) Bioactive molecules or the biological plausibility have been convincingly investigated: Yes (+1)

(11) A clinical endpoint is changed that can be related to a metabolic dysregulation associated with inflammation: Yes (+1)

Inflammatory Score 10

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